m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00517)
| Target Name | Circ_DLC1 | ||||
|---|---|---|---|---|---|
| Gene Name | Circ_DLC1 | ||||
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_DLC1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | METTL3-mediated m6A modification upregulated Circ_DLC1 expression, and circDLC1 promoted CTNNBIP1 transcription by sponging miR-671-5p, thus repressing the malignant proliferation of glioma. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Glioma | ICD-11: 2A00.0 | ||
| In-vitro Model | T98G | Glioblastoma | Homo sapiens | CVCL_0556 |
| LN-229 | Glioblastoma | Homo sapiens | CVCL_0393 | |
| LN-18 | Glioblastoma | Homo sapiens | CVCL_0392 | |
| HEB (human normal glial cell line HEB were obtained from Tongpai (Shanghai) biotechnology co., LTD (Shanghai, China)) | ||||
| A-172 | Glioblastoma | Homo sapiens | CVCL_0131 | |
Protein virilizer homolog (VIRMA) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [2] | |||
| Response Summary | Circ_DLC1, a downstream target of KIAA1429, is a promising prognostic marker for HCC patients, and the circDLC1-HuR-MMP1 axis serve as a potential therapeutic target for HCC treatment. | |||
| Target Regulation | Down regulation | |||
| Responsed Disease | Hepatocellular carcinoma | ICD-11: 2C12.02 | ||
| Pathway Response | RNA degradation | hsa03018 | ||
| Cell Process | RNA stability | |||
| In-vitro Model | SNU-449 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0454 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Homo sapiens | CVCL_0525 | |
| Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 | |
| Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | |
| Hep 3B2.1-7 | Childhood hepatocellular carcinoma | Homo sapiens | CVCL_0326 | |
| In-vivo Model | 5 × 105 cells were injected subcutaneously into the right axilla of mice. Tumor volume was measured by a caliper weekly and calculated as length × width2 × 0.52. For the liver orthotopic-implanted models, each liver of mice was injected with 1 × 106 cells. | |||
Brain cancer [ICD-11: 2A00]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | METTL3-mediated m6A modification upregulated Circ_DLC1 expression, and circDLC1 promoted CTNNBIP1 transcription by sponging miR-671-5p, thus repressing the malignant proliferation of glioma. | |||
| Responsed Disease | Glioma [ICD-11: 2A00.0] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | T98G | Glioblastoma | Homo sapiens | CVCL_0556 |
| LN-229 | Glioblastoma | Homo sapiens | CVCL_0393 | |
| LN-18 | Glioblastoma | Homo sapiens | CVCL_0392 | |
| HEB (human normal glial cell line HEB were obtained from Tongpai (Shanghai) biotechnology co., LTD (Shanghai, China)) | ||||
| A-172 | Glioblastoma | Homo sapiens | CVCL_0131 | |
Liver cancer [ICD-11: 2C12]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [2] | |||
| Response Summary | Circ_DLC1, a downstream target of KIAA1429, is a promising prognostic marker for HCC patients, and the circDLC1-HuR-MMP1 axis serve as a potential therapeutic target for HCC treatment. | |||
| Responsed Disease | Hepatocellular carcinoma [ICD-11: 2C12.02] | |||
| Target Regulator | Protein virilizer homolog (VIRMA) | WRITER | ||
| Target Regulation | Down regulation | |||
| Pathway Response | RNA degradation | hsa03018 | ||
| Cell Process | RNA stability | |||
| In-vitro Model | SNU-449 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0454 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Homo sapiens | CVCL_0525 | |
| Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 | |
| Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | |
| Hep 3B2.1-7 | Childhood hepatocellular carcinoma | Homo sapiens | CVCL_0326 | |
| In-vivo Model | 5 × 105 cells were injected subcutaneously into the right axilla of mice. Tumor volume was measured by a caliper weekly and calculated as length × width2 × 0.52. For the liver orthotopic-implanted models, each liver of mice was injected with 1 × 106 cells. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03317 | ||
| Epigenetic Regulator | Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C) | |
| Regulated Target | Histone H3 lysine 9 monomethylation (H3K9me1) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Brain cancer | |
Non-coding RNA
m6A Regulator: Protein virilizer homolog (VIRMA)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05575 | ||
| Epigenetic Regulator | Circ_DLC1 | |
| Regulated Target | ELAV-like protein 1 (HuR/ELAVL1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Liver cancer | |
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05596 | ||
| Epigenetic Regulator | Circ_DLC1 | |
| Regulated Target | hsa-miR-671-5p | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Brain cancer | |
References