m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0041)
| Name |
Artenimol
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| Synonyms |
Dihydroartemisinin; Artenimol; Dihydroqinghaosu; UNII-6A9O50735X; 81496-82-4; (3r,5as,6r,8as,9r,10s,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j][1,2]benzodioxepin-10-ol; GNF-PF-5634; 6A9O50735X; b-Dihydroartemisinin; GTPL9957; SCHEMBL17156483; CHEBI:135921; HY-N0176; ZINC15449187; AKOS032949625; CS-5595; FT-0649320; BRD-K62213621-001-01-6; Dihydroartemisinin (mixture of alfa and beta isomers); (3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
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| Status | Approved | [1] | |||
| Structure |
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| Formula |
C15H24O5
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| InChI |
InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1
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| InChIKey |
BJDCWCLMFKKGEE-ISOSDAIHSA-N
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Full List of m6A Targets Related to This Drug
Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Drug Response by This Target Gene | [2] | |||
| Response Summary | Renal fibrosis is a key factor in chronic kidney disease (CKD). Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)/miR-145/FAK pathway was involved in the effect of dihydroartemisinin (DHA) on TGF-beta1-induced renal fibrosis in vitro and in vivo. | |||
| Responsed Disease | Chronic kidney disease | ICD-11: GB61 | ||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Cell Process | Epithelial-mesenchymal transition | |||
| In-vitro Model | HK-2 [Human kidney] | Normal | Homo sapiens | CVCL_0302 |
| HK2 | Normal | Acipenser baerii | CVCL_YE28 | |
| In-vivo Model | For the unilateral ureteral obstruction (UUO) model, male C57BL/6J mice at 8 weeks of age (20-22 g body weight) were first anaesthetized with pentobarbital sodium (50 mg/kg) via intraperitoneal injection. Then, the left ureter was ligated using 3-0 silk and a left lateral incision. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 2 item(s) under this drug | ||
| Crosstalk ID: M6ACROT05424 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Regulated Target | MicroRNA 145 (MIR145) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Chronic kidney disease | |
| Crosstalk ID: M6ACROT05930 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | MicroRNA 145 (MIR145) | |
| Regulated Target | Focal adhesion kinase 1 (FAK) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Chronic kidney disease | |
References