m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00264)

Target Name	Negative growth regulatory protein MyD118 (GADD45B)
Synonyms	Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118; MYD118 Click to Show/Hide
Gene Name	GADD45B
Chromosomal Location	19p13.3
Family	GADD45 family
Function	Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Click to Show/Hide
Gene ID	4616
Uniprot ID	GA45B_HUMAN
HGNC ID	HGNC:4096
KEGG ID	hsa:4616

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

GADD45B can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

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Fat mass and obesity-associated protein (FTO) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by FTO*
Cell Line	HEK293 cell line	Homo sapiens
Treatment: FTO knockout HEK293 cells Control: Wild type HEK293 cells		GSE79577
Regulation		logFC: 8.04E-01 p-value: 5.27E-05
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene			[1]
Response Summary	Negative growth regulatory protein MyD118 (GADD45B)-mediated m6A modification in Negative growth regulatory protein MyD118 (GADD45B) mRNA drives skeletal muscle differentiation by activating the p38 MAPK pathway, which provides a molecular mechanism for the regulation of myogenesis via RNA methylation.
Target Regulation	Up regulation
Responsed Disease	Muscular dystrophies	ICD-11: 8C70	Disease Info
Pathway Response	Nucleotide excision repair		hsa03420
	MAPK signaling pathway		hsa04010
Cell Process	DNA repair
In-vitro Model	GPM (Goat primary myoblasts)
In-vivo Model	Sixteen female goats in good body condition and suitable for pregnancy were selected. All selected goats underwent estrus synchronization treatment and were naturally mated. After 75 days of gestation, four male fetuses were removed from five pregnant goats during abortion operations, and their longissimus muscle samples were collected.

Protein virilizer homolog (VIRMA) [WRITER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[2]
Response Summary	VIRMA has an oncogenic role in germ cell tumor confirming our previous tissue-based study and is further involved in response to cisplatin by interfering with DNA repair. Enhanced response to cisplatin after VIRMA knockdown was related to significant increase in DNA damage (with higher Gamma-H2AX and Negative growth regulatory protein MyD118 (GADD45B) levels) and downregulation of XLF and MRE11.
Target Regulation	Down regulation
Responsed Disease	Germ cell tumour of testis		ICD-11: 2C80.2	Disease Info
Responsed Drug	Cisplatin		Approved	Drug Info
In-vitro Model	2102EP	Embryonal carcinoma	Homo sapiens	CVCL_C522
	NCC-IT	Testicular embryonal carcinoma	Homo sapiens	CVCL_1451
	NT2	Malignant neoplasms	Mus musculus	CVCL_JA57
	TCam-2	Testicular seminoma	Homo sapiens	CVCL_T012

Testicular cancer [ICD-11: 2C80]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[2]
Response Summary	VIRMA has an oncogenic role in germ cell tumor confirming our previous tissue-based study and is further involved in response to cisplatin by interfering with DNA repair. Enhanced response to cisplatin after VIRMA knockdown was related to significant increase in DNA damage (with higher Gamma-H2AX and Negative growth regulatory protein MyD118 (GADD45B) levels) and downregulation of XLF and MRE11.
Responsed Disease	Germ cell tumour of testis [ICD-11: 2C80.2]
Target Regulator	Protein virilizer homolog (VIRMA)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Drug	Cisplatin		Approved	Drug Info
In-vitro Model	2102EP	Embryonal carcinoma	Homo sapiens	CVCL_C522
	NCC-IT	Testicular embryonal carcinoma	Homo sapiens	CVCL_1451
	NT2	Malignant neoplasms	Mus musculus	CVCL_JA57
	TCam-2	Testicular seminoma	Homo sapiens	CVCL_T012

