m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0014)

Name	Cataract
ICD	ICD-11: 9B10

Full List of Target Gene(s) of This m6A-centered Disease Response

Intercellular adhesion molecule 1 (ICAM1)

Target Info

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	METTL3 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract. METTL3 targets the 3' UTR of Intercellular adhesion molecule 1 (ICAM1) to stabilize mRNA stability.
Responsed Disease	Diabetic cataract [ICD-11: 9B10.21]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Cell Process	RNA stability
	Cell apoptosis
In-vitro Model	B-3	Normal	Homo sapiens	CVCL_6367

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease

In total 1 item(s) under this disease
Crosstalk ID: M6ACROT05680		Crosstalk Info
m6A Regulator	Methyltransferase-like 3 (METTL3)	Regulator Info
m6A Target	hsa_circ_0007905 (Circ_STX6)	Target Gene
Epigenetic Regulator	Circ_STX6
Regulated Target	hsa-miR-6749-3p
Crosstalk relationship	m6A → ncRNA

References

Ref 1	N(6)-Methyladenosine METTL3 Modulates the Proliferation and Apoptosis of Lens Epithelial Cells in Diabetic Cataract. Mol Ther Nucleic Acids. 2020 Jun 5;20:111-116. doi: 10.1016/j.omtn.2020.02.002. Epub 2020 Feb 11.
Ref 2	Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
Ref 3	Pharmacokinetics, pharmacodynamics, safety and tolerability of APG101, a CD95-Fc fusion protein, in healthy volunteers and two glioma patients. Int Immunopharmacol. 2012 May;13(1):93-100. doi: 10.1016/j.intimp.2012.03.004. Epub 2012 Mar 21.