m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00084)

Target Name	UBA6 divergent transcript (UBA6-DT/UBA6-AS1)
Synonyms	UBA6-DT; UBA6-AS1; UBA6 antisense RNA 1 (head to head); LOC550112 Click to Show/Hide
Gene Name	UBA6-DT
Chromosomal Location	4q13.2
Family	Divergent transcripts
Gene ID	550112
HGNC ID	HGNC:49083

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

UBA6-DT can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

RNA-binding motif protein 15 (RBM15) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by RBM15*
Cell Line	Human BJ Fibroblast	Homo sapiens
Treatment: siRBM15 BJ fibroblast Control: siControl BJ fibroblast		GSE154148
Regulation		logFC: -3.20E+00 p-value: 2.22E-06
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	IGF2BP1 was identified as the m6A reader protein of UBA6 divergent transcript (UBA6-DT/UBA6-AS1)-RBM15-mediated m6A modification of UBA6 mRNA, which enhanced the stability of UBA6 mRNA. UBA6-AS1 suppressed the proliferation, migration and invasion of OC cells via UBA6.
Target Regulation	Up regulation
Responsed Disease	Ovarian cancer		ICD-11: 2C73	Disease Info
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
In-vitro Model	OVCAR-3	Ovarian serous adenocarcinoma	Homo sapiens	CVCL_0465

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	IGF2BP1 was identified as the m6A reader protein of UBA6 divergent transcript (UBA6-DT/UBA6-AS1)-RBM15-mediated m6A modification of UBA6 mRNA, which enhanced the stability of UBA6 mRNA. UBA6-AS1 suppressed the proliferation, migration and invasion of OC cells via UBA6.
Target Regulation	Up regulation
Responsed Disease	Ovarian cancer		ICD-11: 2C73	Disease Info
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
In-vitro Model	OVCAR-3	Ovarian serous adenocarcinoma	Homo sapiens	CVCL_0465

Ovarian cancer [ICD-11: 2C73]

Disease Info

In total 3 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[]
Response Summary	In ovarian cancer, a prognostic signature containing four LI-m6As (AC010894.3, ACAP2-IT1, CACNA1G-AS1, and UBA6 divergent transcript (UBA6-DT/UBA6-AS1)) was constructed according to the LASSO Cox regression analysis of the 10 LI-m6As.
Responsed Disease	Ovarian cancer [ICD-11: 2C73]
Experiment 2 Reporting the m6A-centered Disease Response				[1]
Response Summary	IGF2BP1 was identified as the m6A reader protein of UBA6 divergent transcript (UBA6-DT/UBA6-AS1)-RBM15-mediated m6A modification of UBA6 mRNA, which enhanced the stability of UBA6 mRNA. UBA6-AS1 suppressed the proliferation, migration and invasion of OC cells via UBA6.
Responsed Disease	Ovarian cancer [ICD-11: 2C73]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)		READER	Regulator Info
Target Regulation	Up regulation
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
In-vitro Model	OVCAR-3	Ovarian serous adenocarcinoma	Homo sapiens	CVCL_0465
Experiment 3 Reporting the m6A-centered Disease Response				[1]
Response Summary	IGF2BP1 was identified as the m6A reader protein of UBA6 divergent transcript (UBA6-DT/UBA6-AS1)-RBM15-mediated m6A modification of UBA6 mRNA, which enhanced the stability of UBA6 mRNA. UBA6-AS1 suppressed the proliferation, migration and invasion of OC cells via UBA6.
Responsed Disease	Ovarian cancer [ICD-11: 2C73]
Target Regulator	RNA-binding motif protein 15 (RBM15)		WRITER	Regulator Info
Target Regulation	Up regulation
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
In-vitro Model	OVCAR-3	Ovarian serous adenocarcinoma	Homo sapiens	CVCL_0465

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: RNA-binding motif protein 15 (RBM15)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05591		Crosstalk Info
Epigenetic Regulator	UBA6 divergent transcript (UBA6-DT/UBA6-AS1)
Regulated Target	Ubiquitin-like modifier-activating enzyme 6 (UBA6)
Crosstalk relationship	m6A → ncRNA
Disease	Ovarian cancer	Disease Info

