m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0261)
| Name |
Vorinostat
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| Synonyms |
NHNPODA; SAHA; SHH; Zolinza; Merck brand of Vorinostat; OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE; SAHA cpd; Suberanilohydroxamic acid; Suberoylanilide hydroxamic acid; Vorinostat MSD; Vorinostat [USAN]; M344; MK0683; SKI390; WIN64652; MK-0683; SAHA, Suberoylanilide hydroxamic acid; SW-064652; Zolinza (TN); Vorinostat (JAN/USAN); N1-hydroxy-N8-phenyloctanediamide; Zolinza, MK-0683, SAHA; N'-hydroxy-N-phenyloctanediamide; N-Hydroxy-N'-phenyl octanediamide; N-Hyrdroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide; Vorinostat (HDAC inhibitor)
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| Structure |
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3D MOL
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| Formula |
C14H20N2O3
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| InChI |
InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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| InChIKey |
WAEXFXRVDQXREF-UHFFFAOYSA-N
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Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 4 item(s) under this drug | ||
| Crosstalk ID: M6ACROT03124 | ||
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | |
| m6A Target | Ferroptosis suppressor protein 1 (AIFM2) | |
| Epigenetic Regulator | Histone deacetylase 1 (HDAC1) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Colorectal cancer | |
| Crosstalk ID: M6ACROT03125 | ||
| m6A Regulator | RNA demethylase ALKBH5 (ALKBH5) | |
| m6A Target | Ferroptosis suppressor protein 1 (AIFM2) | |
| Epigenetic Regulator | Histone deacetylase 1 (HDAC1) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Colorectal cancer | |
| Crosstalk ID: M6ACROT03126 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) | |
| m6A Target | Ferroptosis suppressor protein 1 (AIFM2) | |
| Epigenetic Regulator | Histone deacetylase 1 (HDAC1) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Colorectal cancer | |
| Crosstalk ID: M6ACROT05850 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) | |
| m6A Target | Ferroptosis suppressor protein 1 (AIFM2) | |
| Epigenetic Regulator | Histone deacetylase 1 (HDAC1) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Colorectal cancer | |