m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00671)

Target Name	TNF receptor-associated factor 5 (TRAF5)
Synonyms	RING finger protein 84 Click to Show/Hide
Gene Name	TRAF5
Chromosomal Location	1q32.3
Family	TNF receptor-associated factor family, A subfamily
Function	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. Click to Show/Hide
Gene ID	7188
Uniprot ID	TRAF5_HUMAN
HGNC ID	HGNC:12035
KEGG ID	hsa:7188

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

TRAF5 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

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Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	LX2 cell line	Homo sapiens
Treatment: shMETTL3 LX2 cells Control: shLuc LX2 cells		GSE207909
Regulation		logFC: -7.59E-01 p-value: 1.50E-05
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between TRAF5 and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 2.24E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	2-polarized tumor-associated macrophages enabled the oxaliplatin resistance via the elevation of METTL3-mediated m6A modification in Colorectal Cancer cells. Furthermore, they found that TNF receptor-associated factor 5 (TRAF5) contributes to the METTL3-triggered OX resistance in CRC cells.
Target Regulation	Down regulation
Responsed Disease	Colorectal cancer		ICD-11: 2B91	Disease Info
Responsed Drug	Oxaliplatin		Approved	Drug Info
In-vitro Model	LoVo	Colon adenocarcinoma	Homo sapiens	CVCL_0399
In-vitro Model	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291
In-vivo Model	HCT-116 cells (3 × 10⁵ cells in 200 uL of saline) were subcutaneously injected into the nude mice to establish xenograft tumors. After 10 days, 10 mg/kg OX or saline was intraperitoneally injected (n = 5 for each group). Si-METTL3 or si-TRAF5 (10 nmol/20 g body weight) was injected twice intratumorally before the start of OX treatment. The mice were examined every 2 days and sacrificed 4 weeks after the OX treatment.

Colorectal cancer [ICD-11: 2B91]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	2-polarized tumor-associated macrophages enabled the oxaliplatin resistance via the elevation of METTL3-mediated m6A modification in Colorectal Cancer cells. Furthermore, they found that TNF receptor-associated factor 5 (TRAF5) contributes to the METTL3-triggered OX resistance in CRC cells.
Responsed Disease	Colorectal cancer [ICD-11: 2B91]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Drug	Oxaliplatin		Approved	Drug Info
In-vitro Model	LoVo	Colon adenocarcinoma	Homo sapiens	CVCL_0399
In-vitro Model	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291
In-vivo Model	HCT-116 cells (3 × 10⁵ cells in 200 uL of saline) were subcutaneously injected into the nude mice to establish xenograft tumors. After 10 days, 10 mg/kg OX or saline was intraperitoneally injected (n = 5 for each group). Si-METTL3 or si-TRAF5 (10 nmol/20 g body weight) was injected twice intratumorally before the start of OX treatment. The mice were examined every 2 days and sacrificed 4 weeks after the OX treatment.

Oxaliplatin [Approved]

Drug Info

In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response				[1]
Response Summary	2-polarized tumor-associated macrophages enabled the oxaliplatin resistance via the elevation of METTL3-mediated m6A modification in Colorectal Cancer cells. Furthermore, they found that TNF receptor-associated factor 5 (TRAF5) contributes to the METTL3-triggered OX resistance in CRC cells.
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Disease	Colorectal cancer		ICD-11: 2B91	Disease Info
In-vitro Model	LoVo	Colon adenocarcinoma	Homo sapiens	CVCL_0399
In-vitro Model	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291
In-vivo Model	HCT-116 cells (3 × 10⁵ cells in 200 uL of saline) were subcutaneously injected into the nude mice to establish xenograft tumors. After 10 days, 10 mg/kg OX or saline was intraperitoneally injected (n = 5 for each group). Si-METTL3 or si-TRAF5 (10 nmol/20 g body weight) was injected twice intratumorally before the start of OX treatment. The mice were examined every 2 days and sacrificed 4 weeks after the OX treatment.

