m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00711)
Target Name DBH antisense RNA 1 (Lnc_DBH-AS1)
Synonyms
BPR; NCRNA00118
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Gene Name Lnc_DBH-AS1
Chromosomal Location 9q34.2
Gene ID 138948
HGNC ID
HGNC:24155
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Lnc_DBH-AS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary DBH antisense RNA 1 (Lnc_DBH-AS1) expression in pancreatic cancer(PC) was found to be linked to the METTL3-dependent m6A methylation of the lncRNA. MechanisticallyDBH-AS1 was able to increase PC cell sensitivity to gemcitabine by sequestering miR-3163 and thus upregulating USP44 in these tumor cells.
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
Responsed Drug Gemcitabine Approved
 Drug Info 
In-vitro Model MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
HPDE Normal Homo sapiens CVCL_4376
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
Canpan-2 (Pancreatic cancer cell line)
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0152
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary DBH antisense RNA 1 (Lnc_DBH-AS1) expression in pancreatic cancer(PC) was found to be linked to the METTL3-dependent m6A methylation of the lncRNA. MechanisticallyDBH-AS1 was able to increase PC cell sensitivity to gemcitabine by sequestering miR-3163 and thus upregulating USP44 in these tumor cells.
Responsed Disease Pancreatic cancer [ICD-11: 2C10]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Responsed Drug Gemcitabine Approved
 Drug Info 
In-vitro Model MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
HPDE Normal Homo sapiens CVCL_4376
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
Canpan-2 (Pancreatic cancer cell line)
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0152
Gemcitabine [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary DBH antisense RNA 1 (Lnc_DBH-AS1) expression in pancreatic cancer(PC) was found to be linked to the METTL3-dependent m6A methylation of the lncRNA. MechanisticallyDBH-AS1 was able to increase PC cell sensitivity to gemcitabine by sequestering miR-3163 and thus upregulating USP44 in these tumor cells.
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
In-vitro Model MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
HPDE Normal Homo sapiens CVCL_4376
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
Canpan-2 (Pancreatic cancer cell line)
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0152
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
DNA modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02118
 Crosstalk Info 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Pancreatic cancer
 Disease Info 
Drug Gemcitabine
 Drug Info 
Crosstalk ID: M6ACROT02127
 Crosstalk Info 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Pancreatic cancer
 Disease Info 
Drug Gemcitabine
 Drug Info 
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05625
 Crosstalk Info 
Epigenetic Regulator DBH antisense RNA 1 (Lnc_DBH-AS1)
Regulated Target MicroRNA 3163 (MIR3163)
Crosstalk relationship m6A → ncRNA
Disease Pancreatic cancer
 Disease Info 
Drug Gemcitabine
 Drug Info 
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00711)
DBH antisense RNA 1 (Lnc_DBH-AS1)
N6-methyladenosine (m6A)
In total 26 m6A sequence/site(s) in this target gene
mod ID: M6ASITE090197 Click to Show/Hide the Full List
mod site chr9:133654750-133654751:- [2]
Sequence TGTGTGGCCTGAGTGGCTGGACCTCACTGTATCTCCTGGTG
Motif Score 3.622404762
