m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00518)

Target Name	Vimentin (vimentin)
Gene Name	vimentin
Chromosomal Location	10p13
Family	Intermediate filament family
Function	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally;Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Click to Show/Hide
Gene ID	7431
Uniprot ID	VIME_HUMAN
HGNC ID	HGNC:12692
KEGG ID	hsa:7431

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

vimentin can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	Caco-2 cell line	Homo sapiens
Treatment: shMETTL3 Caco-2 cells Control: shNTC Caco-2 cells		GSE167075
Regulation		logFC: -9.97E-01 p-value: 8.40E-43
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 activated the luciferase activity of TOPflash (a reporter for beta-catenin/TCF signaling), and downregulation of METTL3 inhibited the expression of beta-catenin/TCF target genes Vimentin (vimentin) and N-cadherin, which are two regulators of epithelial-mesenchymal transition. METTL3 silencing decreased the m6A methylation and total mRNA levels of Tankyrase, a negative regulator of axin. METTL3 is a therapeutic target for NPC.
Target Regulation	Up regulation
Responsed Disease	Nasopharyngeal carcinoma		ICD-11: 2B6B	Disease Info
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	Neural progenitor cells (NPCs) (The progenitor cells of the CNS)
	NP69 (A human immortalized nasopharyngeal epithelial)
	HNE-2	Nasopharyngeal carcinoma	Homo sapiens	CVCL_FA07
	HNE-1	Nasopharyngeal carcinoma	Homo sapiens	CVCL_0308
	CNE-2	Nasopharyngeal carcinoma	Homo sapiens	CVCL_6889
	CNE-1	Normal	Homo sapiens	CVCL_6888
In-vivo Model	1 × 10⁵ HNE2 cells (with or without METTL3 knockdown) were labeled with luciferase gene and injected into the tail vein of the nude mice.

Nasopharyngeal carcinoma [ICD-11: 2B6B]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 activated the luciferase activity of TOPflash (a reporter for beta-catenin/TCF signaling), and downregulation of METTL3 inhibited the expression of beta-catenin/TCF target genes Vimentin (vimentin) and N-cadherin, which are two regulators of epithelial-mesenchymal transition. METTL3 silencing decreased the m6A methylation and total mRNA levels of Tankyrase, a negative regulator of axin. METTL3 is a therapeutic target for NPC.
Responsed Disease	Nasopharyngeal carcinoma [ICD-11: 2B6B]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Epithelial-mesenchymal transition
In-vitro Model	Neural progenitor cells (NPCs) (The progenitor cells of the CNS)
	NP69 (A human immortalized nasopharyngeal epithelial)
	HNE-2	Nasopharyngeal carcinoma	Homo sapiens	CVCL_FA07
	HNE-1	Nasopharyngeal carcinoma	Homo sapiens	CVCL_0308
	CNE-2	Nasopharyngeal carcinoma	Homo sapiens	CVCL_6889
	CNE-1	Normal	Homo sapiens	CVCL_6888
In-vivo Model	1 × 10⁵ HNE2 cells (with or without METTL3 knockdown) were labeled with luciferase gene and injected into the tail vein of the nude mice.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00518)

Vimentin (vimentin)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000139		Click to Show/Hide the Full List
mod site	chr10:17229723-17229724:+		[7]
Sequence	CGAGTTCAAGAACACCCGCACCAACGAGAAGGTGGAGCTGC
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000487938.5; ENST00000224237.9; ENST00000478746.1; ENST00000544301.7; ENST00000497849.1; ENST00000485947.1
External Link	RMBase: ac4C_site_201

N6-methyladenosine (m6A)

In total 71 m6A sequence/site(s) in this target gene
mod ID: M6ASITE095547		Click to Show/Hide the Full List
mod site	chr10:17228617-17228618:+		[8]
Sequence	CTCCCGCCGTCCGAAGCTGGACTGAGCCCGTTAGGTCCCTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000544301.7; ENST00000478746.1
External Link	RMBase: m6A_site_94148
mod ID: M6ASITE095548		Click to Show/Hide the Full List
mod site	chr10:17228644-17228645:+		[8]
Sequence	CCGTTAGGTCCCTCGACAGAACCTCCCCTCCCCCCAACATC
Motif Score	2.930744048
