m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05876
 [1]
m6A modification OIP5-AS1 OIP5-AS1 IGF2BP2 : m6A sites Indirect Inhibition Non-coding RNA miR-495-3p MMP14  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
m6A Target OIP5 antisense RNA 1 (OIP5-AS1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator hsa-miR-495-3p microRNA View Details
Regulated Target Matrix metalloproteinase-14 (MMP14) View Details
Crosstalk Relationship m6A  →  ncRNA Inhibition
Crosstalk Mechanism m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways
Crosstalk Summary IGF2BP2 enhances the stability of OIP5 antisense RNA 1 (OIP5-AS1), thereby increasing the binding of OIP5-AS1 to hsa-miR-495-3p, weakening the binding of miR-495-3p to the 3'UTR of HIF1A and Matrix metalloproteinase-14 (MMP14) mRNA, and ultimately promoting the formation of VM in glioma.
Responsed Disease Glioma ICD-11: 2A00.00
 Disease Info 
Pathway Response Ubiquitin mediated proteolysis hsa04120
Cell Process Cell growth
In-vitro Model
 U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
U-251MG Astrocytoma Homo sapiens CVCL_0021
In-vivo Model The nude mice were divided into three groups: Control group, IGF2BP2-Wt and IGF2BP2-3KR. The animals were free to autoclaved food and water during the experiment. 3×105 cells were subcutaneously injected in the right flanks of the mice. Tumor volume was measured every 5 days and the volume was calculated by the formula: volume (mm3) = length width 2 /2.44 days after injection, mice were sacrificed and tumors were isolated. For survival analysis in orthotopic inoculations, 3×105 cells were stereotactically implanted into the right striatum of the mice. The number of survived nude mice was recorded, and survival analysis was performed using Kaplan Meier survival curve.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Matrix metalloproteinase-14 (MMP14) 15 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Epigallocatechin gallate Phase 3 [2]
Synonyms
(-)-Epigallocatechin gallate; EGCG; 989-51-5; Epigallocatechin 3-gallate; Epigallocatechin-3-gallate; Tea catechin; (-)-Epigallocatechin-3-o-gallate; Teavigo; Epigallocatechin-3-monogallate; (-)-Epigallocatechol gallate; (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate; Catechin deriv; UNII-BQM438CTEL; Green tea extract; CCRIS 3729; (-)-epigallocatechin 3-gallate; C22H18O11; BQM438CTEL; (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl; EGCG analogs; EGCG, Anagen; Epigallocatechin gallate analogs, Anagen; Epigallocatechin gallate, Anagen; GTPs,Anagen; Green tea polyphenols, Anagen; EPIGALOCATECHIN GALLATE
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 6800 nM
External Link
CID: 65064
TTD: D0U2BH
DrugBank: DB12116
 Compound Name BT1718 Phase 1/2a [3]
MOA Inhibitor
External Link
TTD: DE2Z7V
 Compound Name GM6001 Discontinued in Phase 2 [4]
Synonyms
Ilomastat; Galardin; 142880-36-2; GM 6001; Illomastat; CS 610; GM-6001; UNII-I0403ML141; CHEMBL19611; Ilomastat (GM6001, Galardin); I0403ML141; NCGC00163450-02; 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE; (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide; N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide; (R)-N(sup 1)-Hydroxy-N-((S)-2-indol-3-yl-1-(methylcarbamoyl)ethyl)-2-isobutylsuccinamide; (S-(R*,S*))-N(sup 4)-Hydroxy-N(sup
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.41 nM
External Link
CID: 132519
TTD: D0T9HG
DrugBank: DB02255
 Compound Name DX-2400 Investigative [5]
Synonyms
DX-2410; MMP inhibitors (fully human antibodies), Dyax
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D03XBB
