m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00614)
Target Name Beta-catenin-interacting protein 1 (CTNNBIP1)
Synonyms
Inhibitor of beta-catenin and Tcf-4
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Gene Name CTNNBIP1
Chromosomal Location 1p36.22
Family CTNNBIP1 family
Function
Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.
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Gene ID 56998
Uniprot ID
CNBP1_HUMAN
HGNC ID
HGNC:16913
KEGG ID
hsa:56998
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
CTNNBIP1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: -1.02E+00
p-value: 3.20E-17
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between CTNNBIP1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 1.17E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3-mediated m6A modification upregulated circDLC1 expression, and circDLC1 promoted Beta-catenin-interacting protein 1 (CTNNBIP1) transcription by sponging miR-671-5p, thus repressing the malignant proliferation of glioma.
Target Regulation Up regulation
Responsed Disease Glioma ICD-11: 2A00.0
 Disease Info 
In-vitro Model T98G Glioblastoma Homo sapiens CVCL_0556
LN-229 Glioblastoma Homo sapiens CVCL_0393
LN-18 Glioblastoma Homo sapiens CVCL_0392
HEB (human normal glial cell line HEB were obtained from Tongpai (Shanghai) biotechnology co., LTD (Shanghai, China))
A-172 Glioblastoma Homo sapiens CVCL_0131
Brain cancer [ICD-11: 2A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3-mediated m6A modification upregulated circDLC1 expression, and circDLC1 promoted Beta-catenin-interacting protein 1 (CTNNBIP1) transcription by sponging miR-671-5p, thus repressing the malignant proliferation of glioma.
Responsed Disease Glioma [ICD-11: 2A00.0]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model T98G Glioblastoma Homo sapiens CVCL_0556
LN-229 Glioblastoma Homo sapiens CVCL_0393
LN-18 Glioblastoma Homo sapiens CVCL_0392
HEB (human normal glial cell line HEB were obtained from Tongpai (Shanghai) biotechnology co., LTD (Shanghai, China))
A-172 Glioblastoma Homo sapiens CVCL_0131
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03319
 Crosstalk Info 
Epigenetic Regulator Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C)
Regulated Target Histone H3 lysine 9 monomethylation (H3K9me1)
Crosstalk relationship Histone modification → m6A
Disease Brain cancer
 Disease Info 
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00614)
Beta-catenin-interacting protein 1 (CTNNBIP1)
Adenosine-to-Inosine editing (A-to-I)
In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000697 Click to Show/Hide the Full List
mod site chr1:9863964-9863965:- [2]
Sequence AAATATCTGTGGTCATGGGTAGATCAGCAGAAACCAGGCTG
Transcript ID List ENST00000377263.6; ENST00000377258.5; ENST00000377256.1; ENST00000400904.7
External Link RMBase: RNA-editing_site_1095
mod ID: A2ISITE000699 Click to Show/Hide the Full List
mod site chr1:9887536-9887537:- [2]
Sequence CTAATTTTTGTAATTTTAGTAGAGACAGGGTTTTACTATGT
Transcript ID List ENST00000377258.5; ENST00000400904.7; ENST00000377263.6
External Link RMBase: RNA-editing_site_1096
5-methylcytidine (m5C)
In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005146 Click to Show/Hide the Full List
mod site chr1:9848976-9848977:-
Sequence ACCAAATCTTTCCCCTTTCTCGGGGCTTGGGGCTCGGGCCG
Cell/Tissue List frontalcortex
Seq Type List Bisulfite-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m5C_site_733
mod ID: M5CSITE005147 Click to Show/Hide the Full List
mod site chr1:9849423-9849424:-
Sequence CAGCTCTGGAGTTCTCTCATCGGAGGCCCATGCCCTCCACT
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m5C_site_734
N6-methyladenosine (m6A)
In total 32 m6A sequence/site(s) in this target gene
mod ID: M6ASITE061711 Click to Show/Hide the Full List
mod site chr1:9848297-9848298:- [3]
Sequence TCTGTTGGAGAAAGAAATTAACAATAAAGAATTTTCATAGG
Motif Score 2.168095238
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5983
mod ID: M6ASITE061712 Click to Show/Hide the Full List
mod site chr1:9848401-9848402:- [3]
Sequence TCACAGGCCTTGCTTTTGTAACAATGATGACCCCGGCCTGT
Motif Score 2.168095238
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5984