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05592		Crosstalk Info
Epigenetic Regulator	UBA6 divergent transcript (UBA6-DT/UBA6-AS1)
Regulated Target	Ubiquitin-like modifier-activating enzyme 6 (UBA6)
Crosstalk relationship	m6A → ncRNA
Disease	Ovarian cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00084)

UBA6 divergent transcript (UBA6-DT/UBA6-AS1)

Adenosine-to-Inosine editing (A-to-I)

In total 20 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000399		Click to Show/Hide the Full List
mod site	chr4:67743008-67743009:+		[2]
Sequence	GCTGCCCAGGCTGGAGTGCAATGGTACAATCTTGGCTCACT
Transcript ID List	ENST00000502758.1; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105034
mod ID: A2ISITE000400		Click to Show/Hide the Full List
mod site	chr4:67743015-67743016:+		[2]
Sequence	AGGCTGGAGTGCAATGGTACAATCTTGGCTCACTGCAGCCT
Transcript ID List	ENST00000500538.6; ENST00000502758.1
External Link	RMBase: RNA-editing_site_105035
mod ID: A2ISITE000401		Click to Show/Hide the Full List
mod site	chr4:67743051-67743052:+		[2]
Sequence	AGCCTTTGCCTCCTGGGTTCAAGTGATTCTCTTGCCTCAGC
Transcript ID List	ENST00000502758.1; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105036
mod ID: A2ISITE000402		Click to Show/Hide the Full List
mod site	chr4:67743052-67743053:+		[2]
Sequence	GCCTTTGCCTCCTGGGTTCAAGTGATTCTCTTGCCTCAGCC
Transcript ID List	ENST00000500538.6; ENST00000502758.1
External Link	RMBase: RNA-editing_site_105037
mod ID: A2ISITE000403		Click to Show/Hide the Full List
mod site	chr4:67743081-67743082:+		[2]
Sequence	CTTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCATGTG
Transcript ID List	ENST00000500538.6; ENST00000502758.1
External Link	RMBase: RNA-editing_site_105038
mod ID: A2ISITE000404		Click to Show/Hide the Full List
mod site	chr4:67743091-67743092:+		[2]
Sequence	CCTCCTGAGTAGCTGGGACTACAGGCATGTGCCACCACACC
Transcript ID List	ENST00000500538.6; ENST00000502758.1
External Link	RMBase: RNA-editing_site_105039
mod ID: A2ISITE000405		Click to Show/Hide the Full List
mod site	chr4:67743104-67743105:+		[2]
Sequence	TGGGACTACAGGCATGTGCCACCACACCCGGCTAATTTTTG
Transcript ID List	ENST00000502758.1; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105040
mod ID: A2ISITE000406		Click to Show/Hide the Full List
mod site	chr4:67743126-67743127:+		[2]
Sequence	CACACCCGGCTAATTTTTGTATTTTTGGTAGAGACAGGTTT
Transcript ID List	ENST00000502758.1; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105041
mod ID: A2ISITE000407		Click to Show/Hide the Full List
mod site	chr4:67743135-67743136:+		[2]
Sequence	CTAATTTTTGTATTTTTGGTAGAGACAGGTTTCATCGTCTT
Transcript ID List	ENST00000502758.1; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105042
