m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00109)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR1246
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 2 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | METTL3/microRNA 1246 (MIR1246)/SPRED2 axis plays an important role in tumor metastasis and provides a new m6A modification pattern in Colorectal cancer development. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
| Pathway Response | MAPK signaling pathway | hsa04010 | ||
| Cell Process | Cell migration and invasion | |||
| In-vitro Model | Caco-2 | Colon adenocarcinoma | Homo sapiens | CVCL_0025 |
| DLD-1 | Colon adenocarcinoma | Homo sapiens | CVCL_0248 | |
| HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| NCM460 | Normal | Homo sapiens | CVCL_0460 | |
| HT29 | Colon cancer | Mus musculus | CVCL_A8EZ | |
| LoVo | Colon adenocarcinoma | Homo sapiens | CVCL_0399 | |
| In-vivo Model | The spleen in the upper left lateral abdomen of the anesthetized mice were exposed, 106 cells suspended in 20 uL phosphate-buffered saline (PBS) were injected into the distal tip of the spleen. After injection, replacing the spleen, and closing the incision. | |||
| Experiment 2 Reporting the m6A Methylation Regulator of This Target Gene | [2] | |||
| Response Summary | METTL3 regulates the m6A modification to promote the maturation of microRNA 1246 (MIR1246), which targets PEG3 to participate in occurrence and development of non-small cell lung cancer. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Non-small-cell lung carcinoma | ICD-11: 2C25.Y | ||
| Cell Process | Cell proliferation | |||
| Cell migration | ||||
| Cell invasion | ||||
| Cell apoptosis | ||||
| In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
| BEAS-2B | Normal | Homo sapiens | CVCL_0168 | |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
| NCI-H1975 | Lung adenocarcinoma | Homo sapiens | CVCL_1511 | |
| NCI-H520 | Lung squamous cell carcinoma | Homo sapiens | CVCL_1566 | |
| In-vivo Model | The 40 nude mice of each large group were classified into 8 small groups (n = 5) and subcutaneously injected with transfected cell suspension in the back (5 × 106 cells/mL/mouse). The length and width of tumors were recorded every 4 days, and the tumor volume = (length × width2)/2. The tumor growth curve was thereby graphed. On the 28th day of injection, mice were euthanized by neck dislocation, and the xenografts were harvested, photographed, and weighed. | |||
Colorectal cancer [ICD-11: 2B91]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | METTL3/microRNA 1246 (MIR1246)/SPRED2 axis plays an important role in tumor metastasis and provides a new m6A modification pattern in Colorectal cancer development. | |||
| Responsed Disease | Colorectal cancer [ICD-11: 2B91] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | MAPK signaling pathway | hsa04010 | ||
| Cell Process | Cell migration and invasion | |||
| In-vitro Model | Caco-2 | Colon adenocarcinoma | Homo sapiens | CVCL_0025 |
| DLD-1 | Colon adenocarcinoma | Homo sapiens | CVCL_0248 | |
| HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| NCM460 | Normal | Homo sapiens | CVCL_0460 | |
| HT29 | Colon cancer | Mus musculus | CVCL_A8EZ | |
| LoVo | Colon adenocarcinoma | Homo sapiens | CVCL_0399 | |
| In-vivo Model | The spleen in the upper left lateral abdomen of the anesthetized mice were exposed, 106 cells suspended in 20 uL phosphate-buffered saline (PBS) were injected into the distal tip of the spleen. After injection, replacing the spleen, and closing the incision. | |||
Lung cancer [ICD-11: 2C25]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [2] | |||
| Response Summary | METTL3 regulates the m6A modification to promote the maturation of microRNA 1246 (MIR1246), which targets PEG3 to participate in occurrence and development of non-small cell lung cancer. | |||
| Responsed Disease | Non-small-cell lung carcinoma [ICD-11: 2C25.Y] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Cell Process | Cell proliferation | |||
| Cell migration | ||||
| Cell invasion | ||||
| Cell apoptosis | ||||
| In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
| BEAS-2B | Normal | Homo sapiens | CVCL_0168 | |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
| NCI-H1975 | Lung adenocarcinoma | Homo sapiens | CVCL_1511 | |
| NCI-H520 | Lung squamous cell carcinoma | Homo sapiens | CVCL_1566 | |
| In-vivo Model | The 40 nude mice of each large group were classified into 8 small groups (n = 5) and subcutaneously injected with transfected cell suspension in the back (5 × 106 cells/mL/mouse). The length and width of tumors were recorded every 4 days, and the tumor volume = (length × width2)/2. The tumor growth curve was thereby graphed. On the 28th day of injection, mice were euthanized by neck dislocation, and the xenografts were harvested, photographed, and weighed. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00663 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | Glycogen synthase kinase-3 beta (GSK3Beta/GSK3B) | |
| Crosstalk relationship | m6A → m5C | |
| Crosstalk ID: M6ACROT00664 | ||
| Epigenetic Regulator | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (WDR4) | |
| Regulated Target | Interleukin 6 (IL6) | |
| Crosstalk relationship | m6A → m7G | |
Histone modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03546 | ||
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Colorectal cancer | |
| Crosstalk ID: M6ACROT03591 | ||
| Epigenetic Regulator | N-lysine methyltransferase SMYD2 (SMYD2) | |
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Colorectal cancer | |
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05397 | ||
| Epigenetic Regulator | MicroRNA 1246 (MIR1246) | |
| Regulated Target | Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Colorectal cancer | |
| Crosstalk ID: M6ACROT05490 | ||
| Epigenetic Regulator | MicroRNA 1246 (MIR1246) | |
| Regulated Target | Paternally-expressed gene 3 protein (PEG3) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Non-small cell lung cancer | |
References