 Compound Name PMID23631440C29e Investigative [6]
Synonyms
GTPL8578; BDBM50433865
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 4 nM
External Link
CID: 46175162
TTD: D07DRT
 Compound Name 2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide Investigative [7]
Synonyms
CHEMBL550148; 3f17; BDBM50294120
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 70 nM
External Link
CID: 25049753
TTD: D09ZOA
 Compound Name 2-(4-bromophenylsulfonamido)-N-hydroxyacetamide Investigative [7]
Synonyms
CHEMBL1090283; 1218922-39-4; SCHEMBL7413923
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 360 nM
External Link
CID: 22004198
TTD: D0NV9C
 Compound Name N-hydroxy-2-(4-methoxyphenylsulfonamido)acetamide Investigative [7]
Synonyms
CHEMBL83508; N-Hydroxy-N~2~-[(4-Methoxyphenyl)sulfonyl]glycinamide; Hydroxamate 9; Z79; 3lk8; SCHEMBL7410575; BDBM11328; (4-Methoxyphenylsulfonylamino)acetohydroximic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 210 nM
External Link
CID: 10445302
TTD: D0XK7G
 Compound Name UK-356618 Investigative [8]
Synonyms
UK 356618; 230961-08-7; CHEMBL117225; UK-356,618; SCHEMBL6437730; GTPL6528; CHEBI:94305; DTXSID50438778; MolPort-023-277-089; ZINC3924338; BDBM50097263; AKOS024458021; FT-0675728; PF 03890101; PF-03890101; UK-356618, > J-014983; BRD-K57011718-001-01-5; (R)-N*1*-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-2-[3-(2-methyl-biphenyl-4-yl)-propyl]-succinamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1900 nM
External Link
CID: 10370504
TTD: D0NP8A
 Compound Name 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide Investigative [9]
Synonyms
CHEMBL574589
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 8300 nM
External Link
CID: 44478925
TTD: D05THD
 Compound Name [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid Investigative [9]
Synonyms
CHEMBL573935
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5400 nM
External Link
CID: 44479701
TTD: D07MJD
 Compound Name N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide Investigative [9]
Synonyms
CHEMBL575896
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1300 nM
External Link
CID: 10155934
TTD: D0S9OL
 Compound Name SR-973 Investigative [10]
Synonyms
CHEMBL204357; SCHEMBL4486832; ZINC34801833; BDBM50182403; (2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-phenoxybenzyl)azepan-3-yl)-2-propylsuccinamide; (2R,3S)-N'-Hydroxy-N-[1-(3-phenoxybenzyl)-2,3,4,5,6,7-hexahydro-2-oxo-1H-azepine-3beta-yl]-2-isobutyl-3-propylbutanediamide
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1200 nM
External Link
CID: 9849669
TTD: D03AMR
 Compound Name IK-862 Investigative [11]
Synonyms
YDMIPBHQKFOFQW-NSYGIPOTSA-N; (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE; CHEMBL148169; CHEBI:40083; (2R)-N-hydroxy-2-[(3S)-3-methyl-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]propanamide; IK862; 2fv5; AC1OCAC0; BMCL181958 Compound 1; GTPL8680; SCHEMBL5966106; BDBM26526; IK682; DB07145; C468787000; (R)-2-[(3S)-2-Oxo-3alpha-[4-(2-methyl-4-quinolinylmethoxy)phenyl]-3-methylpyrrolizino]propanehydroximic; IK 862; compound 32; IK-682
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 15872 nM
External Link
CID: 6914621
TTD: D0W2UK
DrugBank: DB07145
 Compound Name MMI270 Investigative [12]
Synonyms
CGS-27023A; CGS-27023; UNII-80AXY59IT2; 80AXY59IT2; N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE; CHEMBL514138; (2R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-3-methylbutanamide; CGS; 1eub; MMI270B free base; hydroxamate analogue 1; 2w0d; 1bm6; MMI-270B free base; AC1L9JQY; 3MP-HAV-MSB; CGS-27023A free base; BMCL16311 Compound 1a; BDBM8465; SCHEMBL3468445; GTPL8846; CHEMBL267178; BSIZUMJRKYHEBR-QGZVFWFLSA-N; CGS 27023; BDBM50066658; DB07556; 161314-70-1