mod ID: M6ASITE061713 Click to Show/Hide the Full List
mod site chr1:9848419-9848420:- [4]
Sequence AGCCTGTCCTTGTCACGATCACAGGCCTTGCTTTTGTAACA
Motif Score 2.047297619
Cell/Tissue List kidney
Seq Type List m6A-REF-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5985
mod ID: M6ASITE061714 Click to Show/Hide the Full List
mod site chr1:9848480-9848481:- [4]
Sequence GTAGCTCCTATAAAGGGCCCACACCTGGTGGATACCTGGTT
Motif Score 2.053113095
Cell/Tissue List liver; hESC-HEK293T
Seq Type List m6A-REF-seq; MAZTER-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5986
mod ID: M6ASITE061715 Click to Show/Hide the Full List
mod site chr1:9848523-9848524:- [3]
Sequence TGGAGTCAGGTGTCGAGGCCACATTGCTGGCTGCCCCCTCT
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5987
mod ID: M6ASITE061716 Click to Show/Hide the Full List
mod site chr1:9848670-9848671:- [3]
Sequence CATGTGCTGTGTGAGTGAGCACACCCGTGTGCACACTCATA
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5988
mod ID: M6ASITE061717 Click to Show/Hide the Full List
mod site chr1:9848746-9848747:- [3]
Sequence CAGCTGTGGGGAACACAGCTACAACCCTACCCTGGCAGGGA
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5989
mod ID: M6ASITE061718 Click to Show/Hide the Full List
mod site chr1:9848817-9848818:- [5]
Sequence GATTCGAGCATCAGGCTAAGACCCTGTGTCCTCCACCATGC
Motif Score 2.876744048
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5990
mod ID: M6ASITE061719 Click to Show/Hide the Full List
mod site chr1:9849509-9849510:- [6]
Sequence CCCAGGAGACCTCCAGCTAAACACCAACCCCTGACCTACCC
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5991
mod ID: M6ASITE061720 Click to Show/Hide the Full List
mod site chr1:9849521-9849522:- [6]
Sequence TGGCTCACAAGGCCCAGGAGACCTCCAGCTAAACACCAACC
Motif Score 2.876744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5992
mod ID: M6ASITE061721 Click to Show/Hide the Full List
mod site chr1:9849562-9849563:- [6]
Sequence GAGGTCTCTGGGAGCCCAGAACCCACATAAAAGCCCCAGCT
Motif Score 2.930744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5993
mod ID: M6ASITE061722 Click to Show/Hide the Full List
mod site chr1:9849602-9849603:- [6]
Sequence CCCAGTGTGAGACCCCAAAGACTCTGGAGGTCATCTGGCGG
Motif Score 3.319380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5994
mod ID: M6ASITE061723 Click to Show/Hide the Full List
mod site chr1:9849611-9849612:- [6]
Sequence GGAGCTTCTCCCAGTGTGAGACCCCAAAGACTCTGGAGGTC
Motif Score 2.876744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5995
mod ID: M6ASITE061769 Click to Show/Hide the Full List
mod site chr1:9849975-9849976:- [3]
Sequence TGAGGGTCCACCTGGAGAGTACATTTGCTTTAATGAGTGCA
Motif Score 2.856142857
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000377263.6
External Link RMBase: m6A_site_5996
mod ID: M6ASITE061770 Click to Show/Hide the Full List
mod site chr1:9850108-9850109:- [3]
Sequence AAGAACTTGCTGCTGCCTTCACATTTGGGGTTTGTGTTTGA
Motif Score 2.047297619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000377263.6; ENST00000400904.7
External Link RMBase: m6A_site_5997
mod ID: M6ASITE061771 Click to Show/Hide the Full List
mod site chr1:9850131-9850132:- [5]
Sequence CGCTTTGCAATATTTATTACACAAAGAACTTGCTGCTGCCT
Motif Score 2.084928571
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000377263.6; ENST00000400904.7
External Link RMBase: m6A_site_5998
mod ID: M6ASITE061772 Click to Show/Hide the Full List
mod site chr1:9850133-9850134:- [5]
Sequence TGCGCTTTGCAATATTTATTACACAAAGAACTTGCTGCTGC
Motif Score 2.07285119
Cell/Tissue List HEK293T; hESC-HEK293T
Seq Type List DART-seq; MAZTER-seq
Transcript ID List ENST00000400904.7; ENST00000377263.6
External Link RMBase: m6A_site_5999
mod ID: M6ASITE061773 Click to Show/Hide the Full List
mod site chr1:9850159-9850160:- [6]
Sequence TTTGACTTGAAAAGAAAGAAACCAAGTGCGCTTTGCAATAT
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000400904.7; ENST00000377263.6
External Link RMBase: m6A_site_6000
mod ID: M6ASITE061774 Click to Show/Hide the Full List
mod site chr1:9850175-9850176:- [5]
Sequence GACATTAGTCGTTATATTTGACTTGAAAAGAAAGAAACCAA
Motif Score 3.28175
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000400904.7; ENST00000377263.6
External Link RMBase: m6A_site_6001
mod ID: M6ASITE061775 Click to Show/Hide the Full List
