m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00520)

Target Name	Alpha-enolase (ENO1)
Synonyms	2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein Click to Show/Hide
Gene Name	ENO1
Chromosomal Location	1p36.23
Family	Enolase family
Function	Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Click to Show/Hide
Gene ID	2023
Uniprot ID	ENOA_HUMAN
HGNC ID	HGNC:3350
KEGG ID	hsa:2023

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

ENO1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	mouse embryonic stem cells	Mus musculus
Treatment: METTL3-/- ESCs Control: Wild type ESCs		GSE145309
Regulation		logFC: -8.80E-01 p-value: 3.03E-81
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Alpha-enolase (ENO1) positively correlated with METTL3 and global m6A levels, and negatively correlated with ALKBH5 in human Lung adenocarcinoma(LUAD). In addition, m6A-dependent elevation of ENO1 was associated with LUAD progression.
Target Regulation	Up regulation
Responsed Disease	Lung adenocarcinoma		ICD-11: 2C25.0	Disease Info
Pathway Response	Carbon metabolism			hsa01200
Pathway Response	Glycolysis / Gluconeogenesis			hsa00010
Cell Process	Glycolysis
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
	NCI-H441	Lung papillary adenocarcinoma	Homo sapiens	CVCL_1561
	NCI-H292	Lung mucoepidermoid carcinoma	Homo sapiens	CVCL_0455
	NCI-H2030	Lung adenocarcinoma	Homo sapiens	CVCL_1517
	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1483
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	3LL	Malignant tumors of the mouse pulmonary system	Mus musculus	CVCL_5653
	HCC827	Lung adenocarcinoma	Homo sapiens	CVCL_2063
	Calu-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0608
	BEAS-2B	Normal	Homo sapiens	CVCL_0168
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	A-427	Lung adenocarcinoma	Homo sapiens	CVCL_1055
	16HBE14o-	Normal	Homo sapiens	CVCL_0112
In-vivo Model	KP and Mettl3^-/- mice were bred to generate KPM^-/- mice. Afterwards, the KP and KPM^-/- mice were intranasally infected under anesthesia with adeno-associated virus type 5 (AAV5) expressing Cre to initiate lung tumorigenesis along with ALKBH5-expressing AAV5 or Empty AAV5 to generate KPE, KPA, KPEM^-/- and KPAM^-/- spontaneous LUAD mouse models. For generation of LLC-based intra-pulmonary tumor mouse models, 1 × 10⁷ LLC cells were injected into C57BL/6 mice via the tail vein.For cell-derived xenograft (CDX) mouse models, 1.0 × 10⁷ H1299 or 1.5 × 10⁷ H1975 cells were subcutaneously injected into 4-6-week-old athymic nude mice. The tumors were monitored at indicated time points and isolated for further analysis after sacrifice.

RNA demethylase ALKBH5 (ALKBH5) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5*
Cell Line	human pluripotent stem cells	Homo sapiens
Treatment: hILO ALKBH5knockout cells Control: hILO wild type cells		GSE163945
Regulation		logFC: -9.52E-01 p-value: 3.98E-04
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Alpha-enolase (ENO1) positively correlated with METTL3 and global m6A levels, and negatively correlated with ALKBH5 in human Lung adenocarcinoma(LUAD). In addition, m6A-dependent elevation of ENO1 was associated with LUAD progression.
Target Regulation	Down regulation
Responsed Disease	Lung adenocarcinoma		ICD-11: 2C25.0	Disease Info
Pathway Response	Carbon metabolism			hsa01200
Pathway Response	Glycolysis / Gluconeogenesis			hsa00010
Cell Process	Glycolysis
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
	NCI-H441	Lung papillary adenocarcinoma	Homo sapiens	CVCL_1561
	NCI-H292	Lung mucoepidermoid carcinoma	Homo sapiens	CVCL_0455
	NCI-H2030	Lung adenocarcinoma	Homo sapiens	CVCL_1517
	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1483
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	3LL	Malignant tumors of the mouse pulmonary system	Mus musculus	CVCL_5653
	HCC827	Lung adenocarcinoma	Homo sapiens	CVCL_2063
	Calu-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0608
	BEAS-2B	Normal	Homo sapiens	CVCL_0168
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	A-427	Lung adenocarcinoma	Homo sapiens	CVCL_1055
	16HBE14o-	Normal	Homo sapiens	CVCL_0112
In-vivo Model	KP and Mettl3^-/- mice were bred to generate KPM^-/- mice. Afterwards, the KP and KPM^-/- mice were intranasally infected under anesthesia with adeno-associated virus type 5 (AAV5) expressing Cre to initiate lung tumorigenesis along with ALKBH5-expressing AAV5 or Empty AAV5 to generate KPE, KPA, KPEM^-/- and KPAM^-/- spontaneous LUAD mouse models. For generation of LLC-based intra-pulmonary tumor mouse models, 1 × 10⁷ LLC cells were injected into C57BL/6 mice via the tail vein.For cell-derived xenograft (CDX) mouse models, 1.0 × 10⁷ H1299 or 1.5 × 10⁷ H1975 cells were subcutaneously injected into 4-6-week-old athymic nude mice. The tumors were monitored at indicated time points and isolated for further analysis after sacrifice.

