m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00456)
Target Name Zinc finger protein 750 (ZNF750)
Gene Name ZNF750
Chromosomal Location 17q25.3
Function
Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.
    Click to Show/Hide
Gene ID 79755
Uniprot ID
ZN750_HUMAN
HGNC ID
HGNC:25843
KEGG ID
hsa:79755
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ZNF750 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Liver Mus musculus
Treatment: Mettl3-deficient liver
Control: Wild type liver cells
 GSE197800
Regulation
logFC: 1.24E+00
p-value: 8.99E-10
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between ZNF750 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 5.92E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary m6A modifications maintained the low expression level of ZNF750 in NPC. Knocking down METTL3 stimulated endogenous Zinc finger protein 750 (ZNF750) expression, and vice versa.
Target Regulation Down regulation
Responsed Disease Nasopharyngeal carcinoma ICD-11: 2B6B
 Disease Info 
Cell Process Cell apoptosis
In-vitro Model 5-8F Nasopharyngeal carcinoma Homo sapiens CVCL_C528
6-10B Nasopharyngeal carcinoma Homo sapiens CVCL_C529
C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
HNE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_0308
HONE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_8706
NP69 (A human immortalized nasopharyngeal epithelial)
S18 Nasopharyngeal carcinoma Homo sapiens CVCL_B0U9
S26 Nasopharyngeal carcinoma Homo sapiens CVCL_B0UB
SUNE1 Nasopharyngeal carcinoma Homo sapiens CVCL_6946
In-vivo Model BALB/c-nu mice (4-6 weeks old, female) were purchased from Charles River Laboratories (Beijing, China), and SUNE1-vector-luciferase or SUNE1-ZNF750-luciferase cells (1 × 106) were subcutaneously injected into the dorsal or ventral flank.
Nasopharyngeal carcinoma [ICD-11: 2B6B]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary m6A modifications maintained the low expression level of ZNF750 in NPC. Knocking down METTL3 stimulated endogenous Zinc finger protein 750 (ZNF750) expression, and vice versa.
Responsed Disease Nasopharyngeal carcinoma [ICD-11: 2B6B]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell apoptosis
In-vitro Model 5-8F Nasopharyngeal carcinoma Homo sapiens CVCL_C528
6-10B Nasopharyngeal carcinoma Homo sapiens CVCL_C529
C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
HNE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_0308
HONE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_8706
NP69 (A human immortalized nasopharyngeal epithelial)
S18 Nasopharyngeal carcinoma Homo sapiens CVCL_B0U9
S26 Nasopharyngeal carcinoma Homo sapiens CVCL_B0UB
SUNE1 Nasopharyngeal carcinoma Homo sapiens CVCL_6946
In-vivo Model BALB/c-nu mice (4-6 weeks old, female) were purchased from Charles River Laboratories (Beijing, China), and SUNE1-vector-luciferase or SUNE1-ZNF750-luciferase cells (1 × 106) were subcutaneously injected into the dorsal or ventral flank.
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00456)
Zinc finger protein 750 (ZNF750)
N6-methyladenosine (m6A)
In total 26 m6A sequence/site(s) in this target gene
mod ID: M6ASITE036397 Click to Show/Hide the Full List
mod site chr17:82830187-82830188:- [2]
Sequence TAAGAAGGCGAAGCTGCAGGACACGGCCAGAGTGTTCACAC
Motif Score 3.643047619
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391404
mod ID: M6ASITE036398 Click to Show/Hide the Full List
mod site chr17:82830245-82830246:- [2]
Sequence GACCCAAAGGACAAAAGAGGACAAGTCTAAGGGATGCTGGA
Motif Score 3.643047619
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391405
mod ID: M6ASITE036399 Click to Show/Hide the Full List
mod site chr17:82830255-82830256:- [2]
Sequence TGTGACCTCAGACCCAAAGGACAAAAGAGGACAAGTCTAAG
Motif Score 3.643047619
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391406
mod ID: M6ASITE036400 Click to Show/Hide the Full List
mod site chr17:82830264-82830265:- [2]
Sequence GAGGCCCAGTGTGACCTCAGACCCAAAGGACAAAAGAGGAC
Motif Score 2.876744048
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391407
mod ID: M6ASITE036401 Click to Show/Hide the Full List
mod site chr17:82830316-82830317:- [2]
Sequence GGAACCTGCCTGCCGGCAAGACACACCCACACTGAGCTCCA
Motif Score 2.897386905
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391408
mod ID: M6ASITE036402 Click to Show/Hide the Full List
mod site chr17:82830518-82830519:- [3]
Sequence ATGGGCCCAGCCACCCTGAGACCAAGCCAGGCAGCCTCGAC
Motif Score 2.876744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391409
