m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00740)

Target Name	Dual specificity protein phosphatase 5 (DUSP5)
Synonyms	Dual specificity protein phosphatase hVH3 Click to Show/Hide
Gene Name	DUSP5
Chromosomal Location	10q25.2
Family	Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Function	Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. Click to Show/Hide
Gene ID	1847
Uniprot ID	DUS5_HUMAN
HGNC ID	HGNC:3071
KEGG ID	hsa:1847

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

DUSP5 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	LNCaP cell line	Homo sapiens
Treatment: shMETTL3 LNCaP cells Control: shControl LNCaP cells		GSE147884
Regulation		logFC: -7.11E-01 p-value: 1.15E-05
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3-mediated m6A-modification profile in gallbladder-cancer cells and identified Dual specificity protein phosphatase 5 (DUSP5) as the downstream gene of METTL3. METTL3 promoted the degradation of DUSP5 mRNA in a YTHDF2-dependent manner.
Target Regulation	Down regulation
Responsed Disease	Gallbladder cancer		ICD-11: 2C13	Disease Info
Cell Process	Cell proliferation
	Cell invasion
	Cell migration
In-vitro Model	NOZ	Gallbladder carcinoma	Homo sapiens	CVCL_3079
	GBC-SD	Human gallbladder	Homo sapiens	CVCL_6903

Gallbladder cancer [ICD-11: 2C13]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3-mediated m6A-modification profile in gallbladder-cancer cells and identified Dual specificity protein phosphatase 5 (DUSP5) as the downstream gene of METTL3. METTL3 promoted the degradation of DUSP5 mRNA in a YTHDF2-dependent manner.
Responsed Disease	Gallbladder cancer [ICD-11: 2C13]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Cell Process	Cell proliferation
	Cell invasion
	Cell migration
In-vitro Model	NOZ	Gallbladder carcinoma	Homo sapiens	CVCL_3079
	GBC-SD	Human gallbladder	Homo sapiens	CVCL_6903

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00740)

Dual specificity protein phosphatase 5 (DUSP5)

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004769		Click to Show/Hide the Full List
mod site	chr10:110497917-110497918:+		[2]
Sequence	GGAATCCCCGGCTTCTAGGGCGGCGAGCGGCCGGGCTGGCT
Seq Type List	Bisulfite-seq
Transcript ID List	rmsk_3417217; ENST00000369583.4
External Link	RMBase: m5C_site_5939
mod ID: M5CSITE004771		Click to Show/Hide the Full List
mod site	chr10:110508288-110508289:+
Sequence	GATGGGTTCAGGGTGGGAAACCCTTGACTTGTTCTCCCTGT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000468749.1; ENST00000369583.4
External Link	RMBase: m5C_site_5940

N6-methyladenosine (m6A)

