m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00774)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SOCS1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Fat mass and obesity-associated protein (FTO) [ERASER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Mechanistically, the FTO/Suppressor of cytokine signaling 1 (SOCS1)/JAK-STAT axis promotes diabetic kidney disease(DKD) pathogenesis via promoting inflammation. Moreover, FTO expression is significantly decreased in DKD, and overexpression of FTO can dramatically alleviate kidney inflammation. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Chronic kidney disease | ICD-11: GB61.Z | ||
Pathway Response | JAK-STAT signaling pathway | hsa04630 | ||
In-vitro Model | HEK293T | Normal | Homo sapiens | CVCL_0063 |
hMC | Normal | Homo sapiens | CVCL_9Q61 | |
HK-2 [Human kidney] | Normal | Homo sapiens | CVCL_0302 | |
In-vivo Model | FTO over-expression db/db mice were generated through injecting the tail vein with Fto-overexpression lentivirus at 12 weeks. | |||
Methyltransferase-like 3 (METTL3) [WRITER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [2] | |||
Response Summary | METTL3 knock-down experiment revealed that expressions of SOCS family members Suppressor of cytokine signaling 1 (SOCS1), SOCS2, SOCS4, SOCS5, and SOCS6 were increased after METTL3 knock-down. It indicated that METTL3 is involved in the development of Graves' disease (GD) by inducing mRNA m6A methylation modification of SOCS family members. | |||
Target Regulation | Down regulation | |||
Responsed Disease | Graves disease | ICD-11: 5A02.0 | ||
In-vitro Model | PBMCs (Human peripheral blood mononuclear cells (PBMCs) are isolated from peripheral blood and identified as any blood cell with a round nucleus) | |||
Thyrotoxicosis [ICD-11: 5A02]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [2] | |||
Response Summary | METTL3 knock-down experiment revealed that expressions of SOCS family members Suppressor of cytokine signaling 1 (SOCS1), SOCS2, SOCS4, SOCS5, and SOCS6 were increased after METTL3 knock-down. It indicated that METTL3 is involved in the development of Graves' disease (GD) by inducing mRNA m6A methylation modification of SOCS family members. | |||
Responsed Disease | Graves disease [ICD-11: 5A02.0] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Down regulation | |||
In-vitro Model | PBMCs (Human peripheral blood mononuclear cells (PBMCs) are isolated from peripheral blood and identified as any blood cell with a round nucleus) | |||
Chronic kidney disease [ICD-11: GB61]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | Mechanistically, the FTO/Suppressor of cytokine signaling 1 (SOCS1)/JAK-STAT axis promotes diabetic kidney disease(DKD) pathogenesis via promoting inflammation. Moreover, FTO expression is significantly decreased in DKD, and overexpression of FTO can dramatically alleviate kidney inflammation. | |||
Responsed Disease | Chronic kidney disease [ICD-11: GB61.Z] | |||
Target Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | ||
Target Regulation | Up regulation | |||
Pathway Response | JAK-STAT signaling pathway | hsa04630 | ||
In-vitro Model | HEK293T | Normal | Homo sapiens | CVCL_0063 |
hMC | Normal | Homo sapiens | CVCL_9Q61 | |
HK-2 [Human kidney] | Normal | Homo sapiens | CVCL_0302 | |
In-vivo Model | FTO over-expression db/db mice were generated through injecting the tail vein with Fto-overexpression lentivirus at 12 weeks. | |||
References