m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00755)

Target Name	Cyclic-AMP-dependent transcription factor ATF-3 (ATF3)
Synonyms	Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3 ; Activating transcription factor 3 Click to Show/Hide
Gene Name	ATF3
Chromosomal Location	1q32.3
Family	BZIP family, ATF subfamily
Function	This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Activates transcription presumably by sequestering inhibitory cofactors away from the promoters. Stress-induced isoform, counteracts the transcriptional repression of isoform 1. Click to Show/Hide
Gene ID	467
Uniprot ID	ATF3_HUMAN
HGNC ID	HGNC:785
KEGG ID	hsa:467

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

ATF3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

YTH domain-containing family protein 2 (YTHDF2) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[3]
Response Summary	The increased expression of Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) in tamoxifen-resistant cells arises from the decreased expression of the m6A reader protein YTHDF2 and the ensuing elevated stability of ATF3 mRNA, which ultimately promotes the translation of ATF3. ATF3 as a candidate therapeutic target for mitigating drug resistance in breast cancer cells.
Target Regulation	Down regulation
Responsed Disease	Breast cancer		ICD-11: 2C60	Disease Info
In-vitro Model	MCF-7	Invasive breast carcinoma	Homo sapiens	CVCL_0031

Breast cancer [ICD-11: 2C60]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[3]
Response Summary	The increased expression of Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) in tamoxifen-resistant cells arises from the decreased expression of the m6A reader protein YTHDF2 and the ensuing elevated stability of ATF3 mRNA, which ultimately promotes the translation of ATF3. ATF3 as a candidate therapeutic target for mitigating drug resistance in breast cancer cells.
Responsed Disease	Breast cancer [ICD-11: 2C60]
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Down regulation
In-vitro Model	MCF-7	Invasive breast carcinoma	Homo sapiens	CVCL_0031

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

RNA modification

m6A Regulator: ELAV-like protein 1 (ELAVL1)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00505		Crosstalk Info
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)
Regulated Target	MicroRNA 222 (MIR222)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00506		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	MicroRNA 222 (MIR222)
Crosstalk relationship	A-to-I → m6A

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00507		Crosstalk Info
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)
Regulated Target	MicroRNA 222 (MIR222)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00508		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	MicroRNA 222 (MIR222)
Crosstalk relationship	A-to-I → m6A

Non-coding RNA

m6A Regulator: Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05264		Crosstalk Info
Epigenetic Regulator	Circ_STX6
Regulated Target	Heterogeneous nuclear ribonucleoprotein D (HNRNPD)
Crosstalk relationship	ncRNA → m6A
Disease	Liver cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00755)

Cyclic-AMP-dependent transcription factor ATF-3 (ATF3)

Adenosine-to-Inosine editing (A-to-I)

In total 3 m6A sequence/site(s) in this target gene
mod ID: A2ISITE002070		Click to Show/Hide the Full List
mod site	chr1:212613923-212613924:+		[4]
Sequence	TAACAGAGGGAGATGAATTTAGCAAATACATCACTGAAGCT
Transcript ID List	ENST00000366985.5; ENST00000341491.9; ENST00000613954.4; ENST00000492118.2; ENST00000366981.8; ENST00000465155.5; ENST00000366987.6
External Link	RMBase: RNA-editing_site_12209
mod ID: A2ISITE002071		Click to Show/Hide the Full List
mod site	chr1:212614401-212614402:+		[5]
Sequence	AAACGCACCTGGCTACAGTTACCTTTCTCATTCCCATTGCT
Transcript ID List	ENST00000613954.4; ENST00000366987.6; ENST00000366981.8; ENST00000341491.9; ENST00000492118.2; ENST00000465155.5; ENST00000366985.5
External Link	RMBase: RNA-editing_site_12210
mod ID: A2ISITE002072		Click to Show/Hide the Full List
mod site	chr1:212614443-212614444:+		[5]
Sequence	GGGCCCAACTTCGGGGGAGAAGCTTCAGAGATGTATTTGCT
Transcript ID List	ENST00000366987.6; ENST00000366981.8; ENST00000492118.2; ENST00000366985.5; ENST00000341491.9; ENST00000465155.5; ENST00000613954.4
External Link	RMBase: RNA-editing_site_12211

