m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00334)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MMP2
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3 | ||
Cell Line | LX2 cell line | Homo sapiens |
Treatment: shMETTL3 LX2 cells
Control: shLuc LX2 cells
|
GSE207909 | |
Regulation |
|
logFC: 7.46E-01 p-value: 1.39E-03 |
More Results | Click to View More RNA-seq Results | |
Representative RIP-seq result supporting the interaction between MMP2 and the regulator | ||
Cell Line | MDA-MB-231 | Homo sapiens |
Regulation | logFC: 1.08E+00 | GSE60213 |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | METTL3 is upregulated in human melanoma and plays a role in invasion/migration through MMP2. METTL3 overexpression promotes accumulation of 72 kDa type IV collagenase (MMP2) and N-cadherin in melanoma cells. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Melanoma | ICD-11: 2C30 | ||
Cell Process | Cell invasion/migration | |||
In-vitro Model | 451Lu | Cutaneous melanoma | Homo sapiens | CVCL_6357 |
A-375 | Amelanotic melanoma | Homo sapiens | CVCL_0132 | |
A375-MA2 | Amelanotic melanoma | Homo sapiens | CVCL_X495 | |
MeWo | Cutaneous melanoma | Homo sapiens | CVCL_0445 | |
SK-MEL-2 | Melanoma | Homo sapiens | CVCL_0069 | |
WM164 | Cutaneous melanoma | Homo sapiens | CVCL_7928 | |
WM3211 | Acral lentiginous melanoma | Homo sapiens | CVCL_6797 | |
WM3918 | Melanoma | Homo sapiens | CVCL_C279 | |
WM793 | Melanoma | Homo sapiens | CVCL_8787 | |
E3 ubiquitin-protein ligase Hakai (CBLL1) [WRITER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [2] | |||
Response Summary | CBLL1 was frequently upregulated in non-small lung cancer (NSCLC) tissues compared to the adjacent nontumor tissues. CBLL1 knockdown inhibited cell invasion via increased E-cadherin protein expression, and decreased expression of 72 kDa type IV collagenase (MMP2) and MMP9 in NSCLC cell lines. | |||
Responsed Disease | Non-small-cell lung carcinoma | ICD-11: 2C25.Y | ||
In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
SK-MES-1 | Lung squamous cell carcinoma | Homo sapiens | CVCL_0630 | |
Lung cancer [ICD-11: 2C25]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [2] | |||
Response Summary | CBLL1 was frequently upregulated in non-small lung cancer (NSCLC) tissues compared to the adjacent nontumor tissues. CBLL1 knockdown inhibited cell invasion via increased E-cadherin protein expression, and decreased expression of 72 kDa type IV collagenase (MMP2) and MMP9 in NSCLC cell lines. | |||
Responsed Disease | Non-small-cell lung carcinoma [ICD-11: 2C25.Y] | |||
Target Regulator | E3 ubiquitin-protein ligase Hakai (CBLL1) | WRITER | ||
In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
SK-MES-1 | Lung squamous cell carcinoma | Homo sapiens | CVCL_0630 | |
Melanoma [ICD-11: 2C30]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | METTL3 is upregulated in human melanoma and plays a role in invasion/migration through MMP2. METTL3 overexpression promotes accumulation of 72 kDa type IV collagenase (MMP2) and N-cadherin in melanoma cells. | |||
Responsed Disease | Melanoma [ICD-11: 2C30] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Cell Process | Cell invasion/migration | |||
In-vitro Model | 451Lu | Cutaneous melanoma | Homo sapiens | CVCL_6357 |
A-375 | Amelanotic melanoma | Homo sapiens | CVCL_0132 | |
A375-MA2 | Amelanotic melanoma | Homo sapiens | CVCL_X495 | |
MeWo | Cutaneous melanoma | Homo sapiens | CVCL_0445 | |
SK-MEL-2 | Melanoma | Homo sapiens | CVCL_0069 | |
WM164 | Cutaneous melanoma | Homo sapiens | CVCL_7928 | |
WM3211 | Acral lentiginous melanoma | Homo sapiens | CVCL_6797 | |
WM3918 | Melanoma | Homo sapiens | CVCL_C279 | |
WM793 | Melanoma | Homo sapiens | CVCL_8787 | |
References