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 7.5 nM
External Link
CID: 446504
TTD: D0A4TC
DrugBank: DB07556
2A00: Brain cancer 53 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Zinostatin stimalamer Approved [13]
Synonyms
Smancs (TN)
    Click to Show/Hide
External Link
CID: 70682998
TTD: D0Z4PE
 Compound Name Motexafin gadolinium Approved [14]
Synonyms
Xcytrin; Gadolinium texaphyrin; GdT2B2; GD-Tex; Motexafin gadolinium (USAN); PCI-0120; Xcytrin (TN)
    Click to Show/Hide
External Link
CID: 158385
TTD: D05BJD
DrugBank: DB05428
 Compound Name Lomustine Approved [15]
Synonyms
Belustine; CCNU; CINU; Cecenu; CeeNU; Chloroethylcyclohexylnitrosourea; Lomustina; Lomustinum; Bristol Myers Squibb Brand of Lomustine; CCNU [Chloroethyl nitrosoureas]; Cyclohexyl chloroethyl nitrosourea; Lomustine medac Brand; Medac Brand of Lomustine; Rhone Poulenc Rorer Brand of Lomustine; OR5087; RB 1509; SRI 2200; Bristol-Myers Squibb Brand of Lomustine; CeeNU (TN); Lomustina [INN-Spanish]; Lomustinum [INN-Latin]; NPFAPI-06; Rhone-Poulenc Rorer Brand of Lomustine; CeeNU, CCNU, Lomustine; Lomustine (USAN/INN); Lomustine [USAN:BAN:INN]; N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea; (Chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea; (Cloro-2-etil)-1-cicloesil-3-nitrosourea; (Cloro-2-etil)-1-cicloesil-3-nitrosourea [Italian];1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea [Chloroethyl nitrosoureas]; 1-(2-Chloroethyl)-3-cyclohexylnitrosourea
    Click to Show/Hide
External Link
CID: 3950
TTD: D04JPJ
DrugBank: DB01206
 Compound Name Borocaptate sodium B 10 Approved [13]
External Link
TTD: D03EOT
 Compound Name DTI-015 Approved [16]
Synonyms
Carmustine; 154-93-8; 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin; Nitrumon; Carmubris; Gliadel; BiCNU; Bi CNU; Carmustinum; Bischlorethylnitrosurea; Bischlorethylnitrosourea; Carmustina; Becenun; Becenum; Bischloroethyl nitrosourea; N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA; Bis(2-chloroethyl)nitrosourea; Urea, N,N'-bis(2-chloroethyl)-N-nitroso-; Gliadel Wafer; FDA 0345; Bischloroethylnitrosourea; SRI 1720; 1,3-Bis(2-chloroethyl)nitrosourea; BiCNU (TN); Carmustinum [INN-Latin]; Carmustina [INN-Spanish]; DTI 015; NCI-C04773; SK; Injectable carmustine, Direct Therapeutics
    Click to Show/Hide
External Link
CID: 2578
TTD: D01OXI
DrugBank: DB00262
 Compound Name Prinomastat Approved [17]
Synonyms
AG-3354; AG-3362; Prinomastat (USAN/INN); (3S)-N-hydroxy-2,2-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonylthiomorpholine-3-carboxamide
    Click to Show/Hide
External Link
CID: 466151
TTD: D00MDP
DrugBank: DB05100
 Compound Name INO-1001 Phase 3 [18]
Synonyms
Hypoxanthine arabinoside; LT00454797; 9-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
    Click to Show/Hide
External Link
CID: 6708742
TTD: D0ZY3E
 Compound Name GliAtak Phase 3 [19]
Synonyms
GliAtak (TN)
    Click to Show/Hide
External Link
TTD: D0T3JF
 Compound Name SOT-107 Phase 3 [20]
Synonyms
TransMID
    Click to Show/Hide
External Link
TTD: D0QL4X
 Compound Name ICT-107 Phase 3 [21]
External Link
TTD: D0M1RD
 Compound Name Cintredekin besudotox Phase 3 [22]
External Link
TTD: D0G6RB
 Compound Name Rindopepimut Phase 3 [23]
External Link
TTD: D05FRP
 Compound Name DCVax-Ovarian Phase 3 [24]
Synonyms
DCVax-L; Dendritic cell-based immunotherapy (ovarian cancer), Northwest Biotherapeutics
    Click to Show/Hide
External Link
TTD: D02XEI
 Compound Name DCVax-Brain Phase 3 [25]
Synonyms
