m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05450
|
[1] | |||
m6A modification
H19
H19
METTL3
Methylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
H19
Regulated Target
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | H19 imprinted maternally expressed transcript (H19) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | H19 imprinted maternally expressed transcript (H19) | LncRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression. | ||||
| Responsed Disease | Abnormalities of breathing | ICD-11: MD11 | |||
| Cell Process | Cell viability | ||||
| Cell apoptosis | |||||
In-vitro Model |
H9c2(2-1) | Normal | Rattus norvegicus | CVCL_0286 | |
| In-vivo Model | In vivo myocardial I/R injury was performed by 60 min of ligation of LAD followed by 5 h of reperfusion. | ||||