Wilms tumor 1-associating protein (WTAP) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by WTAP*
Cell Line	Human umbilical vein endothelial cells	Homo sapiens
Treatment: siWTAP HUVECs Control: siControl HUVECs		GSE167067
Regulation		logFC: -6.99E-01 p-value: 1.98E-02
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[2]
Response Summary	The stabilization of WTAP further promotes RNA m6A methylation of Alpha-enolase (ENO1), impacting the glycolytic activity of BC cells.
Target Regulation	Up regulation
Responsed Disease	Breast cancer		ICD-11: 2C60	Disease Info
Pathway Response	Glycolysis / Gluconeogenesis			hsa00010
Cell Process	Glycolysis
In-vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens	CVCL_0062
	MCF-7	Invasive breast carcinoma	Homo sapiens	CVCL_0031
	HEK293T	Normal	Homo sapiens	CVCL_0063
In-vivo Model	A total of 1 × 10⁶ luciferase-labeled BC cells transfected with shWTAP or shNC were injected subcutaneously with or without C5aR1 neutrophils (tumor cells:neutrophils, 10:1).

Lung cancer [ICD-11: 2C25]

Disease Info

In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	Alpha-enolase (ENO1) positively correlated with METTL3 and global m6A levels, and negatively correlated with ALKBH5 in human Lung adenocarcinoma(LUAD). In addition, m6A-dependent elevation of ENO1 was associated with LUAD progression.
Responsed Disease	Lung adenocarcinoma [ICD-11: 2C25.0]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Carbon metabolism			hsa01200
Pathway Response	Glycolysis / Gluconeogenesis			hsa00010
Cell Process	Glycolysis
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
	NCI-H441	Lung papillary adenocarcinoma	Homo sapiens	CVCL_1561
	NCI-H292	Lung mucoepidermoid carcinoma	Homo sapiens	CVCL_0455
	NCI-H2030	Lung adenocarcinoma	Homo sapiens	CVCL_1517
	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1483
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	3LL	Malignant tumors of the mouse pulmonary system	Mus musculus	CVCL_5653
	HCC827	Lung adenocarcinoma	Homo sapiens	CVCL_2063
	Calu-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0608
	BEAS-2B	Normal	Homo sapiens	CVCL_0168
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	A-427	Lung adenocarcinoma	Homo sapiens	CVCL_1055
	16HBE14o-	Normal	Homo sapiens	CVCL_0112
In-vivo Model	KP and Mettl3^-/- mice were bred to generate KPM^-/- mice. Afterwards, the KP and KPM^-/- mice were intranasally infected under anesthesia with adeno-associated virus type 5 (AAV5) expressing Cre to initiate lung tumorigenesis along with ALKBH5-expressing AAV5 or Empty AAV5 to generate KPE, KPA, KPEM^-/- and KPAM^-/- spontaneous LUAD mouse models. For generation of LLC-based intra-pulmonary tumor mouse models, 1 × 10⁷ LLC cells were injected into C57BL/6 mice via the tail vein.For cell-derived xenograft (CDX) mouse models, 1.0 × 10⁷ H1299 or 1.5 × 10⁷ H1975 cells were subcutaneously injected into 4-6-week-old athymic nude mice. The tumors were monitored at indicated time points and isolated for further analysis after sacrifice.
Experiment 2 Reporting the m6A-centered Disease Response				[1]
Response Summary	Alpha-enolase (ENO1) positively correlated with METTL3 and global m6A levels, and negatively correlated with ALKBH5 in human Lung adenocarcinoma(LUAD). In addition, m6A-dependent elevation of ENO1 was associated with LUAD progression.
Responsed Disease	Lung adenocarcinoma [ICD-11: 2C25.0]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)		ERASER	Regulator Info
Target Regulation	Down regulation
Pathway Response	Carbon metabolism			hsa01200
Pathway Response	Glycolysis / Gluconeogenesis			hsa00010
Cell Process	Glycolysis
In-vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens	CVCL_B260
	NCI-H441	Lung papillary adenocarcinoma	Homo sapiens	CVCL_1561
	NCI-H292	Lung mucoepidermoid carcinoma	Homo sapiens	CVCL_0455
	NCI-H2030	Lung adenocarcinoma	Homo sapiens	CVCL_1517
	NCI-H1975	Lung adenocarcinoma	Homo sapiens	CVCL_1511
	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1483
	NCI-H1299	Lung large cell carcinoma	Homo sapiens	CVCL_0060
	3LL	Malignant tumors of the mouse pulmonary system	Mus musculus	CVCL_5653
	HCC827	Lung adenocarcinoma	Homo sapiens	CVCL_2063
	Calu-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0608
	BEAS-2B	Normal	Homo sapiens	CVCL_0168
	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	A-427	Lung adenocarcinoma	Homo sapiens	CVCL_1055
	16HBE14o-	Normal	Homo sapiens	CVCL_0112
In-vivo Model	KP and Mettl3^-/- mice were bred to generate KPM^-/- mice. Afterwards, the KP and KPM^-/- mice were intranasally infected under anesthesia with adeno-associated virus type 5 (AAV5) expressing Cre to initiate lung tumorigenesis along with ALKBH5-expressing AAV5 or Empty AAV5 to generate KPE, KPA, KPEM^-/- and KPAM^-/- spontaneous LUAD mouse models. For generation of LLC-based intra-pulmonary tumor mouse models, 1 × 10⁷ LLC cells were injected into C57BL/6 mice via the tail vein.For cell-derived xenograft (CDX) mouse models, 1.0 × 10⁷ H1299 or 1.5 × 10⁷ H1975 cells were subcutaneously injected into 4-6-week-old athymic nude mice. The tumors were monitored at indicated time points and isolated for further analysis after sacrifice.

Breast cancer [ICD-11: 2C60]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[2]
Response Summary	The stabilization of WTAP further promotes RNA m6A methylation of Alpha-enolase (ENO1), impacting the glycolytic activity of BC cells.
Responsed Disease	Breast cancer [ICD-11: 2C60]
Target Regulator	Wilms tumor 1-associating protein (WTAP)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Glycolysis / Gluconeogenesis			hsa00010
Cell Process	Glycolysis
In-vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens	CVCL_0062
	MCF-7	Invasive breast carcinoma	Homo sapiens	CVCL_0031
	HEK293T	Normal	Homo sapiens	CVCL_0063
In-vivo Model	A total of 1 × 10⁶ luciferase-labeled BC cells transfected with shWTAP or shNC were injected subcutaneously with or without C5aR1 neutrophils (tumor cells:neutrophils, 10:1).

