m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05946
 [1]
m6A modification FAM225A FAM225A METTL3 Methylation : m6A sites Indirect Inhibition Non-coding RNA miR-590-3p ITGB3  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Family with sequence similarity 225 member A (FAM225A)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator hsa-miR-590-3p LncRNA View Details
Regulated Target Integrin subunit beta 3 (ITGB3) View Details
Crosstalk Relationship m6A  →  ncRNA Inhibition
Crosstalk Mechanism m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways
Crosstalk Summary Silencing METTL3 decreases Family with sequence similarity 225 member A (FAM225A) RNA stability, which serves as the ceRNA for sponging both hsa-miR-590-3p and miR-1275, increasing the levels of their target integrin beta3 (Integrin subunit beta 3 (ITGB3)), finally stimulating FAK/PI3K/Akt signaling. miR-590-3p has been reported as a tumor suppressor in cholangiocarcinoma and hepatocellular carcinoma and miR-1275 can inhibit NPC cell growth and suppress hepatocellular carcinoma cell proliferation.
Responsed Disease Cholangiocarcinoma ICD-11: XH7M15
 Disease Info 
Pathway Response PI3K-Akt signaling pathway hsa04151
Cell Process mRNA stability
Cell proliferation
Cell invasion
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Integrin subunit beta 3 (ITGB3) 77 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name XEMILOFIBAN Discontinued in Phase 3 [2]
Synonyms
Xemilofiban [INN]; 149820-74-6; UNII-P614JI3IYK; SC-54684A; SC 54684A; P614JI3IYK; SC-54684; CHEMBL76098; Ethyl-3S-((4-((4-(aminoiminomethyl)phenyl)amino)-1,4-dioxobutyl)amino)-4-pentynoate; C18H22N4O4; 4-Pentynoic acid, 3-((4-((4-(aminoiminomethyl)phenyl)amino)-1,4-dioxobutyl)amino)-, ethyl ester, (S)-; CS-551; AC1Q5MFX; AC1L1U8F; SCHEMBL50663; DTXSID60164410; ZINC1535967; BDBM50083460; KB-81502; LS-102305; ethyl(3s)-3-[3-[(p-amidinophenyl)carbamoyl]propionamido]-4-pentynoate
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MOA Inhibitor
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CID: 60957
TTD: D07EXV
 Compound Name DMP-802 Discontinued in Phase 1 [3]
Synonyms
CHEMBL117989; CHEMBL275611; SCHEMBL7748060; BDBM50075566; (S)-3-{2-[(R)-3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-(3,5-dimethyl-isoxazole-4-sulfonylamino)-propionic acid
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MOA Inhibitor
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CID: 9812185
TTD: D0K0NP
 Compound Name L-709780 Terminated [4]
Synonyms
CHEMBL32960; BDBM50078448; l709780; N-[2-[2-(4-Piperidinyl)ethyl]-3-oxoisoindoline-5-ylcarbonyl]-beta-alanine; 3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-propionic acid(L-709780); 3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-propionic acid
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MOA Inhibitor
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CID: 9885190
TTD: D03GCN
 Compound Name Ro-43-8857 Terminated [3]
Synonyms
CHEMBL290497; SCHEMBL8381416; BDBM50003852; alpha,alpha'-[[4-[[Methyl(4-amidinobenzoyl)amino]acetyl]-o-phenylene]bis(oxy)]diacetic acid; (4-{2-[(4-Carbamimidoyl-benzoyl)-methyl-amino]-acetyl}-2-carboxymethoxy-phenoxy)-acetic acid; (5-{2-[(4-Carbamimidoyl-benzoyl)-methyl-amino]-acetyl}-2-carboxymethoxy-phenoxy)-acetic acid
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MOA Inhibitor
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CID: 9933077
TTD: D03QHI
 Compound Name SKF-107260 Terminated [5]
Synonyms
F 107260; CHEMBL18734; [(7s,13s)-13-{3-[(diaminomethylidene)amino]propyl}-14-methyl-6,9,12,15-tetraoxo-6,7,8,9,10,11,12,13,14,15-decahydro-5h-dibenzo[c,p][1,2,5,8,11,14]dithiatetraazacycloheptadecin-7-yl]acetic acid; 136620-00-3; Skf 107260; F-107260; AC1L4UPG; AC1Q6GV5; Cyclo-S,S-(mba-(N(alpha)-Me)arg-gly-asp-man); CTK4C0386; DTXSID70159857; BDBM50036088; BDBM50230131; Cyclo-S,S-(2-mercaptobenzoyl-N(alpha)-methylarginyl-glycyl-aspartyl-2-mercaptophenylamide)