Cell/Tissue List	HeLa; GSC-11; HEK293A-TOA; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000544301.7; ENST00000478746.1
External Link	RMBase: m6A_site_94149
mod ID: M6ASITE095549		Click to Show/Hide the Full List
mod site	chr10:17228912-17228913:+		[8]
Sequence	CGCCTGACCGCAGCCCCGAGACCGCCGCGCACCTCCTCCCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; GSC-11; HEK293A-TOA; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000544301.7; ENST00000497849.1; ENST00000478746.1
External Link	RMBase: m6A_site_94150
mod ID: M6ASITE095550		Click to Show/Hide the Full List
mod site	chr10:17228958-17228959:+		[8]
Sequence	CTTTGGCGTGGTGCCACCGGACCCCTCTGGTTCAGTCCCAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; MT4; peripheral-blood; GSC-11; HEK293A-TOA; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000478746.1; ENST00000497849.1; ENST00000544301.7
External Link	RMBase: m6A_site_94151
mod ID: M6ASITE095551		Click to Show/Hide the Full List
mod site	chr10:17228983-17228984:+		[8]
Sequence	TCTGGTTCAGTCCCAGGCGGACCCCCCCCTCACCGCGCGAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; H1A; MT4; A549; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000478746.1; ENST00000544301.7; ENST00000497849.1
External Link	RMBase: m6A_site_94152
mod ID: M6ASITE095552		Click to Show/Hide the Full List
mod site	chr10:17229336-17229337:+		[9]
Sequence	CAGCCGCGCTCCCACCACCCACACCCACCGCGCCCTCGTTC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000224237.9; ENST00000485947.1; ENST00000544301.7; ENST00000478746.1; ENST00000487938.5; ENST00000497849.1
External Link	RMBase: m6A_site_94153
mod ID: M6ASITE095559		Click to Show/Hide the Full List
mod site	chr10:17229515-17229516:+		[10]
Sequence	GCTCCAGCCGGAGCTACGTGACTACGTCCACCCGCACCTAC
Motif Score	3.28175
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000478746.1; ENST00000224237.9; ENST00000487938.5; ENST00000544301.7; ENST00000485947.1; ENST00000497849.1
External Link	RMBase: m6A_site_94160
mod ID: M6ASITE095560		Click to Show/Hide the Full List
mod site	chr10:17229666-17229667:+		[8]
Sequence	CGGGGTGCGGCTCCTGCAGGACTCGGTGGACTTCTCGCTGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; MT4; A549; H1299; MM6; peripheral-blood; GSC-11; HEK293T; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000224237.9; ENST00000478746.1; ENST00000487938.5; ENST00000544301.7; ENST00000497849.1; ENST00000485947.1
External Link	RMBase: m6A_site_94161
mod ID: M6ASITE095561		Click to Show/Hide the Full List
mod site	chr10:17229675-17229676:+		[8]
Sequence	GCTCCTGCAGGACTCGGTGGACTTCTCGCTGGCCGACGCCA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; MT4; A549; H1299; MM6; Jurkat; peripheral-blood; GSC-11; HEK293T; TREX; endometrial; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000224237.9; ENST00000478746.1; ENST00000485947.1; ENST00000544301.7; ENST00000487938.5; ENST00000497849.1
External Link	RMBase: m6A_site_94162
mod ID: M6ASITE095562		Click to Show/Hide the Full List
mod site	chr10:17229699-17229700:+		[9]
Sequence	CTCGCTGGCCGACGCCATCAACACCGAGTTCAAGAACACCC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000487938.5; ENST00000544301.7; ENST00000485947.1; ENST00000497849.1; ENST00000224237.9; ENST00000478746.1
External Link	RMBase: m6A_site_94163
mod ID: M6ASITE095564		Click to Show/Hide the Full List
mod site	chr10:17229714-17229715:+		[8]
Sequence	CATCAACACCGAGTTCAAGAACACCCGCACCAACGAGAAGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; MT4; A549; H1299; MM6; Jurkat; peripheral-blood; GSC-11; TREX; endometrial; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000485947.1; ENST00000487938.5; ENST00000478746.1; ENST00000497849.1; ENST00000224237.9; ENST00000544301.7
External Link	RMBase: m6A_site_94165
mod ID: M6ASITE095565		Click to Show/Hide the Full List
mod site	chr10:17229771-17229772:+		[9]