mod ID: A2ISITE000408		Click to Show/Hide the Full List
mod site	chr4:67779222-67779223:+		[3]
Sequence	GGTCAAAAGAAATTTAATTCAGTAATGAAGCAAACTTTAAC
Transcript ID List	ENST00000502758.1; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105043
mod ID: A2ISITE000409		Click to Show/Hide the Full List
mod site	chr4:67787930-67787931:+		[4]
Sequence	TACTTGAGGTCAAGAGTTCAAAGCCAGCATGGCCAACATGG
Transcript ID List	rmsk_1336573; ENST00000500538.6; ENST00000502758.1
External Link	RMBase: RNA-editing_site_105044
mod ID: A2ISITE000410		Click to Show/Hide the Full List
mod site	chr4:67793901-67793902:+		[4]
Sequence	GAAGCTGAGGCAGGAGAATCACTTGAACCTGGGAGACAGAG
Transcript ID List	rmsk_1336587; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105045
mod ID: A2ISITE000411		Click to Show/Hide the Full List
mod site	chr4:67805599-67805600:+		[2]
Sequence	GAAATAATACTCTAAAGGCCAGGCACAGTGGCTCATGCCTG
Transcript ID List	rmsk_1336612; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105046
mod ID: A2ISITE000412		Click to Show/Hide the Full List
mod site	chr4:67805605-67805606:+		[2]
Sequence	ATACTCTAAAGGCCAGGCACAGTGGCTCATGCCTGTAATCC
Transcript ID List	ENST00000500538.6; rmsk_1336612
External Link	RMBase: RNA-editing_site_105047
mod ID: A2ISITE000413		Click to Show/Hide the Full List
mod site	chr4:67805733-67805734:+		[2]
Sequence	CTACTAGAAATACAAAAATTAGCTGGGCGTTGTGGTGGGTG
Transcript ID List	rmsk_1336612; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105048
mod ID: A2ISITE000414		Click to Show/Hide the Full List
mod site	chr4:67805800-67805801:+		[2]
Sequence	CGGGGCAGGAGAATCACTTGAACCCGGGAGGGGGAAGTTGC
Transcript ID List	rmsk_1336612; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105049
mod ID: A2ISITE000415		Click to Show/Hide the Full List
mod site	chr4:67805801-67805802:+		[2]
Sequence	GGGGCAGGAGAATCACTTGAACCCGGGAGGGGGAAGTTGCA
Transcript ID List	rmsk_1336612; ENST00000500538.6
External Link	RMBase: RNA-editing_site_105050
mod ID: A2ISITE000416		Click to Show/Hide the Full List
mod site	chr4:67806293-67806294:+		[2]
Sequence	TATATGCATTATTTCACTACATATGAAATGTATATACTCTT
Transcript ID List	ENST00000500538.6
External Link	RMBase: RNA-editing_site_105051
mod ID: A2ISITE000417		Click to Show/Hide the Full List
mod site	chr4:67807243-67807244:+		[2]
Sequence	TTGATATAAGCTTAAAAAGAAGCAGCTTTTAAAGATCATAT
Transcript ID List	ENST00000500538.6
External Link	RMBase: RNA-editing_site_105052
mod ID: A2ISITE000418		Click to Show/Hide the Full List
mod site	chr4:68048953-68048954:+		[3]
Sequence	GGAGTTTTGCCCTGTTGGCCAGGCTCATCTCGAACTTCTGA
Transcript ID List	ENST00000500538.6
External Link	RMBase: RNA-editing_site_105053

