m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00519)

Target Name	Poly [ADP-ribose] polymerase tankyrase-1 (Tankyrase)
Synonyms	ADP-ribosyltransferase diphtheria toxin-like 5; ARTD5; Poly [ADP-ribose] polymerase 5A; Protein poly-ADP-ribosyltransferase tankyrase-1; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; Tankyrase I; Tankyrase-1; TANK1 Click to Show/Hide
Gene Name	Tankyrase
Chromosomal Location	8p23.1
Family	ARTD/PARP family
Function	Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking . Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. Click to Show/Hide
Gene ID	8658
Uniprot ID	TNKS1_HUMAN
HGNC ID	HGNC:11941
KEGG ID	hsa:8658

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

Tankyrase can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	Pancreatic islets	Mus musculus
Treatment: Mettl3 knockout mice Control: Mettl3 flox/flox mice		GSE155612
Regulation		logFC: 8.10E-01 p-value: 1.68E-04
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between Tankyrase and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 2.44E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 activated the luciferase activity of TOPflash (a reporter for beta-catenin/TCF signaling), and downregulation of METTL3 inhibited the expression of beta-catenin/TCF target genes vimentin and N-cadherin, which are two regulators of epithelial-mesenchymal transition. METTL3 silencing decreased the m6A methylation and total mRNA levels of Poly [ADP-ribose] polymerase tankyrase-1 (Tankyrase), a negative regulator of axin. METTL3 is a therapeutic target for NPC.
Target Regulation	Up regulation
Responsed Disease	Nasopharyngeal carcinoma		ICD-11: 2B6B	Disease Info
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	Neural progenitor cells (NPCs) (The progenitor cells of the CNS)
	NP69 (A human immortalized nasopharyngeal epithelial)
	HNE-2	Nasopharyngeal carcinoma	Homo sapiens	CVCL_FA07
	HNE-1	Nasopharyngeal carcinoma	Homo sapiens	CVCL_0308
	CNE-2	Nasopharyngeal carcinoma	Homo sapiens	CVCL_6889
	CNE-1	Normal	Homo sapiens	CVCL_6888
In-vivo Model	1 × 10⁵ HNE2 cells (with or without METTL3 knockdown) were labeled with luciferase gene and injected into the tail vein of the nude mice.

Nasopharyngeal carcinoma [ICD-11: 2B6B]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 activated the luciferase activity of TOPflash (a reporter for beta-catenin/TCF signaling), and downregulation of METTL3 inhibited the expression of beta-catenin/TCF target genes vimentin and N-cadherin, which are two regulators of epithelial-mesenchymal transition. METTL3 silencing decreased the m6A methylation and total mRNA levels of Poly [ADP-ribose] polymerase tankyrase-1 (Tankyrase), a negative regulator of axin. METTL3 is a therapeutic target for NPC.