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03576		Crosstalk Info
Epigenetic Regulator	Histone acetyltransferase p300 (P300)
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Colorectal cancer	Disease Info
Drug	Oxaliplatin	Drug Info
Crosstalk ID: M6ACROT03621		Crosstalk Info
Epigenetic Regulator	N-lysine methyltransferase SMYD2 (SMYD2)
Regulated Target	Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship	Histone modification → m6A
Disease	Colorectal cancer	Disease Info
Drug	Oxaliplatin	Drug Info

Non-coding RNA

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05006		Crosstalk Info
Epigenetic Regulator	Long intergenic non-protein coding RNA 467 (LINC00467)
Regulated Target	Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3)
Crosstalk relationship	ncRNA → m6A
Disease	Liver cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00671)

TNF receptor-associated factor 5 (TRAF5)

Adenosine-to-Inosine editing (A-to-I)

In total 9 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001896		Click to Show/Hide the Full List
mod site	chr1:211359007-211359008:+		[3]
Sequence	CTAGGCTGGAGCGCAGTGGCACAATCATAGCTCACTGCAGC
Transcript ID List	ENST00000336184.6; ENST00000261464.10; ENST00000367004.3; ENST00000488428.1; ENST00000462410.5
External Link	RMBase: RNA-editing_site_12123
mod ID: A2ISITE001898		Click to Show/Hide the Full List
mod site	chr1:211359190-211359191:+		[3]
Sequence	GGACTTGAGTCCTGGCCTTAAGTGATCCTCCCATCTCAGCC
Transcript ID List	ENST00000488428.1; ENST00000367004.3; ENST00000336184.6; ENST00000462410.5; ENST00000261464.10
External Link	RMBase: RNA-editing_site_12124
mod ID: A2ISITE001899		Click to Show/Hide the Full List
mod site	chr1:211361862-211361863:+		[4]
Sequence	CCCGCCATCATGCCTGGCTAATTTTTGTATTTTTAGTAGAG
Transcript ID List	ENST00000367004.3; ENST00000336184.6; ENST00000462410.5; ENST00000261464.10
External Link	RMBase: RNA-editing_site_12125
mod ID: A2ISITE001900		Click to Show/Hide the Full List
mod site	chr1:211363768-211363769:+		[5]
Sequence	AAAAAATACAAAAATCAGCCAGGTGTGGTGGCGCACCCTGT
Transcript ID List	rmsk_374188; ENST00000367004.3; ENST00000261464.10; ENST00000336184.6; ENST00000462410.5
External Link	RMBase: RNA-editing_site_12126
mod ID: A2ISITE001901		Click to Show/Hide the Full List
mod site	chr1:211363812-211363813:+		[5]
Sequence	CCCAGCTCCTTGGGAGGCTGAGGTGGGAGAATCCCTTGAGC
Transcript ID List	ENST00000336184.6; rmsk_374188; ENST00000261464.10; ENST00000462410.5; ENST00000367004.3
External Link	RMBase: RNA-editing_site_12127
mod ID: A2ISITE001902		Click to Show/Hide the Full List
mod site	chr1:211363821-211363822:+		[5]
Sequence	TTGGGAGGCTGAGGTGGGAGAATCCCTTGAGCCAGGGAGGC
Transcript ID List	ENST00000462410.5; ENST00000261464.10; rmsk_374188; ENST00000336184.6; ENST00000367004.3
External Link	RMBase: RNA-editing_site_12128
mod ID: A2ISITE001903		Click to Show/Hide the Full List
mod site	chr1:211364004-211364005:+		[5]
Sequence	CCAGTTGGTTTGTATTCTAGAACTTGCCTCAGCACCAGAGC
Transcript ID List	ENST00000462410.5; ENST00000261464.10; ENST00000336184.6; ENST00000367004.3
External Link	RMBase: RNA-editing_site_12129
mod ID: A2ISITE001904		Click to Show/Hide the Full List
mod site	chr1:211373861-211373862:+		[4]
Sequence	CCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCCCG
Transcript ID List	ENST00000261464.10; ENST00000473385.1; ENST00000336184.6
External Link	RMBase: RNA-editing_site_12130
mod ID: A2ISITE001905		Click to Show/Hide the Full List
mod site	chr1:211374863-211374864:+		[5]
Sequence	CATGGTTTGCTTAGGAGTTCAGAGTTCCTTCATCATCGAAA
Transcript ID List	ENST00000261464.10; ENST00000336184.6
External Link	RMBase: RNA-editing_site_12131