Muscular dystrophies [ICD-11: 8C70]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response			[1]
Response Summary	Negative growth regulatory protein MyD118 (GADD45B)-mediated m6A modification in Negative growth regulatory protein MyD118 (GADD45B) mRNA drives skeletal muscle differentiation by activating the p38 MAPK pathway, which provides a molecular mechanism for the regulation of myogenesis via RNA methylation.
Responsed Disease	Muscular dystrophies [ICD-11: 8C70]
Target Regulator	Fat mass and obesity-associated protein (FTO)	ERASER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Nucleotide excision repair		hsa03420
	MAPK signaling pathway		hsa04010
Cell Process	DNA repair
In-vitro Model	GPM (Goat primary myoblasts)
In-vivo Model	Sixteen female goats in good body condition and suitable for pregnancy were selected. All selected goats underwent estrus synchronization treatment and were naturally mated. After 75 days of gestation, four male fetuses were removed from five pregnant goats during abortion operations, and their longissimus muscle samples were collected.

Cisplatin [Approved]

Drug Info

In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response				[2]
Response Summary	VIRMA has an oncogenic role in germ cell tumor confirming our previous tissue-based study and is further involved in response to cisplatin by interfering with DNA repair. Enhanced response to cisplatin after VIRMA knockdown was related to significant increase in DNA damage (with higher Gamma-H2AX and Negative growth regulatory protein MyD118 (GADD45B) levels) and downregulation of XLF and MRE11.
Target Regulator	Protein virilizer homolog (VIRMA)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Disease	Germ cell tumour of testis		ICD-11: 2C80.2	Disease Info
In-vitro Model	2102EP	Embryonal carcinoma	Homo sapiens	CVCL_C522
	NCC-IT	Testicular embryonal carcinoma	Homo sapiens	CVCL_1451
	NT2	Malignant neoplasms	Mus musculus	CVCL_JA57
	TCam-2	Testicular seminoma	Homo sapiens	CVCL_T012

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00264)

Negative growth regulatory protein MyD118 (GADD45B)

N6-methyladenosine (m6A)