Responsed Disease	Nasopharyngeal carcinoma [ICD-11: 2B6B]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	Neural progenitor cells (NPCs) (The progenitor cells of the CNS)
	NP69 (A human immortalized nasopharyngeal epithelial)
	HNE-2	Nasopharyngeal carcinoma	Homo sapiens	CVCL_FA07
	HNE-1	Nasopharyngeal carcinoma	Homo sapiens	CVCL_0308
	CNE-2	Nasopharyngeal carcinoma	Homo sapiens	CVCL_6889
	CNE-1	Normal	Homo sapiens	CVCL_6888
In-vivo Model	1 × 10⁵ HNE2 cells (with or without METTL3 knockdown) were labeled with luciferase gene and injected into the tail vein of the nude mice.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00519)

Poly [ADP-ribose] polymerase tankyrase-1 (Tankyrase)

Adenosine-to-Inosine editing (A-to-I)

In total 8 m6A sequence/site(s) in this target gene
mod ID: A2ISITE002448		Click to Show/Hide the Full List
mod site	chr8:9692264-9692265:+		[2]
Sequence	TTCAGGTGTATTCACTGTTTAGCTCCCTCTTATAAGTGAGA
Transcript ID List	ENST00000518281.5; ENST00000517989.1; ENST00000310430.11; ENST00000519392.5; ENST00000520408.5; ENST00000518027.5
External Link	RMBase: RNA-editing_site_128887
mod ID: A2ISITE002449		Click to Show/Hide the Full List
mod site	chr8:9698126-9698127:+		[2]
Sequence	GAATGGAGCCAGAGGCCATTAACCTAAACGAATTAATGTAG
Transcript ID List	ENST00000520408.5; rmsk_2439753; ENST00000518281.5; ENST00000310430.11; ENST00000517989.1; ENST00000519392.5; ENST00000518027.5
External Link	RMBase: RNA-editing_site_128888
mod ID: A2ISITE002450		Click to Show/Hide the Full List
mod site	chr8:9698193-9698194:+		[2]
Sequence	CTCACTTATAAGTGGGATCTAAACATTGAGCACACGTGGAC
Transcript ID List	ENST00000519392.5; ENST00000518027.5; ENST00000310430.11; ENST00000520408.5; ENST00000518281.5; rmsk_2439753; ENST00000517989.1
External Link	RMBase: RNA-editing_site_128889
mod ID: A2ISITE002451		Click to Show/Hide the Full List
mod site	chr8:9698245-9698246:+		[2]
Sequence	AACAGTAGACATTGCAGACTACTAGAGCGGGCAGCACAGGT
Transcript ID List	rmsk_2439753; ENST00000310430.11; ENST00000518027.5; ENST00000519392.5; ENST00000517989.1; ENST00000520408.5; ENST00000518281.5
External Link	RMBase: RNA-editing_site_128890
mod ID: A2ISITE002452		Click to Show/Hide the Full List
mod site	chr8:9698279-9698280:+		[2]
Sequence	CACAGGTTCAAGAACAAACTACCTATTGGGTACCATGCTCA
Transcript ID List	ENST00000310430.11; ENST00000518281.5; ENST00000520408.5; ENST00000517989.1; ENST00000518027.5; ENST00000519392.5; rmsk_2439753
External Link	RMBase: RNA-editing_site_128891
mod ID: A2ISITE002453		Click to Show/Hide the Full List
mod site	chr8:9703101-9703102:+		[2]
Sequence	TCCCTTATCCTCGGGAGATAACGTTTCAGGAGCCCGGTAGA
Transcript ID List	ENST00000310430.11; ENST00000520408.5; ENST00000518027.5; ENST00000519392.5; ENST00000518281.5; ENST00000517989.1
External Link	RMBase: RNA-editing_site_128892
mod ID: A2ISITE002454		Click to Show/Hide the Full List
mod site	chr8:9755635-9755636:+		[2]
Sequence	TATATCAGTAATATGTGATGATGGTCAATGTATTTGTATAG
Transcript ID List	ENST00000518281.5; ENST00000310430.11
External Link	RMBase: RNA-editing_site_128893
mod ID: A2ISITE002455		Click to Show/Hide the Full List
mod site	chr8:9782011-9782012:+		[2]
Sequence	TTACAGTAAAAGCATTCATTATTTGTCTGAAATTCAAATTT
Transcript ID List	ENST00000310430.11
External Link	RMBase: RNA-editing_site_128894

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004253		Click to Show/Hide the Full List
mod site	chr8:9720451-9720452:+		[3]
