m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0141)
Name
COVID-19
ICD
ICD-11: RA01
Full List of Target Gene(s) of This m6A-centered Disease Response
Mammalian target of rapamycin complex 2 (mTORC2)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Knockdown of RBM15 remarkably suppressed the expression levels of multitarget genes related to programmed cell death and inflammatory response. These findings indicate that RBM15 can serve as a target for the treatment of COVID-19.
Responsed Disease COVID-19 [ICD-11: RA01]
Target Regulator RNA-binding motif protein 15 (RBM15) WRITER
 Regulator Info 
Cell Process Programmed cell death
Inflammatory response
In-vitro Model THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
HuT 78 T lymphocytic leukemia Homo sapiens CVCL_0337
RIG-I-like receptor 1 (RIG-I)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary In SARS-CoV-2 infection, depletion of the host cell m6A methyltransferase METTL3 decreases m6A levels in SARS-CoV-2 and host genes, and m6A reduction in viral RNA increases RIG-I-like receptor 1 (RIG-I) binding and subsequently enhances the downstream innate immune signaling pathway and inflammatory gene expression.
Responsed Disease COVID-19 [ICD-11: RA01]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response RIG-I-like receptor signaling pathway hsa04622
Cell Process Immune responses
In-vitro Model Calu-3 Lung adenocarcinoma Homo sapiens CVCL_0609
Caco-2 Colon adenocarcinoma Homo sapiens CVCL_0025
HEK293-FT Normal Homo sapiens CVCL_6911
References
Ref 1 RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes. Cell Death Dis. 2021 Jul 23;12(8):732. doi: 10.1038/s41419-021-04012-z.
Ref 2 METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection. Cell Rep. 2021 May 11;35(6):109091. doi: 10.1016/j.celrep.2021.109091. Epub 2021 May 3.