m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00509)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PACERR
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | PTGS2 antisense RNA 1 (PACERR) which bound to IGF2BP2 acts as an m6A-dependent manner to enhance the stability of KLF12 and c-myc in cytoplasm. This study found that LncRNA-PACERR functions as key regulator of TAMs in PDAC microenvironment and revealed the novel mechanisms in cytoplasm and in nucleus. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Pancreatic ductal adenocarcinoma | ICD-11: 2C10.0 | ||
| Pathway Response | mRNA surveillance pathway | hsa03015 | ||
| RNA degradation | hsa03018 | |||
| Cell Process | RNA stability | |||
| In-vitro Model | THP-1 | Childhood acute monocytic leukemia | Homo sapiens | CVCL_0006 |
| PATU-8988 (Human pancreatic adenocarcinoma cell) | ||||
| PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens | CVCL_0480 | |
| HEK293T | Normal | Homo sapiens | CVCL_0063 | |
| 37 (Pancreatic cancer cell) | ||||
| In-vivo Model | BALB/c nude mice which were co-injected with THP-1 cells and PATU-8988 cells subcutaneously. | |||
Pancreatic cancer [ICD-11: 2C10]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | PTGS2 antisense RNA 1 (PACERR) which bound to IGF2BP2 acts as an m6A-dependent manner to enhance the stability of KLF12 and c-myc in cytoplasm. This study found that LncRNA-PACERR functions as key regulator of TAMs in PDAC microenvironment and revealed the novel mechanisms in cytoplasm and in nucleus. | |||
| Responsed Disease | Pancreatic ductal adenocarcinoma [ICD-11: 2C10.0] | |||
| Target Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | READER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | mRNA surveillance pathway | hsa03015 | ||
| RNA degradation | hsa03018 | |||
| Cell Process | RNA stability | |||
| In-vitro Model | THP-1 | Childhood acute monocytic leukemia | Homo sapiens | CVCL_0006 |
| PATU-8988 (Human pancreatic adenocarcinoma cell) | ||||
| PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens | CVCL_0480 | |
| HEK293T | Normal | Homo sapiens | CVCL_0063 | |
| 37 (Pancreatic cancer cell) | ||||
| In-vivo Model | BALB/c nude mice which were co-injected with THP-1 cells and PATU-8988 cells subcutaneously. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03474 | ||
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 18 lactylation (H3K18la) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Pancreatic cancer | |
Non-coding RNA
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05574 | ||
| Epigenetic Regulator | PTGS2 antisense RNA 1 (PACERR) | |
| Regulated Target | Krueppel-like factor 12 (KLF12) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Pancreatic ductal adenocarcinoma | |