N6-methyladenosine (m6A)

In total 64 m6A sequence/site(s) in this target gene
mod ID: M6ASITE066022		Click to Show/Hide the Full List
mod site	chr4:67701373-67701374:+		[5]
Sequence	ATCCGGCAGATGTAGATGGAACCAAAGTCCAGAAGTTACGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; U2OS; Huh7; HEK293A-TOA; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000498917.2; ENST00000506606.1; ENST00000500538.6
External Link	RMBase: m6A_site_639322
mod ID: M6ASITE066023		Click to Show/Hide the Full List
mod site	chr4:67701416-67701417:+		[5]
Sequence	CACCCTTGCTCTACAGCCAAACATGCAGGACTCTAGTAACC
Motif Score	2.20572619
Cell/Tissue List	HeLa; U2OS; Huh7; HEK293A-TOA; MSC; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000506606.1; ENST00000500538.6; ENST00000514109.1; ENST00000498917.2
External Link	RMBase: m6A_site_639323
mod ID: M6ASITE066024		Click to Show/Hide the Full List
mod site	chr4:67701425-67701426:+		[5]
Sequence	TCTACAGCCAAACATGCAGGACTCTAGTAACCCGCGAAATG
Motif Score	4.065041667
Cell/Tissue List	HeLa; U2OS; Huh7; HEK293A-TOA; MSC; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000498917.2; ENST00000514109.1; ENST00000506606.1; ENST00000500538.6
External Link	RMBase: m6A_site_639324
mod ID: M6ASITE066025		Click to Show/Hide the Full List
mod site	chr4:67720477-67720478:+		[5]
Sequence	TCGAGTTCATTGTCTCCTAAACCTTGCCATGGAGGCCTGTG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; U2OS; GM12878; Huh7; HEK293A-TOA; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500538.6; ENST00000498917.2; ENST00000506606.1; ENST00000514109.1
External Link	RMBase: m6A_site_639328
mod ID: M6ASITE066026		Click to Show/Hide the Full List
mod site	chr4:67720550-67720551:+		[5]
Sequence	TTCCATGAGCTACAAGCTGGACCCACTGCAGTCCTCCTGAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; GM12878; Huh7; HEK293A-TOA; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000506606.1; ENST00000514109.1; ENST00000498917.2; ENST00000500538.6
External Link	RMBase: m6A_site_639329
mod ID: M6ASITE066027		Click to Show/Hide the Full List
mod site	chr4:67720719-67720720:+		[6]
Sequence	CAGATGGGCAGCTTCGAATGACAGGAGCAAGGCACAAGAGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000498917.2; ENST00000506606.1; ENST00000500538.6; ENST00000514109.1
External Link	RMBase: m6A_site_639332
mod ID: M6ASITE066028		Click to Show/Hide the Full List
mod site	chr4:67720789-67720790:+		[5]
Sequence	CTATAAGATCAACTTTAGAAACATTTGGGGGTTGACAAATT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List	ENST00000498917.2; ENST00000500538.6; ENST00000514109.1; ENST00000506606.1
External Link	RMBase: m6A_site_639333
mod ID: M6ASITE066029		Click to Show/Hide the Full List
mod site	chr4:67720864-67720865:+		[6]
Sequence	ACCACCGGCTTCTCATCAGCACATGATTGGTGCAGGGTTCT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000500538.6; ENST00000498917.2; ENST00000506606.1; ENST00000514109.1
External Link	RMBase: m6A_site_639334
mod ID: M6ASITE066030		Click to Show/Hide the Full List
mod site	chr4:67720973-67720974:+		[5]
Sequence	TCGTGGAGAGATTTCTGAAGACACTCCTGAGCTCCCAACAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000506606.1; ENST00000500538.6; ENST00000498917.2; ENST00000514109.1
External Link	RMBase: m6A_site_639338
mod ID: M6ASITE066031		Click to Show/Hide the Full List
mod site	chr4:67721094-67721095:+		[7]
Sequence	TTCTCCTTTTGCCACCGTAAACCAACTTTTGCTTACAGTTA
Motif Score	2.185083333
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000500538.6; ENST00000498917.2; ENST00000506606.1
External Link	RMBase: m6A_site_639340
mod ID: M6ASITE066032		Click to Show/Hide the Full List
mod site	chr4:67721108-67721109:+		[8]
Sequence	CCGTAAACCAACTTTTGCTTACAGTTAGACACCAGTTTTCG
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000500538.6; ENST00000498917.2; ENST00000506606.1
External Link	RMBase: m6A_site_639341
mod ID: M6ASITE066033		Click to Show/Hide the Full List
mod site	chr4:67721116-67721117:+		[9]
