m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00257)

Target Name	Forkhead box protein D1 (FOXD1)
Synonyms	Forkhead-related protein FKHL8; Forkhead-related transcription factor 4; FREAC-4; FKHL8; FREAC4 Click to Show/Hide
Gene Name	FOXD1
Chromosomal Location	5q13.2
Function	Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes. Click to Show/Hide
Gene ID	2297
Uniprot ID	FOXD1_HUMAN
HGNC ID	HGNC:3802
KEGG ID	hsa:2297

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

FOXD1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	LX2 cell line	Homo sapiens
Treatment: shMETTL3 LX2 cells Control: shLuc LX2 cells		GSE207909
Regulation		logFC: 8.07E-01 p-value: 2.88E-13
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between FOXD1 and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 6.40E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 contributes to renal ischemia-reperfusion injury by regulating Forkhead box protein D1 (FOXD1) methylation. When METTL3 was inhibited, m6A levels were accordingly decreased and cell apoptosis was suppressed in the H/R in vitro model. Based on MeRIP sequencing, transcription factor activating enhancer binding protein 2-alpha (tfap2a), cytochrome P-450 1B1 (cyp1b1), and forkhead box D1 (foxd1) were significantly differentially expressed, as was m6A, which is involved in the negative regulation of cell proliferation and kidney development.
Target Regulation	Down regulation
Responsed Disease	Injury of kidney		ICD-11: NB92.0	Disease Info
Cell Process	Cell proliferation
	Cell apoptosis
In-vitro Model	NRK-52E	Normal	Rattus norvegicus	CVCL_0468
In-vivo Model	Rats were anesthetized and incised through the midline of the abdomen, and the left renal vertebral arch and arteries were blocked for 45 min, thereby resulting in left kidney ischemia. At the same time, the right kidney was removed, further aggravating the degree of left kidney injury.

Urinary/pelvic organs injury [ICD-11: NB92]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 contributes to renal ischemia-reperfusion injury by regulating Forkhead box protein D1 (FOXD1) methylation. When METTL3 was inhibited, m6A levels were accordingly decreased and cell apoptosis was suppressed in the H/R in vitro model. Based on MeRIP sequencing, transcription factor activating enhancer binding protein 2-alpha (tfap2a), cytochrome P-450 1B1 (cyp1b1), and forkhead box D1 (foxd1) were significantly differentially expressed, as was m6A, which is involved in the negative regulation of cell proliferation and kidney development.
Responsed Disease	Injury of kidney [ICD-11: NB92.0]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Cell Process	Cell proliferation
	Cell apoptosis
In-vitro Model	NRK-52E	Normal	Rattus norvegicus	CVCL_0468
In-vivo Model	Rats were anesthetized and incised through the midline of the abdomen, and the left renal vertebral arch and arteries were blocked for 45 min, thereby resulting in left kidney ischemia. At the same time, the right kidney was removed, further aggravating the degree of left kidney injury.

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

RNA modification

m6A Regulator: Fat mass and obesity-associated protein (FTO)

Regulator Info

In total 4 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00033		Crosstalk Info
Epigenetic Regulator	tRNA methyltransferase 10 homolog A (TRMT10A)
Regulated Target	tRNA-Gln (anticodon TTG) 1-1 (TRQ-TTG1-1)
Crosstalk relationship	m1G → m6A
Crosstalk ID: M6ACROT00035		Crosstalk Info
Epigenetic Regulator	tRNA methyltransferase 10 homolog A (TRMT10A)
Regulated Target	tRNA-Arg (anticodon CCG) 1-1 (TRR-CCG1-1)
Crosstalk relationship	m1G → m6A
Crosstalk ID: M6ACROT00037		Crosstalk Info
Epigenetic Regulator	tRNA methyltransferase 10 homolog A (TRMT10A)
Regulated Target	tRNA-Thr (anticodon CGT) 1-1 (TRT-CGT1-1)
Crosstalk relationship	m1G → m6A
Crosstalk ID: M6ACROT00046		Crosstalk Info
Epigenetic Regulator	tRNA methyltransferase 10 homolog A (TRMT10A)
Regulated Target	Forkhead box protein D1 (FOXD1)
Crosstalk relationship	m1G → m6A

