m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0123)
| Name |
Abnormalities of breathing
|
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|---|---|---|---|---|---|
| ICD |
ICD-11: MD11
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Full List of Target Gene(s) of This m6A-centered Disease Response
H19 imprinted maternally expressed transcript (H19)
| In total 2 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression. | |||
| Responsed Disease | Abnormalities of breathing [ICD-11: MD11] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Cell Process | Cell viability | |||
| Cell apoptosis | ||||
| In-vitro Model | H9c2(2-1) | Normal | Rattus norvegicus | CVCL_0286 |
| In-vivo Model | In vivo myocardial I/R injury was performed by 60 min of ligation of LAD followed by 5 h of reperfusion. | |||
| Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression. | |||
| Responsed Disease | Abnormalities of breathing [ICD-11: MD11] | |||
| Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
| Target Regulation | Up regulation | |||
| Cell Process | Cell viability | |||
| Cell apoptosis | ||||
| In-vitro Model | H9c2(2-1) | Normal | Rattus norvegicus | CVCL_0286 |
| In-vivo Model | In vivo myocardial I/R injury was performed by 60 min of ligation of LAD followed by 5 h of reperfusion. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 2 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05450 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | H19 imprinted maternally expressed transcript (H19) | |
| Epigenetic Regulator | H19 imprinted maternally expressed transcript (H19) | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT05451 | ||
| m6A Regulator | Methyltransferase-like 14 (METTL14) | |
| m6A Target | H19 imprinted maternally expressed transcript (H19) | |
| Epigenetic Regulator | H19 imprinted maternally expressed transcript (H19) | |
| Crosstalk relationship | m6A → ncRNA | |