m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00352)

Target Name	Nuclear receptor subfamily 2 group E member 1 (TLX/NR2E1)
Synonyms	Nuclear receptor TLX; Protein tailless homolog; Tll; hTll; TLX Click to Show/Hide
Gene Name	NR2E1
Chromosomal Location	6q21
Family	nuclear hormone receptor family; NR2 subfamily
Function	Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. Click to Show/Hide
Gene ID	7101
Uniprot ID	NR2E1_HUMAN
HGNC ID	HGNC:7973
KEGG ID	hsa:7101

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

NR2E1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	GSEA revealed that KIAA1429, METTL3, and IGF2BP1 were significantly related to multiple biological behaviors, including proliferation, apoptosis, metastasis, energy metabolism, drug resistance, and recurrence, and that KIAA1429 and IGF2BP1 had potential target genes, including E2F3, WTAP, CCND1, CDK4, EGR2, YBX1, and Nuclear receptor subfamily 2 group E member 1 (TLX/NR2E1), which were associated with lung cancers.
Responsed Disease	Lung cancer		ICD-11: 2C25	Disease Info
Cell Process	Cell apoptosis
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	NCI-H520	Lung squamous cell carcinoma	Homo sapiens	CVCL_1566
	HBE (Human bronchial epithelial cell line)
	LTEP-a2	Endocervical adenocarcinoma	Homo sapiens	CVCL_6929
	SK-MES-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0630

Protein virilizer homolog (VIRMA) [WRITER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	GSEA revealed that KIAA1429, METTL3, and IGF2BP1 were significantly related to multiple biological behaviors, including proliferation, apoptosis, metastasis, energy metabolism, drug resistance, and recurrence, and that KIAA1429 and IGF2BP1 had potential target genes, including E2F3, WTAP, CCND1, CDK4, EGR2, YBX1, and Nuclear receptor subfamily 2 group E member 1 (TLX/NR2E1), which were associated with lung cancers.
Responsed Disease	Lung cancer		ICD-11: 2C25	Disease Info
Cell Process	Cell apoptosis
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	NCI-H520	Lung squamous cell carcinoma	Homo sapiens	CVCL_1566
	HBE (Human bronchial epithelial cell line)
	LTEP-a2	Endocervical adenocarcinoma	Homo sapiens	CVCL_6929
	SK-MES-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0630

Lung cancer [ICD-11: 2C25]

Disease Info

In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	GSEA revealed that KIAA1429, METTL3, and IGF2BP1 were significantly related to multiple biological behaviors, including proliferation, apoptosis, metastasis, energy metabolism, drug resistance, and recurrence, and that KIAA1429 and IGF2BP1 had potential target genes, including E2F3, WTAP, CCND1, CDK4, EGR2, YBX1, and Nuclear receptor subfamily 2 group E member 1 (TLX/NR2E1), which were associated with lung cancers.
Responsed Disease	Lung cancer [ICD-11: 2C25]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)		READER	Regulator Info
Cell Process	Cell apoptosis
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	NCI-H520	Lung squamous cell carcinoma	Homo sapiens	CVCL_1566
	HBE (Human bronchial epithelial cell line)
	LTEP-a2	Endocervical adenocarcinoma	Homo sapiens	CVCL_6929
	SK-MES-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0630
Experiment 2 Reporting the m6A-centered Disease Response				[1]
Response Summary	GSEA revealed that KIAA1429, METTL3, and IGF2BP1 were significantly related to multiple biological behaviors, including proliferation, apoptosis, metastasis, energy metabolism, drug resistance, and recurrence, and that KIAA1429 and IGF2BP1 had potential target genes, including E2F3, WTAP, CCND1, CDK4, EGR2, YBX1, and Nuclear receptor subfamily 2 group E member 1 (TLX/NR2E1), which were associated with lung cancers.
Responsed Disease	Lung cancer [ICD-11: 2C25]
Target Regulator	Protein virilizer homolog (VIRMA)		WRITER	Regulator Info
Cell Process	Cell apoptosis
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
	NCI-H520	Lung squamous cell carcinoma	Homo sapiens	CVCL_1566
	HBE (Human bronchial epithelial cell line)
	LTEP-a2	Endocervical adenocarcinoma	Homo sapiens	CVCL_6929
	SK-MES-1	Lung squamous cell carcinoma	Homo sapiens	CVCL_0630

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00352)

Nuclear receptor subfamily 2 group E member 1 (TLX/NR2E1)

N6-methyladenosine (m6A)