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MOA Inhibitor
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CID: 164393
TTD: D08CQL
 Compound Name L-738167 Terminated [3]
Synonyms
CHEMBL298655; L 738167; 163212-43-9; AC1L4BHI; SCHEMBL609722; DTXSID30167534; YLFFZEQHDMFOEC-NRFANRHFSA-N; BDBM50058239; L-Alanine, N-((4-methylphenyl)sulfonyl)-3-(((5,6,7,8-tetrahydro-4-oxo-5-(2-(4-piperidinyl)ethyl)-4H-pyrazolo(1,5-a)(1,4)diazepin-2-yl)carbonyl)amino)-; 3-{[4-Oxo-5-(2-piperidin-4-yl-ethyl)-5,6,7,8-tetrahydro-4H-1,5,8a-triaza-azulene-2-carbonyl]-amino}-2-(toluene-4-sulfonylamino)-propionic acid (L-738167)
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MOA Inhibitor
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CID: 153986
TTD: D08LIG
 Compound Name DMP-757 Terminated [6]
Synonyms
CHEMBL65617; BDBM50285199; [(5S,11S,14S)-11-(3-Guanidino-propyl)-14-isopropyl-12-methyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaaza-bicyclo[15.3.1]henicosa-1(20),17(21),18-trien-5-yl]-acetic acid
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MOA Inhibitor
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CID: 10031011
TTD: D0U4ZY
 Compound Name Ro-43-5054 Terminated [3]
Synonyms
CHEMBL117775; SCHEMBL7306316; BDBM50092124; 2-{2-[3-(4-Carbamimidoyl-benzoylamino)-propionylamino]-3-carboxy-propionylamino}-3-methyl-butyric acid (Ro 43-5054)
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MOA Inhibitor
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CID: 44343754
TTD: D0Z0XQ
 Compound Name SC-47643 Terminated [7]
Synonyms
CHEMBL129921; BDBM50035970; 3-(8-Guanidino-octanoylamino)-N-[2-(4-methoxy-phenyl)-ethyl]-succinamic acid
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MOA Inhibitor
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CID: 124392
TTD: D0G9BX
 Compound Name SB-223245 Terminated [8]
Synonyms
CHEMBL50106; SCHEMBL245523; BDBM50059133; {7-[(1H-Benzoimidazol-2-ylmethyl)-methyl-carbamoyl]-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl}-acetic acid; {(S)-7-[(1H-Benzoimidazol-2-ylmethyl)-methyl-carbamoyl]-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl}-acetic acid
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MOA Inhibitor
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CID: 9823503
TTD: D0LT1S
 Compound Name L-739758 Investigative [3]
Synonyms
CHEMBL78760; BDBM50078437; 3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]thiophene-2-carbonyl]-amino}-2-(pyridine-3-sulfonylamino)-propionic acid(L-739758); (S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]thiophene-2-carbonyl]-amino}-2-(pyridine-3-sulfonylamino)-propionic acid; (2S)-2-[(3-Pyridinyl)sulfonylamino]-3-[[5-[2-(4-piperidinyl)ethyl]thieno[2,3-b]thiophen-2-yl]carbonylamino]propanoic acid
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MOA Inhibitor
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CID: 9958398
TTD: D01XUU
 Compound Name ISIS 25237 Investigative [9]
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TTD: D02MYZ
 Compound Name ROXIFIBAN Investigative [3]
Synonyms
UNII-Q476FMZ72G; DMP754; 170902-47-3; CHEMBL18301; Q476FMZ72G; DMP-754; Roxifiban [INN]; AC1L42MF; SCHEMBL344302; DTXSID70168969; BDBM50075579; methyl (2S)-2-(butoxycarbonylamino)-3-[[2-[(5R)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]acetyl]amino]propanoate; L-Alanine, 3-(((3-(4-(aminoiminomethyl)phenyl)-4,5-dihydro-5-isoxazolyl)acetyl)amino)-N-(butoxycarbonyl)-, methyl ester, (R)-; L-Alanine, 3-((((5R)-3-(4-(aminoiminomethyl)phenyl)-4,5-dihydro-5-isoxazolyl)acetyl)amino)-N-(butoxycarbonyl)-, methy
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MOA Inhibitor
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CID: 177230
TTD: D04BHL
 Compound Name RWJ-53419 Investigative [10]
Synonyms
CHEMBL421547; BDBM50104598; 2-Benzyloxycarbonylamino-3-{[(R)-1-(3-piperidin-4-yl-propionyl)-piperidine-3-carbonyl]-amino}-propionic acid
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MOA Inhibitor
