m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00278)

Target Name	Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1)
Synonyms	HNF-1-alpha; HNF-1A; Liver-specific transcription factor LF-B1; LFB1; Transcription factor 1; TCF-1; TCF1 Click to Show/Hide
Gene Name	HNF1A
Chromosomal Location	12q24.31
Family	HNF1 homeobox family
Function	Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). Click to Show/Hide
Gene ID	6927
Uniprot ID	HNF1A_HUMAN
HGNC ID	HGNC:11621
KEGG ID	hsa:6927

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

HNF1A can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	mouse embryonic stem cells	Mus musculus
Treatment: METTL3-/- ESCs Control: Wild type ESCs		GSE145309
Regulation		logFC: -1.64E+00 p-value: 4.47E-50
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between HNF1A and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 6.55E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Silence of METTL3 inhibited migratory ability and Wnt activity in TPC-1 cells. METTL3 positively regulated the enrichment abundance of Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1) in anti-IGF2BP2. TCF1 was responsible for METTL3-regulated thyroid carcinoma progression via the m6A methylation.
Target Regulation	Up regulation
Responsed Disease	Thyroid Cancer		ICD-11: 2D10	Disease Info
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Cell migratory
In-vitro Model	B-CPAP	Thyroid gland carcinoma	Homo sapiens	CVCL_0153
	Nthy-ori 3-1	Normal	Homo sapiens	CVCL_2659
	TPC-1	Thyroid gland papillary carcinoma	Homo sapiens	CVCL_6298

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Silence of METTL3 inhibited migratory ability and Wnt activity in TPC-1 cells. METTL3 positively regulated the enrichment abundance of Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1) in anti-IGF2BP2. TCF1 was responsible for METTL3-regulated thyroid carcinoma progression via the m6A methylation.
Target Regulation	Up regulation
Responsed Disease	Thyroid Cancer		ICD-11: 2D10	Disease Info
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Cell migratory
In-vitro Model	B-CPAP	Thyroid gland carcinoma	Homo sapiens	CVCL_0153
	Nthy-ori 3-1	Normal	Homo sapiens	CVCL_2659
	TPC-1	Thyroid gland papillary carcinoma	Homo sapiens	CVCL_6298

Thyroid Cancer [ICD-11: 2D10]

Disease Info

In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	Silence of METTL3 inhibited migratory ability and Wnt activity in TPC-1 cells. METTL3 positively regulated the enrichment abundance of Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1) in anti-IGF2BP2. TCF1 was responsible for METTL3-regulated thyroid carcinoma progression via the m6A methylation.
Responsed Disease	Thyroid Cancer [ICD-11: 2D10]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)		READER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Cell migratory
In-vitro Model	B-CPAP	Thyroid gland carcinoma	Homo sapiens	CVCL_0153
	Nthy-ori 3-1	Normal	Homo sapiens	CVCL_2659
	TPC-1	Thyroid gland papillary carcinoma	Homo sapiens	CVCL_6298
Experiment 2 Reporting the m6A-centered Disease Response				[1]
Response Summary	Silence of METTL3 inhibited migratory ability and Wnt activity in TPC-1 cells. METTL3 positively regulated the enrichment abundance of Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1) in anti-IGF2BP2. TCF1 was responsible for METTL3-regulated thyroid carcinoma progression via the m6A methylation.
Responsed Disease	Thyroid Cancer [ICD-11: 2D10]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Wnt signaling pathway			hsa04310
Cell Process	Cell migratory
In-vitro Model	B-CPAP	Thyroid gland carcinoma	Homo sapiens	CVCL_0153
	Nthy-ori 3-1	Normal	Homo sapiens	CVCL_2659
	TPC-1	Thyroid gland papillary carcinoma	Homo sapiens	CVCL_6298

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Methyltransferase-like 14 (METTL14)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05149		Crosstalk Info
Epigenetic Regulator	hsa-miR-103-3p
Regulated Target	Methyltransferase-like protein 14 (METTL14)
Crosstalk relationship	ncRNA → m6A
Disease	Osteoporosis	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00278)

Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1)

N6-methyladenosine (m6A)

