m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0180)
| Name |
Bleomycin
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| Synonyms |
BLM; Blenoxane; Bleo; Bleocin; Bleogin; Bleomicin; Bleomicina; Bleomycine; Bleomycins; Bleomycinum; Bleomycin sulfate; Bleomycin a2; Pingyangmyvin A2; Zhengguangmycin A2; Zhengguangmycin A2 [Chinese]; Blenoxane (TN); Bleomicina [INN-Spanish]; Bleomycin A(2); Bleomycin A2 & Bleomycin B2; Bleomycin B(2); Bleomycine [INN-French]; Bleomycinum [INN-Latin]; NDC 0015-3010; N(1)-[3-(dimethylsulfonio)propyl]bleomycinamide; N1-(3-(Dimethylsulfonio)propyl)bleomycinamide
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| Structure |
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3D MOL
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| Formula |
C55H84N17O21S3+
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| InChI |
1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29,30,34-,35-,36-,37,38,39,40,41-,42,43,53,54/m0/s1
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| InChIKey |
OYVAGSVQBOHSSS-WXFSZRTFSA-O
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Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 3 item(s) under this drug | ||
| Crosstalk ID: M6ACROT03514 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | long intergenic non-protein coding RNA 426 (LINC00426) | |
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Cervical cancer | |
| Crosstalk ID: M6ACROT03527 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | long intergenic non-protein coding RNA 426 (LINC00426) | |
| Epigenetic Regulator | WD repeat-containing protein 5 (WDR5) | |
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Cervical cancer | |
| Crosstalk ID: M6ACROT05714 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Long intergenic non-protein coding RNA 426 (LINC00426) | |
| Epigenetic Regulator | Long intergenic non-protein coding RNA 426 (LINC00426) | |
| Regulated Target | hsa-miR-200a-3p | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Cervical cancer | |