5-methylcytidine (m5C)

In total 10 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004649		Click to Show/Hide the Full List
mod site	chr1:212608807-212608808:+		[6]
Sequence	GCACAGCTCTCTTCTCTCGCCGCCGCCCGAGCGCACCCTTC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000465155.5; ENST00000613954.4; ENST00000366987.6; ENST00000341491.9; ENST00000366981.8
External Link	RMBase: m5C_site_4662
mod ID: M5CSITE004650		Click to Show/Hide the Full List
mod site	chr1:212609048-212609049:+
Sequence	CCCCGGATCCGCGCCCCCAGCCTCCGGCTTGGAAATAACTC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000341491.9; ENST00000366985.5; ENST00000366987.6; ENST00000366981.8; ENST00000613954.4; ENST00000465155.5
External Link	RMBase: m5C_site_4663
mod ID: M5CSITE004651		Click to Show/Hide the Full List
mod site	chr1:212615789-212615790:+
Sequence	CTCCAGCCTGGGTGATGGAGCAAGACTCATTTTGCTTTTAG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000336937.8; ENST00000366985.5; rmsk_376945; ENST00000341491.9; ENST00000366981.8; ENST00000366983.5; ENST00000613104.1; ENST00000492118.2; ENST00000464547.5; ENST00000465155.5; ENST00000613954.4; ENST00000366987.6
External Link	RMBase: m5C_site_4664
mod ID: M5CSITE004652		Click to Show/Hide the Full List
mod site	chr1:212615862-212615863:+
Sequence	GCAGTGGGGTGATCACGGCTCATTGTAGCCTCAGTCTCCTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000613104.1; ENST00000465155.5; ENST00000613954.4; ENST00000366981.8; ENST00000366985.5; ENST00000341491.9; ENST00000492118.2; ENST00000464547.5; ENST00000336937.8; ENST00000366983.5; ENST00000366987.6
External Link	RMBase: m5C_site_4665
mod ID: M5CSITE004653		Click to Show/Hide the Full List
mod site	chr1:212619706-212619707:+		[6]
Sequence	GAGGGCCTGCAGTGATTCAGCAGGCCCTTCCCATTCTGCCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000341491.9; ENST00000366987.6; ENST00000613954.4; ENST00000613104.1; ENST00000492118.2
External Link	RMBase: m5C_site_4666
mod ID: M5CSITE004654		Click to Show/Hide the Full List
mod site	chr1:212619710-212619711:+		[6]
Sequence	GCCTGCAGTGATTCAGCAGGCCCTTCCCATTCTGCCCCAGA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000492118.2; ENST00000366987.6; ENST00000341491.9; ENST00000613954.4; ENST00000613104.1
External Link	RMBase: m5C_site_4667
mod ID: M5CSITE004655		Click to Show/Hide the Full List
mod site	chr1:212619711-212619712:+		[6]
Sequence	CCTGCAGTGATTCAGCAGGCCCTTCCCATTCTGCCCCAGAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000366987.6; ENST00000341491.9; ENST00000613954.4; ENST00000492118.2; ENST00000613104.1
External Link	RMBase: m5C_site_4668
mod ID: M5CSITE004656		Click to Show/Hide the Full List
mod site	chr1:212619712-212619713:+		[6]
Sequence	CTGCAGTGATTCAGCAGGCCCTTCCCATTCTGCCCCAGAGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000492118.2; ENST00000613104.1; ENST00000341491.9; ENST00000366987.6; ENST00000613954.4
External Link	RMBase: m5C_site_4669
mod ID: M5CSITE004657		Click to Show/Hide the Full List
mod site	chr1:212619716-212619717:+		[6]
Sequence	AGTGATTCAGCAGGCCCTTCCCATTCTGCCCCAGAGTGGGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000613104.1; ENST00000366987.6; ENST00000341491.9; ENST00000492118.2; ENST00000613954.4
External Link	RMBase: m5C_site_4670
mod ID: M5CSITE004658		Click to Show/Hide the Full List
mod site	chr1:212619717-212619718:+		[6]
Sequence	GTGATTCAGCAGGCCCTTCCCATTCTGCCCCAGAGTGGGTC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000613954.4; ENST00000366987.6; ENST00000492118.2; ENST00000613104.1; ENST00000341491.9
External Link	RMBase: m5C_site_4671