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CID: 44322318
TTD: D04XTP
 Compound Name L-750034 Investigative [11]
Synonyms
CHEMBL326492; BDBM50076058; 2-((S)-Benzenesulfonylamino)-3-(4-piperazin-1-yl-benzoylamino)-propionic acid; 2-Benzenesulfonylamino-3-(4-piperazin-1-yl-benzoylamino)-propionic acid(L-750034); (S)-2-Benzenesulfonylamino-3-(4-piperazin-1-yl-benzoylamino)-propionic acid
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MOA Inhibitor
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CID: 11743533
TTD: D05AGK
 Compound Name L-756568 Investigative [3]
Synonyms
CHEMBL96097; BDBM50092097; (S)-2-Benzenesulfonylamino-3-{[5-(piperidin-4-ylmethoxy)-1H-indole-2-carbonyl]-amino}-propionic acid; 2-Benzenesulfonylamino-3-{[5-(piperidin-4-ylmethoxy)-1H-indole-2-carbonyl]-amino}-propionic acid(L-756568)
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MOA Inhibitor
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CID: 9805998
TTD: D06LHH
 Compound Name SC-54701A Investigative [12]
Synonyms
UNII-TN585Y92BI; SC-54701; CHEMBL311572; TN585Y92BI; Xemilofiban acid; Xemilofiban acid [MI]; SCHEMBL7080314; BDBM50031565; 4-Pentynoic acid, 3-((4-((4-(aminoiminomethyl)phenyl)amino)-1,4-dioxobutyl)amino)-, (3S)-; 149193-61-3; (S)-3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylamino]-pent-4-ynoic acid; 3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylamino]-pent-4-ynoic acid ethyl ester; 3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylamino]-pent-4-ynoic acid (SC-54701A)
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MOA Inhibitor
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CID: 9862322
TTD: D08RLR
 Compound Name L-734115 Investigative [3]
Synonyms
CHEMBL40502; BDBM50058236; N-(Butylsulfonyl)-3-[[4,5,6,7-tetrahydro-4-oxo-5-[2-(4-piperidinyl)ethyl]pyrazolo[1,5-a]pyrazin]-2-ylcarbonylamino]-L-alanine; (S)-2-(Butane-1-sulfonylamino)-3-{[4-oxo-5-(2-piperidin-4-yl-ethyl)-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carbonyl]-amino}-propionic acid; 2-(Butane-1-sulfonylamino)-3-{[4-oxo-5-(2-piperidin-4-yl-ethyl)-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carbonyl]-amino}-propionic acid(L-734115)
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CID: 9913833
TTD: D0C8LA
 Compound Name SB-207043 Investigative [5]
Synonyms
CHEMBL606910
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CID: 52942958
TTD: D0M7KS
 Compound Name ISIS 196103 Investigative [9]
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TTD: D0Q2ZS
 Compound Name L-746233 Investigative [3]
Synonyms
CHEMBL79294; BDBM50078442; 3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-2-(pyridine-3-sulfonylamino)-propionic acid(L-746233); (2S)-2-[(3-Pyridinyl)sulfonylamino]-3-[[2-[2-(4-piperidinyl)ethyl]-3-oxoisoindolin-5-yl]carbonylamino]propanoic acid; (S)-3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-2-(pyridine-3-sulfonylamino)-propionic acid
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CID: 10324223
TTD: D0S8DT
 Compound Name L-767679 Investigative [3]
Synonyms
CHEMBL57886; L 767679; AC1L42P7; BDBM50054538; 182198-53-4; 3-[2-(1-Oxo-7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)-acetylamino]-pent-4-ynoic acid(L-767679); (S)-3-[2-(1-Oxo-7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)-acetylamino]-pent-4-ynoic acid; (3S)-3-[[2-(1-oxo-7-piperazin-1-yl-3,4-dihydroisoquinolin-2-yl)acetyl]amino]pent-4-ynoic acid; 4-Pentynoic acid, 3-(((3,4-dihydro-1-oxo-7-(1-piperazinyl)-2(1H)-isoquinolinyl)acetyl)amino)-, (3S)-
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MOA Inhibitor
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CID: 177364
TTD: D0W5ZK
 Compound Name C(RGDfF) Investigative [13]
Synonyms
CHEMBL380434
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MOA Inhibitor
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CID: 10699123
TTD: D00YBU
 Compound Name Ac-Asp-Arg-Leu-Asp-Ser-OH Investigative [14]
