m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00033)
Target Name hsa-miR-186-5p
Gene Name hsa-miR-186-5p
miRBase ID
MIMAT0000456
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-186-5p can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Platinum can increase the overall m6A level of esophageal cancer. SNHG3/hsa-miR-186-5p, induced by platinum, was involved in regulating m6A level by targeting METTL3. miR-186-5p binds to the 3'UTR of METTL3 to inhibit its expression. Our manuscript has provided clues that regulating m6A level was a novel way to enhance the platinum efficacy.
Target Regulation Up regulation
Responsed Disease Esophageal cancer ICD-11: 2B70
 Disease Info 
Responsed Drug Pt Investigative
 Drug Info 
Cell Process Cellular Processes
Cell growth and death
Cell apoptosis
In-vitro Model Eca-9706 (Esophageal carcinoma cell line)
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
In-vivo Model Used 1 × 106 SNHG3 knocked down KY-SE150 cells and NC lentivirus to inject into the right flank of mice to generate xenografts.
Esophageal cancer [ICD-11: 2B70]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Platinum can increase the overall m6A level of esophageal cancer. SNHG3/hsa-miR-186-5p, induced by platinum, was involved in regulating m6A level by targeting METTL3. miR-186-5p binds to the 3'UTR of METTL3 to inhibit its expression. Our manuscript has provided clues that regulating m6A level was a novel way to enhance the platinum efficacy.
Responsed Disease Esophageal cancer [ICD-11: 2B70]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Drug Pt Investigative
 Drug Info 
Cell Process Cellular Processes
Cell growth and death
Cell apoptosis
In-vitro Model Eca-9706 (Esophageal carcinoma cell line)
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
In-vivo Model Used 1 × 106 SNHG3 knocked down KY-SE150 cells and NC lentivirus to inject into the right flank of mice to generate xenografts.
Pt [Investigative]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary Platinum can increase the overall m6A level of esophageal cancer. SNHG3/hsa-miR-186-5p, induced by platinum, was involved in regulating m6A level by targeting METTL3. miR-186-5p binds to the 3'UTR of METTL3 to inhibit its expression. Our manuscript has provided clues that regulating m6A level was a novel way to enhance the platinum efficacy.
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Disease Esophageal cancer ICD-11: 2B70
 Disease Info 
Cell Process Cellular Processes
Cell growth and death
Cell apoptosis
In-vitro Model Eca-9706 (Esophageal carcinoma cell line)
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
In-vivo Model Used 1 × 106 SNHG3 knocked down KY-SE150 cells and NC lentivirus to inject into the right flank of mice to generate xenografts.
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05473
 Crosstalk Info 
Epigenetic Regulator hsa-miR-186-5p
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship m6A → ncRNA
Disease Melanoma
 Disease Info 
Drug ML162
 Drug Info 
References
Ref 1 Targeting SNHG3/miR-186-5p reverses the increased m6A level caused by platinum treatment through regulating METTL3 in esophageal cancer. Cancer Cell Int. 2021 Feb 17;21(1):114. doi: 10.1186/s12935-021-01747-9.