In total 35 m6A sequence/site(s) in this target gene
mod ID: M6ASITE015549		Click to Show/Hide the Full List
mod site	chr12:120978735-120978736:+		[3]
Sequence	GGAGGCGGCTAGCGTGGTGGACCCGGGCCGCGTGGCCCTGT
Motif Score	3.622404762
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000402929.5; ENST00000257555.10; ENST00000615446.4; ENST00000538626.2; ENST00000538646.5; ENST00000535955.5; ENST00000544574.5; ENST00000617366.4; ENST00000541924.5; ENST00000400024.6; ENST00000560968.5; ENST00000543427.5
External Link	RMBase: m6A_site_213364
mod ID: M6ASITE015550		Click to Show/Hide the Full List
mod site	chr12:120978779-120978780:+		[4]
Sequence	AGCCGAGCCATGGTTTCTAAACTGAGCCAGCTGCAGACGGA
Motif Score	2.627720238
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000538646.5; ENST00000535955.5; ENST00000402929.5; ENST00000544574.5; ENST00000540108.1; ENST00000541924.5; ENST00000615446.4; ENST00000257555.10; ENST00000560968.5; ENST00000541395.5; ENST00000400024.6; ENST00000544413.2; ENST00000538626.2; ENST00000617366.4; ENST00000543427.5
External Link	RMBase: m6A_site_213365
mod ID: M6ASITE015551		Click to Show/Hide the Full List
mod site	chr12:120978901-120978902:+		[4]
Sequence	GGCTGGAGAAGGCCCCCTGGACAAGGGGGAGTCCTGCGGCG
Motif Score	3.643047619
Cell/Tissue List	HepG2; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541924.5; ENST00000560968.5; ENST00000538646.5; ENST00000544574.5; ENST00000543427.5; ENST00000617366.4; ENST00000544413.2; ENST00000402929.5; ENST00000535955.5; ENST00000400024.6; ENST00000538626.2; ENST00000541395.5; ENST00000615446.4; ENST00000257555.10; ENST00000540108.1
External Link	RMBase: m6A_site_213366
mod ID: M6ASITE015552		Click to Show/Hide the Full List
mod site	chr12:120978966-120978967:+		[4]
Sequence	TGCCCAATGGGCTGGGGGAGACTCGGGGCTCCGAGGACGAG
Motif Score	3.319380952
Cell/Tissue List	HepG2; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000560968.5; ENST00000400024.6; ENST00000540108.1; ENST00000541395.5; ENST00000541924.5; ENST00000544413.2; ENST00000535955.5; ENST00000538646.5; ENST00000402929.5; ENST00000544574.5; ENST00000257555.10; ENST00000615446.4; ENST00000617366.4; ENST00000543427.5; ENST00000538626.2
External Link	RMBase: m6A_site_213367
mod ID: M6ASITE015553		Click to Show/Hide the Full List
mod site	chr12:120979006-120979007:+		[4]
Sequence	GACGGACGACGATGGGGAAGACTTCACGCCACCCATCCTCA
Motif Score	3.319380952
Cell/Tissue List	HepG2; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000544413.2; ENST00000544574.5; ENST00000402929.5; ENST00000617366.4; ENST00000540108.1; ENST00000257555.10; ENST00000535955.5; ENST00000538626.2; ENST00000615446.4; ENST00000538646.5; ENST00000543427.5; ENST00000400024.6; ENST00000541395.5; ENST00000560968.5; ENST00000541924.5
External Link	RMBase: m6A_site_213368
mod ID: M6ASITE015554		Click to Show/Hide the Full List
mod site	chr12:120979039-120979040:+		[4]
Sequence	CATCCTCAAAGAGCTGGAGAACCTCAGCCCTGAGGAGGCGG
Motif Score	2.930744048
Cell/Tissue List	HepG2; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000617366.4; ENST00000540108.1; ENST00000257555.10; ENST00000541395.5; ENST00000538646.5; ENST00000543427.5; ENST00000535955.5; ENST00000615446.4; ENST00000402929.5; ENST00000560968.5; ENST00000544413.2; ENST00000544574.5; ENST00000538626.2; ENST00000400024.6; ENST00000541924.5
External Link	RMBase: m6A_site_213369
mod ID: M6ASITE015556		Click to Show/Hide the Full List
mod site	chr12:120979083-120979084:+		[4]
Sequence	ACCAGAAAGCCGTGGTGGAGACCCTTCTGCAGTAAGGAGCC
Motif Score	2.876744048