Sequence	GAATGACCGCTTCGCCAACTACATCGACAAGGTGCGCTTCC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000478746.1; ENST00000224237.9; ENST00000485947.1; ENST00000487938.5; ENST00000544301.7
External Link	RMBase: m6A_site_94166
mod ID: M6ASITE095566		Click to Show/Hide the Full List
mod site	chr10:17229777-17229778:+		[9]
Sequence	CCGCTTCGCCAACTACATCGACAAGGTGCGCTTCCTGGAGC
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000224237.9; ENST00000478746.1; ENST00000485947.1; ENST00000544301.7; ENST00000487938.5
External Link	RMBase: m6A_site_94167
mod ID: M6ASITE095567		Click to Show/Hide the Full List
mod site	chr10:17229864-17229865:+		[8]
Sequence	AGGCAAGTCGCGCCTGGGGGACCTCTACGAGGAGGAGATGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MT4; A549; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000544301.7; ENST00000485947.1; ENST00000487938.5; ENST00000478746.1; ENST00000224237.9
External Link	RMBase: m6A_site_94168
mod ID: M6ASITE095568		Click to Show/Hide the Full List
mod site	chr10:17229906-17229907:+		[8]
Sequence	GGAGCTGCGCCGGCAGGTGGACCAGCTAACCAACGACAAAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MT4; A549; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000544301.7; ENST00000487938.5; ENST00000224237.9; ENST00000485947.1
External Link	RMBase: m6A_site_94169
mod ID: M6ASITE095569		Click to Show/Hide the Full List
mod site	chr10:17229921-17229922:+		[9]
Sequence	GGTGGACCAGCTAACCAACGACAAAGCCCGCGTCGAGGTGG
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000485947.1; ENST00000224237.9; ENST00000544301.7; ENST00000487938.5
External Link	RMBase: m6A_site_94170
mod ID: M6ASITE095570		Click to Show/Hide the Full List
mod site	chr10:17229963-17229964:+		[8]
Sequence	GCGCGACAACCTGGCCGAGGACATCATGCGCCTCCGGGAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; MT4; A549; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; endometrial; NB4; AML
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000487938.5; ENST00000485947.1; ENST00000224237.9; ENST00000544301.7
External Link	RMBase: m6A_site_94171
mod ID: M6ASITE095571		Click to Show/Hide the Full List
mod site	chr10:17230113-17230114:+		[8]
Sequence	GGGGGAGGCCTGCCAGGGAGACAGCGGAGAGCGGGGCTGTG
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD4T; GSC-11; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000487938.5; ENST00000485947.1; ENST00000224237.9; ENST00000469543.5; ENST00000544301.7
External Link	RMBase: m6A_site_94172
mod ID: M6ASITE095572		Click to Show/Hide the Full List
mod site	chr10:17230160-17230161:+		[8]
Sequence	GTGGCGCAGCCCCGCCCAGAACCCAGACCTTGCAGTTCGCA
Motif Score	2.930744048
Cell/Tissue List	HeLa; GSC-11; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000224237.9; ENST00000485947.1; ENST00000487938.5; ENST00000469543.5; ENST00000544301.7
External Link	RMBase: m6A_site_94173
mod ID: M6ASITE095573		Click to Show/Hide the Full List
mod site	chr10:17230166-17230167:+		[8]
Sequence	CAGCCCCGCCCAGAACCCAGACCTTGCAGTTCGCATTTCCT
Motif Score	2.876744048
Cell/Tissue List	HeLa; GSC-11; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000544301.7; ENST00000469543.5; ENST00000487938.5; ENST00000485947.1; ENST00000224237.9
External Link	RMBase: m6A_site_94174
mod ID: M6ASITE095574		Click to Show/Hide the Full List
mod site	chr10:17230244-17230245:+		[8]
Sequence	CAAGTTACAGATTTCTTAAAACTACCACTTTGTGTGCAGTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000485947.1; ENST00000469543.5; ENST00000224237.9; ENST00000544301.7; ENST00000487938.5
External Link	RMBase: m6A_site_94175
mod ID: M6ASITE095575		Click to Show/Hide the Full List
mod site	chr10:17230301-17230302:+		[11]
Sequence	AATGAGAGCCAGTCCTCCAAACTTTCAGAAAGTTTCCTGCC
Motif Score	2.627720238
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000485947.1; ENST00000224237.9; ENST00000469543.5; ENST00000544301.7; ENST00000487938.5
External Link	RMBase: m6A_site_94176
mod ID: M6ASITE095576		Click to Show/Hide the Full List
mod site	chr10:17230490-17230491:+		[8]
