m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0249)
| Name |
PD-0183812
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| Synonyms |
PLX4032; RG7204; RO5185426; Zelboraf (TN); Vemurafenib (BRAF inhibitor)
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| Structure |
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3D MOL
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| Formula |
C28H35N5O2
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| InChI |
1S/C28H35N5O2/c34-15-1-2-19-11-13-32(14-12-19)24-8-6-23(7-9-24)30-28-29-18-22-5-10-26(35)33(27(22)31-28)25-17-20-3-4-21(25)16-20/h5-10,18-21,25,34H,1-4,11-17H2,(H,29,30,31)
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| InChIKey |
PETCVZZPKYJZAU-UHFFFAOYSA-N
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Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 1 item(s) under this drug | ||
| Crosstalk ID: M6ACROT00203 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Interferon-inducible protein 4 (ADAR1) | |
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | G1/S-specific cyclin-E1 (CCNE1) | |
| Crosstalk relationship | m6A → A-to-I | |