m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00076)
Target Name Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1)
Synonyms
SEPTIN14P20; SEPT14P20LINC00266-1C20orf69NCRNA00266NCRNA00266-1; long intergenic non-protein coding RNA 266-1; chromosome 20 open reading frame 69; non-protein coding RNA 266; non-protein coding RNA 266-1; bA476I15.3; RBRP; RNA-binding regulatory peptide
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Gene Name SEPTIN14P20
Chromosomal Location 20q13.33
Gene ID 107126285
HGNC ID
HGNC:51706
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SEPTIN14P20 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The oncopeptide RBRP encoded by Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1) is a regulatory subunit of m6A readers and strengthens m6A recognition on the target RNAs by the m6A reader to exert its oncogenic functions. RBRP binds to IGF2BP1 and strengthens m6A recognition by IGF2BP1 on RNAs, such as c-Myc mRNA, to increase the mRNA stability and expression of c-Myc, thereby promoting tumorigenesis.
Target Regulation Up regulation
Pathway Response RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model HCT 116 Colon carcinoma Homo sapiens CVCL_0291
HEK293T Normal Homo sapiens CVCL_0063
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
MBA-MD-231 (Human breast cancer cell)
OVCAR-3 Ovarian serous adenocarcinoma Homo sapiens CVCL_0465
SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens CVCL_0532
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
SW620 Colon adenocarcinoma Homo sapiens CVCL_0547
In-vivo Model 1 × 106 HCT-116-Luc-LINC00266-1-ORF-Flag, HCT-116-Luc- LINC00266-1-5'U, or HCT-116-Luc-LINC00266-1-MT cells were subcutaneously injected into the dorsal flanks of each BALB/c nude mouse (n = 6).
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05429
 Crosstalk Info 
Epigenetic Regulator Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1)
Regulated Target Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1)
Crosstalk relationship m6A → ncRNA
References
Ref 1 An oncopeptide regulates m(6)A recognition by the m(6)A reader IGF2BP1 and tumorigenesis. Nat Commun. 2020 Apr 3;11(1):1685. doi: 10.1038/s41467-020-15403-9.