Sequence	GTGCCCGAAGTCCCGCTGAAACCTGCCGAGGGCAGCAGGTC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000487938.5; ENST00000485947.1; ENST00000224237.9; ENST00000469543.5; ENST00000544301.7
External Link	RMBase: m6A_site_94177
mod ID: M6ASITE095577		Click to Show/Hide the Full List
mod site	chr10:17230687-17230688:+		[8]
Sequence	TCAGAGAGAGGAAGCCGAAAACACCCTGCAATCTTTCAGAC
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T; LCLs; H1299; MM6; CD4T; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000637053.1; ENST00000544301.7; ENST00000487938.5; ENST00000469543.5; ENST00000485947.1; ENST00000421459.2; ENST00000224237.9
External Link	RMBase: m6A_site_94178
mod ID: M6ASITE095578		Click to Show/Hide the Full List
mod site	chr10:17230706-17230707:+		[8]
Sequence	AACACCCTGCAATCTTTCAGACAGGTTTGTAGACTCTCTTC
Motif Score	2.897386905
Cell/Tissue List	HeLa; LCLs; H1299; MM6; CD4T; peripheral-blood; HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000485947.1; ENST00000487938.5; ENST00000421459.2; ENST00000224237.9; ENST00000637053.1; ENST00000544301.7; ENST00000469543.5
External Link	RMBase: m6A_site_94179
mod ID: M6ASITE095579		Click to Show/Hide the Full List
mod site	chr10:17230718-17230719:+		[8]
Sequence	TCTTTCAGACAGGTTTGTAGACTCTCTTCCCACTCGCAGCC
Motif Score	3.319380952
Cell/Tissue List	HeLa; LCLs; H1299; MM6; CD4T; peripheral-blood; HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000485947.1; ENST00000224237.9; ENST00000469543.5; ENST00000487938.5; ENST00000421459.2; ENST00000544301.7; ENST00000637053.1
External Link	RMBase: m6A_site_94180
mod ID: M6ASITE095580		Click to Show/Hide the Full List
mod site	chr10:17230809-17230810:+		[8]
Sequence	TCACGTCTAAAAAGTGCAAAACTTCAGGGCTGCGCGTAAAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; H1299; CD4T; peripheral-blood; HEK293T; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000485947.1; ENST00000421459.2; ENST00000487938.5; ENST00000224237.9; ENST00000637053.1; ENST00000469543.5; ENST00000544301.7
External Link	RMBase: m6A_site_94181
mod ID: M6ASITE095581		Click to Show/Hide the Full List
mod site	chr10:17230848-17230849:+		[8]
Sequence	AGCCCTCTAGTGGCGGGAAGACCACAGGTTGGAGCTTCTCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; H1299
Seq Type List	m6A-seq
Transcript ID List	ENST00000469543.5; ENST00000637053.1; ENST00000544301.7; ENST00000421459.2; ENST00000224237.9; ENST00000487938.5; ENST00000485947.1
External Link	RMBase: m6A_site_94182
mod ID: M6ASITE095582		Click to Show/Hide the Full List
mod site	chr10:17230891-17230892:+		[8]
Sequence	ATTAGAAAAATATTAATAAAACCCCTTGAGCGATTTTTTTT
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000637053.1; ENST00000224237.9; ENST00000544301.7; ENST00000421459.2; ENST00000485947.1; ENST00000487938.5; ENST00000469543.5
External Link	RMBase: m6A_site_94183
mod ID: M6ASITE095583		Click to Show/Hide the Full List
mod site	chr10:17233593-17233594:+		[9]
Sequence	CTGTTCAAAATAGGATGTTGACAATGCGTCTCTGGCACGTC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T; AML
Seq Type List	MAZTER-seq; miCLIP
Transcript ID List	ENST00000637053.1; ENST00000544301.7; ENST00000487938.5; ENST00000224237.9; ENST00000495528.1; ENST00000421459.2; ENST00000469543.5
External Link	RMBase: m6A_site_94187
mod ID: M6ASITE095584		Click to Show/Hide the Full List
mod site	chr10:17233669-17233670:+		[8]
Sequence	GAGATTGCCTTTTTGAAGAAACTCCACGAAGAGGTTAGTGG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000495528.1; ENST00000544301.7; ENST00000469543.5; ENST00000637053.1; ENST00000421459.2; ENST00000224237.9; ENST00000487938.5
External Link	RMBase: m6A_site_94188
mod ID: M6ASITE095585		Click to Show/Hide the Full List
mod site	chr10:17233801-17233802:+		[8]
Sequence	CTGCAGGCTCAGATTCAGGAACAGCATGTCCAAATCGATGT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000421459.2; ENST00000469543.5; ENST00000224237.9; ENST00000495528.1; ENST00000544301.7; ENST00000487938.5; ENST00000637053.1