Cell/Tissue List CD4T; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List rmsk_2898259; ENST00000425189.1
External Link RMBase: m6A_site_845464
mod ID: M6ASITE090198 Click to Show/Hide the Full List
mod site chr9:133654902-133654903:- [3]
Sequence GAATGGGGCTGATGGTGGGGACTTGCCTGGGGTGCTCCACC
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; Jurkat; CD4T; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845465
mod ID: M6ASITE090199 Click to Show/Hide the Full List
mod site chr9:133654957-133654958:- [3]
Sequence CTCGCTGGATGCCCGGCAAGACCCTCCCATCCCTGGCCCCG
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; Jurkat; CD4T; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845466
mod ID: M6ASITE090200 Click to Show/Hide the Full List
mod site chr9:133655134-133655135:- [3]
Sequence TGGGCCAGGGAAGCCACAGAACTGCCCACGGGGACGCTGGC
Motif Score 3.373380952
Cell/Tissue List HeLa; HepG2; H1A; H1B; Jurkat; CD4T; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845467
mod ID: M6ASITE090201 Click to Show/Hide the Full List
mod site chr9:133655348-133655349:- [4]
Sequence ACCACAGACATCAAAAGGGAACTGAGTCCGACCCTGTGTAG
Motif Score 3.373380952
Cell/Tissue List iSLK
Seq Type List MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845468
mod ID: M6ASITE090202 Click to Show/Hide the Full List
mod site chr9:133655361-133655362:- [4]
Sequence CCCACCCTCTGCCACCACAGACATCAAAAGGGAACTGAGTC
Motif Score 2.897386905
Cell/Tissue List iSLK
Seq Type List MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845469
mod ID: M6ASITE090203 Click to Show/Hide the Full List
mod site chr9:133655518-133655519:- [2]
Sequence CAGTTCTGCCCAGAGACGAAACCTGGCACCTGTTGGCCAGG
Motif Score 2.185083333
Cell/Tissue List CD4T; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845470
mod ID: M6ASITE090204 Click to Show/Hide the Full List
mod site chr9:133655539-133655540:- [2]
Sequence GTGCAGACAAAGAGCATGGGACAGTTCTGCCCAGAGACGAA
Motif Score 3.643047619
Cell/Tissue List Jurkat; CD4T; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845471
mod ID: M6ASITE090205 Click to Show/Hide the Full List
mod site chr9:133655553-133655554:- [2]
Sequence CGCCCCCTCCTCCCGTGCAGACAAAGAGCATGGGACAGTTC
Motif Score 2.897386905
Cell/Tissue List Jurkat; CD4T; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845472
mod ID: M6ASITE090206 Click to Show/Hide the Full List
mod site chr9:133655610-133655611:- [5]
Sequence CTCTATGGCAGAACAAAGGGACTGGGCAAAGCTTGGCGTGG
Motif Score 4.065041667
Cell/Tissue List HepG2; H1A; Jurkat; CD4T; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845473
mod ID: M6ASITE090207 Click to Show/Hide the Full List
mod site chr9:133655618-133655619:- [5]
Sequence AATCTTTACTCTATGGCAGAACAAAGGGACTGGGCAAAGCT
Motif Score 2.951386905
Cell/Tissue List HepG2; H1A; Jurkat; CD4T; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845474
mod ID: M6ASITE090208 Click to Show/Hide the Full List
mod site chr9:133655736-133655737:- [2]
Sequence CCAGCAGGTCAGGGGCCGGGACATGACGCCCTGGCCACCCT
Motif Score 3.643047619
Cell/Tissue List Jurkat; CD4T; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845475
mod ID: M6ASITE090209 Click to Show/Hide the Full List
mod site chr9:133655820-133655821:- [2]
Sequence CCTCAGCCATAGGAGGAAGAACAGCAGCAGCTTGGAGGAGC
Motif Score 2.951386905
Cell/Tissue List Jurkat; CD4T; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845476
mod ID: M6ASITE090210 Click to Show/Hide the Full List
mod site chr9:133655994-133655995:- [5]
Sequence CAGGGACTCTATAAGACAGGACCGTGACTAGAGGCCGCGAC
Motif Score 3.622404762