Cell/Tissue List	HepG2; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541395.5; ENST00000615446.4; ENST00000617366.4; ENST00000543427.5; ENST00000535955.5; ENST00000402929.5; ENST00000560968.5; ENST00000538646.5; ENST00000544574.5; ENST00000538626.2; ENST00000400024.6; ENST00000541924.5; ENST00000257555.10; ENST00000544413.2; ENST00000540108.1
External Link	RMBase: m6A_site_213370
mod ID: M6ASITE015557		Click to Show/Hide the Full List
mod site	chr12:120988837-120988838:+		[4]
Sequence	CTTGCCCTCTCCCAGGGAGGACCCGTGGCGTGTGGCGAAGA
Motif Score	3.622404762
Cell/Tissue List	HepG2; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541924.5; ENST00000538626.2; ENST00000560968.5; ENST00000544413.2; ENST00000615446.4; ENST00000540108.1; ENST00000538646.5; ENST00000257555.10; ENST00000543427.5; ENST00000402929.5; ENST00000400024.6; ENST00000535955.5; ENST00000541395.5; ENST00000617366.4; ENST00000544574.5
External Link	RMBase: m6A_site_213371
mod ID: M6ASITE015558		Click to Show/Hide the Full List
mod site	chr12:120993597-120993598:+		[4]
Sequence	AACCAAGAAGGGGCGGAGGAACCGTTTCAAGTGGGGCCCAG
Motif Score	2.930744048
Cell/Tissue List	HepG2; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000538646.5; ENST00000541395.5; ENST00000541924.5; ENST00000257555.10; ENST00000538626.2; ENST00000617366.4; ENST00000544413.2; ENST00000560968.5; ENST00000402929.5; ENST00000615446.4; ENST00000543427.5; ENST00000544574.5; ENST00000540108.1; ENST00000400024.6; ENST00000535955.5
External Link	RMBase: m6A_site_213372
mod ID: M6ASITE015559		Click to Show/Hide the Full List
mod site	chr12:120993660-120993661:+		[4]
Sequence	GGCCTATGAGAGGCAGAAGAACCCTAGCAAGGAGGAGCGAG
Motif Score	2.930744048
Cell/Tissue List	HepG2; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000535955.5; ENST00000541395.5; ENST00000560968.5; ENST00000544413.2; ENST00000543427.5; ENST00000538626.2; ENST00000400024.6; ENST00000402929.5; ENST00000541924.5; ENST00000544574.5; ENST00000617366.4; ENST00000615446.4; ENST00000538646.5; ENST00000257555.10; ENST00000540108.1
External Link	RMBase: m6A_site_213373
mod ID: M6ASITE015560		Click to Show/Hide the Full List
mod site	chr12:120994300-120994301:+		[3]
Sequence	CCGGCACAAGCTGGCCATGGACACGTACAGCGGGCCCCCCC
Motif Score	3.643047619
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000538646.5; ENST00000541924.5; ENST00000543427.5; ENST00000538626.2; ENST00000257555.10; ENST00000615446.4; ENST00000544413.2; ENST00000400024.6; ENST00000617366.4; ENST00000560968.5; ENST00000541395.5; ENST00000535955.5; ENST00000402929.5; ENST00000544574.5; ENST00000540108.1
External Link	RMBase: m6A_site_213374
mod ID: M6ASITE015561		Click to Show/Hide the Full List
mod site	chr12:120994337-120994338:+		[3]
Sequence	CCCCCAGGGCCAGGCCCGGGACCTGCGCTGCCCGCTCACAG
Motif Score	3.622404762
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000538626.2; ENST00000257555.10; ENST00000544413.2; ENST00000538646.5; ENST00000400024.6; ENST00000535955.5; ENST00000543427.5; ENST00000541395.5; ENST00000560968.5; ENST00000402929.5; ENST00000544574.5; ENST00000615446.4; ENST00000541924.5; ENST00000617366.4; ENST00000540108.1
External Link	RMBase: m6A_site_213375
mod ID: M6ASITE015562		Click to Show/Hide the Full List
mod site	chr12:120996274-120996275:+		[3]
Sequence	TCTCCAGGTGTGCGCTATGGACAGCCTGCGACCAGTGAGAC
Motif Score	3.643047619
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000543427.5; ENST00000544574.5; ENST00000535955.5; ENST00000400024.6; ENST00000540108.1; ENST00000541395.5; ENST00000541924.5; ENST00000544413.2; ENST00000257555.10; ENST00000402929.5; ENST00000617366.4; ENST00000538646.5; ENST00000538626.2; ENST00000560968.5; ENST00000615446.4