Sequence	CAACTTTTGCTTACAGTTAGACACCAGTTTTCGGCAGATGA
Motif Score	2.897386905
Cell/Tissue List	HEK293T; hESCs; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000498917.2; ENST00000500538.6; ENST00000506606.1
External Link	RMBase: m6A_site_639342
mod ID: M6ASITE066034		Click to Show/Hide the Full List
mod site	chr4:67721193-67721194:+		[9]
Sequence	GCTCAGCAACAATAGGATAAACTTATGAAAAGAAAGGAGTA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; hESCs; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000506606.1; ENST00000500538.6; ENST00000498917.2
External Link	RMBase: m6A_site_639344
mod ID: M6ASITE066035		Click to Show/Hide the Full List
mod site	chr4:67721226-67721227:+		[9]
Sequence	AAGGAGTAGCAGTCCCACAGACAAAGCATCCAGCCCCTGCA
Motif Score	2.897386905
Cell/Tissue List	HEK293T; HEK293A-TOA; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000506606.1; ENST00000500538.6; ENST00000498917.2
External Link	RMBase: m6A_site_639346
mod ID: M6ASITE066036		Click to Show/Hide the Full List
mod site	chr4:67721252-67721253:+		[9]
Sequence	CATCCAGCCCCTGCACTGAGACAGTATAGGGAAGGGACTTG
Motif Score	2.897386905
Cell/Tissue List	HEK293T; HEK293A-TOA; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000498917.2; ENST00000500538.6; ENST00000506606.1; rmsk_1336454
External Link	RMBase: m6A_site_639347
mod ID: M6ASITE066037		Click to Show/Hide the Full List
mod site	chr4:67721268-67721269:+		[9]
Sequence	TGAGACAGTATAGGGAAGGGACTTGGTCCTGGCAGACAGGA
Motif Score	4.065041667
Cell/Tissue List	HEK293T; HEK293A-TOA; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000506606.1; ENST00000500538.6; rmsk_1336454; ENST00000498917.2
External Link	RMBase: m6A_site_639348
mod ID: M6ASITE066038		Click to Show/Hide the Full List
mod site	chr4:67721283-67721284:+		[9]
Sequence	AAGGGACTTGGTCCTGGCAGACAGGACAGATAATCAACATC
Motif Score	2.897386905
Cell/Tissue List	HEK293T; HEK293A-TOA; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000498917.2; rmsk_1336454; ENST00000500538.6; ENST00000506606.1
External Link	RMBase: m6A_site_639349
mod ID: M6ASITE066039		Click to Show/Hide the Full List
mod site	chr4:67721288-67721289:+		[7]
Sequence	ACTTGGTCCTGGCAGACAGGACAGATAATCAACATCCTAGT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; HEK293A-TOA; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000506606.1; ENST00000500538.6; ENST00000498917.2; rmsk_1336454
External Link	RMBase: m6A_site_639350
mod ID: M6ASITE066040		Click to Show/Hide the Full List
mod site	chr4:67721438-67721439:+		[5]
Sequence	GCTGGATTCCTAATCATAAAACCAAAAAAGGAAGAACCTAA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336454; ENST00000500538.6; ENST00000506606.1; ENST00000498917.2
External Link	RMBase: m6A_site_639351
mod ID: M6ASITE066041		Click to Show/Hide the Full List
mod site	chr4:67721453-67721454:+		[5]
Sequence	ATAAAACCAAAAAAGGAAGAACCTAACCATTTCTCTCTTTC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336454; ENST00000506606.1; ENST00000498917.2; ENST00000500538.6
External Link	RMBase: m6A_site_639352
mod ID: M6ASITE066042		Click to Show/Hide the Full List
mod site	chr4:67721525-67721526:+		[5]
Sequence	TTCTGGCCTTCCTGATAAGAACATGACCAGATCCAGCTGGT
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000500538.6; ENST00000498917.2; ENST00000506606.1; rmsk_1336454
External Link	RMBase: m6A_site_639353
mod ID: M6ASITE066043		Click to Show/Hide the Full List
mod site	chr4:67721560-67721561:+		[8]
Sequence	GCTGGTTTGCAACAAGATGAACTTCAGTGCTGAGCTTTCAC
Motif Score	3.373380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq; MeRIP-seq
Transcript ID List	ENST00000498917.2; ENST00000500538.6; ENST00000506606.1; rmsk_1336454
External Link	RMBase: m6A_site_639354
mod ID: M6ASITE066044		Click to Show/Hide the Full List
mod site	chr4:67721656-67721657:+		[6]
Sequence	GGTTATCTGCCATTTTCTGTACATGTGTTACCAGAAAGGGG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000506606.1; ENST00000500538.6; rmsk_1336454; ENST00000498917.2
