m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05680
 [1]
m6A modification Circ_STX6 Circ_STX6 METTL3 Methylation : m6A sites Direct Enhancement Non-coding RNA has_circ_0007905 miR-6749-3p  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target hsa_circ_0007905 (Circ_STX6)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Circ_STX6 circRNA View Details
Regulated Target hsa-miR-6749-3p View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary METTL3-mediated m6A modification of hsa_circ_0007905 (Circ_STX6) promotes age-related cataract progression through hsa-miR-6749-3p/EIF4EBP1
Responsed Disease Age-related cataracts ICD-11: 9B10.0
 Disease Info 
Cell Process Cell proliferation
Cell apoptosis
In-vitro Model
 B-3 Normal Homo sapiens CVCL_6367
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
9B10: Cataract 5 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Acetylcholine Approved [2]
Synonyms
Choline acetate; O-Acetylcholine; Acetyl choline ion; Acetylcholinum; 51-84-3; (2-Acetoxyethyl)trimethylammonium; Acetyl choline cation; Choline acetate (ester); 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Ach; Azetylcholin; ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; UNII-N9YNS0M02X; BRN 1764436; CHEBI:15355; Bromoacetylcholine; EINECS 200-128-9; CHEMBL667; N9YNS0M02X; [2-(acetyloxy)ethyl]trimethylazanium; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl- (9CI); 2-acetyloxyethyl-trimethylazanium; [3H]acetylcholine; Miochol; Miochol-e
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External Link
CID: 187
TTD: D0Q9HF
DrugBank: DB03128
 Compound Name Tirilazad mesylate Approved [3]
Synonyms
Freedox (TN)
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External Link
CID: 104902
TTD: D04APR
 Compound Name Chondroitin Approved [3]
Synonyms
UNSATURATED CHONDROITIN DISACCHARIDE; chondroitin disaccharide; 4-DEOXY-L-THREO-HEX-4-ENOPYRANOSYLURONIC ACID-(1,3)-N-ACETYL-D-GALACTOSAMINE; (2R,3R,4S)-2-[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4-dihydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid; (3R,4R)-2-{[(2R,3S,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-3,4-dihydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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CID: 53477707
TTD: D02HYK
 Compound Name C-KAD Phase 2 [4]
Synonyms
C-KAD ophthalmic solution (cataract/asteroid hyalosis/glaucoma); C-KAD ophthalmic solution (cataract/asteroid hyalosis/glaucoma), Chakshu; Chelating agent (ophthalmic solution, cataract/asteroid hyalosis/glaucoma), Chakshu
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TTD: D07WGE
 Compound Name LPO-1010CA Investigative [5]
External Link
TTD: D06HGM
References
Ref 1 METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p/EIF4EBP1. PeerJ. 2023 Mar 6;11:e14863. doi: 10.7717/peerj.14863. eCollection 2023.
Ref 2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 294).
Ref 3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 4 ClinicalTrials.gov (NCT00793091) Safety and Efficacy Study of an Ophthalmic Solution in Patients With Age-Related Cataract. U.S. National Institutes of Health.
Ref 5 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.