Synonyms
CHEMBL238484; Acetyl-Asp-Arg-Leu-Asp-Ser-OH; ZINC28869420
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MOA Inhibitor
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CID: 11764797
TTD: D01AXA
 Compound Name C[-Arg-Gly-Asp-Acpca21-] Investigative [15]
Synonyms
CHEMBL534711
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MOA Inhibitor
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CID: 11613122
TTD: D01BZH
 Compound Name C-[-Arg-Gly-Asp-Acpca32-] Investigative [15]
Synonyms
CHEMBL556402
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MOA Inhibitor
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CID: 11583738
TTD: D01MGI
 Compound Name 3-(3-(carbamoyl)benzamido)propanoic acid Investigative [16]
Synonyms
CHEMBL219603
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MOA Inhibitor
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CID: 44418280
TTD: D01ZJF
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp22-] Investigative [17]
Synonyms
CHEMBL406912
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MOA Inhibitor
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CID: 24822283
TTD: D03KLT
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp21-] Investigative [17]
Synonyms
CHEMBL411863; BDBM50372589
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MOA Inhibitor
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CID: 24822953
TTD: D03YLY
 Compound Name Cypate-[(RGD)2-NH2]2 Investigative [18]
MOA Inhibitor
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CID: 91936295
TTD: D04MCL
 Compound Name C[-Arg-Gly-Asp-Acpca35-] Investigative [15]
Synonyms
CHEMBL534713
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MOA Inhibitor
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CID: 11540460
TTD: D04WVG
 Compound Name C[RGDf-(S)-alpha-TfmV] Investigative [13]
Synonyms
CHEMBL203693
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MOA Inhibitor
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CID: 10416726
TTD: D05EWB
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp26-] Investigative [17]
Synonyms
CHEMBL406680
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CID: 24822444
TTD: D05GXK
 Compound Name E[c(RGDyK)]2 Investigative [19]
Synonyms
CHEMBL414385
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MOA Inhibitor
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CID: 44388431
TTD: D05MJG
 Compound Name C-[-Arg-Gly-Asp-Acpca30-] Investigative [15]
Synonyms
CHEMBL540622
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MOA Inhibitor
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CID: 11712622
TTD: D05VEC
 Compound Name C[-Arg-Gly-Asp-Acpca36-] Investigative [15]
Synonyms
CHEMBL557157
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MOA Inhibitor
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CID: 11518823
TTD: D06JLN
 Compound Name Gly-Arg-Gly-Asp-Ser Investigative [20]
Synonyms
96426-21-0; GRGDS; glycyl-arginyl-glycyl-aspartyl-serine; H-Gly-Arg-Gly-Asp-Ser-OH; CHEMBL417553; L-Serine, N-(N-(N-(N2-glycyl-L-arginyl)glycyl)-L-alpha-aspartyl)-; GRGDS Peptide; C17H30N8O9; AC1L3XCA; NH2-Gly-Arg-Gly-Asp-Ser; SCHEMBL17440322; RGNVSYKVCGAEHK-GUBZILKMSA-N; HY-P0295; ZINC13455558; MFCD00076459; BDBM50414896; BDBM50006330; AKOS030622941; NCGC00167212-01; Gly-Arg-Gly-Asp-Ser, > LS-178299; FT-0772116; L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl-
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MOA Inhibitor
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CID: 123811
TTD: D06LKH
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp25-] Investigative [17]
Synonyms
CHEMBL270690
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MOA Inhibitor
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CID: 24822784
TTD: D07QJD
 Compound Name C(RGDfMeF) Investigative [13]
Synonyms
CHEMBL383747
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MOA Inhibitor