In total 39 m6A sequence/site(s) in this target gene
mod ID: M6ASITE038066		Click to Show/Hide the Full List
mod site	chr19:2476144-2476145:+		[3]
Sequence	TCAGATCGCCGAAGCGTCGGACTACCGTTGGTTTCCGCAAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; GM12878; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000215631.9; ENST00000592937.1; ENST00000586759.1
External Link	RMBase: m6A_site_409633
mod ID: M6ASITE038067		Click to Show/Hide the Full List
mod site	chr19:2476188-2476189:+		[3]
Sequence	CTGGATTATCCTCGCCAAGGACTTTGCAATATATTTTTCCG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; GM12878; MM6; Huh7; Jurkat; CD4T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000215631.9; ENST00000592937.1; ENST00000587345.1; ENST00000586759.1; ENST00000585359.1
External Link	RMBase: m6A_site_409634
mod ID: M6ASITE038068		Click to Show/Hide the Full List
mod site	chr19:2476317-2476318:+		[3]
Sequence	TTTGCAATTTCTCCCTGGGGACTGCCGTGGAGCCGCATCCA
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; GM12878; MM6; Huh7; Jurkat; CD4T; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000585359.1; ENST00000215631.9; ENST00000592937.1; ENST00000586759.1; ENST00000587345.1
External Link	RMBase: m6A_site_409635
mod ID: M6ASITE038069		Click to Show/Hide the Full List
mod site	chr19:2476639-2476640:+		[3]
Sequence	TTGATGAATGTGTGAGTCAGACCCCCTTCCCGGGCTGGGCG
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; MM6; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000215631.9; ENST00000585359.1; ENST00000587887.5; ENST00000587345.1; ENST00000593043.1; ENST00000592937.1
External Link	RMBase: m6A_site_409636
mod ID: M6ASITE038070		Click to Show/Hide the Full List
mod site	chr19:2476673-2476674:+		[4]
Sequence	CTGGGCGCGGGTGGGACGGGACCTCCCCTCCGCTCTGGACG
Motif Score	3.622404762
Cell/Tissue List	CD34; MM6; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000215631.9; ENST00000593043.1; ENST00000592937.1; ENST00000587345.1; ENST00000587887.5; ENST00000585359.1
External Link	RMBase: m6A_site_409637
mod ID: M6ASITE038071		Click to Show/Hide the Full List
mod site	chr19:2476815-2476816:+		[5]
Sequence	TCCTGATGTATCGTCTGCAAACACCCCTCCCGCCGTGGGCC
Motif Score	2.20572619
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000215631.9; ENST00000593043.1; ENST00000592937.1; ENST00000587345.1; ENST00000587887.5; ENST00000585359.1
External Link	RMBase: m6A_site_409638
mod ID: M6ASITE038072		Click to Show/Hide the Full List
mod site	chr19:2476861-2476862:+		[5]
Sequence	CCCCCTACCCCATACTTTGAACCGTGTGCCCTCCCCTCCCC
Motif Score	2.930744048
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000215631.9; ENST00000592937.1; ENST00000587887.5; ENST00000593043.1; ENST00000587345.1; ENST00000585359.1
External Link	RMBase: m6A_site_409639
mod ID: M6ASITE038073		Click to Show/Hide the Full List
mod site	chr19:2477030-2477031:+		[3]
Sequence	ACCCTTTGGCCCCCTCAGGGACCCAGACAGCGTGGTCCTCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000215631.9; ENST00000587887.5; ENST00000593043.1; ENST00000592937.1; ENST00000585359.1; ENST00000587345.1
External Link	RMBase: m6A_site_409640
mod ID: M6ASITE038074		Click to Show/Hide the Full List
mod site	chr19:2477036-2477037:+		[3]
Sequence	TGGCCCCCTCAGGGACCCAGACAGCGTGGTCCTCTGCCTCT
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HepG2; liver; endometrial
Seq Type List	m6A-seq; m6A-REF-seq
Transcript ID List	ENST00000587345.1; ENST00000592937.1; ENST00000215631.9; ENST00000585359.1; ENST00000593043.1; ENST00000587887.5
External Link	RMBase: m6A_site_409641
mod ID: M6ASITE038075		Click to Show/Hide the Full List
mod site	chr19:2477084-2477085:+		[6]
Sequence	TGACGAGGAGGAGGAGGATGACATCGCCCTGCAAATCCACT
Motif Score	2.859755952
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000587345.1; ENST00000215631.9; ENST00000587887.5; ENST00000593043.1; ENST00000592937.1; ENST00000585359.1
External Link	RMBase: m6A_site_409642
mod ID: M6ASITE038076		Click to Show/Hide the Full List
mod site	chr19:2477203-2477204:+		[3]
Sequence	TCCTGGGAGAGCCGGCCGAGACCCAGGGCACCACCGAGGCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000592937.1; ENST00000215631.9; ENST00000585359.1; ENST00000587345.1