External Link	RMBase: m6A_site_94190
mod ID: M6ASITE095586		Click to Show/Hide the Full List
mod site	chr10:17233896-17233897:+		[8]
Sequence	TGAAAGTGTGGCTGCCAAGAACCTGCAGGAGGCAGAAGAAT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000487938.5; ENST00000637053.1; ENST00000495528.1; ENST00000469543.5; ENST00000224237.9; ENST00000544301.7; ENST00000421459.2
External Link	RMBase: m6A_site_94193
mod ID: M6ASITE095587		Click to Show/Hide the Full List
mod site	chr10:17233920-17233921:+		[9]
Sequence	GCAGGAGGCAGAAGAATGGTACAAATCCAAGGTAGGAAACA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000224237.9; ENST00000637053.1; ENST00000421459.2; ENST00000544301.7; ENST00000495528.1; ENST00000469543.5; ENST00000487938.5
External Link	RMBase: m6A_site_94194
mod ID: M6ASITE095588		Click to Show/Hide the Full List
mod site	chr10:17233938-17233939:+		[8]
Sequence	GTACAAATCCAAGGTAGGAAACAAATCAGTGCGGCTTCAAC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000495528.1; ENST00000637053.1; ENST00000487938.5; ENST00000421459.2; ENST00000224237.9; ENST00000544301.7; ENST00000469543.5
External Link	RMBase: m6A_site_94195
mod ID: M6ASITE095589		Click to Show/Hide the Full List
mod site	chr10:17233984-17233985:+		[8]
Sequence	AAAAGCATTGTGTTCTCAAAACCCCATACCTGTGTGTGATT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000637053.1; ENST00000421459.2; ENST00000544301.7; ENST00000487938.5; ENST00000495528.1; ENST00000469543.5; ENST00000224237.9
External Link	RMBase: m6A_site_94196
mod ID: M6ASITE095590		Click to Show/Hide the Full List
mod site	chr10:17234723-17234724:+		[8]
Sequence	CTCTGAGGCTGCCAACCGGAACAATGACGCCCTGCGCCAGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; A549; H1299; Huh7; endometrial
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000469543.5; ENST00000544301.7; ENST00000224237.9; ENST00000421459.2; ENST00000487938.5; ENST00000495528.1
External Link	RMBase: m6A_site_94197
mod ID: M6ASITE095591		Click to Show/Hide the Full List
mod site	chr10:17234772-17234773:+		[8]
Sequence	GAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; A549; H1299; Huh7; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000544301.7; ENST00000421459.2; ENST00000224237.9; ENST00000469543.5; ENST00000495528.1; ENST00000487938.5
External Link	RMBase: m6A_site_94199
mod ID: M6ASITE095592		Click to Show/Hide the Full List
mod site	chr10:17234815-17234816:+		[8]
Sequence	AAGTGGATGCCCTTAAAGGAACCGTGAGTACCAACCCTGCA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; H1299; Huh7; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000544301.7; ENST00000421459.2; ENST00000224237.9; ENST00000469543.5; ENST00000495528.1; ENST00000487938.5
External Link	RMBase: m6A_site_94201
mod ID: M6ASITE095593		Click to Show/Hide the Full List
mod site	chr10:17234892-17234893:+		[8]
Sequence	AGGCTCATGATGATACCTGAACAAAATGTTGAGTGAGTAAA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; A549; H1299; Huh7; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000421459.2; ENST00000469543.5; ENST00000495528.1; ENST00000544301.7; ENST00000487938.5; ENST00000224237.9
External Link	RMBase: m6A_site_94202
mod ID: M6ASITE095594		Click to Show/Hide the Full List
mod site	chr10:17234950-17234951:+		[8]
Sequence	AAAGAAAATGAGTTATCAAGACAGACTCAAAAGGGACTTCA
Motif Score	2.897386905
Cell/Tissue List	HeLa; H1299
Seq Type List	m6A-seq
Transcript ID List	ENST00000469543.5; ENST00000495528.1; ENST00000224237.9; ENST00000544301.7; ENST00000487938.5; ENST00000421459.2
External Link	RMBase: m6A_site_94203
mod ID: M6ASITE095595		Click to Show/Hide the Full List
mod site	chr10:17235023-17235024:+		[12]
Sequence	CATTGCTTCTAATATGAAGGACTTGGTACTCGCATTCTCCA
Motif Score	4.065041667
Cell/Tissue List	A549; H1299; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000487938.5; ENST00000224237.9; ENST00000495528.1; ENST00000421459.2; ENST00000544301.7; ENST00000469543.5