External Link	RMBase: m6A_site_639355
mod ID: M6ASITE066045		Click to Show/Hide the Full List
mod site	chr4:67721688-67721689:+		[10]
Sequence	AGAAAGGGGTCCTGATCCAGACCCCAAAAGAGGGTTCTTGG
Motif Score	2.876744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000498917.2; ENST00000500538.6; ENST00000506606.1
External Link	RMBase: m6A_site_639356
mod ID: M6ASITE066046		Click to Show/Hide the Full List
mod site	chr4:67721714-67721715:+		[8]
Sequence	AAAGAGGGTTCTTGGATCTCACGCAACAAAGAGTTCGGGGC
Motif Score	2.021232143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000500538.6; ENST00000498917.2; ENST00000506606.1
External Link	RMBase: m6A_site_639357
mod ID: M6ASITE066047		Click to Show/Hide the Full List
mod site	chr4:67721719-67721720:+		[6]
Sequence	GGGTTCTTGGATCTCACGCAACAAAGAGTTCGGGGCGAGTC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000498917.2; ENST00000506606.1; ENST00000500538.6
External Link	RMBase: m6A_site_639358
mod ID: M6ASITE066048		Click to Show/Hide the Full List
mod site	chr4:67722117-67722118:+		[8]
Sequence	TGGTTTTGGCCGGCTTCTTTACCACTTCTTTTTATCAGCAA
Motif Score	2.052208333
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000506606.1; ENST00000500538.6; ENST00000498917.2
External Link	RMBase: m6A_site_639359
mod ID: M6ASITE066049		Click to Show/Hide the Full List
mod site	chr4:67722165-67722166:+		[8]
Sequence	GTGACCTGTACTTAGTGCCGACTTCCTGTCTCATCCTGTGA
Motif Score	3.287565476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000506606.1; ENST00000498917.2; ENST00000500538.6
External Link	RMBase: m6A_site_639360
mod ID: M6ASITE066050		Click to Show/Hide the Full List
mod site	chr4:67722315-67722316:+		[5]
Sequence	GCCTCATGTTTGGGCATGAGACCTCACTGTGTAGGTGCAGA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000498917.2; ENST00000506606.1; ENST00000500538.6; rmsk_1336456
External Link	RMBase: m6A_site_639361
mod ID: M6ASITE066051		Click to Show/Hide the Full List
mod site	chr4:67722340-67722341:+		[5]
Sequence	ACTGTGTAGGTGCAGAGAAGACCCTGCCTAAACATTGCCTA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000506606.1; ENST00000500538.6; rmsk_1336456; ENST00000498917.2
External Link	RMBase: m6A_site_639362
mod ID: M6ASITE066052		Click to Show/Hide the Full List
mod site	chr4:67722351-67722352:+		[5]
Sequence	GCAGAGAAGACCCTGCCTAAACATTGCCTACACGTTGCTCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336456; ENST00000506606.1; ENST00000500538.6; ENST00000498917.2
External Link	RMBase: m6A_site_639363
mod ID: M6ASITE066053		Click to Show/Hide the Full List
mod site	chr4:67722427-67722428:+		[6]
Sequence	CAGAGCCCTTTTGGGAGCTAACATCAGGACTCCTTTTCTGT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	rmsk_1336456; ENST00000498917.2; ENST00000500538.6; ENST00000506606.1
External Link	RMBase: m6A_site_639364
mod ID: M6ASITE066054		Click to Show/Hide the Full List
mod site	chr4:67722435-67722436:+		[5]
Sequence	TTTTGGGAGCTAACATCAGGACTCCTTTTCTGTACTCTGCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; GM12878; Huh7; HEK293A-TOA; MSC; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336456; ENST00000506606.1; ENST00000500538.6; ENST00000498917.2
External Link	RMBase: m6A_site_639365
mod ID: M6ASITE066055		Click to Show/Hide the Full List
mod site	chr4:67722475-67722476:+		[6]
Sequence	TCCGTTGTGCTGCTAGAGCCACAAGCCTATTAAACTTTGCC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	rmsk_1336456; ENST00000498917.2; ENST00000506606.1; ENST00000500538.6
External Link	RMBase: m6A_site_639366
mod ID: M6ASITE066056		Click to Show/Hide the Full List
mod site	chr4:67722488-67722489:+		[5]
Sequence	TAGAGCCACAAGCCTATTAAACTTTGCCTGAAATAAATTCC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; A549; GM12878; Huh7; HEK293A-TOA; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336456; ENST00000506606.1; ENST00000498917.2; ENST00000500538.6
External Link	RMBase: m6A_site_639367
mod ID: M6ASITE066057		Click to Show/Hide the Full List
mod site	chr4:67728596-67728597:+