N6-methyladenosine (m6A)

In total 51 m6A sequence/site(s) in this target gene
mod ID: M6ASITE081582		Click to Show/Hide the Full List
mod site	chr1:211353366-211353367:+		[6]
Sequence	GGAGCGGTTGGAAGAGCGCTACAAATGTGCCTTCTGCCACT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000261464.10; ENST00000462410.5; ENST00000494355.1; ENST00000367004.3; ENST00000488428.1; ENST00000336184.6
External Link	RMBase: m6A_site_77121
mod ID: M6ASITE081583		Click to Show/Hide the Full List
mod site	chr1:211354417-211354418:+		[6]
Sequence	TTTTTTCTCCAGAGAATTAAACACAGTGCCAATCTGCCCTG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000367004.3; ENST00000261464.10; ENST00000336184.6; ENST00000462410.5; ENST00000488428.1
External Link	RMBase: m6A_site_77122
mod ID: M6ASITE081584		Click to Show/Hide the Full List
mod site	chr1:211356910-211356911:+		[7]
Sequence	TGTTTCCCAGCAACTGTGGGACCTGGCCTCATGGGGTTTAT
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000462410.5; ENST00000488428.1; ENST00000261464.10; ENST00000367004.3; ENST00000336184.6
External Link	RMBase: m6A_site_77123
mod ID: M6ASITE081585		Click to Show/Hide the Full List
mod site	chr1:211360747-211360748:+		[6]
Sequence	ATACCCAGTATTTTGTCCCAACAATTGTGCGAAGATTATTC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000367004.3; ENST00000488428.1; ENST00000462410.5; ENST00000336184.6; ENST00000261464.10
External Link	RMBase: m6A_site_77124
mod ID: M6ASITE081586		Click to Show/Hide the Full List
mod site	chr1:211361095-211361096:+		[8]
Sequence	TCCATTTCGTAGGTAGATGAACACCTGGCTGTATGTCCTGA
Motif Score	2.951386905
Cell/Tissue List	CD34; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000261464.10; ENST00000462410.5; ENST00000367004.3; ENST00000488428.1; ENST00000336184.6
External Link	RMBase: m6A_site_77125
mod ID: M6ASITE081587		Click to Show/Hide the Full List
mod site	chr1:211361127-211361128:+		[7]
Sequence	ATGTCCTGAAGCTGAGCAAGACTGTCCTTTTAAGCACTATG
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000261464.10; ENST00000367004.3; ENST00000462410.5; ENST00000488428.1; ENST00000336184.6
External Link	RMBase: m6A_site_77126
mod ID: M6ASITE081588		Click to Show/Hide the Full List
mod site	chr1:211365388-211365389:+		[7]
Sequence	ATTGAAGGATAAACGGAGGAACCTGCAGCAACATGAGCATT
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000261464.10; ENST00000336184.6; ENST00000367004.3; ENST00000462410.5
External Link	RMBase: m6A_site_77127
mod ID: M6ASITE081589		Click to Show/Hide the Full List
mod site	chr1:211365464-211365465:+		[7]
Sequence	AAGAATGTCCAATTAGAAGAACAGGTAAATCTTCAAAGGTT
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000336184.6; ENST00000261464.10; ENST00000367004.3; ENST00000462410.5
External Link	RMBase: m6A_site_77128
mod ID: M6ASITE081590		Click to Show/Hide the Full List
mod site	chr1:211369584-211369585:+		[7]
Sequence	AAATGGAAGCTTCCTCCCAAACATCCAGGTAAGAAATGGCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000367004.3; ENST00000261464.10; ENST00000336184.6; ENST00000473385.1
External Link	RMBase: m6A_site_77129
mod ID: M6ASITE081591		Click to Show/Hide the Full List
mod site	chr1:211371399-211371400:+		[7]
Sequence	CAAAATAAATTTGACCTGAGACCTTTGATGGAAGCAGTTGA
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000336184.6; ENST00000367004.3; ENST00000473385.1; ENST00000261464.10
External Link	RMBase: m6A_site_77130
mod ID: M6ASITE081592		Click to Show/Hide the Full List
mod site	chr1:211371429-211371430:+		[7]
Sequence	GAAGCAGTTGATACAGTGAAACAGAAAATTACCCTGCTAGA
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000261464.10; ENST00000367004.3; ENST00000336184.6; ENST00000473385.1
External Link	RMBase: m6A_site_77131
