m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0033)
| Name |
Diabetic skin lesions
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|---|---|---|---|---|---|
| ICD |
ICD-11: EB90
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Full List of Target Gene(s) of This m6A-centered Disease Response
Sequestosome-1 (SQSTM1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | In diabetes/diabetic skin, YTHDC1 interacted and cooperated with ELAVL1/HuR (ELAV like RNA binding protein 1) in modulating the expression of Sequestosome-1 (SQSTM1). | |||
| Responsed Disease | Diabetic skin lesions [ICD-11: EB90.0] | |||
| Target Regulator | YTH domain-containing protein 1 (YTHDC1) | READER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Autophagy | hsa04140 | ||
| Cell Process | Cellular Processes | |||
| Cellular Transport | ||||
| Cellular catabolism | ||||
| Cell apoptosis | ||||
| Cell autophagy | ||||
| In-vitro Model | HaCaT | Normal | Homo sapiens | CVCL_0038 |
| NHEK (Normal human epithelial keratinocytes) | ||||
| In-vivo Model | The WT-si-NC, WT-si-Ythdc1 and WT-si-Sqstm1 groups were intracutaneously injected with corresponding siRNAs (si-NC, si-Ythdc1, or si-Sqstm1, 2.5 nmol) on the circle. | |||