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 3 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00034		Crosstalk Info
Epigenetic Regulator	tRNA methyltransferase 10 homolog A (TRMT10A)
Regulated Target	tRNA-Gln (anticodon TTG) 1-1 (TRQ-TTG1-1)
Crosstalk relationship	m1G → m6A
Crosstalk ID: M6ACROT00036		Crosstalk Info
Epigenetic Regulator	tRNA methyltransferase 10 homolog A (TRMT10A)
Regulated Target	tRNA-Arg (anticodon CCG) 1-1 (TRR-CCG1-1)
Crosstalk relationship	m1G → m6A
Crosstalk ID: M6ACROT00038		Crosstalk Info
Epigenetic Regulator	tRNA methyltransferase 10 homolog A (TRMT10A)
Regulated Target	tRNA-Thr (anticodon CGT) 1-1 (TRT-CGT1-1)
Crosstalk relationship	m1G → m6A

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00257)

Forkhead box protein D1 (FOXD1)

5-methylcytidine (m5C)

In total 9 m6A sequence/site(s) in this target gene
mod ID: M5CSITE003464		Click to Show/Hide the Full List
mod site	chr5:73447070-73447071:-		[3]
Sequence	ATCCCTCGTGGCCGCCGCGGCCGCCGCCGCCTCCTCAGTCT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m5C_site_35249
mod ID: M5CSITE003465		Click to Show/Hide the Full List
mod site	chr5:73447075-73447076:-		[3]
Sequence	ACCCGATCCCTCGTGGCCGCCGCGGCCGCCGCCGCCTCCTC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m5C_site_35250
mod ID: M5CSITE003466		Click to Show/Hide the Full List
mod site	chr5:73447102-73447103:-		[3]
Sequence	GCGGCCGTGGGCCCGGCGGCCGCGCTCACCCGATCCCTCGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m5C_site_35251
mod ID: M5CSITE003467		Click to Show/Hide the Full List
mod site	chr5:73447103-73447104:-		[3]
Sequence	GGCGGCCGTGGGCCCGGCGGCCGCGCTCACCCGATCCCTCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m5C_site_35252
mod ID: M5CSITE003468		Click to Show/Hide the Full List
mod site	chr5:73447106-73447107:-		[3]
Sequence	GCAGGCGGCCGTGGGCCCGGCGGCCGCGCTCACCCGATCCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m5C_site_35253
mod ID: M5CSITE003469		Click to Show/Hide the Full List
mod site	chr5:73447109-73447110:-		[3]
Sequence	GGCGCAGGCGGCCGTGGGCCCGGCGGCCGCGCTCACCCGAT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m5C_site_35254
mod ID: M5CSITE003470		Click to Show/Hide the Full List
mod site	chr5:73447110-73447111:-		[3]
Sequence	CGGCGCAGGCGGCCGTGGGCCCGGCGGCCGCGCTCACCCGA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m5C_site_35255
mod ID: M5CSITE003471		Click to Show/Hide the Full List
mod site	chr5:73447111-73447112:-		[3]
Sequence	GCGGCGCAGGCGGCCGTGGGCCCGGCGGCCGCGCTCACCCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m5C_site_35256
mod ID: M5CSITE003472		Click to Show/Hide the Full List
mod site	chr5:73447258-73447259:-
Sequence	TTCTCCATCGAGAGCATCATCGGGGGCAGCTTGGGCCCGGC
Cell/Tissue List	testis
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m5C_site_35257

N6-methyladenosine (m6A)