Sequence	ACCTGCAGACCTGCCGCCTCCTGCTGAGTTACGGCTCTGAC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000310430.11; ENST00000518281.5
External Link	RMBase: m5C_site_41017

N6-methyladenosine (m6A)

In total 63 m6A sequence/site(s) in this target gene
mod ID: M6ASITE083606		Click to Show/Hide the Full List
mod site	chr8:9555917-9555918:+		[4]
Sequence	TGGGGGCCGTTGCCGCAGTGACAGTGCTAGGGGAGTCCGAA
Motif Score	2.859755952
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000310430.11; ENST00000520408.5
External Link	RMBase: m6A_site_786719
mod ID: M6ASITE083608		Click to Show/Hide the Full List
mod site	chr8:9556315-9556316:+		[5]
Sequence	CCCAGCCGGCAGTGGCAGTAACAATTCACCGTCGTCCTCTT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11; ENST00000522110.1; ENST00000520408.5
External Link	RMBase: m6A_site_786720
mod ID: M6ASITE083609		Click to Show/Hide the Full List
mod site	chr8:9556570-9556571:+		[5]
Sequence	GGCAAACGTAAATGCAAAGGACATGGCCGGCCGGAAGTCTT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000520408.5; ENST00000310430.11; ENST00000522110.1
External Link	RMBase: m6A_site_786721
mod ID: M6ASITE083610		Click to Show/Hide the Full List
mod site	chr8:9580183-9580184:+		[5]
Sequence	GGAAGGAAGGATGTTGTAGAACACTTACTACAGATGGGTGC
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000520408.5; ENST00000310430.11; ENST00000518281.5
External Link	RMBase: m6A_site_786722
mod ID: M6ASITE083611		Click to Show/Hide the Full List
mod site	chr8:9580329-9580330:+		[6]
Sequence	AAATGCCAGGGATAACTGGAACTATACACCTCTGCATGAAG
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000520408.5; ENST00000518281.5; ENST00000310430.11
External Link	RMBase: m6A_site_786723
mod ID: M6ASITE083612		Click to Show/Hide the Full List
mod site	chr8:9615313-9615314:+		[6]
Sequence	CTGCTGCTTGAAGGAGGCAAACCAAAACTCTACATTGCAAG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000518027.5; ENST00000520408.5; ENST00000310430.11; ENST00000518281.5
External Link	RMBase: m6A_site_786724
mod ID: M6ASITE083613		Click to Show/Hide the Full List
mod site	chr8:9615319-9615320:+		[6]
Sequence	CTTGAAGGAGGCAAACCAAAACTCTACATTGCAAGATTTTT
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000518027.5; ENST00000520408.5; ENST00000518281.5; ENST00000310430.11
External Link	RMBase: m6A_site_786725
mod ID: M6ASITE083614		Click to Show/Hide the Full List
mod site	chr8:9615608-9615609:+		[6]
Sequence	GCAGCACGGAGCTGACCCAAACATTCGGAACACTGATGGGA
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000310430.11; ENST00000520408.5; ENST00000518027.5; ENST00000518281.5
External Link	RMBase: m6A_site_786726
mod ID: M6ASITE083615		Click to Show/Hide the Full List
mod site	chr8:9615617-9615618:+		[6]
Sequence	AGCTGACCCAAACATTCGGAACACTGATGGGAAATCAGCCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000310430.11; ENST00000518281.5; ENST00000518027.5; ENST00000520408.5
External Link	RMBase: m6A_site_786727
mod ID: M6ASITE083616		Click to Show/Hide the Full List
mod site	chr8:9615641-9615642:+		[6]
Sequence	TGATGGGAAATCAGCCCTGGACCTGGCAGATCCTTCAGCAA
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000518281.5; ENST00000520408.5; ENST00000310430.11; ENST00000518027.5
External Link	RMBase: m6A_site_786728
mod ID: M6ASITE083617		Click to Show/Hide the Full List
mod site	chr8:9670189-9670190:+		[6]
Sequence	ATTTCAGAAAAATATGGAGGACACTTTGTAAGTTGAGGAAA