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00520)

Alpha-enolase (ENO1)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE010498		Click to Show/Hide the Full List
mod site	chr1:8876911-8876912:-		[5]
Sequence	GCTGAGGTTGCAGTGAGCCAAAATGGCGCCATTGCACTCCA
Transcript ID List	ENST00000646906.1; ENST00000643438.1; ENST00000414948.1; ENST00000234590.10; ENST00000497492.1; rmsk_15815; ENST00000489867.2; ENST00000645609.1; ENST00000646660.1; ENST00000486051.5; ENST00000492343.2; ENST00000647408.1; ENST00000646156.1; ENST00000646539.1; ENST00000646680.1; ENST00000646370.2
External Link	RMBase: RNA-editing_site_860

5-methylcytidine (m5C)

In total 14 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005072		Click to Show/Hide the Full List
mod site	chr1:8861308-8861309:-		[6]
Sequence	GTTGGCTACACAGACCCCTCCCCTCGTGTCAGCTCAGGCAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000234590.10; ENST00000464920.2; ENST00000647408.1; ENST00000646370.2; ENST00000646539.1
External Link	RMBase: m5C_site_699
mod ID: M5CSITE005081		Click to Show/Hide the Full List
mod site	chr1:8862948-8862949:-
Sequence	CAAATGGCCTTTCTTTTCTCCTAGATCAAGACTGGTGCCCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000647408.1; ENST00000646539.1; ENST00000646370.2; ENST00000234590.10; ENST00000464920.2
External Link	RMBase: m5C_site_700
mod ID: M5CSITE005092		Click to Show/Hide the Full List
mod site	chr1:8864097-8864098:-		[6]
Sequence	ATGAAGCGTGTCCCTCCTTTCCTTAGTGGTGTCTATCGAAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000646370.2; ENST00000645609.1; ENST00000646539.1; ENST00000234590.10; ENST00000647408.1; ENST00000464920.2
External Link	RMBase: m5C_site_701
mod ID: M5CSITE005094		Click to Show/Hide the Full List
mod site	chr1:8864102-8864103:-		[6]
Sequence	CACTGATGAAGCGTGTCCCTCCTTTCCTTAGTGGTGTCTAT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000234590.10; ENST00000646370.2; ENST00000464920.2; ENST00000645609.1; ENST00000646539.1; ENST00000647408.1
External Link	RMBase: m5C_site_702
mod ID: M5CSITE005095		Click to Show/Hide the Full List
mod site	chr1:8866508-8866509:-		[6]
Sequence	CCATGCTTCTCTGCTCTGCTCTCCCCAGGCGTTCAATGTCA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000645609.1; ENST00000646370.2; ENST00000646680.1; ENST00000234590.10; MIMAT0027358; ENST00000497492.1; ENST00000647408.1; ENST00000646539.1; ENST00000618792.1; ENST00000645600.1; ENST00000646660.1; ENST00000464920.2
External Link	RMBase: m5C_site_703
mod ID: M5CSITE005096		Click to Show/Hide the Full List
mod site	chr1:8877314-8877315:-
Sequence	TCCTCAGGATCACCTGAGGTCGGGAGTTAGAGACCAGCCTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000492343.2; ENST00000646660.1; ENST00000497492.1; ENST00000643438.1; ENST00000646539.1; ENST00000234590.10; ENST00000647408.1; ENST00000486051.5; ENST00000646156.1; ENST00000646680.1; ENST00000489867.2; ENST00000646906.1; ENST00000645609.1; ENST00000414948.1; rmsk_15817; ENST00000646370.2
External Link	RMBase: m5C_site_704
mod ID: M5CSITE005097		Click to Show/Hide the Full List
mod site	chr1:8877321-8877322:-
Sequence	GTGGGCCTCCTCAGGATCACCTGAGGTCGGGAGTTAGAGAC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000486051.5; ENST00000234590.10; ENST00000647408.1; ENST00000492343.2; ENST00000646906.1; ENST00000646156.1; ENST00000643438.1; ENST00000497492.1; ENST00000489867.2; ENST00000414948.1; ENST00000646660.1; ENST00000646539.1; ENST00000646680.1; rmsk_15817; ENST00000646370.2; ENST00000645609.1
External Link	RMBase: m5C_site_705
