m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00069)
Target Name hsa_circ_0058493 (Circ_RHBDD1)
Gene Name Circ_RHBDD1
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_RHBDD1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm.
Target Regulation Up regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response Hepatocellular carcinoma hsa05225
Cell Process Cell growth and metastasis
In-vitro Model BEL-7404 Endocervical adenocarcinoma Homo sapiens CVCL_6568
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model Groups of HCT116-Luc-shCtrl, HCT116-Luc-shLINC00460, and HCT116-Luc-shLINC00460 + HMGA1 cells (5 × 106) were injected subcutaneously into the flanks of mice correspondingly.
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm.
Target Regulation Up regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response Hepatocellular carcinoma hsa05225
Cell Process Cell growth and metastasis
In-vitro Model BEL-7404 Endocervical adenocarcinoma Homo sapiens CVCL_6568
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model Groups of HCT116-Luc-shCtrl, HCT116-Luc-shLINC00460, and HCT116-Luc-shLINC00460 + HMGA1 cells (5 × 106) were injected subcutaneously into the flanks of mice correspondingly.
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [2]
Response Summary In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Hepatocellular carcinoma hsa05225
Cell Process Cell growth and metastasis
In-vitro Model BEL-7404 Endocervical adenocarcinoma Homo sapiens CVCL_6568
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model Groups of HCT116-Luc-shCtrl, HCT116-Luc-shLINC00460, and HCT116-Luc-shLINC00460 + HMGA1 cells (5 × 106) were injected subcutaneously into the flanks of mice correspondingly.
Experiment 2 Reporting the m6A-centered Disease Response [2]
Response Summary In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Hepatocellular carcinoma hsa05225
Cell Process Cell growth and metastasis
In-vitro Model BEL-7404 Endocervical adenocarcinoma Homo sapiens CVCL_6568
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
L-02 Endocervical adenocarcinoma Homo sapiens CVCL_6926
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model Groups of HCT116-Luc-shCtrl, HCT116-Luc-shLINC00460, and HCT116-Luc-shLINC00460 + HMGA1 cells (5 × 106) were injected subcutaneously into the flanks of mice correspondingly.
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: YTH domain-containing protein 1 (YTHDC1)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03486
 Crosstalk Info 
Epigenetic Regulator Histone acetyltransferase p300 (P300)
Regulated Target Histone H3 lysine 18 lactylation (H3K18la)
Crosstalk relationship Histone modification → m6A
Disease Liver cancer
 Disease Info 
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05547
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0058493 (Circ_RHBDD1)
Crosstalk relationship m6A → ncRNA
Disease Liver cancer
 Disease Info 
m6A Regulator: YTH domain-containing protein 1 (YTHDC1)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05548
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0058493 (Circ_RHBDD1)
Crosstalk relationship m6A → ncRNA
Disease Liver cancer
 Disease Info 
References
Ref 1 Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens. Mol Pharmacol. 2007 Oct;72(4):967-75.
Ref 2 Methyltransferase-Like 3-Mediated m6A Methylation of Hsa_circ_0058493 Accelerates Hepatocellular Carcinoma Progression by Binding to YTH Domain-Containing Protein 1. Front Cell Dev Biol. 2021 Nov 23;9:762588. doi: 10.3389/fcell.2021.762588. eCollection 2021.