m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00038)
| Target Name | Circ_GFR-Alpha-1 | ||||
|---|---|---|---|---|---|
| Gene Name | Circ_GFRA1 | ||||
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_GFRA1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 14 (METTL14) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | Circ_GFR-Alpha-1 promotes female germline stem cells self-renewal by acting as a ceRNA that sponges miR-449, leading to enhanced GFRalpha-1 expression and activation of the GDNF signaling pathway. circGFRalpha-1 acts as a ceRNA based on METTL14-mediated cytoplasmic export through the GGACU motif. | |||
| Responsed Disease | Female reproductive system disorders | ICD-11: SC4Y | ||
| Pathway Response | Calcium signaling pathway | hsa04020 | ||
| In-vitro Model | HEK293T | Normal | Homo sapiens | CVCL_0063 |
| FGSCs cell line (Female Germline Stem Cells) | ||||
Female reproductive system disorders [ICD-11: SC4Y]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | Circ_GFR-Alpha-1 promotes female germline stem cells self-renewal by acting as a ceRNA that sponges miR-449, leading to enhanced GFRalpha-1 expression and activation of the GDNF signaling pathway. circGFRalpha-1 acts as a ceRNA based on METTL14-mediated cytoplasmic export through the GGACU motif. | |||
| Responsed Disease | Female reproductive system disorders [ICD-11: SC4Y] | |||
| Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
| Pathway Response | Calcium signaling pathway | hsa04020 | ||
| In-vitro Model | HEK293T | Normal | Homo sapiens | CVCL_0063 |
| FGSCs cell line (Female Germline Stem Cells) | ||||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 14 (METTL14)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05491 | ||
| Epigenetic Regulator | Circ_GFR-Alpha-1 | |
| Regulated Target | MicroRNA 449a (MIR449A) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Female reproductive system disorders | |