mod ID: M5CSITE005099		Click to Show/Hide the Full List
mod site	chr1:8877324-8877325:-
Sequence	GAGGTGGGCCTCCTCAGGATCACCTGAGGTCGGGAGTTAGA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000643438.1; rmsk_15817; ENST00000489867.2; ENST00000414948.1; ENST00000497492.1; ENST00000646539.1; ENST00000646906.1; ENST00000646660.1; ENST00000646680.1; ENST00000486051.5; ENST00000234590.10; ENST00000647408.1; ENST00000646370.2; ENST00000645609.1; ENST00000492343.2; ENST00000646156.1
External Link	RMBase: m5C_site_706
mod ID: M5CSITE005102		Click to Show/Hide the Full List
mod site	chr1:8877586-8877587:-
Sequence	CTGGGATTACAGGCGTGAGCCACCGCGCTAGGCCAAGAAGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000414948.1; ENST00000489867.2; ENST00000234590.10; ENST00000645609.1; ENST00000646906.1; ENST00000646539.1; ENST00000646370.2; ENST00000646156.1; ENST00000646660.1; ENST00000647408.1; ENST00000497492.1; ENST00000492343.2; ENST00000643438.1; ENST00000646680.1; ENST00000486051.5
External Link	RMBase: m5C_site_707
mod ID: M5CSITE005111		Click to Show/Hide the Full List
mod site	chr1:8877587-8877588:-
Sequence	GCTGGGATTACAGGCGTGAGCCACCGCGCTAGGCCAAGAAG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000234590.10; ENST00000492343.2; ENST00000646539.1; ENST00000646370.2; ENST00000486051.5; ENST00000646680.1; ENST00000414948.1; ENST00000645609.1; ENST00000497492.1; ENST00000643438.1; ENST00000646906.1; ENST00000489867.2; ENST00000647408.1; ENST00000646156.1; ENST00000646660.1
External Link	RMBase: m5C_site_708
mod ID: M5CSITE005113		Click to Show/Hide the Full List
mod site	chr1:8877593-8877594:-
Sequence	CAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTAGGCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000234590.10; ENST00000492343.2; ENST00000646906.1; ENST00000646680.1; ENST00000414948.1; ENST00000497492.1; ENST00000646660.1; ENST00000647408.1; ENST00000646370.2; ENST00000489867.2; ENST00000645609.1; ENST00000646539.1; ENST00000643438.1; ENST00000646156.1; ENST00000486051.5
External Link	RMBase: m5C_site_709
mod ID: M5CSITE005114		Click to Show/Hide the Full List
mod site	chr1:8877597-8877598:-
Sequence	CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000489867.2; ENST00000234590.10; ENST00000497492.1; ENST00000646680.1; ENST00000492343.2; ENST00000646906.1; ENST00000646660.1; ENST00000643438.1; ENST00000646370.2; ENST00000646539.1; ENST00000647408.1; ENST00000486051.5; ENST00000414948.1; ENST00000646156.1; ENST00000645609.1
External Link	RMBase: m5C_site_710
mod ID: M5CSITE005115		Click to Show/Hide the Full List
mod site	chr1:8877639-8877640:-
Sequence	TGGTCTTGAGCTCCCGACCTCAGGTGATCCGCCCGCCTCGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000492343.2; ENST00000645609.1; ENST00000234590.10; ENST00000646156.1; ENST00000497492.1; ENST00000646539.1; ENST00000646680.1; ENST00000646906.1; ENST00000646660.1; ENST00000489867.2; ENST00000643438.1; ENST00000647408.1; ENST00000486051.5; ENST00000414948.1; ENST00000646370.2
External Link	RMBase: m5C_site_711
mod ID: M5CSITE005116		Click to Show/Hide the Full List
mod site	chr1:8877641-8877642:-
Sequence	GCTGGTCTTGAGCTCCCGACCTCAGGTGATCCGCCCGCCTC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000234590.10; ENST00000489867.2; ENST00000492343.2; ENST00000486051.5; ENST00000647408.1; ENST00000643438.1; ENST00000646906.1; ENST00000497492.1; ENST00000646539.1; ENST00000646680.1; ENST00000646660.1; ENST00000645609.1; ENST00000414948.1; ENST00000646156.1; ENST00000646370.2
External Link	RMBase: m5C_site_712

