m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00099)

Target Name	LIFR antisense RNA 1 (LIFR-AS1)
Synonyms	LIFR-AS1; LIFR antisense RNA 1 (non-protein coding) Click to Show/Hide
Gene Name	LIFR-AS1
Chromosomal Location	5p13.1
Family	Antisense RNAs
Gene ID	100506495
HGNC ID	HGNC:43600

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

LIFR-AS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene			[1]
Response Summary	METTL3 induced m6A hyper-methylation on the 3' UTR of LIFR antisense RNA 1 (LIFR-AS1) to enhance its mRNA stability and LIFR-AS1 could directly interact with miR-150-5p, thereby indirectly up-regulating VEGFA expressions within cells. A noval m6A-LIFR-AS1 axis promotes pancreatic cancer progression at least in part via regulation of the miR-150-5p/VEGFA axis, indicating that this regulatory axis can be a viable clinical target for the treatment of pancreatic cancer.
Target Regulation	Up regulation
Responsed Disease	Pancreatic cancer	ICD-11: 2C10	Disease Info
Pathway Response	PI3K-Akt signaling pathway		hsa04151
Cell Process	Cell proliferation and metastasis

Pancreatic cancer [ICD-11: 2C10]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response			[1]
Response Summary	METTL3 induced m6A hyper-methylation on the 3' UTR of LIFR antisense RNA 1 (LIFR-AS1) to enhance its mRNA stability and LIFR-AS1 could directly interact with miR-150-5p, thereby indirectly up-regulating VEGFA expressions within cells. A noval m6A-LIFR-AS1 axis promotes pancreatic cancer progression at least in part via regulation of the miR-150-5p/VEGFA axis, indicating that this regulatory axis can be a viable clinical target for the treatment of pancreatic cancer.
Responsed Disease	Pancreatic cancer [ICD-11: 2C10]
Target Regulator	Methyltransferase-like 3 (METTL3)	WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	PI3K-Akt signaling pathway		hsa04151
Cell Process	Cell proliferation and metastasis

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02116		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Pancreatic cancer	Disease Info
Crosstalk ID: M6ACROT02125		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Pancreatic cancer	Disease Info

Non-coding RNA

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05526		Crosstalk Info
Epigenetic Regulator	LIFR antisense RNA 1 (LIFR-AS1)
Regulated Target	hsa-miR-150-5p
Crosstalk relationship	m6A → ncRNA
Disease	Pancreatic cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00099)

LIFR antisense RNA 1 (LIFR-AS1)

Adenosine-to-Inosine editing (A-to-I)

In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000651		Click to Show/Hide the Full List
mod site	chr5:38604828-38604829:+		[2]
Sequence	AGCTTGCTTTTATACATTTTAGGGAGACAGGAGACATCACT
Transcript ID List	ENST00000500733.6; ENST00000500817.2
External Link	RMBase: RNA-editing_site_108590
mod ID: A2ISITE000652		Click to Show/Hide the Full List
mod site	chr5:38604860-38604861:+		[2]
Sequence	GACATCACTCAATACATGTAAGATTTACATTGCTTTGATCT
Transcript ID List	ENST00000500733.6; ENST00000500817.2
External Link	RMBase: RNA-editing_site_108591

N6-methyladenosine (m6A)