N6-methyladenosine (m6A)

In total 48 m6A sequence/site(s) in this target gene
mod ID: M6ASITE082441		Click to Show/Hide the Full List
mod site	chr1:212608760-212608761:+		[7]
Sequence	GATGCAACGCTCTCCAAGCCACAGTCGCACGCAGCCAGGCG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000366981.8; ENST00000613954.4; ENST00000465155.5; ENST00000341491.9; ENST00000366987.6
External Link	RMBase: m6A_site_77801
mod ID: M6ASITE082452		Click to Show/Hide the Full List
mod site	chr1:212608874-212608875:+		[8]
Sequence	GGTGCTCGCCCGCCGGCCAGACAAACAGCCCGCCCGACCCC
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; MT4; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000366981.8; ENST00000366987.6; ENST00000465155.5; ENST00000341491.9; ENST00000613954.4
External Link	RMBase: m6A_site_77802
mod ID: M6ASITE082463		Click to Show/Hide the Full List
mod site	chr1:212613504-212613505:+		[8]
Sequence	AAATGACTTAGTTTGTCTAAACCTCAATTATCTCATCTATA
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549; Jurkat; GSC-11; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000366985.5; ENST00000366981.8; ENST00000366987.6; ENST00000492118.2; ENST00000341491.9; ENST00000613954.4; rmsk_376941; ENST00000465155.5
External Link	RMBase: m6A_site_77803
mod ID: M6ASITE082474		Click to Show/Hide the Full List
mod site	chr1:212614107-212614108:+		[9]
Sequence	TGGGTAAAGCAATGGTGGAGACTCAATGCTTGCATTGGAGG
Motif Score	3.319380952
Cell/Tissue List	HepG2; GSC-11; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000366985.5; ENST00000613954.4; ENST00000366987.6; ENST00000366981.8; ENST00000492118.2; ENST00000341491.9; ENST00000465155.5
External Link	RMBase: m6A_site_77804
mod ID: M6ASITE082485		Click to Show/Hide the Full List
mod site	chr1:212615172-212615173:+		[8]
Sequence	GCTGAGGTTTGCCATCCAGAACAAGCACCTCTGCCACCGGA
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; hESC-HEK293T; Huh7; endometrial; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000336937.8; ENST00000613954.4; ENST00000366981.8; ENST00000341491.9; ENST00000366983.5; ENST00000464547.5; ENST00000366985.5; ENST00000366987.6; ENST00000492118.2; ENST00000465155.5
External Link	RMBase: m6A_site_77805
mod ID: M6ASITE082488		Click to Show/Hide the Full List
mod site	chr1:212615230-212615231:+		[8]
Sequence	TCAGTCACTGTCAGCGACAGACCCCTCGGGGTGTCCATCAC
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; hNPCs; Huh7; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000341491.9; ENST00000464547.5; ENST00000613954.4; ENST00000366987.6; ENST00000613104.1; ENST00000366985.5; ENST00000492118.2; ENST00000465155.5; ENST00000366981.8; ENST00000336937.8; ENST00000366983.5
External Link	RMBase: m6A_site_77806
mod ID: M6ASITE082489		Click to Show/Hide the Full List
mod site	chr1:212615249-212615250:+		[7]
Sequence	GACCCCTCGGGGTGTCCATCACAAAAGCCGAGGTGGGTTCT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000366981.8; ENST00000492118.2; ENST00000336937.8; ENST00000613954.4; ENST00000366985.5; ENST00000465155.5; ENST00000613104.1; ENST00000366987.6; ENST00000366983.5; ENST00000464547.5; ENST00000341491.9
External Link	RMBase: m6A_site_77807
mod ID: M6ASITE082490		Click to Show/Hide the Full List
mod site	chr1:212618199-212618200:+		[8]