N6-methyladenosine (m6A)

In total 47 m6A sequence/site(s) in this target gene
mod ID: M6ASITE053300		Click to Show/Hide the Full List
mod site	chr1:8861060-8861061:-		[7]
Sequence	GTGTCATCTCCGGGGTGGCCACAGGCTAGATCCCCGGTGGT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000647408.1; ENST00000646539.1; ENST00000464920.2; ENST00000234590.10; ENST00000646370.2
External Link	RMBase: m6A_site_5351
mod ID: M6ASITE053301		Click to Show/Hide the Full List
mod site	chr1:8861206-8861207:-		[8]
Sequence	GTTCGTACCGCTTCCTTAGAACTTCTACAGAAGCCAAGCTC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; HepG2; AML
Seq Type List	m6A-seq; DART-seq; miCLIP
Transcript ID List	ENST00000234590.10; ENST00000646539.1; ENST00000646370.2; ENST00000647408.1; ENST00000464920.2
External Link	RMBase: m6A_site_5352
mod ID: M6ASITE053302		Click to Show/Hide the Full List
mod site	chr1:8861270-8861271:-		[7]
Sequence	CAGCTCGAGGCCCCCGACCAACACTTGCAGGGGTCCCTGCT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000464920.2; ENST00000234590.10; ENST00000646539.1; ENST00000646370.2; ENST00000647408.1
External Link	RMBase: m6A_site_5353
mod ID: M6ASITE053303		Click to Show/Hide the Full List
mod site	chr1:8861315-8861316:-		[8]
Sequence	GTCACCTGTTGGCTACACAGACCCCTCCCCTCGTGTCAGCT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MT4; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000647408.1; ENST00000464920.2; ENST00000646370.2; ENST00000234590.10; ENST00000646539.1
External Link	RMBase: m6A_site_5354
mod ID: M6ASITE053344		Click to Show/Hide the Full List
mod site	chr1:8861321-8861322:-		[7]
Sequence	CCTTCGGTCACCTGTTGGCTACACAGACCCCTCCCCTCGTG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000464920.2; ENST00000646539.1; ENST00000647408.1; ENST00000646370.2; ENST00000234590.10
External Link	RMBase: m6A_site_5355
mod ID: M6ASITE053445		Click to Show/Hide the Full List
mod site	chr1:8861375-8861376:-		[8]
Sequence	TGCCGGCAGGAACTTCAGAAACCCCTTGGCCAAGTAAGCTG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; MT4; Huh7; endometrial; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000234590.10; ENST00000646370.2; ENST00000647408.1; ENST00000646539.1; ENST00000464920.2
External Link	RMBase: m6A_site_5356
mod ID: M6ASITE053459		Click to Show/Hide the Full List
mod site	chr1:8861384-8861385:-		[8]
Sequence	GGCTAAGTTTGCCGGCAGGAACTTCAGAAACCCCTTGGCCA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; MT4; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000646539.1; ENST00000464920.2; ENST00000646370.2; ENST00000647408.1; ENST00000234590.10
External Link	RMBase: m6A_site_5357
mod ID: M6ASITE053481		Click to Show/Hide the Full List
mod site	chr1:8862901-8862902:-		[7]
Sequence	ATCTGAGCGCTTGGCCAAGTACAACCAGCTCCTCAGGTAAG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000646539.1; ENST00000646370.2; ENST00000647408.1; ENST00000234590.10; ENST00000464920.2
External Link	RMBase: m6A_site_5358
mod ID: M6ASITE053511		Click to Show/Hide the Full List
mod site	chr1:8862938-8862939:-		[8]
Sequence	TTCTTTTCTCCTAGATCAAGACTGGTGCCCCTTGCCGATCT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; Huh7; peripheral-blood; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000646370.2; ENST00000647408.1; ENST00000234590.10; ENST00000464920.2; ENST00000646539.1
External Link	RMBase: m6A_site_5359
mod ID: M6ASITE053512		Click to Show/Hide the Full List
mod site	chr1:8863175-8863176:-		[8]
Sequence	ACTTCCTAGGAAGACCCAAAACCAGTGAGGCTCCATGTCTG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000464920.2; ENST00000646370.2; ENST00000647408.1; ENST00000646539.1; ENST00000645609.1; ENST00000234590.10
External Link	RMBase: m6A_site_5360
mod ID: M6ASITE053513		Click to Show/Hide the Full List
mod site	chr1:8863182-8863183:-		[8]
Sequence	GACCTCAACTTCCTAGGAAGACCCAAAACCAGTGAGGCTCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000464920.2; ENST00000647408.1; ENST00000646539.1; ENST00000646370.2; ENST00000645609.1; ENST00000234590.10
External Link	RMBase: m6A_site_5361
mod ID: M6ASITE053529		Click to Show/Hide the Full List
mod site	chr1:8863284-8863285:-		[8]
Sequence	TGTCTCATCGTTCGGGGGAGACTGAAGATACCTTCATCGCT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000647408.1; ENST00000646370.2; ENST00000646539.1; ENST00000234590.10; ENST00000464920.2; ENST00000645609.1
External Link	RMBase: m6A_site_5362
mod ID: M6ASITE053540		Click to Show/Hide the Full List
mod site	chr1:8865292-8865293:-		[8]
Sequence	GTACAAGTCCTTCATCAAGGACTACCCAGGTGAGTGTTCCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000464920.2; ENST00000646370.2; ENST00000647408.1; ENST00000646539.1; ENST00000645609.1; ENST00000234590.10
External Link	RMBase: m6A_site_5363
mod ID: M6ASITE053541		Click to Show/Hide the Full List
mod site	chr1:8865310-8865311:-		[7]
Sequence	TGACCAGCTGGCTGACCTGTACAAGTCCTTCATCAAGGACT
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000464920.2; ENST00000646539.1; ENST00000234590.10; ENST00000647408.1; ENST00000646370.2; ENST00000645609.1
External Link	RMBase: m6A_site_5364
mod ID: M6ASITE053542		Click to Show/Hide the Full List
mod site	chr1:8865328-8865329:-		[9]
Sequence	CAGCAGGTACATCTCGCCTGACCAGCTGGCTGACCTGTACA
Motif Score	2.839113095
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000464920.2; ENST00000647408.1; ENST00000646370.2; ENST00000646539.1; ENST00000234590.10; ENST00000645609.1
