m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00456)
Target Name Zinc finger protein 750 (ZNF750)
Gene Name ZNF750
Chromosomal Location 17q25.3
Function
Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.
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Gene ID 79755
Uniprot ID
ZN750_HUMAN
HGNC ID
HGNC:25843
Ensembl Gene ID
ENSG00000141579
KEGG ID
hsa:79755
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ZNF750 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Liver Mus musculus
Treatment: Mettl3-deficient liver
Control: Wild type liver cells
 GSE197800
Regulation
logFC: 1.24E+00
p-value: 8.99E-10
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between ZNF750 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 5.92E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary m6A modifications maintained the low expression level of ZNF750 in NPC. Knocking down METTL3 stimulated endogenous Zinc finger protein 750 (ZNF750) expression, and vice versa.
Target Regulation Down regulation
Responsed Disease Nasopharyngeal carcinoma ICD-11: 2B6B
 Disease Info 
Cell Process Cell apoptosis
In-vitro Model 5-8F Nasopharyngeal carcinoma Homo sapiens CVCL_C528
6-10B Nasopharyngeal carcinoma Homo sapiens CVCL_C529
C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
HNE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_0308
HONE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_8706
NP69 (A human immortalized nasopharyngeal epithelial)
S18 Nasopharyngeal carcinoma Homo sapiens CVCL_B0U9
S26 Nasopharyngeal carcinoma Homo sapiens CVCL_B0UB
SUNE1 Nasopharyngeal carcinoma Homo sapiens CVCL_6946
In-vivo Model BALB/c-nu mice (4-6 weeks old, female) were purchased from Charles River Laboratories (Beijing, China), and SUNE1-vector-luciferase or SUNE1-ZNF750-luciferase cells (1 × 106) were subcutaneously injected into the dorsal or ventral flank.
Nasopharyngeal carcinoma [ICD-11: 2B6B]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary m6A modifications maintained the low expression level of ZNF750 in NPC. Knocking down METTL3 stimulated endogenous Zinc finger protein 750 (ZNF750) expression, and vice versa.
Responsed Disease Nasopharyngeal carcinoma [ICD-11: 2B6B]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell apoptosis
In-vitro Model 5-8F Nasopharyngeal carcinoma Homo sapiens CVCL_C528
6-10B Nasopharyngeal carcinoma Homo sapiens CVCL_C529
C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
HNE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_0308
HONE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_8706
NP69 (A human immortalized nasopharyngeal epithelial)
S18 Nasopharyngeal carcinoma Homo sapiens CVCL_B0U9
S26 Nasopharyngeal carcinoma Homo sapiens CVCL_B0UB
SUNE1 Nasopharyngeal carcinoma Homo sapiens CVCL_6946
In-vivo Model BALB/c-nu mice (4-6 weeks old, female) were purchased from Charles River Laboratories (Beijing, China), and SUNE1-vector-luciferase or SUNE1-ZNF750-luciferase cells (1 × 106) were subcutaneously injected into the dorsal or ventral flank.
References
Ref 1 m(6)A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression. Cell Death Dis. 2018 Dec 5;9(12):1169. doi: 10.1038/s41419-018-1224-3.