In total 27 m6A sequence/site(s) in this target gene
mod ID: M6ASITE001737		Click to Show/Hide the Full List
mod site	chr10:110507048-110507049:+		[3]
Sequence	TGCTGAATGTCTCCCGACGGACCTCCGAGGCCTGCGCGACC
Motif Score	3.622404762
Cell/Tissue List	Huh7; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000369583.4; ENST00000468749.1
External Link	RMBase: m6A_site_117917
mod ID: M6ASITE001738		Click to Show/Hide the Full List
mod site	chr10:110507074-110507075:+		[4]
Sequence	GAGGCCTGCGCGACCCACCTACACTACAAATGGATCCCTGT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000468749.1; ENST00000369583.4
External Link	RMBase: m6A_site_117918
mod ID: M6ASITE001739		Click to Show/Hide the Full List
mod site	chr10:110507100-110507101:+		[3]
Sequence	CAAATGGATCCCTGTGGAAGACAGCCACACGGCTGACATTA
Motif Score	2.897386905
Cell/Tissue List	Huh7; HEK293A-TOA; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000369583.4; ENST00000468749.1
External Link	RMBase: m6A_site_117919
mod ID: M6ASITE001740		Click to Show/Hide the Full List
mod site	chr10:110507145-110507146:+		[5]
Sequence	CCACTTTCAAGAAGCAATAGACTTCATTGGTAGGTTTAGCC
Motif Score	3.319380952
Cell/Tissue List	H1299; Huh7; HEK293A-TOA; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4; ENST00000468749.1
External Link	RMBase: m6A_site_117920
mod ID: M6ASITE001741		Click to Show/Hide the Full List
mod site	chr10:110510111-110510112:+		[5]
Sequence	GCATGGCTTACCTTATGAAGACCAAGCAGTTCCGCCTGAAG
Motif Score	2.876744048
Cell/Tissue List	A549; H1299; Huh7; HEK293A-TOA; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000468749.1; ENST00000369583.4
External Link	RMBase: m6A_site_117921
mod ID: M6ASITE001742		Click to Show/Hide the Full List
mod site	chr10:110510300-110510301:+		[6]
Sequence	CACTGATAGGCCATTTGCAGACACTGAGCCCTGACATGCAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; hESCs; GM12878; H1299; Huh7; CD4T; GSC-11; HEK293A-TOA; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4; ENST00000468749.1
External Link	RMBase: m6A_site_117922
mod ID: M6ASITE001743		Click to Show/Hide the Full List
mod site	chr10:110510427-110510428:+		[6]
Sequence	AACGGCCACATCCTGCTAAAACTGGGATGGAGGAATCGGCC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hESCs; fibroblasts; GM12878; LCLs; H1299; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4; ENST00000468749.1
External Link	RMBase: m6A_site_117923
mod ID: M6ASITE001744		Click to Show/Hide the Full List
mod site	chr10:110510483-110510484:+		[6]
Sequence	CTGTGATTTTTGTTTTTAAGACTCATGGACATTTCATACCT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hESCs; fibroblasts; GM12878; LCLs; H1299; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117924
mod ID: M6ASITE001745		Click to Show/Hide the Full List
mod site	chr10:110510491-110510492:+		[6]
Sequence	TTTGTTTTTAAGACTCATGGACATTTCATACCTGTGCAATA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117925
mod ID: M6ASITE001746		Click to Show/Hide the Full List
mod site	chr10:110510518-110510519:+		[6]
Sequence	ATACCTGTGCAATACTGAAGACCTCATTCTGTCATGCTGCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117926
mod ID: M6ASITE001747		Click to Show/Hide the Full List
mod site	chr10:110510577-110510578:+		[6]
Sequence	GTCACCAGGCTTGCAAATGAACTTCAGACGGACCTCAGGGT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117927
mod ID: M6ASITE001748		Click to Show/Hide the Full List
mod site	chr10:110510588-110510589:+		[6]
Sequence	TGCAAATGAACTTCAGACGGACCTCAGGGTAGGTTCTCGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117928
mod ID: M6ASITE001749		Click to Show/Hide the Full List
mod site	chr10:110510609-110510610:+		[6]
Sequence	CCTCAGGGTAGGTTCTCGGGACTGAAGGAAGGCCAAGCCAT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117929
mod ID: M6ASITE001750		Click to Show/Hide the Full List
mod site	chr10:110510668-110510669:+		[6]
Sequence	GCTGACTACTGTACTTCCAGACCCCTGCCCTCTTGGGACTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117930
mod ID: M6ASITE001751		Click to Show/Hide the Full List
mod site	chr10:110510685-110510686:+		[6]
Sequence	CAGACCCCTGCCCTCTTGGGACTGCCCAGTCCTTGCACCTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117931
