m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0146)
Name
Gallbladder cancer
ICD
ICD-11: 2C13
Full List of Target Gene(s) of This m6A-centered Disease Response
Dual specificity protein phosphatase 5 (DUSP5)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary METTL3-mediated m6A-modification profile in gallbladder-cancer cells and identified Dual specificity protein phosphatase 5 (DUSP5) as the downstream gene of METTL3. METTL3 promoted the degradation of DUSP5 mRNA in a YTHDF2-dependent manner.
Responsed Disease Gallbladder cancer [ICD-11: 2C13]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell proliferation
Cell invasion
Cell migration
In-vitro Model NOZ Gallbladder carcinoma Homo sapiens CVCL_3079
GBC-SD Human gallbladder Homo sapiens CVCL_6903
References
Ref 1 Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. doi: 10.1038/nbt.1990.
Ref 2 METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression. Cancer Gene Ther. 2022 Jul;29(7):1012-1020. doi: 10.1038/s41417-021-00406-5. Epub 2021 Nov 19.
Ref 3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7920).