Sequence	TGCAGCTGCAAAGTGCCGAAACAAGAAGAAGGAGAAGACGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; hESC-HEK293T; hNPCs; Huh7; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000336937.8; ENST00000465155.5; ENST00000613104.1; ENST00000341491.9; ENST00000366985.5; ENST00000613954.4; ENST00000464547.5; ENST00000366981.8; ENST00000492118.2; ENST00000366983.5; ENST00000366987.6
External Link	RMBase: m6A_site_77808
mod ID: M6ASITE082491		Click to Show/Hide the Full List
mod site	chr1:212618318-212618319:+		[8]
Sequence	ATCAGAAGAAGAGTTAGAAAACCCCCTACTTGGTTATAGTT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000465155.5; ENST00000464547.5; ENST00000613954.4; ENST00000366983.5; ENST00000366985.5; ENST00000492118.2; ENST00000366981.8; ENST00000366987.6; ENST00000341491.9; ENST00000613104.1; ENST00000336937.8
External Link	RMBase: m6A_site_77809
mod ID: M6ASITE082492		Click to Show/Hide the Full List
mod site	chr1:212618439-212618440:+		[10]
Sequence	GTGACGGTGGATGTATAAAAACAGGTGTGTGAATTCGTCTG
Motif Score	2.20572619
Cell/Tissue List	Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000464547.5; ENST00000336937.8; ENST00000465155.5; ENST00000366983.5; ENST00000613104.1; ENST00000366981.8; ENST00000341491.9; ENST00000366985.5; ENST00000366987.6; ENST00000492118.2; ENST00000613954.4
External Link	RMBase: m6A_site_77810
mod ID: M6ASITE082493		Click to Show/Hide the Full List
mod site	chr1:212618521-212618522:+		[11]
Sequence	ATCAGCTTCCAGGCTGCAGGACATGCCAGCCCAGTTAAAGA
Motif Score	3.643047619
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000366987.6; ENST00000366983.5; ENST00000366981.8; ENST00000613104.1; ENST00000613954.4; ENST00000341491.9; ENST00000366985.5; ENST00000465155.5; ENST00000492118.2; ENST00000464547.5; ENST00000336937.8
External Link	RMBase: m6A_site_77811
mod ID: M6ASITE082494		Click to Show/Hide the Full List
mod site	chr1:212618628-212618629:+		[12]
Sequence	CCTTTAATTAATCTCTTCAAACAAGTTATTTCCTTAATCCA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000492118.2; ENST00000366981.8; ENST00000465155.5; ENST00000336937.8; ENST00000366985.5; ENST00000366987.6; ENST00000613954.4; ENST00000464547.5; ENST00000613104.1; ENST00000341491.9; ENST00000366983.5
External Link	RMBase: m6A_site_77812
mod ID: M6ASITE082495		Click to Show/Hide the Full List
mod site	chr1:212618765-212618766:+		[13]
Sequence	TCAGCCGGCCCGCCTGAGAGACACTAGGGGAAATAGCTTTT
Motif Score	2.897386905
Cell/Tissue List	A549; HEK293T; Huh7; HEK293A-TOA; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000336937.8; ENST00000464547.5; ENST00000492118.2; ENST00000366985.5; ENST00000613954.4; ENST00000366981.8; ENST00000465155.5; ENST00000341491.9; ENST00000613104.1; ENST00000366983.5; ENST00000366987.6
External Link	RMBase: m6A_site_77813
mod ID: M6ASITE082496		Click to Show/Hide the Full List
mod site	chr1:212618855-212618856:+		[13]
Sequence	TGTCCCTCCTCCAAATGTGGACAGGCCATGACAGAGTCTTA
Motif Score	3.643047619
Cell/Tissue List	A549; HEK293A-TOA; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366983.5; ENST00000366981.8; ENST00000465155.5; ENST00000464547.5; ENST00000366987.6; ENST00000613954.4; ENST00000492118.2; ENST00000366985.5; ENST00000336937.8; ENST00000341491.9; ENST00000613104.1
External Link	RMBase: m6A_site_77814
mod ID: M6ASITE082497		Click to Show/Hide the Full List
mod site	chr1:212619072-212619073:+		[13]
Sequence	GGCCCTTTTGGGTCCAGAAGACCTGCATATGGGCTGTTGAC
Motif Score	2.876744048