Cell/Tissue List HepG2; H1A; H1B; Jurkat; CD4T; HEK293A-TOA; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845477
mod ID: M6ASITE090211 Click to Show/Hide the Full List
mod site chr9:133655999-133656000:- [5]
Sequence GGGAGCAGGGACTCTATAAGACAGGACCGTGACTAGAGGCC
Motif Score 2.897386905
Cell/Tissue List HepG2; H1A; H1B; Jurkat; CD4T; HEK293A-TOA; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845478
mod ID: M6ASITE090212 Click to Show/Hide the Full List
mod site chr9:133656009-133656010:- [5]
Sequence TGGCTCTGAGGGGAGCAGGGACTCTATAAGACAGGACCGTG
Motif Score 4.065041667
Cell/Tissue List HepG2; H1A; H1B; Jurkat; CD4T; HEK293A-TOA; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845479
mod ID: M6ASITE090213 Click to Show/Hide the Full List
mod site chr9:133656032-133656033:- [6]
Sequence GTCCACCAGTCATTTCTCCAACGTGGCTCTGAGGGGAGCAG
Motif Score 2.147845238
Cell/Tissue List CD8T
Seq Type List m6A-CLIP/IP
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845480
mod ID: M6ASITE090214 Click to Show/Hide the Full List
mod site chr9:133656089-133656090:- [3]
Sequence GCGAGAGCCTGGAGCCAAGGACTGCAAGGGAGGCCCTTTCC
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; Jurkat; CD4T; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845481
mod ID: M6ASITE090215 Click to Show/Hide the Full List
mod site chr9:133656223-133656224:- [3]
Sequence CCCATTTTATGGGTACAGAAACTGAGTCTCAGAGCAGGCAA
Motif Score 2.627720238
Cell/Tissue List HeLa; HepG2; H1A; H1B; Huh7; Jurkat; CD4T; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845482
mod ID: M6ASITE090216 Click to Show/Hide the Full List
mod site chr9:133656267-133656268:- [3]
Sequence GTGAGGAAAAATGAAACGGGACAAGCGGATGGGGTGTTATT
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; H1A; H1B; hNPCs; Huh7; Jurkat; CD4T; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845483
mod ID: M6ASITE090217 Click to Show/Hide the Full List
mod site chr9:133656343-133656344:- [3]
Sequence TGCCACCATTGGCAGGAGAGACAGGCAGTGAGTGAGTGAGT
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; hNPCs; Jurkat; CD4T; HEK293A-TOA; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845484
mod ID: M6ASITE090218 Click to Show/Hide the Full List
mod site chr9:133656387-133656388:- [3]
Sequence TGCCAGGCATGCTCTGGGGAACCGAGTCCCTGCCCTCAAGG
Motif Score 2.930744048
Cell/Tissue List HeLa; HepG2; Jurkat; CD4T; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845485
mod ID: M6ASITE090219 Click to Show/Hide the Full List
mod site chr9:133656505-133656506:- [3]
Sequence CCCCCTGCAAGTTGGAGGAGACCCGTCAGCCCCGGGCCATG
Motif Score 2.876744048
Cell/Tissue List HeLa; Jurkat; CD4T; MSC; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845486
mod ID: M6ASITE090220 Click to Show/Hide the Full List
mod site chr9:133657131-133657132:- [3]
Sequence GGTTGAAGGAGTTCCAGGGAACAGAGGTGAACTGCTGAGAC
Motif Score 2.951386905
Cell/Tissue List HeLa; Jurkat; CD4T; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845487
mod ID: M6ASITE090221 Click to Show/Hide the Full List
mod site chr9:133657208-133657209:- [3]
Sequence CTGGAAGCGGACGGCTGAGGACTTGTTGCAGTGCATGGAGA
Motif Score 4.065041667
Cell/Tissue List HeLa; H1A; H1B; Jurkat; CD4T; iSLK; MSC; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845490
mod ID: M6ASITE090222 Click to Show/Hide the Full List
mod site chr9:133657303-133657304:- [2]
Sequence GCCAGCAGTTTGGAGTGCAGACCCATCACCCCTCACTGGGG
Motif Score 2.876744048
Cell/Tissue List Jurkat; CD4T
Seq Type List m6A-seq
Transcript ID List ENST00000425189.1
External Link RMBase: m6A_site_845491