In total 35 m6A sequence/site(s) in this target gene
mod ID: M6ASITE069362		Click to Show/Hide the Full List
mod site	chr5:73444902-73444903:-		[4]
Sequence	GCGGAATCCAAACGGCACAGACACTGCTGGCGCGCCTGGTA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; H1299; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000513595.1
External Link	RMBase: m6A_site_672598
mod ID: M6ASITE069363		Click to Show/Hide the Full List
mod site	chr5:73444959-73444960:-		[4]
Sequence	TTGAACCCGAGAACGTCCGGACTCCACGCGCCGCCCCGGGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; H1299; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000513595.1
External Link	RMBase: m6A_site_672599
mod ID: M6ASITE069364		Click to Show/Hide the Full List
mod site	chr5:73444975-73444976:-		[4]
Sequence	TAAGAGAGAGGAGTCATTGAACCCGAGAACGTCCGGACTCC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; H1299; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000513595.1
External Link	RMBase: m6A_site_672600
mod ID: M6ASITE069365		Click to Show/Hide the Full List
mod site	chr5:73445038-73445039:-		[5]
Sequence	ACAAATTGAAATACTGTTAGACCAAAGTCTTATATACAAAA
Motif Score	2.876744048
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000513595.1
External Link	RMBase: m6A_site_672601
mod ID: M6ASITE069366		Click to Show/Hide the Full List
mod site	chr5:73445080-73445081:-		[6]
Sequence	TTAAACCCTCTCACTCTCAAACTTACCACTAAATCTATAGA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; H1299; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000513595.1
External Link	RMBase: m6A_site_672602
mod ID: M6ASITE069367		Click to Show/Hide the Full List
mod site	chr5:73445096-73445097:-		[6]
Sequence	AAATGTTTGGAGGAGGTTAAACCCTCTCACTCTCAAACTTA
Motif Score	2.185083333
Cell/Tissue List	HEK293T; H1299; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000513595.1
External Link	RMBase: m6A_site_672603
mod ID: M6ASITE069368		Click to Show/Hide the Full List
mod site	chr5:73445165-73445166:-		[7]
Sequence	TCTTTTTAGGGAGAAAACGGACTCTCACGGGCTCAAATGAA
Motif Score	4.065041667
Cell/Tissue List	HEK293T; fibroblasts; A549; H1299; MM6; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000513595.1
External Link	RMBase: m6A_site_672604
mod ID: M6ASITE069369		Click to Show/Hide the Full List
mod site	chr5:73446305-73446306:-		[8]
Sequence	ATTCTAAATGTAAGATTTTTACACTTTTTCAGAAATAAAAA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000513595.1; ENST00000615637.3
External Link	RMBase: m6A_site_672605
mod ID: M6ASITE069370		Click to Show/Hide the Full List
mod site	chr5:73446367-73446368:-		[9]
Sequence	GTACTTACTGCGTATTCTTTACAAGGAGTATTGTAAATTTT
Motif Score	2.07285119
Cell/Tissue List	HEK293; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000615637.3; ENST00000513595.1
External Link	RMBase: m6A_site_672606
mod ID: M6ASITE069371		Click to Show/Hide the Full List
mod site	chr5:73446385-73446386:-		[10]
Sequence	AGACGTGTGGATTTTTTTGTACTTACTGCGTATTCTTTACA
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000615637.3; ENST00000513595.1
External Link	RMBase: m6A_site_672607
mod ID: M6ASITE069372		Click to Show/Hide the Full List
mod site	chr5:73446460-73446461:-		[10]
Sequence	AAAATGGTTAACATGTTTACACAAGAAAAAAAGTCAAAATT
Motif Score	2.084928571
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000615637.3; ENST00000513595.1
External Link	RMBase: m6A_site_672609
mod ID: M6ASITE069373		Click to Show/Hide the Full List
mod site	chr5:73446470-73446471:-		[8]
Sequence	ATGAAAAGGAAAAATGGTTAACATGTTTACACAAGAAAAAA
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000615637.3; ENST00000513595.1
External Link	RMBase: m6A_site_672611
mod ID: M6ASITE069374		Click to Show/Hide the Full List
mod site	chr5:73446513-73446514:-		[8]