Sequence	CTTTCAGCCTGAAGCCAGGAACAATTGTTCAAAGTTTCTTT
Motif Score	2.951386905
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000500538.6
External Link	RMBase: m6A_site_639368
mod ID: M6ASITE066058		Click to Show/Hide the Full List
mod site	chr4:67728620-67728621:+
Sequence	TTGTTCAAAGTTTCTTTGGAACATCAAGGAAGGAAATCCAG
Motif Score	2.951386905
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000500538.6
External Link	RMBase: m6A_site_639369
mod ID: M6ASITE066059		Click to Show/Hide the Full List
mod site	chr4:67730086-67730087:+
Sequence	TGTGAAGATACAGCAAAAAGACAACAATCTTCAAGCCACAA
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	rmsk_1336474; ENST00000500538.6
External Link	RMBase: m6A_site_639370
mod ID: M6ASITE066060		Click to Show/Hide the Full List
mod site	chr4:67730121-67730122:+
Sequence	CCACAATGGCCCTCACCAGAACCCAGCCATGTGGTCAGCCT
Motif Score	2.930744048
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	rmsk_1336474; ENST00000500538.6
External Link	RMBase: m6A_site_639371
mod ID: M6ASITE066061		Click to Show/Hide the Full List
mod site	chr4:67730150-67730151:+
Sequence	TGTGGTCAGCCTGATCTCGGACTTCACAGCCAGCAGAACTG
Motif Score	4.065041667
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000500538.6; rmsk_1336474
External Link	RMBase: m6A_site_639372
mod ID: M6ASITE066062		Click to Show/Hide the Full List
mod site	chr4:67730167-67730168:+
Sequence	CGGACTTCACAGCCAGCAGAACTGTGAGAATTAAATCTTAT
Motif Score	3.373380952
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	rmsk_1336474; ENST00000500538.6
External Link	RMBase: m6A_site_639373
mod ID: M6ASITE066063		Click to Show/Hide the Full List
mod site	chr4:67731615-67731616:+
Sequence	TTCTTATACACCAATAACAGACAAACAGCCAAATCATGAGT
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639374
mod ID: M6ASITE066064		Click to Show/Hide the Full List
mod site	chr4:67731638-67731639:+		[7]
Sequence	AACAGCCAAATCATGAGTGAACTTCCATTCATAATTGCACA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639375
mod ID: M6ASITE066065		Click to Show/Hide the Full List
mod site	chr4:67731705-67731706:+		[7]
Sequence	GCTTACAAGGGATGTGAAGGACCTCTTCAAGGAGAACTACA
Motif Score	3.622404762
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639376
mod ID: M6ASITE066066		Click to Show/Hide the Full List
mod site	chr4:67731720-67731721:+		[7]
Sequence	GAAGGACCTCTTCAAGGAGAACTACAAACCACTGCTCAATG
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639377
mod ID: M6ASITE066067		Click to Show/Hide the Full List
mod site	chr4:67731727-67731728:+		[7]
Sequence	CTCTTCAAGGAGAACTACAAACCACTGCTCAATGAAATAAA
Motif Score	2.185083333
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639378
mod ID: M6ASITE066068		Click to Show/Hide the Full List
mod site	chr4:67731753-67731754:+		[7]
Sequence	GCTCAATGAAATAAAAGGGGACACAAACAAATGGAAGAACA
Motif Score	3.643047619
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639379
mod ID: M6ASITE066069		Click to Show/Hide the Full List
mod site	chr4:67731759-67731760:+		[7]
Sequence	TGAAATAAAAGGGGACACAAACAAATGGAAGAACATTCCAT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000500538.6; rmsk_1336476
External Link	RMBase: m6A_site_639380
mod ID: M6ASITE066070		Click to Show/Hide the Full List
mod site	chr4:67731771-67731772:+		[7]
Sequence	GGACACAAACAAATGGAAGAACATTCCATGCTCATGGTTAG
Motif Score	2.951386905
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639381
mod ID: M6ASITE066071		Click to Show/Hide the Full List
mod site	chr4:67731896-67731897:+		[7]
Sequence	TCTTCACAGAATTGGAAGAAACTACGTTAAAGTTCATATGG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000500538.6; rmsk_1336476
External Link	RMBase: m6A_site_639382
mod ID: M6ASITE066072		Click to Show/Hide the Full List
mod site	chr4:67731918-67731919:+		[5]
Sequence	TACGTTAAAGTTCATATGGAACCAGAAAAGAGCCTGCACTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639383
mod ID: M6ASITE066073		Click to Show/Hide the Full List
mod site	chr4:67731944-67731945:+		[5]
