m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0162)
| Name |
Dactolisib
|
||||
|---|---|---|---|---|---|
| Synonyms |
dactolisib, 915019-65-7, NVP-BEZ235, BEZ235, NVP-BEZ 235, BEZ-235, 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile, NVPBEZ235, BEZ 235, NVP-BEZ-235, NVP BEZ235, Dactolisib [USAN], RTB101, RTB-101, Dactolisib [USAN:INN], RUJ6Z9Y0DT, NSC-751249, CHEBI:71952, DACTOLISIB [INN], DACTOLISIB [WHO-DD], 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile, DTXSID10238599, NSC 751249, 2-methyl-2-(4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-1h-imidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile, 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile, 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile, Benzeneacetonitrile, 4-(2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo(4,5-c)quinolin-1-yl)-alpha,alpha-dimethyl-, dactolisibum, 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile, 2-methyl-2-(4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile, 2-Methyl-2-(4-{3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl}phenyl)propanenitrile, DTXCID10161090, BEZ235 (NVP-BEZ235, Dactolisib), 915019-65-7 (free base), 2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile, S1009, BEZ235 (NVP-BEZ235), 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile., UNII-RUJ6Z9Y0DT, MFCD10565944, Kinome_2911, CT-BEZ, Dactolisib (BEZ235), Dactolisib; BEZ-235, Dactolisib (USAN/INN), Nvp-bez235, free base, mTOR Inhibitor, BEZ235, NVP BEZ 235, NVP-BEZ235, SCHEMBL143623, GTPL7950, CHEMBL1879463, BDBM92862, EX-A404, BCPP000344, HMS3244G21, HMS3244G22, HMS3244H21, HMS3672E19, BCP00216, IVB20674, NSC751249, NSC755807, NSC800085, AKOS005217097, BCP9000397, CCG-207981, CS-0080, DB11651, ES-0038, FD26487, NSC-755807, NSC-800085, PB26555, SDCCGSBI-0646961.P003, Dactolisib (BEZ235, NVP-BEZ235), NCGC00187481-01, NCGC00187481-02, NCGC00187481-04, NCGC00187481-05, NCGC00187481-06, NCGC00187481-11, NCGC00187481-15, 2-(4-(2,3-dihydro-3-methyl-2-oxo-8-(quinolin-3-yl)imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile, AC-25486, HY-50673, NS00071714, EN300-60135, D10552, Q4835503, BRD-K12184916-001-01-4, BRD-K12184916-001-15-4, BRD-K12184916-001-19-6, Z329731510, 1028385-31-0, 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)phenyl)propionitrile, 2-methyl-2-[4-[3-methyl-2-oxo-8-(3-quinolyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile, 2-METHYL-2-{4-[3-METHYL-2-OXO-8-(QUINOLIN-3-YL)-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-1-YL]PHENYL}PROPANENITRILE, 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4, 5-c]quinolin-1-yl]-.alpha.,.alpha.-dimethylbenzeneacetonitrile, 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-,-dimethyl-benzeneacetonitrile;2-Methyl-2-[4-[3-met hyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile;BEZ 235
Click to Show/Hide
|
||||
| Structure |
 |
||||
|
3D MOL
|
|||||
| Formula |
C30H23N5O
|
||||
| InChI |
InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
|
||||
| InChIKey |
JOGKUKXHTYWRGZ-UHFFFAOYSA-N
|
||||
| PubChem CID | |||||
| DrugBank ID | |||||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 2 item(s) under this drug | ||
| Crosstalk ID: M6ACROT05720 | ||
| m6A Regulator | YTH domain-containing protein 1 (YTHDC1) | |
| m6A Target | Circ_TET2 | |
| Epigenetic Regulator | Circ_TET2 | |
| Regulated Target | Heterogeneous nuclear ribonucleoprotein C (HNRNPC) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Chronic lymphocytic leukemia | |
| Crosstalk ID: M6ACROT05723 | ||
| m6A Regulator | RNA binding protein X (RBMX) | |
| m6A Target | Circ_TET2 | |
| Epigenetic Regulator | Circ_TET2 | |
| Regulated Target | Heterogeneous nuclear ribonucleoprotein C (HNRNPC) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Chronic lymphocytic leukemia | |
References