m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0044)
Name
Papillomaviruses
ICD
ICD-11: 1D9Z
Full List of Target Gene(s) of This m6A-centered Disease Response
Interferon beta (IFNB1)
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Responsed Disease Unspecified viral infection [ICD-11: 1D9Z]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Responses to nonmicrobial dsDNA in uninfected cells, which shape host immunity and contribute to autoimmune disease, are regulated by enzymes controlling m6A epitranscriptomic changes. While METTL14 depletion reduced virus reproduction and stimulated dsDNA- or HCMV-induced Interferon beta (IFNB1) mRNA accumulation, ALKBH5 depletion had the opposite effect.
Responsed Disease Unspecified viral infection [ICD-11: 1D9Z]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Cellular senescence hsa04218
Cell Process Metabolic reprogramming
Stress responses
Aging
In-vitro Model BSC40 Normal Chlorocebus pygerythrus CVCL_3656
HCMV AD169GFP (Human cytomegalovirus)
NHDF (Primary Normal Human Dermal Fibroblasts)
Vero Normal Chlorocebus sabaeus CVCL_0059
Circ_E7
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary Oncogenic human papillomaviruses (HPVs) generate circRNAs, some of which encompass the E7 oncogene (circE7). Circ_E7 is N6-methyladenosine (m6A) modified, preferentially localized to the cytoplasm, associated with polysomes, and translated to produce E7 oncoprotein.
Responsed Disease Papillomaviruses [ICD-11: 1D9Z]
Cell Process RNA metabolism
In-vitro Model C-4-I Cervical squamous cell carcinoma Homo sapiens CVCL_2253
Ca Ski Cervical squamous cell carcinoma Homo sapiens CVCL_1100
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
SiHa Cervical squamous cell carcinoma Homo sapiens CVCL_0032
SW756 Cervical squamous cell carcinoma Homo sapiens CVCL_1727
UPCI-SCC-154 Tongue squamous cell carcinoma Homo sapiens CVCL_2230
In-vivo Model Mice were anesthetized and shaved on both flanks and injected subcutaneously with 4 × 106 tumor cells in 200 uL of PBS.
References
Ref 1 RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon Beta. Genes Dev. 2018 Dec 1;32(23-24):1472-1484. doi: 10.1101/gad.319475.118. Epub 2018 Nov 21.
Ref 2 Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus. Nat Commun. 2019 May 24;10(1):2300. doi: 10.1038/s41467-019-10246-5.