m6A-centered Drug Response Information

General Information of the Drug (ID: M6ADRUG0127)
Name
Oxymatrine
Synonyms
Oxymatrine, Matrine, 1-oxide, 16837-52-8, 85U4C366QS, OXYMATRINE [WHO-DD], UNII-85U4C366QS, Matrine N-oxide, HSDB 8102, Matrine 1beta-oxide, Matridin-15-one, 1-oxide, (1-beta)-, (4R,7AS,13AR,13BR,13CS)-DODECAHYDRO-1H,5H,10H-DIPYRIDO(2,1-F:3',2',1'-IJ)(1,6)NAPHTHYRIDIN-10-ONE 4-OXIDE, (7AS,13AR,13BR,13CS)-DODECAHYDRO-1H,5H,10H-DIPYRIDO(2,1-F:3',2',1'-IJ)(1,6)NAPHTHYRIDIN-10-ONE 4-OXIDE, 1H,5H,10H-Dipyrido(2,1-f:3',2',1'-ij)(1,6)naphthyridin-10-one, dodecahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-, (7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one 4-oxide, 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-, 605-514-4, (1r,2r,9s,17s)-13-oxido-7-aza-13-azoniatetracyclo(7.7.1.02,7.013,17)heptadecan-6-one, (1r,2r,9s,17s)-13-oxido-7-aza-13-azoniatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one, 5-hydroxy-5,6-dihydrobenzo(b)(1)benzazepine-11-carboxamide, 5-hydroxy-5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide, xvpbinopnyfxid-lhduffhysa-n, Ammothamnine, Matrine oxide, Oxymatrine (Standard), HY-N0158R, HY-N0158, CS-6157, Q63396010
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Structure
3D MOL
2D MOL
Formula
C15H24N2O2
InChI
InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17+/m0/s1
InChIKey
XVPBINOPNYFXID-JARXUMMXSA-N
PubChem CID
24864132
DrugBank ID
DB16276
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
In total 1 item(s) under this drug
Crosstalk ID: M6ACROT05745
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target hsa-miR-27a-3p
 Target Gene 
Epigenetic Regulator hsa-miR-27a-3p
Regulated Target Peroxisome proliferator-activated receptor gamma (PPARG)
Crosstalk relationship m6A → ncRNA
Disease Infantile hemangioma
 Disease Info 
References
Ref 1 Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1Alpha and IL-1Beta. MAbs. 2015;7(3):605-19. doi: 10.1080/19420862.2015.1026501.