m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00075)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
THORLNC
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Methyltransferase-like 3 (METTL3) [WRITER]
| Representative RNA-seq result indicating the expression of this target gene regulated by METTL3 | ||
| Cell Line | Caco-2 cell line | Homo sapiens |
|
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
|
GSE167075 | |
| Regulation |
  |
logFC: -1.63E+00 p-value: 1.51E-02 |
| More Results | Click to View More RNA-seq Results | |
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | The significantly reduced gene expression of the lncRNA THOR and the decreased m6A level on the lncRNA THOR in the METTL3stop/stop cells were determined by qRT-PCR and methylated RNA immunoprecipitation (MeRIP) assay. RIP-qRT-PCR and RNA pull-down assay results revealed that the specific m6A readers YTHDF1 and YTHDF2 can read the m6A motifs and regulate the stability of the lncRNA THOR (stabilization and decay). | |||
| Target Regulation | Up regulation | |||
| Pathway Response | RNA degradation | hsa03018 | ||
| Cell Process | RNA stability | |||
| In-vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 |
| In-vivo Model | 2 × 106 cells were suspended in 200 uL of serum-free RPMI 1640 for injection into each mouse. | |||
YTH domain-containing family protein 1 (YTHDF1) [READER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | The significantly reduced gene expression of the lncRNA THOR and the decreased m6A level on the lncRNA THOR in the METTL3stop/stop cells were determined by qRT-PCR and methylated RNA immunoprecipitation (MeRIP) assay. RIP-qRT-PCR and RNA pull-down assay results revealed that the specific m6A readers YTHDF1 and YTHDF2 can read the m6A motifs and regulate the stability of the lncRNA THOR (stabilization and decay). | |||
| Target Regulation | Up regulation | |||
| Pathway Response | RNA degradation | hsa03018 | ||
| Cell Process | RNA stability | |||
| In-vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 |
| In-vivo Model | 2 × 106 cells were suspended in 200 uL of serum-free RPMI 1640 for injection into each mouse. | |||
YTH domain-containing family protein 2 (YTHDF2) [READER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | The significantly reduced gene expression of the lncRNA THOR and the decreased m6A level on the lncRNA THOR in the METTL3stop/stop cells were determined by qRT-PCR and methylated RNA immunoprecipitation (MeRIP) assay. RIP-qRT-PCR and RNA pull-down assay results revealed that the specific m6A readers YTHDF1 and YTHDF2 can read the m6A motifs and regulate the stability of the lncRNA THOR (stabilization and decay). | |||
| Target Regulation | Down regulation | |||
| Pathway Response | RNA degradation | hsa03018 | ||
| Cell Process | RNA stability | |||
| In-vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 |
| In-vivo Model | 2 × 106 cells were suspended in 200 uL of serum-free RPMI 1640 for injection into each mouse. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05441 | ||
| Epigenetic Regulator | Testis associated oncogenic lncRNA (THORLNC) | |
| Crosstalk relationship | m6A → ncRNA | |
m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05442 | ||
| Epigenetic Regulator | Testis associated oncogenic lncRNA (THORLNC) | |
| Crosstalk relationship | m6A → ncRNA | |
m6A Regulator: YTH domain-containing family protein 1 (YTHDF1)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05443 | ||
| Epigenetic Regulator | Testis associated oncogenic lncRNA (THORLNC) | |
| Crosstalk relationship | m6A → ncRNA | |
References