Cell/Tissue List	HEK293T; A549; HEK293A-TOA; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366985.5; ENST00000465155.5; ENST00000341491.9; ENST00000336937.8; ENST00000492118.2; ENST00000464547.5; ENST00000366981.8; ENST00000613104.1; ENST00000613954.4; ENST00000366987.6; ENST00000366983.5
External Link	RMBase: m6A_site_77815
mod ID: M6ASITE082498		Click to Show/Hide the Full List
mod site	chr1:212619114-212619115:+		[13]
Sequence	CATGCAAATGAGGTATCTGAACTGCAGCTTCAGTATTAGCA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; A549; HEK293A-TOA; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000336937.8; ENST00000613104.1; ENST00000366985.5; ENST00000613954.4; ENST00000366981.8; ENST00000366987.6; ENST00000366983.5; ENST00000492118.2; ENST00000464547.5; ENST00000465155.5; ENST00000341491.9
External Link	RMBase: m6A_site_77816
mod ID: M6ASITE082499		Click to Show/Hide the Full List
mod site	chr1:212619201-212619202:+		[8]
Sequence	GAGGGTCTGCATTTTCCTAAACCCAGTGCTGCTCTCCCATC
Motif Score	2.185083333
Cell/Tissue List	HeLa; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000613104.1; ENST00000341491.9; ENST00000366985.5; ENST00000336937.8; ENST00000613954.4; ENST00000464547.5; ENST00000366987.6; ENST00000465155.5; ENST00000366981.8; ENST00000366983.5; ENST00000492118.2
External Link	RMBase: m6A_site_77817
mod ID: M6ASITE082500		Click to Show/Hide the Full List
mod site	chr1:212619389-212619390:+		[8]
Sequence	CTGGAAAGTGTGAATGCTGAACTGAAGGCTCAGATTGAGGA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; hNPCs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000613104.1; ENST00000366981.8; ENST00000464547.5; ENST00000341491.9; ENST00000366983.5; ENST00000492118.2; ENST00000366985.5; ENST00000613954.4; ENST00000366987.6
External Link	RMBase: m6A_site_77818
mod ID: M6ASITE082501		Click to Show/Hide the Full List
mod site	chr1:212619439-212619440:+		[7]
Sequence	CGAGAAGCAGCATTTGATATACATGCTCAACCTTCATCGGC
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000366981.8; ENST00000366985.5; ENST00000492118.2; ENST00000366987.6; ENST00000366983.5; ENST00000613104.1; ENST00000341491.9; ENST00000613954.4; ENST00000464547.5
External Link	RMBase: m6A_site_77819
mod ID: M6ASITE082502		Click to Show/Hide the Full List
mod site	chr1:212619492-212619493:+		[8]
Sequence	TCCGGGCTCAGAATGGGAGGACTCCAGAAGATGAGAGAAAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; hNPCs; fibroblasts; Huh7; Jurkat; CD4T; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000341491.9; ENST00000464547.5; ENST00000613954.4; ENST00000366987.6; ENST00000366983.5; ENST00000366985.5; ENST00000366981.8; ENST00000613104.1; ENST00000492118.2
External Link	RMBase: m6A_site_77820
mod ID: M6ASITE082503		Click to Show/Hide the Full List
mod site	chr1:212619511-212619512:+		[8]
Sequence	GACTCCAGAAGATGAGAGAAACCTCTTTATCCAACAGATAA
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; hNPCs; fibroblasts; Huh7; Jurkat; CD4T; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000613954.4; ENST00000341491.9; ENST00000366987.6; ENST00000366985.5; ENST00000464547.5; ENST00000613104.1; ENST00000366983.5; ENST00000492118.2; ENST00000366981.8
External Link	RMBase: m6A_site_77821
mod ID: M6ASITE082504		Click to Show/Hide the Full List
mod site	chr1:212619524-212619525:+		[7]
