m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05231
 [1]
Non-coding RNA MALAT1 miR-141-3p  lncRNA       miRNA   circRNA Indirect Enhancement m6A modification MMP2 MMP2 ALKBH5 Demethylation : m6A sites
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target 72 kDa type IV collagenase (MMP2)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) LncRNA View Details
Regulated Target hsa-miR-141-3p View Details
Crosstalk Relationship ncRNA  →  m6A Enhancement
Crosstalk Mechanism ncRNAs indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary Silencing MALAT1 led to down-regulation of the N6-methyladenosine (m6A) demethylase ALKBH5 via regulating hsa-miR-141-3p expression, which caused a decrease in the expression levels of 72 kDa type IV collagenase (MMP2) and MMP9 expression, thereby suppressing cell migration and invasion.
Responsed Disease Cervical cancer ICD-11: 2C77
 Disease Info 
In-vitro Model
 C-33 A Cervical squamous cell carcinoma Homo sapiens CVCL_1094
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
Ca Ski Cervical squamous cell carcinoma Homo sapiens CVCL_1100
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
72 kDa type IV collagenase (MMP2) 56 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Prinomastat Approved [2]
Synonyms
AG-3354; AG-3362; Prinomastat (USAN/INN); (3S)-N-hydroxy-2,2-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonylthiomorpholine-3-carboxamide
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MOA Inhibitor
Activity Ki = 0.05 nM
External Link
CID: 466151
TTD: D00MDP
DrugBank: DB05100
 Compound Name Marimastat Phase 3 [3]
Synonyms
Marimastat [USAN]; BB 2516; BB-2516; Marimastat (USAN/INN); (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide; (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic acid; (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoyl)propyl)carbamoyl)-2-hydroxy-5-methylhexanohydroxamic acid; (2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.43 nM
External Link
CID: 119031
TTD: D05VZE
DrugBank: DB00786
 Compound Name Epigallocatechin gallate Phase 3 [4]
Synonyms
(-)-Epigallocatechin gallate; EGCG; 989-51-5; Epigallocatechin 3-gallate; Epigallocatechin-3-gallate; Tea catechin; (-)-Epigallocatechin-3-o-gallate; Teavigo; Epigallocatechin-3-monogallate; (-)-Epigallocatechol gallate; (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate; Catechin deriv; UNII-BQM438CTEL; Green tea extract; CCRIS 3729; (-)-epigallocatechin 3-gallate; C22H18O11; BQM438CTEL; (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl; EGCG analogs; EGCG, Anagen; Epigallocatechin gallate analogs, Anagen; Epigallocatechin gallate, Anagen; GTPs,Anagen; Green tea polyphenols, Anagen; EPIGALOCATECHIN GALLATE
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MOA Inhibitor
Activity IC50 = 9600 nM
External Link
CID: 65064
TTD: D0U2BH
DrugBank: DB12116
 Compound Name Metastat Phase 1 [5]
MOA Inhibitor
External Link
CID: 54678924
TTD: D0IJ7O
DrugBank: DB11647
 Compound Name Neovastat Phase 1 [6]
MOA Inhibitor
External Link
TTD: D0T4BL
 Compound Name PMID29130358-Compound-Figure16(9b) Patented [7]
MOA Inhibitor
Activity IC50 = 510 nM
External Link
TTD: D0A9ZW
 Compound Name PMID29130358-Compound-SB-3CT Patented [7]
MOA Inhibitor
Activity IC50 = 14 nM
External Link
TTD: D0DB0Z
 Compound Name PMID29130358-Compound-Figure16(9a) Patented [7]
MOA Inhibitor
Activity IC50 = 53 nM
External Link
CID: 58107501
TTD: D0LS4Y
 Compound Name PMID29130358-Compound-Figure18(14) Patented [7]
MOA Inhibitor
External Link
TTD: D0O8RQ
 Compound Name PMID29130358-Compound-Figure13(4) Patented [7]
MOA Inhibitor
External Link
TTD: D0Q4QB
 Compound Name PMID29130358-Compound-Figure16(9c) Patented [7]
MOA Inhibitor
Activity IC50 = 140 nM
External Link
TTD: D0S3PN