In total 26 m6A sequence/site(s) in this target gene
mod ID: M6ASITE076480		Click to Show/Hide the Full List
mod site	chr6:108166123-108166124:+		[2]
Sequence	CGGGGTAATGAACTTCGGGGACCCTTCGCCGCTGCGTGCGC
Motif Score	3.622404762
Cell/Tissue List	GSC-11; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8
External Link	RMBase: m6A_site_729534
mod ID: M6ASITE076481		Click to Show/Hide the Full List
mod site	chr6:108166158-108166159:+		[2]
Sequence	GTGCGCGGCTCTCCCCGGAAACCCGGACCTGGCCGCCTCTT
Motif Score	2.185083333
Cell/Tissue List	GSC-11; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8
External Link	RMBase: m6A_site_729535
mod ID: M6ASITE076482		Click to Show/Hide the Full List
mod site	chr6:108166164-108166165:+		[2]
Sequence	GGCTCTCCCCGGAAACCCGGACCTGGCCGCCTCTTCCCTCG
Motif Score	3.622404762
Cell/Tissue List	GSC-11; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8
External Link	RMBase: m6A_site_729536
mod ID: M6ASITE076483		Click to Show/Hide the Full List
mod site	chr6:108166259-108166260:+		[2]
Sequence	GGAGCCCGTCTGCCTCTGAGACTGCGGTAGTGTTTTCCTTC
Motif Score	3.319380952
Cell/Tissue List	GSC-11; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8
External Link	RMBase: m6A_site_729537
mod ID: M6ASITE076484		Click to Show/Hide the Full List
mod site	chr6:108166292-108166293:+		[2]
Sequence	TTTCCTTCTTTCCTTGGGAGACCAGCGGTCGGCAGAGATTG
Motif Score	2.876744048
Cell/Tissue List	GSC-11; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8
External Link	RMBase: m6A_site_729538
mod ID: M6ASITE076485		Click to Show/Hide the Full List
mod site	chr6:108166352-108166353:+		[2]
Sequence	TGTAGAGGGAGAGATCGAAGACTGAGTGACAGGAATGGGGA
Motif Score	3.319380952
Cell/Tissue List	GSC-11; HEK293A-TOA; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8
External Link	RMBase: m6A_site_729539
mod ID: M6ASITE076486		Click to Show/Hide the Full List
mod site	chr6:108166721-108166722:+		[2]
Sequence	GGCGGGCGCTGCCGGCCGGGACTCGGGCAGCGCCCACCAAC
Motif Score	4.065041667
Cell/Tissue List	GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8
External Link	RMBase: m6A_site_729540
mod ID: M6ASITE076487		Click to Show/Hide the Full List
mod site	chr6:108166756-108166757:+		[2]
Sequence	ACCAACCGCTCCGCCCCGGGACAGCCAGCATGAGCAAGCCA
Motif Score	3.643047619
Cell/Tissue List	GSC-11; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8
External Link	RMBase: m6A_site_729541
mod ID: M6ASITE076488		Click to Show/Hide the Full List
mod site	chr6:108168090-108168091:+		[2]
Sequence	GCGGCCGGAATGCAGAGCGGACCCTGGCCCAGGACTGGGTT
Motif Score	3.622404762
Cell/Tissue List	GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000368983.3; ENST00000368986.8
External Link	RMBase: m6A_site_729542
mod ID: M6ASITE076489		Click to Show/Hide the Full List
mod site	chr6:108168866-108168867:+		[2]
Sequence	CCCGCCTGGGTGGTAACGAGACCCTGGCCAGTCACCCCTGC
Motif Score	2.876744048
Cell/Tissue List	GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000426403.1; ENST00000368983.3; ENST00000368986.8
External Link	RMBase: m6A_site_729543
mod ID: M6ASITE076490		Click to Show/Hide the Full List
mod site	chr6:108168894-108168895:+		[2]
Sequence	CAGTCACCCCTGCAGCCCAGACTAACTTCTTTCAACAGCCT
Motif Score	3.319380952
Cell/Tissue List	GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000426403.1; ENST00000368986.8; ENST00000368983.3
External Link	RMBase: m6A_site_729544
mod ID: M6ASITE076491		Click to Show/Hide the Full List
mod site	chr6:108187426-108187427:+		[3]
Sequence	GGCAATGTGCCAATTACAAGACTGCTTTCAGATATGTACAA
Motif Score	3.319380952
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000368986.8; ENST00000368983.3
External Link	RMBase: m6A_site_729545
mod ID: M6ASITE076492		Click to Show/Hide the Full List
mod site	chr6:108187493-108187494:+		[4]
Sequence	TACCCACTTTTCAGGATGGGACAGTATCAGATGAACTTCAA
Motif Score	3.643047619
Cell/Tissue List	HEK293T; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000368986.8; ENST00000368983.3
External Link	RMBase: m6A_site_729546
mod ID: M6ASITE076493		Click to Show/Hide the Full List
mod site	chr6:108187507-108187508:+		[4]
Sequence	GATGGGACAGTATCAGATGAACTTCAACCCATGGAGAACAA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000368986.8; ENST00000368983.3
External Link	RMBase: m6A_site_729547