Sequence	GAGAGAAACCTCTTTATCCAACAGATAAAAGAAGGAACATT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000366981.8; ENST00000366987.6; ENST00000366983.5; ENST00000464547.5; ENST00000341491.9; ENST00000613104.1; ENST00000366985.5; ENST00000492118.2; ENST00000613954.4
External Link	RMBase: m6A_site_77822
mod ID: M6ASITE082505		Click to Show/Hide the Full List
mod site	chr1:212619540-212619541:+		[8]
Sequence	TCCAACAGATAAAAGAAGGAACATTGCAGAGCTAAGCAGTC
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; hNPCs; LCLs; CD8T; Huh7; Jurkat; CD4T; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366987.6; ENST00000366983.5; ENST00000613104.1; ENST00000366985.5; ENST00000613954.4; ENST00000492118.2; ENST00000341491.9; ENST00000464547.5
External Link	RMBase: m6A_site_77823
mod ID: M6ASITE082506		Click to Show/Hide the Full List
mod site	chr1:212619614-212619615:+		[8]
Sequence	ATCCTCATTTTATACCCAAAACCCTGAAGCCATTGGAGAGC
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1B; hNPCs; LCLs; Huh7; CD4T; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000341491.9; ENST00000366987.6; ENST00000613104.1; ENST00000613954.4; ENST00000492118.2
External Link	RMBase: m6A_site_77824
mod ID: M6ASITE082507		Click to Show/Hide the Full List
mod site	chr1:212619673-212619674:+		[8]
Sequence	TAGAATCCCAGCAGCAGAGAACCATCAAGGCGGGAGGGCCT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; Huh7; iSLK; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000613954.4; ENST00000341491.9; ENST00000613104.1; ENST00000492118.2; ENST00000366987.6
External Link	RMBase: m6A_site_77825
mod ID: M6ASITE082508		Click to Show/Hide the Full List
mod site	chr1:212619742-212619743:+		[8]
Sequence	TGCCCCAGAGTGGGTCTTGGACCAGGGCAAGTGCATCTTTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; iSLK; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000613104.1; ENST00000341491.9; ENST00000366987.6; ENST00000613954.4; ENST00000492118.2
External Link	RMBase: m6A_site_77826
mod ID: M6ASITE082509		Click to Show/Hide the Full List
mod site	chr1:212619768-212619769:+		[14]
Sequence	GCAAGTGCATCTTTGCCTCAACTCCAGGATTTAGGCCTTAA
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000613954.4; ENST00000492118.2; ENST00000341491.9; ENST00000366987.6
External Link	RMBase: m6A_site_77827
mod ID: M6ASITE082510		Click to Show/Hide the Full List
mod site	chr1:212619788-212619789:+		[7]
Sequence	ACTCCAGGATTTAGGCCTTAACACACTGGCCATTCTTATGT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000613954.4; ENST00000366987.6; ENST00000341491.9; ENST00000492118.2
External Link	RMBase: m6A_site_77828
mod ID: M6ASITE082511		Click to Show/Hide the Full List
mod site	chr1:212619857-212619858:+		[14]
Sequence	CCGCCTTTCATCTGGATTCTACAAAAAACCAGGATGCCCAC
Motif Score	2.078666667
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000492118.2; ENST00000341491.9; ENST00000366987.6; ENST00000613954.4
External Link	RMBase: m6A_site_77829
mod ID: M6ASITE082512		Click to Show/Hide the Full List
mod site	chr1:212619864-212619865:+		[15]
Sequence	TCATCTGGATTCTACAAAAAACCAGGATGCCCACCGTTAGG
Motif Score	2.185083333
Cell/Tissue List	HEK293T; HeLa; A549
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366987.6; ENST00000492118.2; ENST00000613954.4; ENST00000341491.9
External Link	RMBase: m6A_site_77830
mod ID: M6ASITE082513		Click to Show/Hide the Full List
mod site	chr1:212619980-212619981:+		[15]
