m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05491
|
[1] | |||
m6A modification
Circ_GFRA1
Circ_GFRA1
METTL14
Methylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
circGFRAlpha-1
MIR449A
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 14 (METTL14) | WRITER | |||
| m6A Target | Circ_GFR-Alpha-1 | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Circ_GFR-Alpha-1 | circRNA | View Details | ||
| Regulated Target | MicroRNA 449a (MIR449A) | View Details | |||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | Circ_GFR-Alpha-1 promotes female germline stem cells self-renewal by acting as a ceRNA that sponges MicroRNA 449a (MIR449A), leading to enhanced GFRalpha-1 expression and activation of the GDNF signaling pathway. circGFRalpha-1 acts as a ceRNA based on METTL14-mediated cytoplasmic export through the GGACU motif. | ||||
| Responsed Disease | Female reproductive system disorders | ICD-11: SC4Y | |||
| Cell Process | Cells growth | ||||
| Cells self-renewal | |||||
In-vitro Model |
HEK293T | Normal | Homo sapiens | CVCL_0063 | |
| FGSCs cell line (Female Germline Stem Cells) | |||||