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CID: 44408450
TTD: D07UOF
 Compound Name C[RGDf-(R)-alpha-TfmV] Investigative [13]
Synonyms
CHEMBL203077
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MOA Inhibitor
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CID: 11505585
TTD: D08CFM
 Compound Name C(Arg-Gly-Asp-D-Phe-Val) Investigative [21]
Synonyms
CHEMBL383412
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CID: 44411994
TTD: D08DSG
 Compound Name C-[-Arg-Gly-Asp-Acpca31-] Investigative [15]
Synonyms
CHEMBL534934
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MOA Inhibitor
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CID: 11533023
TTD: D09PLA
 Compound Name RGDechi Investigative [21]
MOA Inhibitor
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CID: 91936353
TTD: D0D4QZ
 Compound Name 3-(3-(benzamido)-5-nitrobenzamido)propanoic acid Investigative [16]
Synonyms
CHEMBL218226
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MOA Inhibitor
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CID: 44418282
TTD: D0G7QJ
 Compound Name Cyclo(RGDfV) (control) Investigative [18]
Synonyms
CHEMBL206344
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MOA Inhibitor
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CID: 44409460
TTD: D0G8JI
 Compound Name C[RGDf-(R)-N-Me-alpha-TfmF] Investigative [13]
Synonyms
CHEMBL381590
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CID: 11643340
TTD: D0H4EK
 Compound Name ISONIPECOTAMIDE Investigative [22]
Synonyms
Piperidine-4-carboxamide; 39546-32-2; 4-Piperidinecarboxamide; Hexahydroisonicotinamide; 4-carbamoylpiperidine; UNII-CZE2810T4X; CZE2810T4X; DPBWFNDFMCCGGJ-UHFFFAOYSA-N; Piperidine-4-carboxylic acid amide; MFCD00038012; 4-Piperdinecarboxamide; Isonipecotamide, 98%; piperidin-4-carboxamid; iso nipecotamide; iso-nipecotamide; Isonipecotinamide; Piperidine-4-carboxylicacidamide; NSC82318; EINECS 254-501-6; NSC 82318; ISONIPECTOAMIDE; ACMC-20aipw; PubChem9754; Isonipecotic acid amide; 4-piperidine-carboxamide
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MOA Inhibitor
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CID: 3772
TTD: D0H4MB
 Compound Name C[RGDf-(S)-alpha-TfmF] Investigative [13]
Synonyms
CHEMBL204309
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CID: 9831456
TTD: D0I5BY
 Compound Name CYCLORGDFV Investigative [23]
Synonyms
cyclo(Arg-Gly-Asp-D-Phe-Val); CHEMBL411941; cyclo[Arg-Gly-Asp-D-Phe-Val]; Cyclo(-Arg-Gly-Asp-D-Phe-Val); 137813-35-5; c-[-Arg-Gly-Asp-fV-]; c[Arg-Gly-Asp-(R)-Phe-Val]; cyclo-(Arg-Gly-Asp-D-Phe-Val); Cyclo(Arg-Gly-Asp-D-Phe-Val-); cyclo(-Arg-Gly-Asp-D-Phe-Val-); BDBM50237601; ZINC17655303; NCGC00167283-01; [(2S,5R,8S,11S)-5-Benzyl-11-(3-guanidino-propyl)-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl]-acetic acid
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MOA Inhibitor
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CID: 9851104
TTD: D0ID6U
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp28-] Investigative [17]
Synonyms
CHEMBL270683
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CID: 24824620
TTD: D0J6SP
 Compound Name E[c(RGDyK)]2-PTX conjugate Investigative [19]
MOA Inhibitor
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CID: 91933274
TTD: D0K5DM
 Compound Name Cypate-[(RGD)3-NH2]1 Investigative [18]
MOA Inhibitor
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CID: 91936298
TTD: D0L2PQ
 Compound Name C[-Arg-Gly-Asp-Acpca19-] Investigative [15]
Synonyms
CHEMBL539338
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CID: 11569720
TTD: D0LF7W
 Compound Name Gly-Arg-Gly-Asp-Ser-Pro-Lys Investigative [24]
Synonyms
Grgdspk; 111119-28-9; Glycyl-arginyl-glycyl-aspartyl-seryl-prolyl-lysine; CHEMBL58763; AC1L2XSM; SCHEMBL891576; DTXSID20149506; HY-P0322; BDBM50079446; ZINC38989354; MFCD00076462; AKOS027382824; N2-(1-(N-(N-(N-(N2-Glycyl-L-arginyl)glycyl)-L-alpha-aspartyl)-L-seryl)-L-prolyl)-L-lysine; NCGC00167196-01; FT-0773649; Gly-Arg-Gly-Asp-Ser-Pro-Lys, > glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine; L-Lysine,glycyl-L-arginylglycyl-L-a-aspartyl-L-seryl-L-prolyl-