Sequence	CAATTCTTTTTTATTTGAGGACACTTGTCTGGTGTACTTTT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; hESC-HEK293T; fibroblasts; A549; HEK293A-TOA
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000615637.3; ENST00000513595.1
External Link	RMBase: m6A_site_672613
mod ID: M6ASITE069375		Click to Show/Hide the Full List
mod site	chr5:73446570-73446571:-		[10]
Sequence	ATAATGGTCAAAAGAATAATACAAAAATAGTAAAGGTCTTG
Motif Score	2.110482143
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000513595.1; ENST00000615637.3
External Link	RMBase: m6A_site_672615
mod ID: M6ASITE069376		Click to Show/Hide the Full List
mod site	chr5:73446641-73446642:-		[11]
Sequence	TGACGTTTGGCAGATGAAAAACAACTAAGCCTTTTTGAGGT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; hESC-HEK293T; U2OS; fibroblasts; H1299; MM6; HEK293A-TOA; iSLK
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000615637.3; ENST00000513595.1
External Link	RMBase: m6A_site_672617
mod ID: M6ASITE069377		Click to Show/Hide the Full List
mod site	chr5:73446659-73446660:-		[12]
Sequence	AGGCACTAGAGGCTCCCTTGACGTTTGGCAGATGAAAAACA
Motif Score	2.833690476
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000615637.3; ENST00000513595.1
External Link	RMBase: m6A_site_672618
mod ID: M6ASITE069378		Click to Show/Hide the Full List
mod site	chr5:73446729-73446730:-		[10]
Sequence	CTACAGCCCCCCAACCCCCGACCTGGGGTAGGGAGGAAGAG
Motif Score	2.844928571
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000513595.1; ENST00000615637.3
External Link	RMBase: m6A_site_672621
mod ID: M6ASITE069379		Click to Show/Hide the Full List
mod site	chr5:73446816-73446817:-		[4]
Sequence	GCTGCGAATTCTCGGACAAAACTGTCAACAGCCCGGGCGCG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; fibroblasts; H1299; MM6; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000513595.1; ENST00000615637.3
External Link	RMBase: m6A_site_672622
mod ID: M6ASITE069380		Click to Show/Hide the Full List
mod site	chr5:73446821-73446822:-		[4]
Sequence	TCGCCGCTGCGAATTCTCGGACAAAACTGTCAACAGCCCGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; fibroblasts; H1299; MM6; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000513595.1; ENST00000615637.3
External Link	RMBase: m6A_site_672623
mod ID: M6ASITE069381		Click to Show/Hide the Full List
mod site	chr5:73446858-73446859:-		[12]
Sequence	TCCAGGCGCGGCCCCTCTCGACCTCGCGCGCCCATTTTCGC
Motif Score	2.844928571
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000615637.3; ENST00000513595.1
External Link	RMBase: m6A_site_672624
mod ID: M6ASITE069382		Click to Show/Hide the Full List
mod site	chr5:73446987-73446988:-		[10]
Sequence	TGTCCAGTGTCGAGAACTTTACTGCTAGGATTTCCAATTGT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000513595.1; ENST00000615637.3
External Link	RMBase: m6A_site_672625
mod ID: M6ASITE069383		Click to Show/Hide the Full List
mod site	chr5:73446992-73446993:-		[4]
Sequence	TGCCCTGTCCAGTGTCGAGAACTTTACTGCTAGGATTTCCA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hESCs; fibroblasts; H1299; MM6; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672626
mod ID: M6ASITE069384		Click to Show/Hide the Full List
mod site	chr5:73447014-73447015:-		[4]
Sequence	TGGGGACTCTGCACCAAGGGACTGCCCTGTCCAGTGTCGAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1B; hESCs; fibroblasts; H1299; MM6; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672627
mod ID: M6ASITE069385		Click to Show/Hide the Full List
mod site	chr5:73447029-73447030:-		[4]
Sequence	CCTCGTCCGCCGCCTTGGGGACTCTGCACCAAGGGACTGCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1B; hESCs; fibroblasts; H1299; MM6; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672628
mod ID: M6ASITE069386		Click to Show/Hide the Full List
mod site	chr5:73447389-73447390:-		[13]
Sequence	CGGCCGCCGAGCTGGCCCGGACCGCCTTCGGCTACCGGCCG
