m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00048)
Target Name S-mu-GLT (SugLT)
Gene Name S-mu-GLT
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
S-mu-GLT can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Direct suppression of m6A modification of S-mu-GLT (SugLT) or of m6A reader YTHDC1 reduces CSR. METTL3 enzyme-catalyzed N6-methyladenosine (m6A) RNA modification drives recognition and 3' end processing of S-mu-GLT by the RNA exosome, promoting class switch recombination and suppressing chromosomal translocations. Tamoxifen affects the role of METTL3 in B cell development.
Target Regulation Up regulation
Responsed Drug Tamoxifen Approved
 Drug Info 
Pathway Response Nucleotide excision repair hsa03420
Cell Process DNA repair
In-vitro Model CH12F3 Mouse lymphoma Mus musculus CVCL_E067
CH12F3 Mouse lymphoma Mus musculus CVCL_E067
HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model 6- to 12-week-old mice were used for experiments.
Tamoxifen [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary Direct suppression of m6A modification of S-mu-GLT (SugLT) or of m6A reader YTHDC1 reduces CSR. METTL3 enzyme-catalyzed N6-methyladenosine (m6A) RNA modification drives recognition and 3' end processing of S-mu-GLT by the RNA exosome, promoting class switch recombination and suppressing chromosomal translocations. Tamoxifen affects the role of METTL3 in B cell development.
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Nucleotide excision repair hsa03420
Cell Process DNA repair
In-vitro Model CH12F3 Mouse lymphoma Mus musculus CVCL_E067
CH12F3 Mouse lymphoma Mus musculus CVCL_E067
HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model 6- to 12-week-old mice were used for experiments.
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: YTH domain-containing protein 1 (YTHDC1)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05553
 Crosstalk Info 
Epigenetic Regulator S-mu-GLT (SugLT)
Crosstalk relationship m6A → ncRNA
Drug Tamoxifen*
 Drug Info 
References
Ref 1 Mechanism of noncoding RNA-associated N(6)-methyladenosine recognition by an RNA processing complex during IgH DNA recombination. Mol Cell. 2021 Oct 7;81(19):3949-3964.e7. doi: 10.1016/j.molcel.2021.07.037. Epub 2021 Aug 26.