External Link	RMBase: m6A_site_5365
mod ID: M6ASITE053543		Click to Show/Hide the Full List
mod site	chr1:8865340-8865341:-		[7]
Sequence	TCCCGATGACCCCAGCAGGTACATCTCGCCTGACCAGCTGG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000646370.2; ENST00000646539.1; ENST00000464920.2; ENST00000645609.1; ENST00000234590.10; ENST00000647408.1
External Link	RMBase: m6A_site_5366
mod ID: M6ASITE053544		Click to Show/Hide the Full List
mod site	chr1:8865370-8865371:-		[8]
Sequence	GTCTGGGAAGTATGACCTGGACTTCAAGTCTCCCGATGACC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000646539.1; ENST00000234590.10; ENST00000645609.1; ENST00000647408.1; ENST00000464920.2; ENST00000646370.2
External Link	RMBase: m6A_site_5367
mod ID: M6ASITE053545		Click to Show/Hide the Full List
mod site	chr1:8865442-8865443:-		[7]
Sequence	TGCTATTGGGAAAGCTGGCTACACTGATAAGGTGGTCATCG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000464920.2; ENST00000645609.1; ENST00000647408.1; ENST00000234590.10; ENST00000646539.1; ENST00000646370.2
External Link	RMBase: m6A_site_5368
mod ID: M6ASITE053546		Click to Show/Hide the Full List
mod site	chr1:8865464-8865465:-		[8]
Sequence	CAGGCCTGGAGCTGCTGAAGACTGCTATTGGGAAAGCTGGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000646370.2; ENST00000645609.1; ENST00000646539.1; ENST00000464920.2; ENST00000234590.10; ENST00000647408.1
External Link	RMBase: m6A_site_5369
mod ID: M6ASITE053547		Click to Show/Hide the Full List
mod site	chr1:8866298-8866299:-		[7]
Sequence	TGAAGGCGGGTTTGCTCCCAACATCCTGGAGAATAAAGAAG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000647408.1; ENST00000645609.1; ENST00000645600.1; ENST00000646539.1; ENST00000234590.10; ENST00000646370.2; ENST00000464920.2
External Link	RMBase: m6A_site_5370
mod ID: M6ASITE053582		Click to Show/Hide the Full List
mod site	chr1:8866376-8866377:-		[7]
Sequence	CATTGGAGCAGAGGTTTACCACAACCTGAAGAATGTCATCA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000646370.2; ENST00000645609.1; ENST00000464920.2; ENST00000645600.1; ENST00000647408.1; ENST00000646539.1; ENST00000497492.1; ENST00000234590.10
External Link	RMBase: m6A_site_5371
mod ID: M6ASITE053621		Click to Show/Hide the Full List
mod site	chr1:8866415-8866416:-		[8]
Sequence	CCTCCCAGTCGGTGCAGCAAACTTCAGGGAAGCCATGCGCA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000645609.1; ENST00000464920.2; ENST00000234590.10; ENST00000497492.1; ENST00000645600.1; ENST00000646370.2; ENST00000647408.1; ENST00000646539.1
External Link	RMBase: m6A_site_5372
mod ID: M6ASITE053622		Click to Show/Hide the Full List
mod site	chr1:8866463-8866464:-		[10]
Sequence	TGGCGGTTCTCATGCTGGCAACAAGCTGGCCATGCAGGAGT
Motif Score	2.173910714
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000647408.1; ENST00000645609.1; ENST00000646370.2; ENST00000464920.2; ENST00000234590.10; ENST00000645600.1; ENST00000646660.1; ENST00000497492.1; ENST00000646539.1
External Link	RMBase: m6A_site_5373
mod ID: M6ASITE053659		Click to Show/Hide the Full List
mod site	chr1:8867162-8867163:-		[7]
Sequence	GGGGGTCCCCCTGTACCGCCACATCGCTGACTTGGCTGGCA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000647408.1; ENST00000645600.1; ENST00000645609.1; ENST00000464920.2; ENST00000646680.1; ENST00000646539.1; ENST00000497492.1; ENST00000646660.1; ENST00000234590.10; ENST00000646370.2
External Link	RMBase: m6A_site_5374
mod ID: M6ASITE053724		Click to Show/Hide the Full List
mod site	chr1:8867999-8868000:-		[8]
Sequence	TGATGATCGAGATGGATGGAACAGAAAATAAATGTGAGTGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000646680.1; ENST00000646370.2; ENST00000234590.10; ENST00000645600.1; ENST00000645609.1; ENST00000646906.1; ENST00000646539.1; ENST00000647408.1; ENST00000497492.1; ENST00000464920.2; ENST00000646660.1
External Link	RMBase: m6A_site_5375
mod ID: M6ASITE053725		Click to Show/Hide the Full List
mod site	chr1:8868021-8868022:-		[8]
Sequence	GAACAAGAGAAGATTGACAAACTGATGATCGAGATGGATGG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000464920.2; ENST00000646906.1; ENST00000645609.1; ENST00000646539.1; ENST00000646660.1; ENST00000645600.1; ENST00000646680.1; ENST00000234590.10; ENST00000646370.2; ENST00000497492.1; ENST00000647408.1
External Link	RMBase: m6A_site_5376
mod ID: M6ASITE053762		Click to Show/Hide the Full List
mod site	chr1:8868025-8868026:-		[11]
Sequence	CACAGAACAAGAGAAGATTGACAAACTGATGATCGAGATGG
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T; AML
Seq Type List	DART-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000464920.2; ENST00000645609.1; ENST00000646539.1; ENST00000645600.1; ENST00000646370.2; ENST00000646906.1; ENST00000234590.10; ENST00000646660.1; ENST00000647408.1; ENST00000497492.1; ENST00000646680.1
External Link	RMBase: m6A_site_5377
mod ID: M6ASITE053763		Click to Show/Hide the Full List
mod site	chr1:8868039-8868040:-		[8]
Sequence	TAGAAACTGAACGTCACAGAACAAGAGAAGATTGACAAACT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000646660.1; ENST00000645609.1; ENST00000646680.1; ENST00000497492.1; ENST00000464920.2; ENST00000646370.2; ENST00000646539.1; ENST00000647408.1; ENST00000234590.10; ENST00000646156.1; ENST00000646906.1; ENST00000645600.1
External Link	RMBase: m6A_site_5378
mod ID: M6ASITE053801		Click to Show/Hide the Full List
mod site	chr1:8868054-8868055:-		[8]