Dendritic cell-based immunotherapy (brain cancer), Northwest Biotherapeutics
    Click to Show/Hide
External Link
TTD: D02RED
 Compound Name TVI-Brain-1 Phase 2/3 [26]
External Link
TTD: D5A6JN
 Compound Name NLG8189 Phase 2/3 [27]
Synonyms
1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189
    Click to Show/Hide
External Link
CID: 405012
TTD: D0B5HS
DrugBank: DB12827
 Compound Name Synthetic survivin peptide vaccine Phase 2 [28]
External Link
TTD: DWZ02M
 Compound Name Fresolimumab Phase 2 [29]
Synonyms
GC-1008
    Click to Show/Hide
External Link
TTD: DB35WK
 Compound Name DNX-2401 Phase 2 [30]
Synonyms
Tasadenoturev
    Click to Show/Hide
External Link
TTD: D8SV9R
 Compound Name TVI-Brain-1 cancer vaccine Phase 2 [31]
External Link
TTD: D0ZR6E
 Compound Name PDT with Photofrin Phase 2 [27]
External Link
TTD: D0XL1T
 Compound Name F18-ML-10 Phase 2 [32]
External Link
TTD: D0K9NJ
 Compound Name PT2385 Phase 2 [33]
Synonyms
ONBSHRSJOPSEGS-INIZCTEOSA-N; PT-2385; UNII-6O16716DXP; 1672665-49-4; 6O16716DXP; SCHEMBL16555810; ZINC230453533; AKOS030526641; HY-12867; PT2385,1672665-49-4, PT 2385,PT-2385; Benzonitrile, 3-(((1S)-2,2-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl)oxy)-5-fluoro-; 3-{[(1s)-2,2-Difluoro-1-Hydroxy-7-(Methylsulfonyl)-2,3-Dihydro-1h-Inden-4-Yl]oxy}-5-Fluorobenzonitrile; 3-(((1S)-2,2-Difluoro-1-hydroxy-7-methanesulfonyl-2,3-dihydro-1hinden-4-yl)oxy)-5-fluorobenzonitrile; 79A
    Click to Show/Hide
External Link
CID: 91754484
TTD: D0C9PZ
 Compound Name ABT-414 Phase 2 [34]
External Link
TTD: D06XIT
 Compound Name CLR1404-I-124 Phase 1/2 [35]
External Link
TTD: D06EWT
 Compound Name DM-CHOC-PEN Phase 2 [36]
External Link
CID: 16126905
TTD: D02ZZU
DrugBank: DB15075
 Compound Name L-alanosine Phase 2 [37]
Synonyms
SDX-102
    Click to Show/Hide
External Link
CID: 135409347
TTD: D02ELS
DrugBank: DB05540
 Compound Name APX005M Phase 2 [27]
External Link
TTD: D01ZLK
 Compound Name WP-1066 Phase 1/2 [31]
Synonyms
WP1066; 857064-38-1; (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide; WP 1066; UNII-63V8AIE65T; 63V8AIE65T; AK-99218; C17H14BrN3O; (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide; MLS006010178; SCHEMBL1315826; QCR-16; SCHEMBL1315831; GTPL7972; CHEMBL1923234; EX-A760; AOB1497; DTXSID50235007; MolPort-044-723-708; MolPort-023-219-149; ZINC13983221; AKOS016007983; WP1066/WP-1066; CS-2736; DB12679; 2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-, (2E)-; HY-15312
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External Link
CID: 11210478
TTD: D0IV4C
DrugBank: DB12679
 Compound Name Anti-EGFRvIII CAR transduced PBL Phase 1/2 [38]
External Link
TTD: D08RJY
 Compound Name RG6156 Phase 1 [39]
External Link
TTD: DF8X5N
 Compound Name rhenium-186 Phase 1 [40]
Synonyms
(~186~Re)Rhenium; 14998-63-1; 186Re; DTXSID60933825; Q18882928; RHENIUM (186-RE); Rhenium Re-186; Rhenium, isotope of mass 186; Rhenium-186; RHENIUM-186 [WHO-DD]; UNII-ZU7F1ET6TM; ZU7F1ET6TM
    Click to Show/Hide
External Link
CID: 161105
TTD: DB7W8H
 Compound Name IGV-001 Phase 1 [41]
External Link
TTD: D9PM2E
 Compound Name DA-3607 Phase 1 [42]
Synonyms
Ad-stTRAIL; TRAIL adenoviral gene therapy (cancer), Dong-A
    Click to Show/Hide
External Link
TTD: D0V3ZX
 Compound Name DC/I540/KLH vaccine Phase 1 [43]
Synonyms
HTERT:540-548; Telomerase: 540-548 peptide vaccine; DC/I540/KLH vaccine (cancer); Dendritic cell/hTERT peptide I540/keyhole limpet hemocyanin vaccine, Dana-Farber; DC/I540/KLH vaccine (cancer), Dana-Farber
    Click to Show/Hide
External Link
TTD: D0RH3S
 Compound Name KX2-361 Phase 1 [44]
Synonyms
KX-02
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External Link