 Compound Name PMID29130358-Compound-LonimacranthoideVII Patented [7]
MOA Inhibitor
Activity IC50 = 6200 nM
External Link
TTD: D0W7HO
 Compound Name PMID29130358-Compound-Figure11(3) Patented [7]
MOA Inhibitor
External Link
TTD: D0Y1LO
 Compound Name PMID29130358-Compound-Figure10(2a) Patented [7]
MOA Inhibitor
External Link
TTD: D05GAP
 Compound Name PMID29130358-Compound-Figure18(14a) Patented [7]
MOA Inhibitor
Activity IC50 = 2500 nM
External Link
TTD: D0X6GG
 Compound Name Tanomastat Discontinued in Phase 3 [8]
Synonyms
Tanomastat (USAN/INN); (2S)-4-[4-(4-chlorophenyl)phenyl]-4-oxo-2-(phenylsulfanylmethyl)butanoic acid
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 11 nM
External Link
CID: 6918336
TTD: D0Q1CD
DrugBank: DB06276
 Compound Name BMS 275291 Discontinued in Phase 3 [9]
Synonyms
D 2163; N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamide; (2S)-N-[(2S)-3,3-dimethyl-2-(methylamino)butanoyl]-4-methyl-2-[[(2S)-2-sulfanyl-4-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)butanoyl]amino]pentanamide
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 148203
TTD: D01EUF
 Compound Name Galarubicin Discontinued in Phase 2 [10]
Synonyms
DA-125; Metalloprotease inhibitors (cancer), Dong-A
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MOA Inhibitor
External Link
CID: 114759
TTD: D05WTZ
 Compound Name RS-130830 Discontinued in Phase 2 [11]
Synonyms
CTS-1027; 193022-04-7; UNII-2QD3F58224; CHEMBL440498; 2QD3F58224; 4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE; 4-[[[4-(4-Chlorophenoxy)phenyl]sulfonyl]methyl]tetrahydro-N-hydroxy-2H-pyran-4-carboxamide; 4-(4-(4-Chloro-phenoxy)-benzenesulfonylmethyl)-tetrahydro-pyran-4-carboxylic acid hydroxyamide; Ro-1130830; AC1MOE9A; SCHEMBL2381112; BDBM11863; DTXSID90172907; 830c; CTS 1027; ZINC1488366; BCP13018; 3563AH; alpha-tetrahydropyran beta-sulfone 1B; AKOS030526690
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MOA Inhibitor
Activity Ki = 0.22 nM
External Link
CID: 3342298
TTD: D03BOZ
DrugBank: DB08490
 Compound Name GM6001 Discontinued in Phase 2 [12]
Synonyms
Ilomastat; Galardin; 142880-36-2; GM 6001; Illomastat; CS 610; GM-6001; UNII-I0403ML141; CHEMBL19611; Ilomastat (GM6001, Galardin); I0403ML141; NCGC00163450-02; 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE; (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide; N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide; (R)-N(sup 1)-Hydroxy-N-((S)-2-indol-3-yl-1-(methylcarbamoyl)ethyl)-2-isobutylsuccinamide; (S-(R*,S*))-N(sup 4)-Hydroxy-N(sup
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MOA Inhibitor
Activity IC50 = 0.104 nM
External Link
CID: 132519
TTD: D0T9HG
DrugBank: DB02255
 Compound Name RO-26-2853 Preclinical [13]
MOA Inhibitor
External Link
TTD: D0C0ME
 Compound Name CDP-845 Terminated [14]
MOA Modulator
External Link
TTD: D02GYD
 Compound Name L-696418 Terminated [15]
Synonyms
CHEMBL8494; BDBM50057083; (R)-2-[(S)-1-(3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-propionic acid; (R)-2-((S)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pentan-2-ylamino)-1-oxo-4-phenylbutan-2-ylamino)propanoic acid; (R)-2-[(S)-1-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-propionic acid
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 200 nM
External Link
CID: 10478364
TTD: D08CEE
 Compound Name BB-3644 Terminated [16]
Synonyms
SCHEMBL609641
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MOA Inhibitor
External Link
CID: 9822724
TTD: D08WBF
 Compound Name BB-1101 Terminated [17]
Synonyms
CHEMBL432079; SCHEMBL1844243; BDBM50070453
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.8 nM
External Link
CID: 9908389
TTD: D05VNG
 Compound Name SC-44463 Terminated [18]
Synonyms