External Link	RMBase: m6A_site_409643
mod ID: M6ASITE038077		Click to Show/Hide the Full List
mod site	chr19:2477228-2477229:+		[3]
Sequence	GGGCACCACCGAGGCCCGAGACCTGCATTGTCTCCTGGTCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000587345.1; ENST00000215631.9; ENST00000592937.1; ENST00000585359.1
External Link	RMBase: m6A_site_409644
mod ID: M6ASITE038078		Click to Show/Hide the Full List
mod site	chr19:2477464-2477465:+		[3]
Sequence	GGAGAGGGAGGCTCCACTAAACCCCTTCTTTTCCCTCCTAC
Motif Score	2.185083333
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000215631.9; ENST00000585359.1; ENST00000592937.1
External Link	RMBase: m6A_site_409645
mod ID: M6ASITE038079		Click to Show/Hide the Full List
mod site	chr19:2477488-2477489:+		[3]
Sequence	CTTCTTTTCCCTCCTACAGAACCCTCACACGGACGCCTGGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; MT4; MM6; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000585359.1; ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409646
mod ID: M6ASITE038080		Click to Show/Hide the Full List
mod site	chr19:2477494-2477495:+		[7]
Sequence	TTCCCTCCTACAGAACCCTCACACGGACGCCTGGAAGAGCC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000215631.9; ENST00000585359.1; ENST00000592937.1
External Link	RMBase: m6A_site_409647
mod ID: M6ASITE038081		Click to Show/Hide the Full List
mod site	chr19:2477560-2477561:+		[7]
Sequence	CTGCGAAGAAAGCCGGGGCAACAACCAGTGGGTCCCCTACA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000215631.9; ENST00000585359.1; ENST00000592937.1
External Link	RMBase: m6A_site_409648
mod ID: M6ASITE038082		Click to Show/Hide the Full List
mod site	chr19:2477578-2477579:+		[7]
Sequence	CAACAACCAGTGGGTCCCCTACATCTCTCTTCAGGAACGCT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000585359.1; ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409649
mod ID: M6ASITE038083		Click to Show/Hide the Full List
mod site	chr19:2477638-2477639:+		[7]
Sequence	GAATCTGTTGAGTTGCTGCCACAAACAAAAAATACAATAAA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000592937.1; ENST00000585359.1; ENST00000215631.9
External Link	RMBase: m6A_site_409650
mod ID: M6ASITE038084		Click to Show/Hide the Full List
mod site	chr19:2477642-2477643:+		[3]
Sequence	CTGTTGAGTTGCTGCCACAAACAAAAAATACAATAAATATT
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; GM12878; LCLs; CD8T; MT4; H1299; MM6; Huh7; CD4T; peripheral-blood; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000592937.1; ENST00000585359.1; ENST00000215631.9
External Link	RMBase: m6A_site_409651
mod ID: M6ASITE038085		Click to Show/Hide the Full List
mod site	chr19:2477666-2477667:+		[3]
Sequence	AAAATACAATAAATATTTGAACCCCCTCCCCCCCAGCACAA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592937.1; ENST00000215631.9
External Link	RMBase: m6A_site_409652
mod ID: M6ASITE038086		Click to Show/Hide the Full List
mod site	chr19:2477697-2477698:+		[3]
Sequence	CCCAGCACAACCCCCCCAAAACAACCCAACCCACGAGGACC
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000592937.1; rmsk_4914468; ENST00000215631.9
External Link	RMBase: m6A_site_409653
mod ID: M6ASITE038087		Click to Show/Hide the Full List
mod site	chr19:2477715-2477716:+		[3]
Sequence	AAACAACCCAACCCACGAGGACCATCGGGGGCAGAGTCGTT
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409654
mod ID: M6ASITE038088		Click to Show/Hide the Full List
mod site	chr19:2477740-2477741:+		[3]
Sequence	CGGGGGCAGAGTCGTTGGAGACTGAAGAGGAAGAGGAGGAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409655
mod ID: M6ASITE038089		Click to Show/Hide the Full List
mod site	chr19:2477837-2477838:+		[3]
Sequence	GATCCGATGGAGAAGGGGGGACCCAGGCCAGCAGGAGACAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409656
mod ID: M6ASITE038090		Click to Show/Hide the Full List
mod site	chr19:2477854-2477855:+		[3]
Sequence	GGGACCCAGGCCAGCAGGAGACAGGACCCCCGAAGCTGAGG
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592937.1; ENST00000215631.9
External Link	RMBase: m6A_site_409657
mod ID: M6ASITE038091		Click to Show/Hide the Full List
mod site	chr19:2477859-2477860:+		[3]
Sequence	CCAGGCCAGCAGGAGACAGGACCCCCGAAGCTGAGGCCTTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592937.1; ENST00000215631.9
External Link	RMBase: m6A_site_409658