External Link	RMBase: m6A_site_213376
mod ID: M6ASITE015563		Click to Show/Hide the Full List
mod site	chr12:120996293-120996294:+		[3]
Sequence	GACAGCCTGCGACCAGTGAGACTGCAGAAGTACCCTCAAGC
Motif Score	3.319380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000560968.5; ENST00000400024.6; ENST00000538626.2; ENST00000541924.5; ENST00000543427.5; ENST00000538646.5; ENST00000535955.5; ENST00000615446.4; ENST00000402929.5; ENST00000541395.5; ENST00000540108.1; ENST00000257555.10; ENST00000544574.5; ENST00000544413.2; ENST00000617366.4
External Link	RMBase: m6A_site_213377
mod ID: M6ASITE015564		Click to Show/Hide the Full List
mod site	chr12:120996606-120996607:+		[3]
Sequence	CACTGCACAGCTTGGAGCAGACATCCCCAGGCCTCAACCAG
Motif Score	2.897386905
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000543427.5; ENST00000257555.10; ENST00000544574.5; ENST00000543255.1; ENST00000541395.5; ENST00000535955.5; ENST00000541924.5; ENST00000400024.6; ENST00000538626.2; ENST00000402929.5; ENST00000538646.5; ENST00000544413.2; ENST00000615446.4; ENST00000540108.1; ENST00000560968.5; ENST00000617366.4
External Link	RMBase: m6A_site_213378
mod ID: M6ASITE015565		Click to Show/Hide the Full List
mod site	chr12:120996637-120996638:+		[3]
Sequence	CCTCAACCAGCAGCCCCAGAACCTCATCATGGCCTCACTTC
Motif Score	2.930744048
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000541395.5; ENST00000538646.5; ENST00000257555.10; ENST00000402929.5; ENST00000535955.5; ENST00000615446.4; ENST00000544413.2; ENST00000543255.1; ENST00000400024.6; ENST00000560968.5; ENST00000544574.5; ENST00000617366.4; ENST00000543427.5; ENST00000538626.2; ENST00000540108.1; ENST00000541924.5
External Link	RMBase: m6A_site_213379
mod ID: M6ASITE015567		Click to Show/Hide the Full List
mod site	chr12:120999495-120999496:+		[4]
Sequence	CCCCCAGGTCTTCACCTCAGACACTGAGGCCTCCAGTGAGT
Motif Score	2.897386905
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541395.5; ENST00000540108.1; ENST00000543427.5; ENST00000560968.5; ENST00000257555.10; ENST00000615446.4; ENST00000544413.2; ENST00000617366.4
External Link	RMBase: m6A_site_213380
mod ID: M6ASITE015568		Click to Show/Hide the Full List
mod site	chr12:120999570-120999571:+		[4]
Sequence	CCTCCACGTCCCCAGCCAGGACCCTGCCAGCATCCAGCACC
Motif Score	3.622404762
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541395.5; ENST00000257555.10; rmsk_3928444; ENST00000543427.5; ENST00000544413.2; ENST00000617366.4; ENST00000560968.5; ENST00000615446.4; ENST00000540108.1
External Link	RMBase: m6A_site_213381
mod ID: M6ASITE015569		Click to Show/Hide the Full List
mod site	chr12:121001100-121001101:+		[4]
Sequence	GGTGCTGTACCAGAGCTCAGACTCCAGCAATGGCCAGAGCC
Motif Score	3.319380952
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540108.1; ENST00000257555.10; ENST00000544413.2; ENST00000615446.4; ENST00000543427.5; ENST00000541395.5; ENST00000560968.5; ENST00000617366.4
External Link	RMBase: m6A_site_213385
mod ID: M6ASITE015570		Click to Show/Hide the Full List
mod site	chr12:121001153-121001154:+		[4]
Sequence	CCAACCACAGCGTCATCGAGACCTTCATCTCCACCCAGATG
Motif Score	2.876744048
Cell/Tissue List	HepG2; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000543427.5; ENST00000544413.2; ENST00000560968.5; ENST00000540108.1; ENST00000257555.10; ENST00000617366.4; ENST00000541395.5; ENST00000615446.4
External Link	RMBase: m6A_site_213386