Sequence	AAAGAGCCTGCACTGCCAAGACAACCCTAAGCAAAAAGAAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500538.6; rmsk_1336476
External Link	RMBase: m6A_site_639384
mod ID: M6ASITE066074		Click to Show/Hide the Full List
mod site	chr4:67731963-67731964:+		[5]
Sequence	GACAACCCTAAGCAAAAAGAACAAAGCTGGAGGCATCATGC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500538.6; rmsk_1336476
External Link	RMBase: m6A_site_639385
mod ID: M6ASITE066075		Click to Show/Hide the Full List
mod site	chr4:67731997-67731998:+		[5]
Sequence	ATCATGCCACCTGACTTCAAACTATACTACAAGGCTACAGT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639386
mod ID: M6ASITE066076		Click to Show/Hide the Full List
mod site	chr4:67732047-67732048:+		[5]
Sequence	AGCATGGTACTGGTACCAAAACAGAGATATAGACCAACGGA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000500538.6; rmsk_1336476
External Link	RMBase: m6A_site_639387
mod ID: M6ASITE066077		Click to Show/Hide the Full List
mod site	chr4:67732059-67732060:+		[5]
Sequence	GTACCAAAACAGAGATATAGACCAACGGAACAGAACAGAGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639388
mod ID: M6ASITE066078		Click to Show/Hide the Full List
mod site	chr4:67732068-67732069:+		[5]
Sequence	CAGAGATATAGACCAACGGAACAGAACAGAGGCCTCAGAAA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639389
mod ID: M6ASITE066079		Click to Show/Hide the Full List
mod site	chr4:67732073-67732074:+		[5]
Sequence	ATATAGACCAACGGAACAGAACAGAGGCCTCAGAAATAACA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1336476; ENST00000500538.6
External Link	RMBase: m6A_site_639390
mod ID: M6ASITE066080		Click to Show/Hide the Full List
mod site	chr4:67732315-67732316:+		[10]
Sequence	AGCTCCTTGCAGAGGAATGAACAATTGTTTGAACATTAATG
Motif Score	2.951386905
Cell/Tissue List	HEK293T; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000502758.1; ENST00000500538.6
External Link	RMBase: m6A_site_639391
mod ID: M6ASITE066081		Click to Show/Hide the Full List
mod site	chr4:67732327-67732328:+		[10]
Sequence	AGGAATGAACAATTGTTTGAACATTAATGAATATTAAAGTA
Motif Score	2.951386905
Cell/Tissue List	HEK293T; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000500538.6; ENST00000502758.1
External Link	RMBase: m6A_site_639392
mod ID: M6ASITE066082		Click to Show/Hide the Full List
mod site	chr4:67751690-67751691:+		[10]
Sequence	TTATTTATAGCTTCTAGGAGACTTCTTCTAAGAAGAATCAA
Motif Score	3.319380952
Cell/Tissue List	HEK293T; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000500538.6; ENST00000502758.1
External Link	RMBase: m6A_site_639393
mod ID: M6ASITE066083		Click to Show/Hide the Full List
mod site	chr4:68038713-68038714:+		[5]
Sequence	ATCTTTGACTCTTTTGCCAAACTGAAAGCCGCCATTGCAGA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000500538.6; ENST00000509133.1
External Link	RMBase: m6A_site_639394
mod ID: M6ASITE066084		Click to Show/Hide the Full List
mod site	chr4:68038761-68038762:+		[5]
Sequence	GAAGTTAGAAGAAAAAATGAACTGTTTCACCCTGTTAGTTT
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000500538.6; ENST00000509133.1
External Link	RMBase: m6A_site_639395
mod ID: M6ASITE066085		Click to Show/Hide the Full List
mod site	chr4:68038784-68038785:+		[5]
Sequence	GTTTCACCCTGTTAGTTTAGACTGTAAGCTAAGGCAAAAAG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000509133.1; ENST00000500538.6
External Link	RMBase: m6A_site_639396

Ref 1	Long noncoding RNA UBA6-AS1 inhibits the malignancy of ovarian cancer cells via suppressing the decay of UBA6 mRNA. Bioengineered. 2022 Jan;13(1):178-189. doi: 10.1080/21655979.2021.2011640.
Ref 2	Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 2004 Sep;14(9):1719-25. doi: 10.1101/gr.2855504.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.
Ref 8	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 9	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 10	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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