mod ID: M6ASITE001752		Click to Show/Hide the Full List
mod site	chr10:110510777-110510778:+		[7]
Sequence	TGGGAGAAAGAAGTTGCTGGACCAGGAGAAAAGGCAGTTAT
Motif Score	3.622404762
Cell/Tissue List	HepG2; HEK293T; HeLa; A549; U2OS; H1B; H1A; hESCs; fibroblasts; GM12878; LCLs; H1299; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117932
mod ID: M6ASITE001753		Click to Show/Hide the Full List
mod site	chr10:110510846-110510847:+		[7]
Sequence	ATTTCCACCTTATTTTTTGAACTTTGGCAGTTTCAATGTCT
Motif Score	3.373380952
Cell/Tissue List	HepG2; HEK293T; HeLa; A549; U2OS; GM12878; LCLs; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117933
mod ID: M6ASITE001754		Click to Show/Hide the Full List
mod site	chr10:110510937-110510938:+		[8]
Sequence	ACCCTACAGGGTTTGTAGGGACATGATCAGCATCCTGATTT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; HeLa; A549; U2OS; fibroblasts; GM12878; LCLs; H1299; Huh7; HEK293A-TOA; MSC; TIME; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117934
mod ID: M6ASITE001755		Click to Show/Hide the Full List
mod site	chr10:110510960-110510961:+		[6]
Sequence	TGATCAGCATCCTGATTTGAACCCTGAAATGTTGTGTAGAC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; hESCs; fibroblasts; GM12878; LCLs; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117935
mod ID: M6ASITE001756		Click to Show/Hide the Full List
mod site	chr10:110510979-110510980:+		[6]
Sequence	AACCCTGAAATGTTGTGTAGACACCCTCTTGGGTCCAATGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hESCs; fibroblasts; GM12878; LCLs; Huh7; HEK293A-TOA; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117936
mod ID: M6ASITE001757		Click to Show/Hide the Full List
mod site	chr10:110511072-110511073:+		[6]
Sequence	GGGTTCTTCACTGACCTTGGACTTTGGCATGATTCTTAGTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hESCs; fibroblasts; GM12878; LCLs; CD8T; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117937
mod ID: M6ASITE001758		Click to Show/Hide the Full List
mod site	chr10:110511101-110511102:+		[6]
Sequence	TGATTCTTAGTCATACTTGAACTTGTCTCATTCCACCTCTT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hESCs; fibroblasts; GM12878; LCLs; CD8T; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117938
mod ID: M6ASITE001759		Click to Show/Hide the Full List
mod site	chr10:110511167-110511168:+		[6]
Sequence	AAGAGTTCTTCAGATCATAGACCAAAAAAGTCATACCTTCG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; A549; H1B; H1A; hESCs; fibroblasts; GM12878; LCLs; Huh7; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117939
mod ID: M6ASITE001760		Click to Show/Hide the Full List
mod site	chr10:110511256-110511257:+		[8]
Sequence	CTGGGTCAGTGGCGGTGCAAACTGGTTTCCTCAGCTGCCTG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; HeLa; A549; GM12878; Huh7; MSC; TIME; TREX; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117940
mod ID: M6ASITE001761		Click to Show/Hide the Full List
mod site	chr10:110511304-110511305:+		[4]
Sequence	GTGTGCTTATGTCTCTTGTGACAATTGTTTTCCTCCCTGCC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117941
mod ID: M6ASITE001762		Click to Show/Hide the Full List
mod site	chr10:110511350-110511351:+		[9]
Sequence	AGGTTGTCTTCAAGCTGTGGACTTCTGGGATTTGCAGATTT
Motif Score	4.065041667
Cell/Tissue List	A549; GM12878; Huh7; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117942
mod ID: M6ASITE001763		Click to Show/Hide the Full List
mod site	chr10:110511447-110511448:+		[3]
Sequence	AAAGGCAATAATTTTCTAAGACCCGTGTGAATGTGAAGAAA
Motif Score	2.876744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000369583.4
External Link	RMBase: m6A_site_117943

Ref 1	METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression. Cancer Gene Ther. 2022 Jul;29(7):1012-1020. doi: 10.1038/s41417-021-00406-5. Epub 2021 Nov 19.
Ref 2	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 3	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 May 5;62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 8	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 9	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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