In total 34 m6A sequence/site(s) in this target gene
mod ID: M6ASITE068913		Click to Show/Hide the Full List
mod site	chr5:38556978-38556979:+		[3]
Sequence	GCGACGGCTCTGCGGGGAGGACCGCGCCTCCCCGAATGCGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666175
mod ID: M6ASITE068914		Click to Show/Hide the Full List
mod site	chr5:38557017-38557018:+		[3]
Sequence	GGCCGCTGCTGCCGCTGCAAACAGTGCCTTGAGGAGAGGAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666176
mod ID: M6ASITE068915		Click to Show/Hide the Full List
mod site	chr5:38557046-38557047:+		[3]
Sequence	TGAGGAGAGGAAAGCGGGGAACCGTGTTTTCGCCGCCTCTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666177
mod ID: M6ASITE068916		Click to Show/Hide the Full List
mod site	chr5:38557087-38557088:+		[3]
Sequence	TAACCACTGCACACAAGAAAACCAGCTTCTGGGAGAGGGGG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666178
mod ID: M6ASITE068917		Click to Show/Hide the Full List
mod site	chr5:38557120-38557121:+		[3]
Sequence	AGAGGGGGATGATTGTTGGGACTTTGCGAATTACCTAAACA
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666179
mod ID: M6ASITE068918		Click to Show/Hide the Full List
mod site	chr5:38557138-38557139:+		[3]
Sequence	GGACTTTGCGAATTACCTAAACAGCCCAGGGCCGAGGCGCC
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666180
mod ID: M6ASITE068919		Click to Show/Hide the Full List
mod site	chr5:38557516-38557517:+		[3]
Sequence	AAAGTTCAGAAATGTGCCAGACAGAGCCCCTGGCACGCAGT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666185
mod ID: M6ASITE068920		Click to Show/Hide the Full List
mod site	chr5:38557541-38557542:+		[3]
Sequence	GCCCCTGGCACGCAGTCAGGACTCTACAGACACACCTTGAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666186
mod ID: M6ASITE068921		Click to Show/Hide the Full List
mod site	chr5:38557550-38557551:+		[3]
Sequence	ACGCAGTCAGGACTCTACAGACACACCTTGAGTAGGAAACA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666187
mod ID: M6ASITE068922		Click to Show/Hide the Full List
mod site	chr5:38557568-38557569:+		[3]
Sequence	AGACACACCTTGAGTAGGAAACAGGCTTGTTTGTTTCATCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666188
mod ID: M6ASITE068923		Click to Show/Hide the Full List
mod site	chr5:38557636-38557637:+		[3]
Sequence	GGCCAACGTGTTTTTTAAAGACCTTTCGATGAAACTCCAAA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666189
mod ID: M6ASITE068924		Click to Show/Hide the Full List
mod site	chr5:38557649-38557650:+		[3]
Sequence	TTTAAAGACCTTTCGATGAAACTCCAAAGCAATTTATAAAT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666190
mod ID: M6ASITE068925		Click to Show/Hide the Full List
mod site	chr5:38557738-38557739:+		[4]
Sequence	GTAATTAAATGGGCAACAAAACACCTGAAAGGACATTTACT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HeLa; hESC-HEK293T; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666191
mod ID: M6ASITE068926		Click to Show/Hide the Full List
mod site	chr5:38557750-38557751:+		[4]
Sequence	GCAACAAAACACCTGAAAGGACATTTACTGAAAAGTAGACT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; HeLa; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666192
mod ID: M6ASITE068927		Click to Show/Hide the Full List
mod site	chr5:38557768-38557769:+		[4]
Sequence	GGACATTTACTGAAAAGTAGACTCCCAAAACAAAAATATGT
Motif Score	3.319380952
Cell/Tissue List	HEK293T; HeLa; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666193
mod ID: M6ASITE068928		Click to Show/Hide the Full List
mod site	chr5:38557777-38557778:+		[3]
Sequence	CTGAAAAGTAGACTCCCAAAACAAAAATATGTATTTCACAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666194
mod ID: M6ASITE068929		Click to Show/Hide the Full List
mod site	chr5:38557856-38557857:+		[3]
Sequence	CATCCATGTGCGTATTTTGAACACTAAAAACGCCTCCTGTT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666195
mod ID: M6ASITE068930		Click to Show/Hide the Full List
mod site	chr5:38557886-38557887:+		[3]
Sequence	CGCCTCCTGTTACCCCTAAGACCTTGTTTGGATAACATTTT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666196
mod ID: M6ASITE068931		Click to Show/Hide the Full List
mod site	chr5:38557926-38557927:+		[3]
Sequence	TTCTATTATAAGTACTCGAAACCAACCCCATTTAAGATGTT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666197