Sequence	GTAGGGGATGTGGAGTGAGAACAGCATTTAGTGAAGTTGTG
Motif Score	2.951386905
Cell/Tissue List	HEK293T; HeLa; A549
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000341491.9; ENST00000366987.6; ENST00000613954.4; ENST00000492118.2
External Link	RMBase: m6A_site_77831
mod ID: M6ASITE082514		Click to Show/Hide the Full List
mod site	chr1:212620003-212620004:+		[14]
Sequence	GCATTTAGTGAAGTTGTGCAACGGCCAGGGTTGTGCTTTCT
Motif Score	2.147845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000341491.9; ENST00000366987.6; ENST00000492118.2; ENST00000613954.4
External Link	RMBase: m6A_site_77832
mod ID: M6ASITE082515		Click to Show/Hide the Full List
mod site	chr1:212620066-212620067:+		[14]
Sequence	GAAATTGTGTGTGCAAGAAAACTAGGCAATGTACTCTTCCG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; HeLa; A549
Seq Type List	MeRIP-seq; DART-seq; m6A-seq
Transcript ID List	ENST00000492118.2; ENST00000366987.6; ENST00000341491.9; ENST00000613954.4
External Link	RMBase: m6A_site_77833
mod ID: M6ASITE082516		Click to Show/Hide the Full List
mod site	chr1:212620078-212620079:+		[14]
Sequence	GCAAGAAAACTAGGCAATGTACTCTTCCGATGTTTGTGTCA
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000492118.2; ENST00000613954.4; ENST00000366987.6; ENST00000341491.9
External Link	RMBase: m6A_site_77834
mod ID: M6ASITE082517		Click to Show/Hide the Full List
mod site	chr1:212620098-212620099:+		[7]
Sequence	ACTCTTCCGATGTTTGTGTCACACAACACTGATGTGACTTT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000492118.2; ENST00000366987.6; ENST00000613954.4; ENST00000341491.9
External Link	RMBase: m6A_site_77835
mod ID: M6ASITE082518		Click to Show/Hide the Full List
mod site	chr1:212620103-212620104:+		[14]
Sequence	TCCGATGTTTGTGTCACACAACACTGATGTGACTTTTATAT
Motif Score	2.173910714
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000492118.2; ENST00000341491.9; ENST00000613954.4; ENST00000366987.6
External Link	RMBase: m6A_site_77836
mod ID: M6ASITE082519		Click to Show/Hide the Full List
mod site	chr1:212620105-212620106:+		[14]
Sequence	CGATGTTTGTGTCACACAACACTGATGTGACTTTTATATGC
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000492118.2; ENST00000613954.4; ENST00000341491.9; ENST00000366987.6
External Link	RMBase: m6A_site_77837
mod ID: M6ASITE082520		Click to Show/Hide the Full List
mod site	chr1:212620231-212620232:+		[15]
Sequence	AGCTTGTCAGCAAGAGGAGGACAGAATTCTCCCAGCGTTAA
Motif Score	3.643047619
Cell/Tissue List	HEK293T; HeLa; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366987.6; ENST00000492118.2; ENST00000613954.4; ENST00000341491.9
External Link	RMBase: m6A_site_77838
mod ID: M6ASITE082521		Click to Show/Hide the Full List
mod site	chr1:212620295-212620296:+		[16]
Sequence	TGGCAGGTCCTCTGTTGCAAACTCAGTTCCAAAGTCACAGG
Motif Score	2.627720238
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000613954.4; ENST00000492118.2; ENST00000341491.9; ENST00000366987.6
External Link	RMBase: m6A_site_77839
mod ID: M6ASITE082522		Click to Show/Hide the Full List
mod site	chr1:212620351-212620352:+		[16]
Sequence	TCAACTTCCAAAGGGTTAGGACTCTCCACTCAATGTCTTAG
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000366987.6; ENST00000492118.2; ENST00000613954.4; ENST00000341491.9
External Link	RMBase: m6A_site_77840
mod ID: M6ASITE082523		Click to Show/Hide the Full List
mod site	chr1:212620589-212620590:+		[14]