Motif Score	3.622404762
Cell/Tissue List	U2OS; H1299; GSC-11; HEK293T; HEK293A-TOA; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672629
mod ID: M6ASITE069387		Click to Show/Hide the Full List
mod site	chr5:73447742-73447743:-		[8]
Sequence	GCTGGACCCGGAGTCCGCCGACATGTTCGACAACGGCAGCT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672630
mod ID: M6ASITE069388		Click to Show/Hide the Full List
mod site	chr5:73447757-73447758:-		[4]
Sequence	GGGCAACTACTGGACGCTGGACCCGGAGTCCGCCGACATGT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; fibroblasts; H1299; MM6; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672631
mod ID: M6ASITE069389		Click to Show/Hide the Full List
mod site	chr5:73447838-73447839:-		[8]
Sequence	CTGGCAGAACAGCATCCGCCACAACCTCTCGCTCAACGACT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672632
mod ID: M6ASITE069390		Click to Show/Hide the Full List
mod site	chr5:73447850-73447851:-		[4]
Sequence	GAAGTTCCCCGCCTGGCAGAACAGCATCCGCCACAACCTCT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; fibroblasts; H1299; MM6; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672633
mod ID: M6ASITE069391		Click to Show/Hide the Full List
mod site	chr5:73448000-73448001:-		[13]
Sequence	CGCGGGTAGCGGCGCCAAGAACCCGCTGGTGAAGCCGCCCT
Motif Score	2.930744048
Cell/Tissue List	U2OS; H1299; MM6; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672634
mod ID: M6ASITE069392		Click to Show/Hide the Full List
mod site	chr5:73448313-73448314:-		[4]
Sequence	CCTCTGGCCTCGCCGAGGAAACAGACATCGACGTGGTGGGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; U2OS; H1B; H1A; HEK293T; H1299; MM6; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672635
mod ID: M6ASITE069393		Click to Show/Hide the Full List
mod site	chr5:73448436-73448437:-		[13]
Sequence	GGCCGGGCCTGCCGCCCGGGACCCGGGCTGGGGCGCAGAGG
Motif Score	3.622404762
Cell/Tissue List	U2OS; H1299; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; MM6
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672636
mod ID: M6ASITE069394		Click to Show/Hide the Full List
mod site	chr5:73448530-73448531:-		[13]
Sequence	TTATAAAGTCGGCGCGCGAGACTCCGCCGCCACCCGGCAGC
Motif Score	3.319380952
Cell/Tissue List	U2OS; H1299; MM6; GSC-11; HEK293T; HEK293A-TOA; MSC; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672637
mod ID: M6ASITE069395		Click to Show/Hide the Full List
mod site	chr5:73448740-73448741:-		[4]
Sequence	TCGCCGAGCTCTGTTCTTAGACTCTCACCCGTCCCGCACGT
Motif Score	3.319380952
Cell/Tissue List	HeLa; MM6; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672638
mod ID: M6ASITE069396		Click to Show/Hide the Full List
mod site	chr5:73448774-73448775:-		[14]
Sequence	GAAGGTCCGCCCTCTCCTGGACTCAGCCCTGGCCTCGCCGA
Motif Score	4.065041667
Cell/Tissue List	MM6; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615637.3
External Link	RMBase: m6A_site_672639

Ref 1	METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F839-F847. doi: 10.1152/ajprenal.00222.2020. Epub 2020 Sep 21.
Ref 2	Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components. J Bone Joint Surg Am. 2001 Jul;83(7):1057-61. doi: 10.2106/00004623-200107000-00012.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 5	The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.
Ref 6	The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 May 5;62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21.
Ref 7	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 8	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 11	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 12	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 13	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.
Ref 14	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

Visitor Map