mod ID: M6ASITE015571		Click to Show/Hide the Full List
mod site	chr12:121001268-121001269:+		[5]
Sequence	CAGCCAGCCCTGCCTGGAGGACCTGAGCCTGCCGAGCAACC
Motif Score	3.622404762
Cell/Tissue List	HepG2; A549; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541395.5; ENST00000543427.5; ENST00000257555.10; ENST00000540108.1; ENST00000560968.5; ENST00000615446.4; ENST00000544413.2; ENST00000617366.4
External Link	RMBase: m6A_site_213387
mod ID: M6ASITE015572		Click to Show/Hide the Full List
mod site	chr12:121001303-121001304:+		[6]
Sequence	GCAACCGTGGCCCTTCCTGGACAGCTGTGCCTCGCTCCCCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000543427.5; ENST00000615446.4; ENST00000257555.10; ENST00000560968.5; ENST00000540108.1; ENST00000617366.4; ENST00000541395.5
External Link	RMBase: m6A_site_213388
mod ID: M6ASITE015574		Click to Show/Hide the Full List
mod site	chr12:121001450-121001451:+		[5]
Sequence	TCATGGCAGATGTAGGAGGGACTGTCGCTGCTTCGTGGGAT
Motif Score	4.065041667
Cell/Tissue List	HepG2; A549; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615446.4; ENST00000540108.1; ENST00000541395.5; ENST00000560968.5; ENST00000543427.5; ENST00000257555.10; ENST00000617366.4
External Link	RMBase: m6A_site_213390
mod ID: M6ASITE015575		Click to Show/Hide the Full List
mod site	chr12:121001489-121001490:+		[5]
Sequence	ATACAGTCTTCTTACTTGGAACTGAAGGGGGCGGCCTATGA
Motif Score	3.373380952
Cell/Tissue List	HepG2; A549; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000543427.5; ENST00000540108.1; ENST00000541395.5; ENST00000615446.4; ENST00000257555.10; ENST00000560968.5; ENST00000617366.4
External Link	RMBase: m6A_site_213392
mod ID: M6ASITE015576		Click to Show/Hide the Full List
mod site	chr12:121001549-121001550:+		[5]
Sequence	GGCCTATGGAGAGCCCTGGGACCGCTACACCACTCTGGCAG
Motif Score	3.622404762
Cell/Tissue List	HepG2; A549; Huh7; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541395.5; ENST00000617366.4; ENST00000543427.5; ENST00000615446.4; ENST00000540108.1; ENST00000560968.5; ENST00000257555.10
External Link	RMBase: m6A_site_213393
mod ID: M6ASITE015577		Click to Show/Hide the Full List
mod site	chr12:121001584-121001585:+		[5]
Sequence	TGGCAGCCACACTTCTCAGGACACAGGCCTGTGTAGCTGTG
Motif Score	3.643047619
Cell/Tissue List	HepG2; A549; Huh7; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000560968.5; ENST00000617366.4; ENST00000615446.4; ENST00000543427.5; ENST00000257555.10; ENST00000541395.5; ENST00000540108.1
External Link	RMBase: m6A_site_213394
mod ID: M6ASITE015578		Click to Show/Hide the Full List
mod site	chr12:121001710-121001711:+		[7]
Sequence	CTCCTTCCAGCTAGTGACCCACATGCCATTTGTACTGACCC
Motif Score	2.053113095
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000540108.1; ENST00000543427.5; ENST00000257555.10; ENST00000560968.5; ENST00000617366.4; ENST00000541395.5; ENST00000615446.4
External Link	RMBase: m6A_site_213396
mod ID: M6ASITE015580		Click to Show/Hide the Full List
mod site	chr12:121002069-121002070:+		[6]
Sequence	CTGTCTCGAGCGCCCTGCAGACCCTGCCCTTGTTTGGGGCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; HEK293A-TOA; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000543427.5; ENST00000617366.4; ENST00000615446.4; ENST00000560968.5; ENST00000541395.5; ENST00000540108.1; ENST00000257555.10
External Link	RMBase: m6A_site_213401
mod ID: M6ASITE015581		Click to Show/Hide the Full List
mod site	chr12:121002145-121002146:+		[6]