Sequence	CTCCCCTCTCCCTCGTAGAAACTGAACGTCACAGAACAAGA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000646680.1; ENST00000646370.2; ENST00000646156.1; ENST00000646660.1; ENST00000645609.1; ENST00000643438.1; ENST00000646539.1; ENST00000497492.1; ENST00000234590.10; ENST00000464920.2; ENST00000647408.1; ENST00000489867.2; ENST00000645600.1; ENST00000646906.1
External Link	RMBase: m6A_site_5379
mod ID: M6ASITE053802		Click to Show/Hide the Full List
mod site	chr1:8870189-8870190:-		[8]
Sequence	TCCCCCCTGCAACTCTCTGGACCTTTGAAGAAATTAAGATC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000489867.2; ENST00000646680.1; ENST00000234590.10; ENST00000497492.1; ENST00000645600.1; ENST00000464920.2; ENST00000646370.2; ENST00000486051.5; ENST00000646156.1; ENST00000643438.1; ENST00000646539.1; ENST00000646660.1; ENST00000646906.1; ENST00000645609.1; ENST00000647408.1
External Link	RMBase: m6A_site_5380
mod ID: M6ASITE053829		Click to Show/Hide the Full List
mod site	chr1:8870232-8870233:-		[8]
Sequence	AATTGCATCAGAAGAATGAGACACTTCGAGCCCTGAGGTTT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000486051.5; ENST00000647408.1; ENST00000234590.10; ENST00000646156.1; ENST00000464920.2; ENST00000497492.1; ENST00000643438.1; ENST00000646660.1; ENST00000646539.1; ENST00000645609.1; ENST00000646906.1; ENST00000645600.1; ENST00000646370.2; ENST00000489867.2; ENST00000646680.1
External Link	RMBase: m6A_site_5381
mod ID: M6ASITE053863		Click to Show/Hide the Full List
mod site	chr1:8870316-8870317:-		[8]
Sequence	ATTCCCTGTCACGCACGAGAACAATCCATGCATGACATAAT
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000645600.1; ENST00000645609.1; ENST00000489867.2; ENST00000486051.5; ENST00000647408.1; ENST00000646370.2; ENST00000646680.1; ENST00000464920.2; ENST00000643438.1; ENST00000234590.10; ENST00000646660.1; ENST00000646539.1; ENST00000646156.1; ENST00000497492.1; ENST00000646906.1
External Link	RMBase: m6A_site_5382
mod ID: M6ASITE053928		Click to Show/Hide the Full List
mod site	chr1:8870477-8870478:-		[8]
Sequence	CTGTTGAGCACATCAATAAAACTATTGCGCCTGCCCTGGTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; HepG2
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000646539.1; ENST00000646156.1; ENST00000464920.2; ENST00000234590.10; ENST00000646660.1; ENST00000643438.1; ENST00000646370.2; ENST00000647408.1; ENST00000646680.1; ENST00000645600.1; ENST00000646906.1; ENST00000645609.1; ENST00000497492.1; ENST00000489867.2; ENST00000486051.5
External Link	RMBase: m6A_site_5383
mod ID: M6ASITE053929		Click to Show/Hide the Full List
mod site	chr1:8870488-8870489:-		[10]
Sequence	TGTCTCAAAGGCTGTTGAGCACATCAATAAAACTATTGCGC
Motif Score	2.830589286
Cell/Tissue List	liver; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000645609.1; ENST00000234590.10; ENST00000486051.5; ENST00000646370.2; ENST00000647408.1; ENST00000645600.1; ENST00000489867.2; ENST00000646660.1; ENST00000497492.1; ENST00000464920.2; ENST00000646906.1; ENST00000646680.1; ENST00000646156.1; ENST00000646539.1; ENST00000643438.1
External Link	RMBase: m6A_site_5384
mod ID: M6ASITE053983		Click to Show/Hide the Full List
mod site	chr1:8870872-8870873:-		[8]
Sequence	TGCTGGGCAGGCGTCTCCAGACCCATTAAGTATATTAATGA
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000646370.2; ENST00000646906.1; ENST00000645600.1; ENST00000643438.1; ENST00000646539.1; ENST00000645609.1; ENST00000497492.1; ENST00000646660.1; ENST00000464920.2; ENST00000489867.2; ENST00000234590.10; ENST00000646156.1; ENST00000646680.1; ENST00000486051.5; ENST00000647408.1
External Link	RMBase: m6A_site_5385
mod ID: M6ASITE053984		Click to Show/Hide the Full List
mod site	chr1:8871877-8871878:-		[8]
Sequence	GGGGAAGGGTAAGCCTTAGAACCCACAGCCCATGGCCTCCC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; Huh7; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000234590.10; ENST00000646906.1; ENST00000643438.1; ENST00000486051.5; ENST00000489867.2; ENST00000645600.1; ENST00000645609.1; ENST00000647408.1; ENST00000646680.1; ENST00000646156.1; ENST00000492343.2; ENST00000646660.1; ENST00000646539.1; ENST00000646370.2; ENST00000497492.1
External Link	RMBase: m6A_site_5386
mod ID: M6ASITE054044		Click to Show/Hide the Full List
mod site	chr1:8871908-8871909:-		[8]
Sequence	AGCTCCGGGACAATGATAAGACTCGCTATATGGGGAAGGGT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; HepG2; Huh7; iSLK; MSC; TIME
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000643438.1; ENST00000645609.1; ENST00000234590.10; ENST00000646680.1; ENST00000486051.5; ENST00000497492.1; ENST00000646370.2; ENST00000646156.1; ENST00000646660.1; ENST00000645600.1; ENST00000647408.1; ENST00000489867.2; ENST00000492343.2; ENST00000646906.1; ENST00000646539.1
External Link	RMBase: m6A_site_5387
mod ID: M6ASITE054123		Click to Show/Hide the Full List
mod site	chr1:8871919-8871920:-		[8]
Sequence	TGAGGCCCTAGAGCTCCGGGACAATGATAAGACTCGCTATA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; HepG2; Huh7; iSLK; MSC; TIME
Seq Type List	m6A-seq; DART-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000645600.1; ENST00000234590.10; ENST00000647408.1; ENST00000646660.1; ENST00000492343.2; ENST00000646906.1; ENST00000645609.1; ENST00000646539.1; ENST00000646370.2; ENST00000646680.1; ENST00000486051.5; ENST00000489867.2; ENST00000643438.1; ENST00000646156.1; ENST00000497492.1
External Link	RMBase: m6A_site_5388
mod ID: M6ASITE054124		Click to Show/Hide the Full List
mod site	chr1:8873799-8873800:-		[8]