Sequence	GTTTGCAGCTGTGAGAAGTCACTCACACTGGCCACAAGGAC
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000492118.2; ENST00000341491.9; ENST00000366987.6; ENST00000613954.4
External Link	RMBase: m6A_site_77841
mod ID: M6ASITE082524		Click to Show/Hide the Full List
mod site	chr1:212620593-212620594:+		[7]
Sequence	GCAGCTGTGAGAAGTCACTCACACTGGCCACAAGGACGCTG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000492118.2; ENST00000613954.4; ENST00000366987.6; ENST00000341491.9
External Link	RMBase: m6A_site_77842
mod ID: M6ASITE082525		Click to Show/Hide the Full List
mod site	chr1:212620602-212620603:+		[7]
Sequence	AGAAGTCACTCACACTGGCCACAAGGACGCTGGCTACTGTC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000341491.9; ENST00000492118.2; ENST00000613954.4; ENST00000366987.6
External Link	RMBase: m6A_site_77843
mod ID: M6ASITE082526		Click to Show/Hide the Full List
mod site	chr1:212620608-212620609:+		[14]
Sequence	CACTCACACTGGCCACAAGGACGCTGGCTACTGTCTATTAA
Motif Score	3.616982143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000492118.2; ENST00000341491.9; ENST00000613954.4; ENST00000366987.6
External Link	RMBase: m6A_site_77844
mod ID: M6ASITE082527		Click to Show/Hide the Full List
mod site	chr1:212620670-212620671:+		[14]
Sequence	TTCTCAGAGTGTTTAATTGTACTCAATGGTATCATTACAAT
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000492118.2; ENST00000613954.4; ENST00000366987.6; ENST00000341491.9
External Link	RMBase: m6A_site_77845
mod ID: M6ASITE082528		Click to Show/Hide the Full List
mod site	chr1:212620686-212620687:+		[14]
Sequence	TTGTACTCAATGGTATCATTACAATTTTCTGTAAGAGAAAA
Motif Score	2.07285119
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000492118.2; ENST00000613954.4; ENST00000341491.9; ENST00000366987.6
External Link	RMBase: m6A_site_77846
mod ID: M6ASITE082529		Click to Show/Hide the Full List
mod site	chr1:212620711-212620712:+		[14]
Sequence	TTTCTGTAAGAGAAAATATTACTTATTTATCCTAGTATTCC
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000492118.2; ENST00000613954.4; ENST00000341491.9; ENST00000366987.6
External Link	RMBase: m6A_site_77847
mod ID: M6ASITE082530		Click to Show/Hide the Full List
mod site	chr1:212620765-212620766:+		[7]
Sequence	TAATAAATATTGGAACCAAGACATGGTAAACATGTGTTGTG
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000492118.2; ENST00000613954.4; ENST00000341491.9; ENST00000366987.6
External Link	RMBase: m6A_site_77848

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Ref 3	ATF3 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an N(6)-Methyladenosine-Based Epitranscriptomic Mechanism. Chem Res Toxicol. 2021 Jul 19;34(7):1814-1821. doi: 10.1021/acs.chemrestox.1c00206. Epub 2021 Jul 2.
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Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
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Ref 9	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
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Ref 12	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 13	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
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Ref 15	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.
Ref 16	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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