m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0184)
| Name |
Azacitidine
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| Synonyms |
Azacitidina; Azacitidinum; Azacytidine; Ladakamycin; Mylosar; Vidaza; Mylo sar; Pharmion Brand of Azacitidine;A 2385; Antibiotic U 18496; U 18496; Wr 183027; Azacitidina [INN-Spanish]; Azacitidine [USAN:INN]; Azacitidinum [INN-Latin]; NS-17; Pyrimidine antimetabolite: inhibits nucleic acid replication; U-18496; Vidaz (TN); Vidaza (TN); WR-183027; Azacitidine (JAN/USAN/INN); S-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-(8CI); 2-(beta-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-one; 4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one; 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one; 4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one; 4-Amino-1-beta-d-ribofuranosyl-1,3,5-triazin-2(1H)-one; 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triaz; 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one; 4-amino-1-beta-L-ribofuranosyl-1,3,5-triazin-2(1H)-one; 5 AZC; 5 Azacytidine; 5-AC; 5-AZAC; 5-AZCR; 5-aza-CR; 5-azacitidine; 5-azacytidine; 5-azacytidine, Mylosar, Ladakamycin, Vidaza, Azacitidine; 5AzaC
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| Structure |
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3D MOL
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| Formula |
C8H12N4O5
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| InChI |
1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
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| InChIKey |
NMUSYJAQQFHJEW-KVTDHHQDSA-N
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Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 6 item(s) under this drug | ||
| Crosstalk ID: M6ACROT02019 | ||
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | |
| m6A Target | Peroxisome proliferator-activated receptor alpha (PPARalpha/PPARA) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | FTO alpha-ketoglutarate dependent dioxygenase (FTO) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Renal ischemia-reperfusion injury | |
| Crosstalk ID: M6ACROT02020 | ||
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | |
| m6A Target | Peroxisome proliferator-activated receptor alpha (PPARalpha/PPARA) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | FTO alpha-ketoglutarate dependent dioxygenase (FTO) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Renal ischemia-reperfusion injury | |
| Crosstalk ID: M6ACROT02021 | ||
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | |
| m6A Target | Peroxisome proliferator-activated receptor alpha (PPARalpha/PPARA) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 3B (DNMT3B) | |
| Regulated Target | FTO alpha-ketoglutarate dependent dioxygenase (FTO) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Renal ischemia-reperfusion injury | |
| Crosstalk ID: M6ACROT02022 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Peroxisome proliferator-activated receptor alpha (PPARalpha/PPARA) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | FTO alpha-ketoglutarate dependent dioxygenase (FTO) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Renal ischemia-reperfusion injury | |
| Crosstalk ID: M6ACROT02023 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Peroxisome proliferator-activated receptor alpha (PPARalpha/PPARA) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | FTO alpha-ketoglutarate dependent dioxygenase (FTO) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Renal ischemia-reperfusion injury | |
| Crosstalk ID: M6ACROT02024 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Peroxisome proliferator-activated receptor alpha (PPARalpha/PPARA) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 3B (DNMT3B) | |
| Regulated Target | FTO alpha-ketoglutarate dependent dioxygenase (FTO) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Renal ischemia-reperfusion injury | |