External Link	RMBase: m6A_site_94204
mod ID: M6ASITE095596		Click to Show/Hide the Full List
mod site	chr10:17235208-17235209:+		[13]
Sequence	GATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTA
Motif Score	3.373380952
Cell/Tissue List	HepG2; H1299
Seq Type List	m6A-seq
Transcript ID List	ENST00000469543.5; ENST00000544301.7; ENST00000224237.9; ENST00000487938.5
External Link	RMBase: m6A_site_94205
mod ID: M6ASITE095597		Click to Show/Hide the Full List
mod site	chr10:17235229-17235230:+		[14]
Sequence	CTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCC
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000487938.5; ENST00000544301.7; ENST00000469543.5; ENST00000224237.9
External Link	RMBase: m6A_site_94206
mod ID: M6ASITE095598		Click to Show/Hide the Full List
mod site	chr10:17235238-17235239:+		[9]
Sequence	TGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGG
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; HepG2; H1299
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000469543.5; ENST00000487938.5; ENST00000544301.7; ENST00000224237.9
External Link	RMBase: m6A_site_94207
mod ID: M6ASITE095599		Click to Show/Hide the Full List
mod site	chr10:17235313-17235314:+		[13]
Sequence	TCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGG
Motif Score	2.876744048
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000544301.7; ENST00000224237.9; ENST00000469543.5; ENST00000487938.5
External Link	RMBase: m6A_site_94208
mod ID: M6ASITE095600		Click to Show/Hide the Full List
mod site	chr10:17235340-17235341:+		[9]
Sequence	CAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000469543.5; ENST00000487938.5; ENST00000224237.9; ENST00000544301.7
External Link	RMBase: m6A_site_94209
mod ID: M6ASITE095601		Click to Show/Hide the Full List
mod site	chr10:17235396-17235397:+		[13]
Sequence	GCGAGGAGAGCAGGTAGGGAACTCAGACTTGGATGCGTGAA
Motif Score	3.373380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000469543.5; ENST00000224237.9; ENST00000487938.5; ENST00000544301.7
External Link	RMBase: m6A_site_94210
mod ID: M6ASITE095602		Click to Show/Hide the Full List
mod site	chr10:17235402-17235403:+		[13]
Sequence	AGAGCAGGTAGGGAACTCAGACTTGGATGCGTGAACTAATG
Motif Score	3.319380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000487938.5; ENST00000224237.9; ENST00000544301.7; ENST00000469543.5
External Link	RMBase: m6A_site_94211
mod ID: M6ASITE095603		Click to Show/Hide the Full List
mod site	chr10:17235416-17235417:+		[13]
Sequence	ACTCAGACTTGGATGCGTGAACTAATGGTGACCATTTGTTA
Motif Score	3.373380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000224237.9; ENST00000469543.5; ENST00000544301.7; ENST00000487938.5
External Link	RMBase: m6A_site_94212
mod ID: M6ASITE095604		Click to Show/Hide the Full List
mod site	chr10:17235865-17235866:+		[14]
Sequence	GATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; Huh7
Seq Type List	DART-seq; MeRIP-seq
Transcript ID List	ENST00000224237.9; ENST00000544301.7; ENST00000487938.5; ENST00000469543.5
External Link	RMBase: m6A_site_94213
mod ID: M6ASITE095605		Click to Show/Hide the Full List
mod site	chr10:17235880-17235881:+		[15]
Sequence	TCCAAACTTTTCCTCCCTGAACCTGAGGGGTAAGCATTTTA
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000224237.9; ENST00000469543.5; ENST00000544301.7; ENST00000487938.5
External Link	RMBase: m6A_site_94214
mod ID: M6ASITE095606		Click to Show/Hide the Full List
mod site	chr10:17236000-17236001:+		[15]
Sequence	AAAATGCCATATAAGAGAAAACTCTATAAAACATCTATAAT
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000487938.5; ENST00000469543.5; ENST00000224237.9; ENST00000544301.7
External Link	RMBase: m6A_site_94215
mod ID: M6ASITE095607		Click to Show/Hide the Full List
mod site	chr10:17236010-17236011:+		[15]
Sequence	ATAAGAGAAAACTCTATAAAACATCTATAATTTTCGAACCC
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000487938.5; ENST00000469543.5; ENST00000224237.9; ENST00000544301.7