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CID: 130667
TTD: D0LV6B
 Compound Name C[RGDf-(R)-alpha-TfmF] Investigative [13]
Synonyms
CHEMBL381589
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CID: 11636164
TTD: D0M0BN
 Compound Name C[RGDf-(S)-N-Me-alpha-TfmF] Investigative [13]
Synonyms
CHEMBL413574
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MOA Inhibitor
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CID: 10372586
TTD: D0M6NQ
 Compound Name Cypate-[(RGD)4-NH2]2 Investigative [18]
MOA Inhibitor
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CID: 91936297
TTD: D0N9NA
 Compound Name C[-Arg-Gly-Asp-Acpca34-] Investigative [15]
Synonyms
CHEMBL534933
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MOA Inhibitor
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CID: 11584047
TTD: D0O6DN
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp24-] Investigative [17]
Synonyms
CHEMBL437072
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MOA Inhibitor
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CID: 24823110
TTD: D0O9FL
 Compound Name Cypate-[(RGD)2-NH2]1 Investigative [18]
Synonyms
CHEMBL438186
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MOA Inhibitor
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CID: 44409497
TTD: D0P4RB
 Compound Name N-(3,5-dichlorophenyl)imidodicarbonimidic diamide Investigative [25]
Synonyms
CHEMBL40929; 1672-93-1; Imidodicarbonimidic diamide, N-(3,5-dichlorophenyl)-; 1-(diaminomethylidene)-2-(3,5-dichlorophenyl)guanidine; AC1LBJDA; Maybridge1_007061; SCHEMBL891475; CTK7D2196; CTK0E5441; DTXSID50339817; 1-(3,5-dichlorophenyl)biguanide; BUXACHZAYWAZJL-UHFFFAOYSA-N; MolPort-003-943-662; ZINC4370978; ZX-AN037609; ALBB-022022; CCG-43794; STL482580; RJF 00091; BDBM50100971; AKOS003623024; MCULE-3366928787; CCG-245923; Biguanidine, 1-(3,5-dichlorophenyl)-; NCGC00331378-01
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MOA Inhibitor
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CID: 558969
TTD: D0R9AD
 Compound Name C[-Arg-Gly-Asp-Acpca22-] Investigative [15]
Synonyms
CHEMBL539850
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MOA Inhibitor
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CID: 11540715
TTD: D0R9GW
 Compound Name ST-1646 Investigative [17]
Synonyms
CHEMBL392303
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MOA Inhibitor
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CID: 44439175
TTD: D0R9SJ
 Compound Name Cyclo[RGDfK(cypate)] Investigative [18]
Synonyms
CHEMBL407126
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MOA Inhibitor
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CID: 44409643
TTD: D0T1II
 Compound Name 3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid Investigative [16]
Synonyms
CHEMBL220128; BDBM50323318; 3-phenyl-3-(3-(1,2,3,4-tetrahydroisoquinolin-7-ylcarbamoyl)benzamido)propanoic acid
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MOA Inhibitor
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CID: 44418281
TTD: D0TP8S
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp27-] Investigative [17]
Synonyms
CHEMBL272436
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MOA Inhibitor
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CID: 44456982
TTD: D0U0VF
 Compound Name C[RGD-(R)-alpha-TfmfV] Investigative [13]
Synonyms
CHEMBL377066
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MOA Inhibitor
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CID: 44408397
TTD: D0U2NV
 Compound Name C-[-Arg-Gly-Asp-Acpca33-] Investigative [15]
Synonyms
CHEMBL534712
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MOA Inhibitor
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CID: 11670104
TTD: D0UE7H
 Compound Name Cypate-[(RGD)3-NH2]2 Investigative [18]
MOA Inhibitor
External Link