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000520408.5; ENST00000518281.5; ENST00000310430.11; ENST00000518027.5; ENST00000521039.5
External Link	RMBase: m6A_site_786729
mod ID: M6ASITE083619		Click to Show/Hide the Full List
mod site	chr8:9670753-9670754:+		[6]
Sequence	CTTGGATTAACTTGTGATAAACATCAGACTTCATGCATACA
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000520408.5; ENST00000521039.5; ENST00000518281.5; ENST00000518027.5; ENST00000310430.11
External Link	RMBase: m6A_site_786730
mod ID: M6ASITE083620		Click to Show/Hide the Full List
mod site	chr8:9670760-9670761:+		[6]
Sequence	TAACTTGTGATAAACATCAGACTTCATGCATACAAAGCCTT
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000518027.5; ENST00000518281.5; ENST00000521039.5; ENST00000310430.11; ENST00000520408.5
External Link	RMBase: m6A_site_786731
mod ID: M6ASITE083621		Click to Show/Hide the Full List
mod site	chr8:9679956-9679957:+		[5]
Sequence	TTGCAATCATCTAGGTGAATACAAGAAAGACGAACTCCTAG
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000520408.5; ENST00000518281.5; ENST00000517989.1; ENST00000310430.11; ENST00000519392.5; ENST00000518027.5; ENST00000521039.5
External Link	RMBase: m6A_site_786732
mod ID: M6ASITE083622		Click to Show/Hide the Full List
mod site	chr8:9704673-9704674:+		[5]
Sequence	CTTTTCTAGTCGACTCCTTTACATCTAGCAGCGGGCTACAA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000518281.5; ENST00000518027.5; ENST00000517989.1; ENST00000520408.5; ENST00000519392.5; ENST00000310430.11
External Link	RMBase: m6A_site_786733
mod ID: M6ASITE083623		Click to Show/Hide the Full List
mod site	chr8:9704750-9704751:+		[5]
Sequence	TGCTGATGTTCATGCAAAAGACAAAGGGTAGGTCTATCAGT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000519392.5; ENST00000518281.5; ENST00000517989.1; ENST00000520408.5; ENST00000310430.11; ENST00000518027.5
External Link	RMBase: m6A_site_786734
mod ID: M6ASITE083624		Click to Show/Hide the Full List
mod site	chr8:9706924-9706925:+		[5]
Sequence	TTAGCCATGGCGCTGATCCTACATTAGTCAACTGCCATGGC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000518281.5; ENST00000310430.11; ENST00000518027.5; ENST00000519392.5; ENST00000520408.5; ENST00000517989.1
External Link	RMBase: m6A_site_786735
mod ID: M6ASITE083625		Click to Show/Hide the Full List
mod site	chr8:9708395-9708396:+		[5]
Sequence	TTTAAAGGTCATTCTTTACTACAAGCAGCCAGAGAAGCAGA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11; ENST00000518281.5; ENST00000517989.1; ENST00000520408.5
External Link	RMBase: m6A_site_786736
mod ID: M6ASITE083626		Click to Show/Hide the Full List
mod site	chr8:9720489-9720490:+		[5]
Sequence	GACCCCTCCATCATCTCCTTACAAGGCTTCACAGCAGCACA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000519930.1; ENST00000518281.5; ENST00000310430.11
External Link	RMBase: m6A_site_786737
mod ID: M6ASITE083627		Click to Show/Hide the Full List
mod site	chr8:9733314-9733315:+		[5]
Sequence	CATAATGCCTGTTCATATGGACACTATGAGGTGGCTGAGCT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11; ENST00000518281.5
External Link	RMBase: m6A_site_786738
mod ID: M6ASITE083628		Click to Show/Hide the Full List
mod site	chr8:9733443-9733444:+		[5]
Sequence	ATCTGCAAGCTCCTTTTAAAAGTATGTAGTTTAAAAAGTTA
Motif Score	1.756488095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000518281.5; ENST00000310430.11
External Link	RMBase: m6A_site_786739
mod ID: M6ASITE083630		Click to Show/Hide the Full List