mod ID: M6ASITE081593		Click to Show/Hide the Full List
mod site	chr1:211371452-211371453:+		[7]
Sequence	GAAAATTACCCTGCTAGAAAACAATGATCAAAGATTAGGTA
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HEK293T; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000261464.10; ENST00000336184.6; ENST00000473385.1; ENST00000367004.3
External Link	RMBase: m6A_site_77132
mod ID: M6ASITE081594		Click to Show/Hide the Full List
mod site	chr1:211372144-211372145:+		[7]
Sequence	CAGCCGTTTTAGAAGAGGAAACTAACAAACATGATACCCAC
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HEK293T; fibroblasts; LCLs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000261464.10; ENST00000473385.1; ENST00000367004.3; ENST00000336184.6
External Link	RMBase: m6A_site_77133
mod ID: M6ASITE081595		Click to Show/Hide the Full List
mod site	chr1:211372152-211372153:+		[7]
Sequence	TTAGAAGAGGAAACTAACAAACATGATACCCACATTAATAT
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HEK293T; fibroblasts; LCLs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000336184.6; ENST00000473385.1; ENST00000367004.3; ENST00000261464.10
External Link	RMBase: m6A_site_77134
mod ID: M6ASITE081596		Click to Show/Hide the Full List
mod site	chr1:211372212-211372213:+		[7]
Sequence	AAAAATGAAGAGCGATTTAAACTGCTGGAGGGTACTTGCTA
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HEK293T; hNPCs; fibroblasts; LCLs; CD8T; Huh7
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000473385.1; ENST00000261464.10; ENST00000336184.6; ENST00000367004.3
External Link	RMBase: m6A_site_77135
mod ID: M6ASITE081597		Click to Show/Hide the Full List
mod site	chr1:211372474-211372475:+		[9]
Sequence	GGCCATTCAGGCAGAGGGTGACCCTGATGCTTCTGGACCAG
Motif Score	2.839113095
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000367004.3; ENST00000261464.10; ENST00000473385.1; ENST00000336184.6
External Link	RMBase: m6A_site_77136
mod ID: M6ASITE081598		Click to Show/Hide the Full List
mod site	chr1:211372490-211372491:+		[7]
Sequence	GGTGACCCTGATGCTTCTGGACCAGAGTGGCAAAAAGAACA
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000261464.10; ENST00000367004.3; ENST00000473385.1; ENST00000336184.6
External Link	RMBase: m6A_site_77137
mod ID: M6ASITE081599		Click to Show/Hide the Full List
mod site	chr1:211372508-211372509:+		[7]
Sequence	GGACCAGAGTGGCAAAAAGAACATTATGGAGACCTTCAAAC
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000367004.3; ENST00000473385.1; ENST00000336184.6; ENST00000261464.10
External Link	RMBase: m6A_site_77138
mod ID: M6ASITE081600		Click to Show/Hide the Full List
mod site	chr1:211372519-211372520:+		[7]
Sequence	GCAAAAAGAACATTATGGAGACCTTCAAACCTGACCCCAAT
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000336184.6; ENST00000367004.3; ENST00000473385.1; ENST00000261464.10
External Link	RMBase: m6A_site_77139
mod ID: M6ASITE081601		Click to Show/Hide the Full List
mod site	chr1:211372527-211372528:+		[7]
Sequence	AACATTATGGAGACCTTCAAACCTGACCCCAATAGCAGCAG
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000261464.10; ENST00000473385.1; ENST00000367004.3; ENST00000336184.6
External Link	RMBase: m6A_site_77140
mod ID: M6ASITE081602		Click to Show/Hide the Full List
mod site	chr1:211372532-211372533:+		[9]
Sequence	TATGGAGACCTTCAAACCTGACCCCAATAGCAGCAGCTTTA
Motif Score	2.839113095
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000336184.6; ENST00000261464.10; ENST00000473385.1; ENST00000367004.3
External Link	RMBase: m6A_site_77141
mod ID: M6ASITE081603		Click to Show/Hide the Full List
mod site	chr1:211372557-211372558:+		[7]
Sequence	AATAGCAGCAGCTTTAAAAGACCTGATGGGGAGATGAACAT