CID: 91936296
TTD: D0UO0Y
 Compound Name C[RGD-(S)-alpha-TfmfV] Investigative [13]
Synonyms
CHEMBL379056
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MOA Inhibitor
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CID: 9986643
TTD: D0V0JC
 Compound Name C[-Arg-Gly-Asp-Acpca20-] Investigative [15]
Synonyms
CHEMBL540618
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MOA Inhibitor
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CID: 11656381
TTD: D0W6CJ
 Compound Name C[RGDf-(S,R)-alpha-Dfm-F] Investigative [13]
Synonyms
CHEMBL379911
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MOA Inhibitor
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CID: 11614485
TTD: D0WK2F
 Compound Name AcDRGDS Investigative [26]
Synonyms
CHEMBL241297; Acetyl-Asp-Arg-Gly-Asp-Ser-OH
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MOA Inhibitor
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CID: 10415998
TTD: D0X4EE
 Compound Name Cypate-[(RGD)4-NH2]1 Investigative [18]
MOA Inhibitor
External Link
CID: 91936299
TTD: D0Y8UD
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp23-] Investigative [17]
Synonyms
CHEMBL410050
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MOA Inhibitor
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CID: 24822282
TTD: D0Z6WZ
 Compound Name SB-265123 Investigative [27]
Synonyms
CHEMBL288493; SCHEMBL244383; HODBWQCCKYDYPY-NRFANRHFSA-N; {3-[3-(Pyridin-2-ylamino)-propoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl}-acetic acid; BDBM50078714; {(S)-3-[3-(Pyridin-2-ylamino)-propoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl}-acetic acid; (S)-10,11-Dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid
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MOA Inhibitor
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CID: 9952958
TTD: D0R3CY
 Compound Name C(-GRGDfL-) Investigative [28]
Synonyms
CHEMBL235999
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MOA Inhibitor
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CID: 15409414
TTD: D0B4JU
References
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Ref 13 Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study of their conformational and biological behavior. J Med Chem. 2006 Mar 9;49(5):1808-17. doi: 10.1021/jm0511334.
Ref 14 Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one scaffolds. Bioorg Med Chem. 2007 Dec 1;15(23):7380-90. doi: 10.1016/j.bmc.2007.07.049. Epub 2007 Aug 22.
Ref 15 Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. doi: 10.1021/jm050698x.
Ref 16 Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. doi: 10.1016/j.bmcl.2006.07.090. Epub 2006 Aug 21.
Ref 17 Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. doi: 10.1021/jm701214z. Epub 2008 Feb 28.
Ref 18 Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. doi: 10.1021/jm050947h.
Ref 19 Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J Med Chem. 2005 Feb 24;48(4):1098-106. doi: 10.1021/jm049165z.
Ref 20 alphavbeta3 Integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers. J Med Chem. 2009 Nov 26;52(22):7029-43. doi: 10.1021/jm901133z.
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Ref 22 Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32. doi: 10.1016/j.bmcl.2004.06.061.
Ref 23 Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics. J Med Chem. 2010 Jan 14;53(1):106-18. doi: 10.1021/jm9013532.
Ref 24 N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999 Aug 12;42(16):3033-40. doi: 10.1021/jm970832g.
Ref 25 Emerging targets in osteoporosis disease modification. J Med Chem. 2010 Jun 10;53(11):4332-53. doi: 10.1021/jm9018756.
Ref 26 Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2329-33. doi: 10.1016/j.bmcl.2007.01.073. Epub 2007 Jan 27.
Ref 27 1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41. doi: 10.1016/j.bmcl.2004.08.067.
Ref 28 Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81. doi: 10.1021/jm701044r. Epub 2007 Nov 1.