m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05819
|
[1] | |||
m6A modification
MIR145
MIR145
YTHDF2
 : m6A sites
Direct
Inhibition
Non-coding RNA
miR-145
Regulated Target
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | READER | |||
| m6A Target | microRNA 145 (MIR145) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | MicroRNA 145 (MIR145) | microRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Inhibition | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | YTHDF2 has been identified as a direct target of microRNA 145 (MIR145), and downregulation of miR-145 has been shown to decrease Caspase-9 expression in the hippocampus. This reduction in Caspase-9 levels leads to decreased hippocampal neuronal apoptosis, which positively impacts memory and learning in epileptic rats | ||||
| Responsed Disease | Epilepsy due to structural or metabolic conditions or diseases | ICD-11: 8A60.5 | |||