mod ID: M6ASITE076494		Click to Show/Hide the Full List
mod site	chr6:108187524-108187525:+		[4]
Sequence	TGAACTTCAACCCATGGAGAACAAGCCTCAACTAACAAACC
Motif Score	2.951386905
Cell/Tissue List	HEK293T; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000368986.8; ENST00000368983.3
External Link	RMBase: m6A_site_729548
mod ID: M6ASITE076495		Click to Show/Hide the Full List
mod site	chr6:108187542-108187543:+		[4]
Sequence	GAACAAGCCTCAACTAACAAACCCTTCAGGAAGCATATACC
Motif Score	2.185083333
Cell/Tissue List	HEK293T; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000368983.3; ENST00000368986.8
External Link	RMBase: m6A_site_729549
mod ID: M6ASITE076496		Click to Show/Hide the Full List
mod site	chr6:108187677-108187678:+		[4]
Sequence	AAGGAGAGGGGTGCAACAGGACCGCCTGCACTGAAAACTCA
Motif Score	3.622404762
Cell/Tissue List	HEK293T; GSC-11; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8; ENST00000368983.3
External Link	RMBase: m6A_site_729550
mod ID: M6ASITE076497		Click to Show/Hide the Full List
mod site	chr6:108187693-108187694:+		[4]
Sequence	CAGGACCGCCTGCACTGAAAACTCACTGCTGCCATGCCCTG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; GSC-11; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368983.3; ENST00000368986.8
External Link	RMBase: m6A_site_729551
mod ID: M6ASITE076498		Click to Show/Hide the Full List
mod site	chr6:108187725-108187726:+		[2]
Sequence	CATGCCCTGGGAGGGGGCAAACTGGGGGTTGCCACAGGCCG
Motif Score	2.627720238
Cell/Tissue List	GSC-11; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8; ENST00000368983.3
External Link	RMBase: m6A_site_729552
mod ID: M6ASITE076499		Click to Show/Hide the Full List
mod site	chr6:108187797-108187798:+		[2]
Sequence	CTGAACGATCAAAAGCTGAAACATAAGTAGTGCTTTCTCTT
Motif Score	2.20572619
Cell/Tissue List	GSC-11
Seq Type List	m6A-seq
Transcript ID List	ENST00000368983.3; ENST00000368986.8
External Link	RMBase: m6A_site_729553
mod ID: M6ASITE076500		Click to Show/Hide the Full List
mod site	chr6:108188309-108188310:+		[5]
Sequence	CCCGTTAACATAGTGCTGAAACCAAAGGCAGTGGGGGTCCA
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000368983.3; ENST00000368986.8
External Link	RMBase: m6A_site_729554
mod ID: M6ASITE076501		Click to Show/Hide the Full List
mod site	chr6:108188391-108188392:+		[3]
Sequence	TGGACGTAATTGCAGAAGGAACTTCAAGGAGATGAATGAAT
Motif Score	3.373380952
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000368986.8; ENST00000368983.3
External Link	RMBase: m6A_site_729555
mod ID: M6ASITE076502		Click to Show/Hide the Full List
mod site	chr6:108188453-108188454:+		[5]
Sequence	TCCATTGCTAACAGCCTGAGACTCTTCAATGCCTTTCCGAA
Motif Score	3.319380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000368986.8; ENST00000368983.3
External Link	RMBase: m6A_site_729556
mod ID: M6ASITE076503		Click to Show/Hide the Full List
mod site	chr6:108188475-108188476:+		[5]
Sequence	TCTTCAATGCCTTTCCGAAAACTGGTTTCTAGTAAAGCCTT
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000368983.3; ENST00000368986.8
External Link	RMBase: m6A_site_729557
mod ID: M6ASITE076504		Click to Show/Hide the Full List
mod site	chr6:108188502-108188503:+		[5]
Sequence	TCTAGTAAAGCCTTGAATGAACACACACACACACACACACA
Motif Score	2.951386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000368986.8; ENST00000368983.3; rmsk_2035794
External Link	RMBase: m6A_site_729558
mod ID: M6ASITE076505		Click to Show/Hide the Full List
mod site	chr6:108188609-108188610:+		[5]
Sequence	ATACTTATGGAAATGTAGAAACAAACATTTTTAAATAGCTG
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000368983.3; ENST00000368986.8
External Link	RMBase: m6A_site_729559

Ref 1	Identification of pathology-specific regulators of m(6)A RNA modification to optimize lung cancer management in the context of predictive, preventive, and personalized medicine. EPMA J. 2020 Jul 29;11(3):485-504. doi: 10.1007/s13167-020-00220-3. eCollection 2020 Sep.
Ref 2	m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 Apr 10;31(4):591-606.e6. doi: 10.1016/j.ccell.2017.02.013. Epub 2017 Mar 23.
Ref 3	The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.
Ref 4	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 5	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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