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000261464.10; ENST00000473385.1; ENST00000367004.3; ENST00000336184.6
External Link	RMBase: m6A_site_77142
mod ID: M6ASITE081604		Click to Show/Hide the Full List
mod site	chr1:211372574-211372575:+		[7]
Sequence	AAGACCTGATGGGGAGATGAACATTGCATCTGGCTGTCCCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000336184.6; ENST00000367004.3; ENST00000473385.1; ENST00000261464.10
External Link	RMBase: m6A_site_77143
mod ID: M6ASITE081605		Click to Show/Hide the Full List
mod site	chr1:211372631-211372632:+		[9]
Sequence	TGTTTTGGAGAATGCCAAGAACGCCTACATTAAAGATGACA
Motif Score	2.925321429
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000261464.10; ENST00000473385.1; ENST00000367004.3; ENST00000336184.6
External Link	RMBase: m6A_site_77144
mod ID: M6ASITE081606		Click to Show/Hide the Full List
mod site	chr1:211372676-211372677:+		[7]
Sequence	GTTCTTGAAAGTGGCCGTGGACTTAACTGACCTGGAGGATC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000367004.3; ENST00000261464.10; ENST00000336184.6; ENST00000473385.1
External Link	RMBase: m6A_site_77145
mod ID: M6ASITE081607		Click to Show/Hide the Full List
mod site	chr1:211372726-211372727:+		[7]
Sequence	TGTTATGGGGTGATAAGAGGACTTCTTGGGGCCAGAACTGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; MM6; Huh7; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000336184.6; ENST00000261464.10; ENST00000473385.1; ENST00000367004.3
External Link	RMBase: m6A_site_77146
mod ID: M6ASITE081608		Click to Show/Hide the Full List
mod site	chr1:211372742-211372743:+		[7]
Sequence	GAGGACTTCTTGGGGCCAGAACTGTGGAGGAGAGCACATTT
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; MM6; Huh7; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000367004.3; ENST00000473385.1; ENST00000261464.10; ENST00000336184.6
External Link	RMBase: m6A_site_77147
mod ID: M6ASITE081609		Click to Show/Hide the Full List
mod site	chr1:211372776-211372777:+		[9]
Sequence	CACATTTGATTATCATATTGACCTGGATTTAGACTCAAAGC
Motif Score	2.839113095
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000261464.10; ENST00000367004.3; ENST00000473385.1; ENST00000336184.6
External Link	RMBase: m6A_site_77148
mod ID: M6ASITE081610		Click to Show/Hide the Full List
mod site	chr1:211372788-211372789:+		[7]
Sequence	TCATATTGACCTGGATTTAGACTCAAAGCACATTTGTATTT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000261464.10; ENST00000336184.6; ENST00000367004.3; ENST00000473385.1
External Link	RMBase: m6A_site_77149
mod ID: M6ASITE081611		Click to Show/Hide the Full List
mod site	chr1:211372842-211372843:+		[7]
Sequence	ACGTTTGAAGTCAGTTTAAAACTTCTGAAGTGCTGTCTTTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; CD4T; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000336184.6; ENST00000473385.1; ENST00000261464.10
External Link	RMBase: m6A_site_77150
mod ID: M6ASITE081612		Click to Show/Hide the Full List
mod site	chr1:211372889-211372890:+		[10]
Sequence	TTACTCTGTCCCAGTTTGAAACTTAAAACTCTTAGAATATT
Motif Score	2.627720238
Cell/Tissue List	A549; GM12878; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000261464.10; ENST00000336184.6; ENST00000473385.1
External Link	RMBase: m6A_site_77151
mod ID: M6ASITE081613		Click to Show/Hide the Full List
mod site	chr1:211372896-211372897:+		[10]
Sequence	GTCCCAGTTTGAAACTTAAAACTCTTAGAATATTCTCTTAT
Motif Score	2.627720238
Cell/Tissue List	A549; GM12878; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000473385.1; ENST00000261464.10; ENST00000336184.6
External Link	RMBase: m6A_site_77152
mod ID: M6ASITE081614		Click to Show/Hide the Full List
mod site	chr1:211373103-211373104:+		[11]
Sequence	GTTTGGCCTATTGATTCTAGACCTGGCCTTAAGTCTGCAAA
Motif Score	2.876744048