mod ID: M6ASITE068932		Click to Show/Hide the Full List
mod site	chr5:38558599-38558600:+		[3]
Sequence	TTCTCACACTGCTATAAAGAACTGCGCGAGACTGGGTAATT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666198
mod ID: M6ASITE068933		Click to Show/Hide the Full List
mod site	chr5:38558609-38558610:+		[3]
Sequence	GCTATAAAGAACTGCGCGAGACTGGGTAATTTATAAAGGAA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666199
mod ID: M6ASITE068934		Click to Show/Hide the Full List
mod site	chr5:38558669-38558670:+		[3]
Sequence	AGTTCCACATGGCTGGGGAGACCTCAGGAAACTTAACAATC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; U2OS; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666200
mod ID: M6ASITE068935		Click to Show/Hide the Full List
mod site	chr5:38558679-38558680:+		[3]
Sequence	GGCTGGGGAGACCTCAGGAAACTTAACAATCGTGGTGGAAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; U2OS; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666201
mod ID: M6ASITE068936		Click to Show/Hide the Full List
mod site	chr5:38558752-38558753:+		[3]
Sequence	AAAGAATTGTGAGCGGAGGAACTTGCCAAACACAAAACCGT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; U2OS; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666202
mod ID: M6ASITE068937		Click to Show/Hide the Full List
mod site	chr5:38558761-38558762:+		[3]
Sequence	TGAGCGGAGGAACTTGCCAAACACAAAACCGTCAGATCGCG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; U2OS; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666203
mod ID: M6ASITE068938		Click to Show/Hide the Full List
mod site	chr5:38558768-38558769:+		[3]
Sequence	AGGAACTTGCCAAACACAAAACCGTCAGATCGCGTGAGAAT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; U2OS; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666204
mod ID: M6ASITE068939		Click to Show/Hide the Full List
mod site	chr5:38558807-38558808:+		[3]
Sequence	ATTCAGTTACTATCACGAGAACAACACGGGAAAACTGTCCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666205
mod ID: M6ASITE068940		Click to Show/Hide the Full List
mod site	chr5:38558820-38558821:+		[3]
Sequence	CACGAGAACAACACGGGAAAACTGTCCCCATAATCAAGTCA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6
External Link	RMBase: m6A_site_666206
mod ID: M6ASITE068941		Click to Show/Hide the Full List
mod site	chr5:38558893-38558894:+		[3]
Sequence	AAGATGAGGTTTGGGTAGGAACACAAAGCCTGACCCTATCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6; ENST00000500817.2
External Link	RMBase: m6A_site_666207
mod ID: M6ASITE068942		Click to Show/Hide the Full List
mod site	chr5:38558989-38558990:+		[3]
Sequence	GAAAGTCCTAGTGGAAAGAGACCTCAGTCTCAGCTAATTGT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6; ENST00000500817.2; ENST00000514291.1
External Link	RMBase: m6A_site_666208
mod ID: M6ASITE068943		Click to Show/Hide the Full List
mod site	chr5:38559045-38559046:+		[3]
Sequence	CTTTTGCAAATTGTACATAAACATATGACCAGGTGAATGTA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500733.6; ENST00000500817.2; ENST00000514291.1
External Link	RMBase: m6A_site_666209
mod ID: M6ASITE068944		Click to Show/Hide the Full List
mod site	chr5:38559147-38559148:+		[5]
Sequence	CTGTGTGAGCTTCACAGAAGACCTGCCTTCCATGTATACCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000500817.2; ENST00000514291.1; ENST00000500733.6
External Link	RMBase: m6A_site_666210
mod ID: M6ASITE068945		Click to Show/Hide the Full List
mod site	chr5:38595026-38595027:+		[3]
Sequence	GAGACTGAAGACTGAGGAAGACCATCTCTGTAGGATGCCAA
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000500733.6; ENST00000500817.2
External Link	RMBase: m6A_site_666212
mod ID: M6ASITE068946		Click to Show/Hide the Full List
mod site	chr5:38607631-38607632:+		[3]
Sequence	TCTTGCACAAGAGGAGTGGAACAGCGGTCAGAGCATTACAG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000500817.2; ENST00000500733.6
External Link	RMBase: m6A_site_666215

Ref 1	M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling. Cell Cycle. 2021 Dec;20(23):2507-2518. doi: 10.1080/15384101.2021.1991122. Epub 2021 Oct 17.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 5	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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