CHEMBL45483; n-[3-(n'-hydroxycarboxamido)-2-(2-methylpropyl)-propanoyl]-o-tyrosine-n-methylamide; 104408-38-0; Ihp-tyr-menh2; HTA; AC1L2U0O; SCHEMBL9284838; sc44463; BDBM50104969; DB07926; N-(2-Isobutyl-3-(N'-hydroxycarbonylamido)propanoyl)-O-methyltyrosinemethylamide; N*4*-Hydroxy-2-isobutyl-N*1*-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethyl]-succinamide; (2R)-N-hydroxy-N'-[(1S)-2-(4-methoxyphenyl)-1-(methylcarbamoyl)ethyl]-2-(2-methylpropyl)butanediamide; Butanediamide, N4-hydroxy-N1-(1-((4-methoxyphenyl)meth
    Click to Show/Hide
MOA Inhibitor
Activity Ki < 1 nM
External Link
CID: 128564
TTD: D0Y1XT
DrugBank: DB07926
 Compound Name Lithospermic acid Investigative [19]
Synonyms
28831-65-4; UNII-100IP83JAC; CHEMBL518243; 100IP83JAC; Lithospermic-acid; AC1O5VFB; 4-(3-(1-Carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylic acid; SCHEMBL13284084; MolPort-020-005-934; ZINC4097774; BDBM50250808; AKOS026674259; 4-{(E)-2-[1-Carboxy-2-(3,4-dihydroxy-phenyl)-ethoxycarbonyl]-vinyl}-2-(3,4-dihydroxy-phenyl)-7-hydroxy-2,3-dihydro-benzofuran-3-carboxylic acid; 3-Benzofurancarboxylic acid, 4-(3-(1-carboxy-2-(3,4-dihydr
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MOA Inhibitor
External Link
CID: 6441498
TTD: D06ALC
 Compound Name SC-74020 Investigative [20]
Synonyms
CHEMBL1233506; N-{4-[(1-HYDROXYCARBAMOYL-2-METHYL-PROPYL)-(2-MORPHOLIN-4-YL-ETHYL)-SULFAMOYL]-4-PENTYL-BENZAMIDE; I52; SC 74020; AC1NRBR8; BDBM50026872; DB01630; SC74020; N-(4-{[(1R)-1-(hydroxycarbamoyl)-2-methylpropyl](2-morpholin-4-ylethyl)sulfamoyl}phenyl)-4-pentylbenzamide; N-(4-{[(1R)-1-(hydroxycarbamoyl)-2-methylpropyl][2-(morpholin-4-yl)ethyl]sulfamoyl}phenyl)-4-pentylbenzamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 0.1 nM
External Link
CID: 5288596
TTD: D08NSS
DrugBank: DB01630
 Compound Name Clinopodic acid C Investigative [19]
Synonyms
CHEMBL1080779; BDBM50310832; (R)-3-(3,4-Dihydroxyphenyl)-2-[3-[2beta-(3,4-dihydroxyphenyl)-3beta-carboxy-2,3-dihydro-1,4-benzodioxin-6-yl]propenoyloxy]propionic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44254596
TTD: D0H9BL
 Compound Name Cis-2-aminocyclohexylcarbamoylphosphonic acid Investigative [21]
Synonyms
cis-ACCP; 777075-44-2; CHEMBL270083; SCHEMBL569075; C7H15N2O4P; CTK8E9417; MolPort-039-139-066; BDBM50234465; 1683AH; ZINC29134634
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4000 nM
External Link
CID: 44457233
TTD: D0T1FR
 Compound Name Methotrexate gamma-L-proline-hydroxamic acid Investigative [22]
Synonyms
CHEMBL388879
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MOA Inhibitor
External Link
CID: 44428667
TTD: D01HKU
 Compound Name PD-169469 Investigative [23]
Synonyms
CHEMBL42420; SCHEMBL7404078; BDBM12074; alpha-arylsulfonylamino carboxylate 2R; (2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-methylbutanoic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5 nM
External Link
CID: 10549609
TTD: D02EFQ
 Compound Name 4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid Investigative [24]
Synonyms
CHEMBL373275; BDBM50180608
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MOA Inhibitor
Activity IC50 = 3070 nM
External Link
CID: 44406790
TTD: D05JPV
 Compound Name 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione Investigative [25]
Synonyms
CHEMBL176517; 219311-20-3; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(4-phenoxyphenyl)-; SCHEMBL6380971; CTK0J6997; DTXSID60470422; NNRYJLARUIVRRO-UHFFFAOYSA-N; 5-(4'-phenoxyphenyl)barbituric acid; 5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione
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MOA Inhibitor
External Link
CID: 53742316
TTD: D07LTB
 Compound Name Methotrexate gamma-hydroxamic acid Investigative [22]
Synonyms
CHEMBL244883
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MOA Inhibitor