mod site	chr8:9735045-9735046:+		[5]
Sequence	AGAGAATATCAACTGCAGAGACACCCAGGGCAGAAATTCAA
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11; ENST00000518635.1; ENST00000518281.5
External Link	RMBase: m6A_site_786740
mod ID: M6ASITE083631		Click to Show/Hide the Full List
mod site	chr8:9735442-9735443:+		[5]
Sequence	AGCTGATGTTAATGCCCAGGACAAGGGTGGTTTAATTCCTC
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000518281.5; ENST00000518635.1; ENST00000310430.11
External Link	RMBase: m6A_site_786741
mod ID: M6ASITE083632		Click to Show/Hide the Full List
mod site	chr8:9761518-9761519:+		[5]
Sequence	TTTGTTTCATTTTTCAGATTACACTAGATGTGTTGGCTGAT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11; ENST00000518281.5
External Link	RMBase: m6A_site_786742
mod ID: M6ASITE083633		Click to Show/Hide the Full List
mod site	chr8:9761591-9761592:+		[5]
Sequence	CAATGCATATGGGCACCGCCACAAATTAATCAAAGGAGTAG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000518281.5; ENST00000310430.11
External Link	RMBase: m6A_site_786743
mod ID: M6ASITE083634		Click to Show/Hide the Full List
mod site	chr8:9765773-9765774:+		[5]
Sequence	TGAGGAGAATCACAACCATCACAATGAGCGCATGTTGTTTC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000518281.5; ENST00000310430.11
External Link	RMBase: m6A_site_786744
mod ID: M6ASITE083635		Click to Show/Hide the Full List
mod site	chr8:9766284-9766285:+		[5]
Sequence	CATAAAGGGTTTGATGAGCGACATGCATACATAGGAGGAAT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11; ENST00000518281.5
External Link	RMBase: m6A_site_786745
mod ID: M6ASITE083636		Click to Show/Hide the Full List
mod site	chr8:9766292-9766293:+		[5]
Sequence	GTTTGATGAGCGACATGCATACATAGGAGGAATGTTTGGGG
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11; ENST00000518281.5
External Link	RMBase: m6A_site_786746
mod ID: M6ASITE083637		Click to Show/Hide the Full List
mod site	chr8:9776771-9776772:+		[4]
Sequence	GAAGGCCAGATCAGATTTCAACCTGGGACTGGATTACAGAG
Motif Score	2.153267857
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000310430.11; ENST00000517770.1; ENST00000518281.5
External Link	RMBase: m6A_site_786747
mod ID: M6ASITE083638		Click to Show/Hide the Full List
mod site	chr8:9776778-9776779:+		[7]
Sequence	AGATCAGATTTCAACCTGGGACTGGATTACAGAGGATTGTT
Motif Score	4.065041667
Cell/Tissue List	A549
Seq Type List	m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000518281.5; ENST00000310430.11; ENST00000517770.1
External Link	RMBase: m6A_site_786748
mod ID: M6ASITE083639		Click to Show/Hide the Full List
mod site	chr8:9776959-9776960:+		[5]
Sequence	TTTACAGGGGCGGCCTTTTAACATATCTCAGGCTCATTTTC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11; ENST00000517770.1
External Link	RMBase: m6A_site_786749
mod ID: M6ASITE083641		Click to Show/Hide the Full List
mod site	chr8:9777002-9777003:+		[5]
Sequence	TGCAATTATCCATTTCTAAAACAAGATTGCTTCGATCTAGA
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000517770.1; ENST00000310430.11
External Link	RMBase: m6A_site_786750
mod ID: M6ASITE083642		Click to Show/Hide the Full List
mod site	chr8:9777067-9777068:+		[5]
Sequence	CAATGCTTTTTCAAATGTTCACAATTCACACACTACATTTG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786751
mod ID: M6ASITE083643		Click to Show/Hide the Full List
mod site	chr8:9777161-9777162:+		[5]
Sequence	GCTTGTTTTTGATTTGCCAGACATGCATCATTGGCTATTGT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786752