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000336184.6; ENST00000261464.10; ENST00000473385.1
External Link	RMBase: m6A_site_77153
mod ID: M6ASITE081619		Click to Show/Hide the Full List
mod site	chr1:211373545-211373546:+		[12]
Sequence	CTATATATGTGTGTATACAAACAGTTCGAATGTATTTTGGT
Motif Score	2.20572619
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000261464.10; ENST00000336184.6; ENST00000473385.1
External Link	RMBase: m6A_site_77154
mod ID: M6ASITE081620		Click to Show/Hide the Full List
mod site	chr1:211373661-211373662:+		[12]
Sequence	ATTTACAACTTGAGGAGAAAACCTTTACAATTTCCTATGGG
Motif Score	2.185083333
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000261464.10; ENST00000473385.1; ENST00000336184.6
External Link	RMBase: m6A_site_77155
mod ID: M6ASITE081621		Click to Show/Hide the Full List
mod site	chr1:211373705-211373706:+		[12]
Sequence	CAGAAGTACTCTCAGCGAAAACTGATGGCTAAAACAGTATC
Motif Score	2.627720238
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000261464.10; ENST00000473385.1; ENST00000336184.6
External Link	RMBase: m6A_site_77156
mod ID: M6ASITE081622		Click to Show/Hide the Full List
mod site	chr1:211374036-211374037:+		[6]
Sequence	CCCACCGCGTCAAGCCTCTGACAACTATTGAATTTGTAAGC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000261464.10; ENST00000473385.1; ENST00000336184.6
External Link	RMBase: m6A_site_77157
mod ID: M6ASITE081623		Click to Show/Hide the Full List
mod site	chr1:211374083-211374084:+		[13]
Sequence	GCAAATGGGCATTTATATAAACTTGTGATGTTTCTTGTCAG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; HeLa; hNPCs; hESCs; fibroblasts; A549; LCLs; CD8T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000473385.1; ENST00000261464.10; ENST00000336184.6
External Link	RMBase: m6A_site_77158
mod ID: M6ASITE081624		Click to Show/Hide the Full List
mod site	chr1:211374126-211374127:+		[7]
Sequence	TTCTGAGTACTCTGTGAAGAACAGAAATGATCATATTCTTA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts; A549; LCLs; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000473385.1; ENST00000336184.6; ENST00000261464.10
External Link	RMBase: m6A_site_77159
mod ID: M6ASITE081633		Click to Show/Hide the Full List
mod site	chr1:211374184-211374185:+		[7]
Sequence	GTCTGAAGGTGTATATACAAACTGAGATGAGTCCTTATGAC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; HepG2; hNPCs; hESCs; fibroblasts; A549; GM12878; LCLs; CD8T; Huh7; HEK293A-TOA; TIME
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000473385.1; ENST00000261464.10; ENST00000336184.6
External Link	RMBase: m6A_site_77160
mod ID: M6ASITE081644		Click to Show/Hide the Full List
mod site	chr1:211374391-211374392:+		[7]
Sequence	ATGCACCTTACAATTTCTGAACAGTTAACCCTATAGAAGCA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; fibroblasts; A549; GM12878; LCLs; CD8T; HEK293A-TOA; TIME
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000336184.6; ENST00000261464.10; ENST00000473385.1
External Link	RMBase: m6A_site_77161
mod ID: M6ASITE081655		Click to Show/Hide the Full List
mod site	chr1:211374443-211374444:+		[7]
Sequence	AGTGTCTTCTGGGAAGAGGAACCTTCTTAATCTCTTCTGTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000336184.6; ENST00000473385.1; ENST00000261464.10
External Link	RMBase: m6A_site_77162
mod ID: M6ASITE081666		Click to Show/Hide the Full List
mod site	chr1:211374484-211374485:+		[7]
Sequence	GGATTTTCAAAATGCTAAAGACTCACACTGCAGCAATCATC
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HEK293T; A549; HepG2; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000336184.6; ENST00000261464.10; ENST00000473385.1
External Link	RMBase: m6A_site_77163
mod ID: M6ASITE081677		Click to Show/Hide the Full List