External Link
CID: 44428664
TTD: D0B0UI
 Compound Name 2-(4'-chloro-biphenyl-4-sulfonyl)-pentanoic acid Investigative [26]
Synonyms
CHEMBL378740; BDBM50185874; 2-(4''-chloro-biphenyl-4-sulfonyl)-pentanoic acid
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MOA Inhibitor
Activity IC50 = 792 nM
External Link
CID: 44411812
TTD: D0E5MB
 Compound Name PNU-107859 Investigative [27]
Synonyms
2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-UREIDO]-N-METHYL-3-PHENYL-PROPIONAMIDE; CHEMBL249847; ATT; 3usn; AC1N9ZM9; SCHEMBL6954588; RKWXKADYTDWZIJ-VIFPVBQESA-N; ZINC6379443; BDBM50241372; DB07390; N-methyl-Nalpha-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]-L-phenylalaninamide; (2S)-N-methyl-3-phenyl-2-{[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]amino}propanamide; (S)-1-(1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-3-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)urea
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MOA Inhibitor
Activity Ki = 3000 nM
External Link
CID: 4369084
TTD: D0F7BE
DrugBank: DB07390
 Compound Name 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione Investigative [25]
Synonyms
5-Hexyl-5-phenylbarbituric acid; BRN 0297956; BARBITURIC ACID, 5-HEXYL-5-PHENYL-; 67051-21-2; CHEMBL173075; AC1L2LKK; 4-24-00-02103 (Beilstein Handbook Reference); CTK8J9653; DTXSID20217355; 5-hexyl-5-phenyl barbituric acid; BDBM50099125; LS-24512
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1300 nM
External Link
CID: 49292
TTD: D0K4TI
 Compound Name 5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione Investigative [25]
Synonyms
CHEMBL175282; BDBM50099116
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MOA Inhibitor
Activity IC50 = 868 nM
External Link
CID: 44385624
TTD: D0Q9LC
 Compound Name Roche 28-2653 Investigative [28]
MOA Inhibitor
External Link
CID: 56603788
TTD: D0U7CD
 Compound Name Folate gamma-L-proline-hydroxamic acid Investigative [22]
Synonyms
CHEMBL388878
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MOA Inhibitor
External Link
CID: 44428663
TTD: D0ZB6O
 Compound Name N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide Investigative [29]
Synonyms
CHEMBL252674; 2H-1-Benzopyran-3-propanamide, N-hydroxy-2-oxo-; BDBM50224963
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MOA Inhibitor
Activity IC50 = 200 nM
External Link
CID: 44446270
TTD: D00RNA
 Compound Name N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl) Investigative [29]
Synonyms
CHEMBL402990
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MOA Inhibitor
Activity IC50 = 590 nM
External Link
CID: 44446277
TTD: D08ICI
 Compound Name 3-(4-Phenylethynylbenzoyl)nonanoic acid Investigative [24]
Synonyms
CHEMBL201298
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MOA Inhibitor
Activity IC50 = 1660 nM
External Link
CID: 11581319
TTD: D0A5MV
 Compound Name Folate gamma-hydroxamic acid Investigative [22]
MOA Inhibitor
External Link
CID: 136177317
TTD: D0P8EY
 Compound Name 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione Investigative [25]
Synonyms
CHEMBL367524; 94209-48-0; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[1,1'-biphenyl]-4-yl-5-ethyl-; ACMC-20lyhc; AC1M3WRE; Oprea1_691960; MLS001000776; NIOSH/CQ0532020; CTK3G9325; DTXSID20367041; MolPort-002-095-507; HMS2827O03; BDBM50099119; ZINC96299878; STK760260; AKOS005616072; MCULE-2406616532; Acido 5-etil 5-(p-difenilil)barbiturici; NCGC00245692-01; 5-(4-Biphenylyl)-5-ethylbarbituric acid; SMR000498104; LS-23825; M.G. 3419; CQ05320200; Barbituric acid, 5-(4-biphenylyl)-5-ethyl-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 898 nM
External Link
CID: 2220392
TTD: D0Y7NV
 Compound Name (+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid Investigative [30]