External Link	RMBase: m6A_site_94216
mod ID: M6ASITE095608		Click to Show/Hide the Full List
mod site	chr10:17236027-17236028:+		[15]
Sequence	AAAACATCTATAATTTTCGAACCCAAGTACACTCTTGCATT
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000544301.7; ENST00000224237.9; ENST00000469543.5; ENST00000487938.5
External Link	RMBase: m6A_site_94217
mod ID: M6ASITE095609		Click to Show/Hide the Full List
mod site	chr10:17236070-17236071:+		[15]
Sequence	ATGCTTTAAGTTAAATGCAAACTCCTTTTTCCTTCTTCCTG
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000544301.7; ENST00000487938.5; ENST00000224237.9; ENST00000469543.5
External Link	RMBase: m6A_site_94218
mod ID: M6ASITE095610		Click to Show/Hide the Full List
mod site	chr10:17236340-17236341:+		[9]
Sequence	TTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000544301.7; ENST00000224237.9; ENST00000469543.5; ENST00000487938.5
External Link	RMBase: m6A_site_94219
mod ID: M6ASITE095611		Click to Show/Hide the Full List
mod site	chr10:17236355-17236356:+		[14]
Sequence	AAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGA
Motif Score	2.871321429
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000544301.7; ENST00000469543.5; ENST00000224237.9; ENST00000487938.5
External Link	RMBase: m6A_site_94220
mod ID: M6ASITE095612		Click to Show/Hide the Full List
mod site	chr10:17236364-17236365:+		[8]
Sequence	TTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTGGT
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000544301.7; ENST00000469543.5; ENST00000224237.9; ENST00000487938.5
External Link	RMBase: m6A_site_94221
mod ID: M6ASITE095613		Click to Show/Hide the Full List
mod site	chr10:17236375-17236376:+		[8]
Sequence	ACGGTTGAAACTAGAGATGGACAGGTTGGTATCTTTTAAGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000224237.9; ENST00000469543.5; ENST00000487938.5; ENST00000544301.7
External Link	RMBase: m6A_site_94222
mod ID: M6ASITE095614		Click to Show/Hide the Full List
mod site	chr10:17237241-17237242:+		[8]
Sequence	TTAAACAGGTTATCAACGAAACTTCTCAGCATCACGATGAC
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000469543.5; ENST00000487938.5; ENST00000544301.7; ENST00000224237.9
External Link	RMBase: m6A_site_94223
mod ID: M6ASITE095615		Click to Show/Hide the Full List
mod site	chr10:17237278-17237279:+		[9]
Sequence	TGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATAT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000544301.7; ENST00000487938.5; ENST00000469543.5; ENST00000224237.9
External Link	RMBase: m6A_site_94224
mod ID: M6ASITE095616		Click to Show/Hide the Full List
mod site	chr10:17237282-17237283:+		[14]
Sequence	CTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTA
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000544301.7; ENST00000224237.9; ENST00000469543.5; ENST00000487938.5
External Link	RMBase: m6A_site_94225
mod ID: M6ASITE095617		Click to Show/Hide the Full List
mod site	chr10:17237340-17237341:+		[8]
Sequence	GAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000224237.9; ENST00000544301.7; ENST00000469543.5; ENST00000487938.5
External Link	RMBase: m6A_site_94226
mod ID: M6ASITE095618		Click to Show/Hide the Full List
mod site	chr10:17237416-17237417:+		[9]
Sequence	GGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGA
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T; AML
Seq Type List	MAZTER-seq; miCLIP
Transcript ID List	ENST00000544301.7; ENST00000224237.9; ENST00000487938.5; ENST00000469543.5
External Link	RMBase: m6A_site_94227
mod ID: M6ASITE095619		Click to Show/Hide the Full List
mod site	chr10:17237423-17237424:+		[14]
Sequence	GCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAA
Motif Score	2.865571429
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000224237.9; ENST00000544301.7; ENST00000469543.5; ENST00000487938.5
External Link	RMBase: m6A_site_94228