mod site	chr1:211374488-211374489:+		[6]
Sequence	TTTCAAAATGCTAAAGACTCACACTGCAGCAATCATCCCAG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000473385.1; ENST00000336184.6; ENST00000261464.10
External Link	RMBase: m6A_site_77164
mod ID: M6ASITE081688		Click to Show/Hide the Full List
mod site	chr1:211374535-211374536:+		[6]
Sequence	AAATTCAAAGAAATAGGTTCACAACAGGAATATACTGAAGA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000261464.10; ENST00000336184.6; ENST00000473385.1
External Link	RMBase: m6A_site_77165
mod ID: M6ASITE081699		Click to Show/Hide the Full List
mod site	chr1:211374556-211374557:+		[7]
Sequence	CAACAGGAATATACTGAAGAACTAGAGTGTCACTGCTGGTG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; H1B; H1A; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000473385.1; ENST00000261464.10; ENST00000336184.6
External Link	RMBase: m6A_site_77166
mod ID: M6ASITE081707		Click to Show/Hide the Full List
mod site	chr1:211374578-211374579:+		[7]
Sequence	TAGAGTGTCACTGCTGGTGAACTGTGGCACGGTTGCTCAAC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; H1B; H1A; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000261464.10; ENST00000473385.1; ENST00000336184.6
External Link	RMBase: m6A_site_77167
mod ID: M6ASITE081708		Click to Show/Hide the Full List
mod site	chr1:211374597-211374598:+		[6]
Sequence	AACTGTGGCACGGTTGCTCAACACATCACCTCGGACAAATT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000473385.1; ENST00000261464.10; ENST00000336184.6
External Link	RMBase: m6A_site_77168
mod ID: M6ASITE081709		Click to Show/Hide the Full List
mod site	chr1:211374611-211374612:+		[7]
Sequence	TGCTCAACACATCACCTCGGACAAATTCAGGAAGCATTTCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; hESC-HEK293T; HepG2; H1B; H1A; hNPCs; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000336184.6; ENST00000473385.1; ENST00000261464.10
External Link	RMBase: m6A_site_77169
mod ID: M6ASITE081710		Click to Show/Hide the Full List
mod site	chr1:211374649-211374650:+		[7]
Sequence	TCTTTAGCCCACAAGTCCAGACCCAGGTGCTCTGTATGTTT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; H1B; H1A; hESCs; fibroblasts; GM12878; LCLs; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000473385.1; ENST00000261464.10; ENST00000336184.6
External Link	RMBase: m6A_site_77170
mod ID: M6ASITE081711		Click to Show/Hide the Full List
mod site	chr1:211374764-211374765:+		[14]
Sequence	TTAAGTAGTTGATGTGGAAAACATTTTAAAGTGAATTTGTC
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000336184.6; ENST00000473385.1; ENST00000261464.10
External Link	RMBase: m6A_site_77171

Ref 1	Tumor-Associated Macrophages Promote Oxaliplatin Resistance via METTL3-Mediated m(6)A of TRAF5 and Necroptosis in Colorectal Cancer. Mol Pharm. 2021 Mar 1;18(3):1026-1037. doi: 10.1021/acs.molpharmaceut.0c00961. Epub 2021 Feb 8.
Ref 2	Clinical pipeline report, company report or official report of Deciphera Pharmaceuticals.
Ref 3	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 4	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 5	Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 2004 Sep;14(9):1719-25. doi: 10.1101/gr.2855504.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 8	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 9	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 10	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 11	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 12	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 13	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 14	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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