m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0022)
Name
Skeletal anomaly
ICD
ICD-11: LD24
Full List of Target Gene(s) of This m6A-centered Disease Response
Myeloid differentiation primary response protein MyD88 (MYD88)
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary METTL3 positively regulates expression of Myeloid differentiation primary response protein MyD88 (MYD88), a critical upstream regulator of NF-Kappa-B signaling, by facilitating m6A methylation modification to MYD88-RNA, subsequently inducing the activation of NF-Kappa-B which is widely regarded as a repressor of osteogenesis and therefore suppressing osteogenic progression. The METTL3-mediated m6A methylation is found to be dynamically reversed by the demethylase ALKBH5.
Responsed Disease Skeletal anomaly [ICD-11: LD24]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Central carbon metabolism in cancer hsa05230
Cell Process Glucose metabolism
In-vitro Model Mesenchymal stem cell line (NP tissues were used to isolate NP cells)
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary METTL3 positively regulates expression of Myeloid differentiation primary response protein MyD88 (MYD88), a critical upstream regulator of NF-Kappa-B signaling, by facilitating m6A methylation modification to MYD88-RNA, subsequently inducing the activation of NF-Kappa-B which is widely regarded as a repressor of osteogenesis and therefore suppressing osteogenic progression. The METTL3-mediated m6A methylation is found to be dynamically reversed by the demethylase ALKBH5.
Responsed Disease Skeletal anomaly [ICD-11: LD24]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Central carbon metabolism in cancer hsa05230
Cell Process Glucose metabolism
In-vitro Model Mesenchymal stem cell line (NP tissues were used to isolate NP cells)
References
Ref 1 The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-KappaB signaling. Mol Cell Biochem. 2020 Jan;463(1-2):203-210. doi: 10.1007/s11010-019-03641-5. Epub 2019 Oct 23.