m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05429
 [1]
m6A modification SEPTIN14P20 SEPTIN14P20 IGF2BP1 : m6A sites Direct Enhancement Non-coding RNA LINC00266-1 SEPTIN14P20  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) READER
 Regulator Info 
m6A Target Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1) LncRNA View Details
Regulated Target Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1) View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary The oncopeptide Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1) encoded by Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1) is a regulatory subunit of m6A readers and strengthens m6A recognition on the target RNAs by the m6A reader to exert its oncogenic functions. RBRP binds to IGF2BP1 and strengthens m6A recognition by IGF2BP1 on RNAs, such as c-Myc mRNA, to increase the mRNA stability and expression of c-Myc, thereby promoting tumorigenesis.
Pathway Response RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model
 SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
SW620 Colon adenocarcinoma Homo sapiens CVCL_0547
HCT 116 Colon carcinoma Homo sapiens CVCL_0291
MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens CVCL_0532
OVCAR-3 Ovarian serous adenocarcinoma Homo sapiens CVCL_0465
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model 1 × 106 HCT-116-Luc-LINC00266-1-ORF-Flag, HCT-116-Luc- LINC00266-1-5'U, or HCT-116-Luc-LINC00266-1-MT cells were subcutaneously injected into the dorsal flanks of each BALB/c nude mouse (n = 6).
References
Ref 1 An oncopeptide regulates m(6)A recognition by the m(6)A reader IGF2BP1 and tumorigenesis. Nat Commun. 2020 Apr 3;11(1):1685. doi: 10.1038/s41467-020-15403-9.