Sequence	CGGTGCTAAACTCACAGAGAACTGCCAGTCGGAGCTGAGTC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000486051.5; ENST00000646539.1; ENST00000645609.1; ENST00000497492.1; ENST00000646680.1; ENST00000489867.2; ENST00000646370.2; ENST00000492343.2; ENST00000646906.1; ENST00000643438.1; ENST00000646156.1; ENST00000647408.1; ENST00000234590.10; ENST00000646660.1
External Link	RMBase: m6A_site_5389
mod ID: M6ASITE054125		Click to Show/Hide the Full List
mod site	chr1:8873810-8873811:-		[8]
Sequence	GAATCACTCAGCGGTGCTAAACTCACAGAGAACTGCCAGTC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000646906.1; ENST00000492343.2; ENST00000489867.2; ENST00000645609.1; ENST00000234590.10; ENST00000643438.1; ENST00000647408.1; ENST00000486051.5; ENST00000497492.1; ENST00000646660.1; ENST00000646539.1; ENST00000646680.1; ENST00000646370.2; ENST00000646156.1
External Link	RMBase: m6A_site_5390
mod ID: M6ASITE054126		Click to Show/Hide the Full List
mod site	chr1:8873866-8873867:-		[8]
Sequence	TCCAGCACATGGCGCGATGGACAGAGTGGGTGAGGTTGGCA
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000646680.1; ENST00000643438.1; ENST00000646906.1; ENST00000646370.2; ENST00000486051.5; ENST00000647408.1; ENST00000492343.2; ENST00000234590.10; ENST00000489867.2; ENST00000646156.1; ENST00000645609.1; ENST00000646660.1; ENST00000497492.1; ENST00000646539.1
External Link	RMBase: m6A_site_5391
mod ID: M6ASITE054127		Click to Show/Hide the Full List
mod site	chr1:8873936-8873937:-		[8]
Sequence	AAAAATTAGAGAATTGTGAAACTCCTTCCTTTAAGAAGAAA
Motif Score	2.627720238
Cell/Tissue List	HeLa; A549; HepG2; LCLs; H1299; Huh7; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000646660.1; ENST00000647408.1; ENST00000643438.1; ENST00000486051.5; ENST00000492343.2; ENST00000646156.1; ENST00000489867.2; ENST00000646370.2; ENST00000646539.1; ENST00000234590.10; ENST00000497492.1; ENST00000646906.1; ENST00000645609.1; ENST00000646680.1
External Link	RMBase: m6A_site_5392
mod ID: M6ASITE054128		Click to Show/Hide the Full List
mod site	chr1:8874870-8874871:-		[9]
Sequence	CCATGCCAGGGAGATCTTTGACTCTCGCGGGAATCCCACTG
Motif Score	3.28175
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000646156.1; ENST00000646370.2; ENST00000646539.1; ENST00000646906.1; ENST00000645609.1; ENST00000647408.1; ENST00000489867.2; ENST00000486051.5; ENST00000234590.10; ENST00000492343.2; ENST00000643438.1; ENST00000646660.1; ENST00000497492.1; ENST00000646680.1
External Link	RMBase: m6A_site_5393
mod ID: M6ASITE054148		Click to Show/Hide the Full List
mod site	chr1:8875806-8875807:-		[8]
Sequence	AGCCTGGGCAGCATAGTGAGACCGCCATCTCTTAAAAAAGT
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; HepG2; fibroblasts; LCLs; H1299; MM6; Huh7; CD4T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000647408.1; ENST00000486051.5; ENST00000646660.1; ENST00000234590.10; ENST00000646370.2; ENST00000414948.1; ENST00000646156.1; ENST00000492343.2; ENST00000643438.1; rmsk_15811; ENST00000497492.1; ENST00000646680.1; ENST00000489867.2; ENST00000645609.1; ENST00000646539.1; ENST00000646906.1
External Link	RMBase: m6A_site_5394
mod ID: M6ASITE054149		Click to Show/Hide the Full List
mod site	chr1:8878591-8878592:-		[8]
Sequence	TTCCTCTCCTAGGCGACGAGACCCAGTGGCTAGGTAATGAT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; H1B; H1A; HEK293T; fibroblasts; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000643438.1; ENST00000486051.5; ENST00000646370.2; ENST00000646680.1; ENST00000489867.2; ENST00000492343.2; ENST00000647408.1; ENST00000646156.1; ENST00000646539.1; ENST00000645609.1; ENST00000234590.10
External Link	RMBase: m6A_site_5395
mod ID: M6ASITE054150		Click to Show/Hide the Full List
mod site	chr1:8878687-8878688:-		[8]
Sequence	AGTCGGCGCGGGCGGCGCGGACAGTATCTGTGGGTACCCGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; H1B; H1A; hESCs; HEK293T; fibroblasts; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000646539.1; ENST00000647408.1; ENST00000646156.1; ENST00000492343.2; ENST00000489867.2; ENST00000646680.1; ENST00000486051.5; ENST00000645609.1; ENST00000646370.2
External Link	RMBase: m6A_site_5396
mod ID: M6ASITE054312		Click to Show/Hide the Full List
mod site	chr1:8879057-8879058:-		[8]
Sequence	CGACGCTGAGTGCGTGCGGGACTCGGAGTACGTGACGGAGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1B; A549; GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000645609.1; ENST00000489867.2; ENST00000646539.1
External Link	RMBase: m6A_site_5400

Ref 1	The essential roles of m(6)A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma. J Exp Clin Cancer Res. 2022 Jan 25;41(1):36. doi: 10.1186/s13046-021-02200-5.
Ref 2	C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1. Cell Death Dis. 2021 Jul 26;12(8):737. doi: 10.1038/s41419-021-04028-5.
Ref 3	The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):121-38. doi: 10.1016/j.mam.2012.07.001.
Ref 4	Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac ?. Chem Res Toxicol. 2020 Jan 21;33(1):249-257. doi: 10.1021/acs.chemrestox.9b00268. Epub 2019 Dec 23.
Ref 5	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 6	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 9	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 10	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 11	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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