mod ID: M6ASITE083644		Click to Show/Hide the Full List
mod site	chr8:9777257-9777258:+		[5]
Sequence	CCTTCTTGAGGATATTTTGCACAAAGTCACGCTGACAAAAT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786753
mod ID: M6ASITE083645		Click to Show/Hide the Full List
mod site	chr8:9777398-9777399:+		[5]
Sequence	ATTGAGATGAAAAGGAAAAAACATCAAGTTTTAGTACCTTT
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786754
mod ID: M6ASITE083646		Click to Show/Hide the Full List
mod site	chr8:9777438-9777439:+		[8]
Sequence	TTTATGAATTGGCCTATCTTACAAGAGAAGGGCACAAACAC
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786755
mod ID: M6ASITE083647		Click to Show/Hide the Full List
mod site	chr8:9777705-9777706:+		[9]
Sequence	AGGGGATGCCTCCAAAAAATACATGCTTCCCTTCCCTTAAT
Motif Score	2.110482143
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786756
mod ID: M6ASITE083648		Click to Show/Hide the Full List
mod site	chr8:9777856-9777857:+		[8]
Sequence	TTGAGAATGCTGGGATTCAGACTCGAATAGTGGATAGATAC
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786757
mod ID: M6ASITE083649		Click to Show/Hide the Full List
mod site	chr8:9778016-9778017:+		[8]
Sequence	AGTGTGTTTAGACAAGGAGAACAAAAATTGAAACCAAAGCC
Motif Score	2.951386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786758
mod ID: M6ASITE083650		Click to Show/Hide the Full List
mod site	chr8:9778171-9778172:+		[5]
Sequence	AATGATCCTTTATAGTTCTTACACTTGCCCTTTTCACCTTA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786759
mod ID: M6ASITE083652		Click to Show/Hide the Full List
mod site	chr8:9778244-9778245:+		[8]
Sequence	ACTTGATATACTGTGCATCTACTCTGCTTTGAAGCGAAAGA
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786760
mod ID: M6ASITE083653		Click to Show/Hide the Full List
mod site	chr8:9778272-9778273:+		[5]
Sequence	TTGAAGCGAAAGAAATATAAACACGAGGAGGAATAGGAAAG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786761
mod ID: M6ASITE083654		Click to Show/Hide the Full List
mod site	chr8:9778293-9778294:+		[9]
Sequence	CACGAGGAGGAATAGGAAAGACAGTGTGACACAAACTTGCC
Motif Score	2.897386905
Cell/Tissue List	brain; kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786762
mod ID: M6ASITE083655		Click to Show/Hide the Full List
mod site	chr8:9778405-9778406:+		[5]
Sequence	TGAAGCAAAATAAAATGGTTACATGCAAAACTTCTAGAAAT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786763
mod ID: M6ASITE083656		Click to Show/Hide the Full List
mod site	chr8:9778710-9778711:+		[5]
Sequence	TTTCCTTCTCTTTTGCTGTAACAAAGGGTTGAAGAAATTGC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786764
mod ID: M6ASITE083657		Click to Show/Hide the Full List
mod site	chr8:9778768-9778769:+		[8]
Sequence	GTAGCTGTCAAGTGTGTCTTACTTACCTTCCCCCAGACGTA
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786765
mod ID: M6ASITE083658		Click to Show/Hide the Full List
mod site	chr8:9778784-9778785:+		[8]
Sequence	TCTTACTTACCTTCCCCCAGACGTAGTTTAAAATGGTAAAC
Motif Score	2.871321429
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786766
mod ID: M6ASITE083659		Click to Show/Hide the Full List
mod site	chr8:9778803-9778804:+		[5]
Sequence	GACGTAGTTTAAAATGGTAAACACAGCTGTGATTTTTAGTT
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786767
mod ID: M6ASITE083660		Click to Show/Hide the Full List
mod site	chr8:9778922-9778923:+		[8]
Sequence	TTGTATGTTGTTTCCATCATACTAACTAGATGAATGGATGC
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786768
