m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00136)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR145
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Fat mass and obesity-associated protein (FTO) [ERASER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | Loss of m6A RNA methylation and increased translation in human glioblastoma cells as well as a role for miRNAs in the modulation of m6A RNA demethylation in genes that are most efficiently translated during glioma stem cells differentiation. Ectopic expression of the RRACH-binding miR-145 induces loss of m6A, formation of FTO/AGO1/ILF3/microRNA 145 (MIR145) complexes on a clinically relevant tumor suppressor gene (CLIP3) and significant increase in its nascent translation. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Glioblastoma | ICD-11: 2A00.00 | ||
| In-vitro Model | GBM1 | Glioblastoma | Homo sapiens | CVCL_DG57 |
| GBM2 | Glioblastoma | Homo sapiens | CVCL_DG58 | |
| GBM3 | Glioblastoma | Homo sapiens | CVCL_DG59 | |
Brain cancer [ICD-11: 2A00]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | Loss of m6A RNA methylation and increased translation in human glioblastoma cells as well as a role for miRNAs in the modulation of m6A RNA demethylation in genes that are most efficiently translated during glioma stem cells differentiation. Ectopic expression of the RRACH-binding miR-145 induces loss of m6A, formation of FTO/AGO1/ILF3/microRNA 145 (MIR145) complexes on a clinically relevant tumor suppressor gene (CLIP3) and significant increase in its nascent translation. | |||
| Responsed Disease | Glioblastoma [ICD-11: 2A00.00] | |||
| Target Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | GBM1 | Glioblastoma | Homo sapiens | CVCL_DG57 |
| GBM2 | Glioblastoma | Homo sapiens | CVCL_DG58 | |
| GBM3 | Glioblastoma | Homo sapiens | CVCL_DG59 | |
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05819 | ||
| Epigenetic Regulator | MicroRNA 145 (MIR145) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Epilepsy due to structural or metabolic conditions or diseases | |