Synonyms
CHEMBL572982; SCHEMBL5613354; ILGSIIFHQGOKKV-UHFFFAOYSA-N; BDBM50300465; 5-biphenyl-4-yl-3-hydroxy-pentanoic acid; 5-(biphenyl-4-yl)-3-hydroxypentanoic acid
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MOA Inhibitor
Activity IC50 = 4520 nM
External Link
CID: 11391583
TTD: D0G3YZ
 Compound Name 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid Investigative [24]
Synonyms
CHEMBL202875
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MOA Inhibitor
Activity IC50 = 440 nM
External Link
CID: 11609208
TTD: D0L4EO
 Compound Name UK-356618 Investigative [18]
Synonyms
UK 356618; 230961-08-7; CHEMBL117225; UK-356,618; SCHEMBL6437730; GTPL6528; CHEBI:94305; DTXSID50438778; MolPort-023-277-089; ZINC3924338; BDBM50097263; AKOS024458021; FT-0675728; PF 03890101; PF-03890101; UK-356618, &gt; J-014983; BRD-K57011718-001-01-5; (R)-N*1*-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-2-[3-(2-methyl-biphenyl-4-yl)-propyl]-succinamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1790 nM
External Link
CID: 10370504
TTD: D0NP8A
 Compound Name Ro-37-9790 Investigative [31]
Synonyms
CHEMBL306412; BDBM50290086
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MOA Inhibitor
External Link
CID: 44313734
TTD: D0XL8K
 Compound Name 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide Investigative [32]
Synonyms
CHEMBL574589
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MOA Inhibitor
Activity IC50 = 1300 nM
External Link
CID: 44478925
TTD: D05THD
 Compound Name [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid Investigative [32]
Synonyms
CHEMBL573935
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MOA Inhibitor
Activity IC50 = 510 nM
External Link
CID: 44479701
TTD: D07MJD
 Compound Name N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide Investigative [32]
Synonyms
CHEMBL575896
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MOA Inhibitor
Activity IC50 = 1200 nM
External Link
CID: 10155934
TTD: D0S9OL
 Compound Name SR-973 Investigative [33]
Synonyms
CHEMBL204357; SCHEMBL4486832; ZINC34801833; BDBM50182403; (2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-phenoxybenzyl)azepan-3-yl)-2-propylsuccinamide; (2R,3S)-N'-Hydroxy-N-[1-(3-phenoxybenzyl)-2,3,4,5,6,7-hexahydro-2-oxo-1H-azepine-3beta-yl]-2-isobutyl-3-propylbutanediamide
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 7 nM
External Link
CID: 9849669
TTD: D03AMR
 Compound Name IK-862 Investigative [34]
Synonyms
YDMIPBHQKFOFQW-NSYGIPOTSA-N; (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE; CHEMBL148169; CHEBI:40083; (2R)-N-hydroxy-2-[(3S)-3-methyl-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]propanamide; IK862; 2fv5; AC1OCAC0; BMCL181958 Compound 1; GTPL8680; SCHEMBL5966106; BDBM26526; IK682; DB07145; C468787000; (R)-2-[(3S)-2-Oxo-3alpha-[4-(2-methyl-4-quinolinylmethoxy)phenyl]-3-methylpyrrolizino]propanehydroximic; IK 862; compound 32; IK-682
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2050 nM
External Link
CID: 6914621
TTD: D0W2UK
DrugBank: DB07145
 Compound Name MMI270 Investigative [35]
Synonyms
CGS-27023A; CGS-27023; UNII-80AXY59IT2; 80AXY59IT2; N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE; CHEMBL514138; (2R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-3-methylbutanamide; CGS; 1eub; MMI270B free base; hydroxamate analogue 1; 2w0d; 1bm6; MMI-270B free base; AC1L9JQY; 3MP-HAV-MSB; CGS-27023A free base; BMCL16311 Compound 1a; BDBM8465; SCHEMBL3468445; GTPL8846; CHEMBL267178; BSIZUMJRKYHEBR-QGZVFWFLSA-N; CGS 27023; BDBM50066658; DB07556; 161314-70-1
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MOA Inhibitor
Activity IC50 = 3 nM
External Link
CID: 446504
TTD: D0A4TC
DrugBank: DB07556
References
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