mod site chr1:9850194-9850195:- [6]
Sequence TGCAGAAAACAGGGTCTGGGACATTAGTCGTTATATTTGAC
Motif Score 3.643047619
Cell/Tissue List HeLa; HEK293T; hESC-HEK293T
Seq Type List m6A-seq; DART-seq; MAZTER-seq
Transcript ID List ENST00000377263.6; ENST00000400904.7
External Link RMBase: m6A_site_6002
mod ID: M6ASITE061795 Click to Show/Hide the Full List
mod site chr1:9850206-9850207:- [6]
Sequence CCCTATTTTGAATGCAGAAAACAGGGTCTGGGACATTAGTC
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000377263.6; ENST00000400904.7
External Link RMBase: m6A_site_6003
mod ID: M6ASITE061800 Click to Show/Hide the Full List
mod site chr1:9850233-9850234:- [4]
Sequence CAGGTGTTCTGCTGATATCAACAGCTTCCCTATTTTGAATG
Motif Score 2.173910714
Cell/Tissue List kidney
Seq Type List m6A-REF-seq
Transcript ID List ENST00000400904.7; ENST00000377263.6
External Link RMBase: m6A_site_6004
mod ID: M6ASITE061801 Click to Show/Hide the Full List
mod site chr1:9850309-9850310:- [5]
Sequence AGGTCTGATTGGCTGCTTAAACTGGAAAGGATCTGTGATTG
Motif Score 2.627720238
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000400904.7; ENST00000377263.6
External Link RMBase: m6A_site_6005
mod ID: M6ASITE061802 Click to Show/Hide the Full List
mod site chr1:9850429-9850430:- [5]
Sequence ACCTTTTATTTTTATTTCTGACTCTTATTTTTTAAAAAATT
Motif Score 3.28175
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000400904.7; ENST00000377263.6
External Link RMBase: m6A_site_6006
mod ID: M6ASITE061803 Click to Show/Hide the Full List
mod site chr1:9850449-9850450:- [7]
Sequence TTAAATCTTGACCAACAGAAACCTTTTATTTTTATTTCTGA
Motif Score 2.185083333
Cell/Tissue List hESCs
Seq Type List m6A-seq
Transcript ID List ENST00000400904.7; ENST00000377263.6; ENST00000377258.5
External Link RMBase: m6A_site_6007
mod ID: M6ASITE061804 Click to Show/Hide the Full List
mod site chr1:9850482-9850483:- [7]
Sequence GTGATTGGCTGCAGGAAGAAACTTTTTTATTTTTTAAATCT
Motif Score 2.627720238
Cell/Tissue List hESCs
Seq Type List m6A-seq
Transcript ID List ENST00000400904.7; ENST00000377263.6; ENST00000377258.5
External Link RMBase: m6A_site_6008
mod ID: M6ASITE061805 Click to Show/Hide the Full List
mod site chr1:9850506-9850507:- [7]
Sequence TAATTGGCTTAAAGGGATGGACTTGTGATTGGCTGCAGGAA
Motif Score 4.065041667
Cell/Tissue List hESCs
Seq Type List m6A-seq
Transcript ID List ENST00000400904.7; ENST00000377263.6; ENST00000377258.5
External Link RMBase: m6A_site_6009
mod ID: M6ASITE061806 Click to Show/Hide the Full List
mod site chr1:9850544-9850545:- [3]
Sequence TGGGGCTGGCATCAAGGGAGACACCAGTGGTGCGTTTATAA
Motif Score 2.897386905
Cell/Tissue List hESC-HEK293T; hESCs
Seq Type List MAZTER-seq; m6A-seq
Transcript ID List ENST00000377258.5; ENST00000377263.6; ENST00000400904.7
External Link RMBase: m6A_site_6010
mod ID: M6ASITE061807 Click to Show/Hide the Full List
mod site chr1:9850700-9850701:- [8]
Sequence GTAGCTGCAAAGCCCTTGGAACACCCTGGATGCTGTTGAGG
Motif Score 2.951386905
Cell/Tissue List HepG2; hESC-HEK293T; peripheral-blood
Seq Type List m6A-seq; MAZTER-seq
Transcript ID List ENST00000377258.5; ENST00000377256.1; ENST00000377263.6; ENST00000400904.7
External Link RMBase: m6A_site_6011
mod ID: M6ASITE061808 Click to Show/Hide the Full List
mod site chr1:9850730-9850731:- [9]
Sequence TTCCAGGTCGGAGACGGAAGACCGGAGGCAGTAGCTGCAAA
Motif Score 2.876744048
Cell/Tissue List HepG2; peripheral-blood
Seq Type List m6A-seq
Transcript ID List ENST00000377256.1; ENST00000377258.5; ENST00000400904.7; ENST00000377263.6
External Link RMBase: m6A_site_6012
mod ID: M6ASITE061809 Click to Show/Hide the Full List
mod site chr1:9872020-9872021:- [3]
Sequence GAAGAGTCCGGAGGAGATGTACATTCAGCAGAAGGTCCGAG
Motif Score 2.856142857
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000377256.1; ENST00000377263.6; ENST00000377258.5; ENST00000400904.7
External Link RMBase: m6A_site_6013
mod ID: M6ASITE061810 Click to Show/Hide the Full List
mod site chr1:9872059-9872060:- [8]
Sequence AGAGCCAGGCAGGGGGATGAACCGCGAGGGAGCTCCCGGGA
Motif Score 2.930744048
Cell/Tissue List HepG2; endometrial; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000377263.6; ENST00000400904.7; ENST00000377256.1; ENST00000377258.5
External Link RMBase: m6A_site_6014