CID: 11545920
TTD: D0RE4L
 Compound Name MR1-1 Phase 1 [45]
Synonyms
MR1-1KDEL; EGFR-specific immunotoxin, IVAX; Anticancer immunotoxin (EGFR-specific), IVAX
    Click to Show/Hide
External Link
TTD: D0N3PC
 Compound Name INdoximod + temozolomide Phase 1 [31]
External Link
TTD: D0B8BY
 Compound Name Anti-CD133-CAR vector-transduced T cells Phase 1 [46]
External Link
TTD: D09HRH
 Compound Name 8H9 Phase 1 [47]
External Link
TTD: D06JAL
 Compound Name CC-8490 Phase 1 [48]
External Link
TTD: D03YGP
 Compound Name Sitimagene ceradenovec Discontinued in Phase 3 [49]
Synonyms
Cerepro; EG-009; HSV thymidine kinase gene therapy, Ark
    Click to Show/Hide
External Link
TTD: D0W8RX
 Compound Name Ranagengliotucel-T Discontinued in Phase 3 [50]
Synonyms
Glionix; Brain tumor vaccine, NovaRx; Antisense (TGFbeta) brain tumor vaccine, NovaRx
    Click to Show/Hide
External Link
TTD: D0N5AY
 Compound Name Oncolysin S Discontinued in Phase 2 [51]
Synonyms
N901-bR
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External Link
TTD: D0H0VW
 Compound Name Labradimil Discontinued in Phase 2 [52]
Synonyms
Cereport; Lobradimil; Receptor mediated permeabilizer; RMP 7; DRG-0182; RMP-7; N2-((S)-2-(L-Arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-L-prolinamido)-3-(p-methoxyphenyl)propyl)-L-arginine; (S-(R*,R*))-L-Arginyl-L-prolyl-trans-4-hydroxy-L-prolyl-3-(2-thienyl)-L-alanylglycyl-L-seryl-N-(2-((4-((aminoiminomethyl)amino)-1-carboxybutyl)amino)-1-((4-methoxyphenyl)methyl)ethyl)-L-prolinamide
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External Link
CID: 6918284
TTD: D0G0IZ
DrugBank: DB06549
 Compound Name Brain tumor vaccine Discontinued in Phase 1 [53]
Synonyms
Brain cancer vaccine, IRC; Brain tumor vaccine, IRC; IR-850; Established cancer cell line therapy (brain cancer), IRC; GM-CSF vaccine (brain cancer), IRC
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External Link
TTD: D0JT1P
 Compound Name PCNU Terminated [54]
Synonyms
NSC-95466
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External Link
CID: 26328
TTD: D0JI5G
 Compound Name 131I-81C6 Terminated [55]
Synonyms
Neuradiab; MAb-81C6; Iodine-131-81C6; Astatine-211-MAb-81C6; Iodine-131-MAb-81C6; Iodine-131-ch-81C6; Iodine-131-ch-81C6-F(ab)2; 211At-MAb-81C6
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External Link
TTD: D07ZKK
 Compound Name NSD-551 Terminated [56]
Synonyms
BK channel activator (cancer), NeuroSearch/TopoTarget
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External Link
TTD: D03QTB
 Compound Name AGT-2000 Investigative [57]
Synonyms
Gene therapy (intravenous, brain cancer), ArmaGen
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External Link
TTD: D0C5WE
 Compound Name NV.XOD.09 Investigative [58]
External Link
TTD: D02RDC
 Compound Name EDP-19 Investigative [58]
Synonyms
SiRNA (convection-enhanced delivery, brain tumor), Sheba Medical Center/BioLineRx
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External Link
TTD: D02JIF
 Compound Name MIQ-004 Investigative [58]
Synonyms
M-IQ-004
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External Link
TTD: D01KZV
References
Ref 1 SUMOylation of IGF2BP2 promotes vasculogenic mimicry of glioma via regulating OIP5-AS1/miR-495-3p axis. Int J Biol Sci. 2021 Jul 13;17(11):2912-2930. doi: 10.7150/ijbs.58035. eCollection 2021.
Ref 2 Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4171-4. doi: 10.1016/j.bmcl.2009.05.111. Epub 2009 Jun 2.
Ref 3 ClinicalTrials.gov (NCT03486730) BT1718 in Patients With Advanced Solid Tumours.. U.S. National Institutes of Health.
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