mod ID: M6ASITE083661		Click to Show/Hide the Full List
mod site	chr8:9778965-9778966:+		[5]
Sequence	CAGTTTTCATCTTGGTCCTTACACTTGAGAAGTTAAACTGT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786769
mod ID: M6ASITE083663		Click to Show/Hide the Full List
mod site	chr8:9779059-9779060:+		[5]
Sequence	GAAGGTACTGTGTAAGGAAGACATTTGCGGTGCTTCTTGTC
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786770
mod ID: M6ASITE083664		Click to Show/Hide the Full List
mod site	chr8:9779179-9779180:+		[5]
Sequence	ATATATCAGAGGAGCCAAATACATTTTTTTCAGAACTTGAA
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786771
mod ID: M6ASITE083665		Click to Show/Hide the Full List
mod site	chr8:9779647-9779648:+		[8]
Sequence	AGCTCCAGCAATGACCTTTGACTCCATTCATTTTCTCCTCA
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786772
mod ID: M6ASITE083666		Click to Show/Hide the Full List
mod site	chr8:9779904-9779905:+		[5]
Sequence	AAGCAGCATAAGTAGAATCAACATTAGGATGTTTTCATGAA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786773
mod ID: M6ASITE083667		Click to Show/Hide the Full List
mod site	chr8:9780319-9780320:+		[5]
Sequence	CCTCTTGTGTGATATCTGTGACAAATAGCCTTCTTCTTGTG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786774
mod ID: M6ASITE083668		Click to Show/Hide the Full List
mod site	chr8:9780579-9780580:+		[5]
Sequence	TCGAAAACTACTATTCTAGAACATGAGGCTTCTTCAGCAAC
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786775
mod ID: M6ASITE083669		Click to Show/Hide the Full List
mod site	chr8:9780606-9780607:+		[8]
Sequence	GCTTCTTCAGCAACTTGTGCACTCTGCCATTAATAAATTAA
Motif Score	3.252583333
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786776
mod ID: M6ASITE083670		Click to Show/Hide the Full List
mod site	chr8:9780695-9780696:+		[8]
Sequence	TTTATATTTTAATAAATAAAACATTGTAGTCCCATTTCTTA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786777
mod ID: M6ASITE083671		Click to Show/Hide the Full List
mod site	chr8:9780815-9780816:+		[5]
Sequence	TTCATAAGTAATATTCCCTTACATGCAATGGAGCTGATTAA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786778
mod ID: M6ASITE083672		Click to Show/Hide the Full List
mod site	chr8:9781840-9781841:+		[9]
Sequence	TTTAGTCTCTGTGTGACCCAACAGTGGCAGGGGTTACAACC
Motif Score	2.173910714
Cell/Tissue List	HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786779
mod ID: M6ASITE083674		Click to Show/Hide the Full List
mod site	chr8:9781855-9781856:+		[5]
Sequence	ACCCAACAGTGGCAGGGGTTACAACCCCCTCTCCTTTCTTT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786780
mod ID: M6ASITE083675		Click to Show/Hide the Full List
mod site	chr8:9781913-9781914:+		[5]
Sequence	GTAGGATTGTCAGATCAAGTACAAGATGCCCAGTTAAGTTT
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000310430.11
External Link	RMBase: m6A_site_786781

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000258		Click to Show/Hide the Full List
mod site	chr8:9781854-9781855:+		[10]
Sequence	GACCCAACAGTGGCAGGGGTTACAACCCCCTCTCCTTTCTT
Transcript ID List	ENST00000310430.11
External Link	RMBase: Pseudo_site_4534

Ref 1	Upregulated METTL3 in nasopharyngeal carcinoma enhances the motility of cancer cells. Kaohsiung J Med Sci. 2020 Nov;36(11):895-903. doi: 10.1002/kjm2.12266. Epub 2020 Jul 15.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 8	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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