mod ID: M6ASITE036403 Click to Show/Hide the Full List
mod site chr17:82830554-82830555:- [3]
Sequence CTGTTCCACAGAAGACTGGGACAGAAGGTTCTGAGGATGGG
Motif Score 3.643047619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391410
mod ID: M6ASITE036404 Click to Show/Hide the Full List
mod site chr17:82830560-82830561:- [3]
Sequence CTGCTGCTGTTCCACAGAAGACTGGGACAGAAGGTTCTGAG
Motif Score 3.319380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391411
mod ID: M6ASITE036405 Click to Show/Hide the Full List
mod site chr17:82830585-82830586:- [3]
Sequence GGTCGACCACGAGCTGCAGAACCTGCTGCTGCTGTTCCACA
Motif Score 2.930744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391412
mod ID: M6ASITE036406 Click to Show/Hide the Full List
mod site chr17:82830643-82830644:- [3]
Sequence ACTCAATCTCTCGGTGAAGGACCCCTGTAACACCCAGGCTC
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391413
mod ID: M6ASITE036407 Click to Show/Hide the Full List
mod site chr17:82830670-82830671:- [3]
Sequence CAGCTTCTCAGAGCTGCAGGACCTTCCACTCAATCTCTCGG
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391414
mod ID: M6ASITE036408 Click to Show/Hide the Full List
mod site chr17:82830695-82830696:- [3]
Sequence AAGGCAGCCCCCAGGCGGAAACCGCCAGCTTCTCAGAGCTG
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391415
mod ID: M6ASITE036409 Click to Show/Hide the Full List
mod site chr17:82830726-82830727:- [3]
Sequence AACCTGGCAGCCACCCACGAACCCACGTACCAAGGCAGCCC
Motif Score 2.930744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391416
mod ID: M6ASITE036410 Click to Show/Hide the Full List
mod site chr17:82831273-82831274:- [3]
Sequence CTCCAAGGCTGGGCAGAGAGACACGGAAGGGTCCAAAATGA
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391417
mod ID: M6ASITE036411 Click to Show/Hide the Full List
mod site chr17:82831297-82831298:- [3]
Sequence TCCAATTCCTGAGGCTAAAGACTCCTCCAAGGCTGGGCAGA
Motif Score 3.319380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391418
mod ID: M6ASITE036412 Click to Show/Hide the Full List
mod site chr17:82831335-82831336:- [3]
Sequence CCTTCGGACCCCAACAGAAAACACGTCGAGTTCGAAAGTCC
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391419
mod ID: M6ASITE036413 Click to Show/Hide the Full List
mod site chr17:82831348-82831349:- [3]
Sequence TTCCAGGTTAAACCCTTCGGACCCCAACAGAAAACACGTCG
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391420
mod ID: M6ASITE036414 Click to Show/Hide the Full List
mod site chr17:82831357-82831358:- [3]
Sequence CTCGAGTCCTTCCAGGTTAAACCCTTCGGACCCCAACAGAA
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391421
mod ID: M6ASITE036415 Click to Show/Hide the Full List
mod site chr17:82831452-82831453:- [3]
Sequence TTTTCCTCCTATGGTCTCAGACTCCCACCTGTCACTGGCCT
Motif Score 3.319380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391422
mod ID: M6ASITE036416 Click to Show/Hide the Full List
mod site chr17:82831913-82831914:- [2]
Sequence ACAACGCCGAGGCGCCCGAGACACTGGCTTTACACAACCCC
Motif Score 2.897386905
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391423
mod ID: M6ASITE036417 Click to Show/Hide the Full List
mod site chr17:82831933-82831934:- [2]
Sequence GCACAGACTCAAGGGGCCAGACAACGCCGAGGCGCCCGAGA
Motif Score 2.897386905
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391424
mod ID: M6ASITE036418 Click to Show/Hide the Full List
mod site chr17:82831947-82831948:- [2]
Sequence GTTCCAGTCGGCGAGCACAGACTCAAGGGGCCAGACAACGC
Motif Score 3.319380952
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391425
mod ID: M6ASITE036419 Click to Show/Hide the Full List
mod site chr17:82832073-82832074:- [2]
Sequence GGAACCCACAGGTGCCTGGGACAGAAGCCAGCCCTCCACAG
Motif Score 3.643047619
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391426
mod ID: M6ASITE036420 Click to Show/Hide the Full List
mod site chr17:82832090-82832091:- [2]
Sequence TGGAGCTGCAAGCCCGGGGAACCCACAGGTGCCTGGGACAG
Motif Score 2.930744048
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391427
mod ID: M6ASITE036421 Click to Show/Hide the Full List
mod site chr17:82832113-82832114:- [2]
Sequence CAGGGAAGACATCAAGGAAAACCTGGAGCTGCAAGCCCGGG
Motif Score 2.185083333
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000572562.1; ENST00000269394.4
External Link RMBase: m6A_site_391428
mod ID: M6ASITE036422 Click to Show/Hide the Full List
mod site chr17:82832125-82832126:- [2]
Sequence GCACAGCTCTGCCAGGGAAGACATCAAGGAAAACCTGGAGC
Motif Score 2.897386905
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000269394.4; ENST00000572562.1
External Link RMBase: m6A_site_391429