mod ID: M6ASITE038092		Click to Show/Hide the Full List
mod site	chr19:2477942-2477943:+		[3]
Sequence	CCCCATCACGGAGGGTCCAGACTGTCCACTCGGGGGTGGAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592937.1; ENST00000215631.9
External Link	RMBase: m6A_site_409659
mod ID: M6ASITE038093		Click to Show/Hide the Full List
mod site	chr19:2477967-2477968:+		[3]
Sequence	CCACTCGGGGGTGGAGTGAGACTGACTGCAAGCCCCACCCT
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592937.1; ENST00000215631.9
External Link	RMBase: m6A_site_409660
mod ID: M6ASITE038094		Click to Show/Hide the Full List
mod site	chr19:2477971-2477972:+		[8]
Sequence	TCGGGGGTGGAGTGAGACTGACTGCAAGCCCCACCCTCCTT
Motif Score	3.28175
Cell/Tissue List	CD8T; AML
Seq Type List	m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409661
mod ID: M6ASITE038095		Click to Show/Hide the Full List
mod site	chr19:2477995-2477996:+		[3]
Sequence	CAAGCCCCACCCTCCTTGAGACTGGAGCTGGCGTCTGCATA
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409662
mod ID: M6ASITE038096		Click to Show/Hide the Full List
mod site	chr19:2478022-2478023:+		[3]
Sequence	CTGGCGTCTGCATACGAGAGACTTGGTTGAACTTGGTTGGT
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000592937.1; ENST00000215631.9
External Link	RMBase: m6A_site_409663
mod ID: M6ASITE038097		Click to Show/Hide the Full List
mod site	chr19:2478032-2478033:+		[3]
Sequence	CATACGAGAGACTTGGTTGAACTTGGTTGGTCCTTGTCTGC
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409664
mod ID: M6ASITE038098		Click to Show/Hide the Full List
mod site	chr19:2478060-2478061:+		[7]
Sequence	GGTCCTTGTCTGCACCCTCGACAAGACCACACTTTGGGACT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T; A549
Seq Type List	MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409665
mod ID: M6ASITE038099		Click to Show/Hide the Full List
mod site	chr19:2478065-2478066:+		[3]
Sequence	TTGTCTGCACCCTCGACAAGACCACACTTTGGGACTTGGGA
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; BGC823; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592937.1; ENST00000215631.9
External Link	RMBase: m6A_site_409666
mod ID: M6ASITE038100		Click to Show/Hide the Full List
mod site	chr19:2478068-2478069:+		[6]
Sequence	TCTGCACCCTCGACAAGACCACACTTTGGGACTTGGGAGCT
Motif Score	2.053113095
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409667
mod ID: M6ASITE038101		Click to Show/Hide the Full List
mod site	chr19:2478078-2478079:+		[3]
Sequence	CGACAAGACCACACTTTGGGACTTGGGAGCTGGGGCTGAAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; BGC823; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409668
mod ID: M6ASITE038102		Click to Show/Hide the Full List
mod site	chr19:2478116-2478117:+		[3]
Sequence	AAGTTGCTCTGTACCCATGAACTCCCAGTTTGCGAATTATA
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; BGC823; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592937.1; ENST00000215631.9
External Link	RMBase: m6A_site_409669
mod ID: M6ASITE038103		Click to Show/Hide the Full List
mod site	chr19:2478140-2478141:+		[3]
Sequence	CCAGTTTGCGAATTATAGAGACAATCTATTTTGTTACTTGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; kidney; liver; A549; hESC-HEK293T; BGC823; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000215631.9; ENST00000592937.1
External Link	RMBase: m6A_site_409670
mod ID: M6ASITE038104		Click to Show/Hide the Full List
mod site	chr19:2478174-2478175:+		[3]
Sequence	TACTTGCACTTGTTATTCGAACCACTGAGAGCGAGATGGGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; BGC823; U2OS; H1A; H1B; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000592937.1; ENST00000215631.9
External Link	RMBase: m6A_site_409671

Ref 1	FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway. Mol Ther Nucleic Acids. 2021 Jun 24;26:34-48. doi: 10.1016/j.omtn.2021.06.013. eCollection 2021 Dec 3.
Ref 2	The component of the m(6)A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors. J Exp Clin Cancer Res. 2021 Aug 25;40(1):268. doi: 10.1186/s13046-021-02072-9.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 5	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 6	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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