mod ID: M6ASITE095620		Click to Show/Hide the Full List
mod site	chr10:17237469-17237470:+		[14]
Sequence	TTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGA
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000487938.5; ENST00000544301.7; ENST00000469543.5; ENST00000224237.9
External Link	RMBase: m6A_site_94229
mod ID: M6ASITE095621		Click to Show/Hide the Full List
mod site	chr10:17237492-17237493:+		[14]
Sequence	GAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGA
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000487938.5; ENST00000469543.5; ENST00000224237.9; ENST00000544301.7
External Link	RMBase: m6A_site_94230
mod ID: M6ASITE095622		Click to Show/Hide the Full List
mod site	chr10:17237524-17237525:+		[8]
Sequence	GTATTTTGAATACCATTAAAACTGCTTTTTTTTTTCCAGCA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000544301.7; ENST00000487938.5; ENST00000224237.9; ENST00000469543.5
External Link	RMBase: m6A_site_94231
mod ID: M6ASITE095623		Click to Show/Hide the Full List
mod site	chr10:17237557-17237558:+		[14]
Sequence	TTCCAGCAAGTATCCAACCAACTTGGTTCTGCTTCAATAAA
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000469543.5; ENST00000487938.5; ENST00000224237.9; ENST00000544301.7
External Link	RMBase: m6A_site_94232
mod ID: M6ASITE095624		Click to Show/Hide the Full List
mod site	chr10:17237589-17237590:+		[8]
Sequence	TTCAATAAATCTTTGGAAAAACTCTTTTGTTGTGTTATTTA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000544301.7; ENST00000224237.9; ENST00000487938.5; ENST00000469543.5
External Link	RMBase: m6A_site_94233

2'-O-Methylation (2'-O-Me)

In total 2 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000505		Click to Show/Hide the Full List
mod site	chr10:17233615-17233616:+		[16]
Sequence	AATGCGTCTCTGGCACGTCTTGACCTTGAACGCAAAGTGGA
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000224237.9; ENST00000469543.5; ENST00000637053.1; ENST00000495528.1; ENST00000421459.2; ENST00000487938.5; ENST00000544301.7
External Link	RMBase: Nm_site_661
mod ID: 2OMSITE000507		Click to Show/Hide the Full List
mod site	chr10:17233867-17233868:+		[16]
Sequence	GCTGCCCTGCGTGACGTACGTCAGCAATATGAAAGTGTGGC
Cell/Tissue List	HEK293
Seq Type List	Nm-seq
Transcript ID List	ENST00000469543.5; ENST00000421459.2; ENST00000637053.1; ENST00000224237.9; ENST00000544301.7; ENST00000487938.5; ENST00000495528.1
External Link	RMBase: Nm_site_662

Ref 1	Upregulated METTL3 in nasopharyngeal carcinoma enhances the motility of cancer cells. Kaohsiung J Med Sci. 2020 Nov;36(11):895-903. doi: 10.1002/kjm2.12266. Epub 2020 Jul 15.
Ref 2	Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in?vitro. Pulm Pharmacol Ther. 2014 Aug;28(2):130-7. doi: 10.1016/j.pupt.2014.02.004. Epub 2014 Mar 21.
Ref 3	Impact of drug transporters on cellular resistance towards saquinavir and darunavir. J Antimicrob Chemother. 2010 Nov;65(11):2319-28.
Ref 4	Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system. Antimicrob Agents Chemother. 2009 Nov;53(11):4753-61. doi: 10.1128/AAC.01541-08. Epub 2009 Aug 31.
Ref 5	Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9.
Ref 6	Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3638-40. doi: 10.1016/j.bmcl.2008.04.046. Epub 2008 Apr 25.
Ref 7	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 8	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 9	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 10	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 11	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 12	The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 May 5;62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21.
Ref 13	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 14	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 15	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 16	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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