Sequence	CAGCTGAGCAGGGCCGGGGAACTGGCCAAGCTGAGGTGCCC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; A549; Huh7; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000257555.10; ENST00000540108.1; ENST00000615446.4; ENST00000617366.4; ENST00000543427.5; ENST00000541395.5; ENST00000560968.5
External Link	RMBase: m6A_site_213403
mod ID: M6ASITE015582		Click to Show/Hide the Full List
mod site	chr12:121002212-121002213:+		[6]
Sequence	CACAGGAGCTACCTGTGTGGACAGGACTAACACTCAGAAGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; Huh7; HEK293A-TOA; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000560968.5; ENST00000615446.4; ENST00000540108.1; ENST00000617366.4; ENST00000257555.10; ENST00000543427.5; ENST00000541395.5
External Link	RMBase: m6A_site_213404
mod ID: M6ASITE015583		Click to Show/Hide the Full List
mod site	chr12:121002217-121002218:+		[6]
Sequence	GAGCTACCTGTGTGGACAGGACTAACACTCAGAAGCCTGGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; A549; Huh7; HEK293A-TOA; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615446.4; ENST00000617366.4; ENST00000543427.5; ENST00000257555.10; ENST00000541395.5; ENST00000560968.5; ENST00000540108.1
External Link	RMBase: m6A_site_213405
mod ID: M6ASITE015584		Click to Show/Hide the Full List
mod site	chr12:121002307-121002308:+		[6]
Sequence	CCTGAGCACTGCCAGGAGGGACAAAGGAGCCTGTGAACCCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; hESC-HEK293T; Huh7; HEK293A-TOA; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000257555.10; ENST00000617366.4; ENST00000540108.1; ENST00000541395.5; ENST00000543427.5; ENST00000560968.5; ENST00000615446.4
External Link	RMBase: m6A_site_213409
mod ID: M6ASITE015586		Click to Show/Hide the Full List
mod site	chr12:121002323-121002324:+		[6]
Sequence	AGGGACAAAGGAGCCTGTGAACCCAGGACAAGCATGGTCCC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; Huh7; HEK293A-TOA; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540108.1; ENST00000615446.4; ENST00000543427.5; ENST00000617366.4; ENST00000257555.10; ENST00000541395.5; ENST00000560968.5
External Link	RMBase: m6A_site_213410
mod ID: M6ASITE015587		Click to Show/Hide the Full List
mod site	chr12:121002330-121002331:+		[6]
Sequence	AAGGAGCCTGTGAACCCAGGACAAGCATGGTCCCACATCCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; Huh7; HEK293A-TOA; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540108.1; ENST00000617366.4; ENST00000543427.5; ENST00000541395.5; ENST00000257555.10; ENST00000560968.5; ENST00000615446.4
External Link	RMBase: m6A_site_213411
mod ID: M6ASITE015588		Click to Show/Hide the Full List
mod site	chr12:121002368-121002369:+		[6]
Sequence	CCCTGGGCCTGCTGCTGAGAACCTGGCCTTCAGTGTACCGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; Huh7; HEK293A-TOA; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000617366.4; ENST00000543427.5; ENST00000560968.5; ENST00000541395.5; ENST00000257555.10; ENST00000615446.4; ENST00000540108.1
External Link	RMBase: m6A_site_213413

Ref 1	Progression of Thyroid Carcinoma Is Promoted by the m6A Methyltransferase METTL3 Through Regulating m(6)A Methylation on TCF1. Onco Targets Ther. 2020 Feb 21;13:1605-1612. doi: 10.2147/OTT.S234751. eCollection 2020.
Ref 2	Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. Pharmazie. 2011 Mar;66(3):216-21.
Ref 3	[Action myoclonias and paranoid alternative psychosis in progressive myoclonic epilepsy (late form of the Lafora type)]. Nervenarzt. 1986 Apr;57(4):233-7.
Ref 4	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 5	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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