m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00115)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR576
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Fat mass and obesity-associated protein (FTO) [ERASER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | FTO promoted bladder cancer cell proliferation, migration and invasion via the FTO/microRNA 576 (MIR576)/CDK6 pathways in an m6A-dependent manner. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Bladder cancer | ICD-11: 2C94 | ||
| Cell Process | Cell proliferation | |||
| Cell migration | ||||
| Cell invasion | ||||
| In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
| T24 | Bladder carcinoma | Homo sapiens | CVCL_0554 | |
| UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
| In-vivo Model | Approximately 1 × 107 stably transfected T24 cells were subcutaneously injected into BALB/c nude mice. The length (L) and width (W) of the tumours were measured weekly using callipers, while their volume was calculated using the equation: V = (L × W2)/2. After 4 weeks of injections, the mice were euthanised, and the tumour tissues were removed and weighed. | |||
Bladder cancer [ICD-11: 2C94]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | FTO promoted bladder cancer cell proliferation, migration and invasion via the FTO/microRNA 576 (MIR576)/CDK6 pathways in an m6A-dependent manner. | |||
| Responsed Disease | Bladder cancer [ICD-11: 2C94] | |||
| Target Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | ||
| Target Regulation | Up regulation | |||
| Cell Process | Cell proliferation | |||
| Cell migration | ||||
| Cell invasion | ||||
| In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
| T24 | Bladder carcinoma | Homo sapiens | CVCL_0554 | |
| UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
| In-vivo Model | Approximately 1 × 107 stably transfected T24 cells were subcutaneously injected into BALB/c nude mice. The length (L) and width (W) of the tumours were measured weekly using callipers, while their volume was calculated using the equation: V = (L × W2)/2. After 4 weeks of injections, the mice were euthanised, and the tumour tissues were removed and weighed. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Fat mass and obesity-associated protein (FTO)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00655 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → m5C | |
| Crosstalk ID: M6ACROT00656 | ||
| Epigenetic Regulator | H/ACA ribonucleoprotein complex subunit DKC1 (DKC1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → Pseudouridine | |
Non-coding RNA
m6A Regulator: Fat mass and obesity-associated protein (FTO)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05536 | ||
| Epigenetic Regulator | MicroRNA 576 (MIR576) | |
| Regulated Target | Cyclin-dependent kinase 6 (CDK6) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Bladder cancer | |